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All Journal Journal of Dentistry Indonesia Sriwijaya Journal of Dentistry Cakradonya Dental Journal
Sri Angky Soekanto
Department Of Oral Biology, Faculty Of Dentistry, Universitas Indonesia
Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Public Health

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Mechanism Underlying the Alveolar Bone Destruction by Prevotella intermedia: Systematic Review Erik Idrus; Sammy Fajar Nugraha; Sri Angky Soekanto
Sriwijaya Journal of Dentistry Vol. 4 No. 1 (2023): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjd.v4i1.40

Abstract

Introduction: Periodontitis is an inflammatory disorder caused by oral microorganisms, including Prevotella intermedia, that destroy the periodontal ligament and alveolar bone. The detailed mechanism of P. intermedia-inducing bone damage is essential to establish a novel approach to controlling P. intermedia that prevents alveolar bone loss. Purpose: To elucidate the mechanism of P. intermedia's role in alveolar bone destruction by systematically reviewing various related publications. Methods: From September 2020 through February 2021, this systematic review was performed by selecting publications for relevant material from two electronic databases, PubMed and Scopus. The literature must be in English, published within the last ten years, be available in full-text form, and be a research article to meet the criteria for inclusion. Results: Three final articles passed the eligibility evaluation stage and met the inclusion requirements. They all discussed how P. intermedia lipopolysaccharide (LPS) affects target cells to destroy bone, including human dental follicle stem cells (hDFSCs), human periodontal ligament fibroblasts (hPDLs), and macrophages. Tumor necrosis factor (TNF), interleukin-6 (IL-6), IL-8, and prostaglandin E2 (PGE2) are a few of the inflammatory mediators that LPS P. intermedia cause a rise in target cells, leading to bone damage. These inflammatory mediators stimulate nuclear factor-kappa ligand receptor (RANKL) expression, resulting in osteoclast activation and differentiation, leading to bone loss. Conclusion: P. intermedia significantly contributes to alveolar bone degradation by enhancing inflammatory mediators. As observed in periodontitis, these mediators stimulate RANKL expression and osteoclast activation, resulting in alveolar bone damage.
Analysis of Bone Destruction Mechanism by Aggregatibacter Actinomycetemcomitans: A Systematic Review Idrus, Erik; Ardiman, Karenina Raihani Amalia; Lestari, Widya; Mandasari, Masita; Soekanto, Sri Angky
Journal of Dentistry Indonesia Vol. 31, No. 2
Publisher : UI Scholars Hub

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Abstract

Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor. Objective : To systematically review the mechanism of bone destruction by A. actinomycetecomitans based on its interaction with bone cells and its precursors. Methods: A comprehensive search was performed in two database (Scopus, PubMed) from September 2021 to June 2022, according to the Preferred Reporting Items for SystematicvReviews and Meta-Analyses (PRISMA) protocol. The terms used in the search were ”Aggregatibacter actinomycetemcomitans” OR “A. actinomycetemcomitans” AN” bone”OR “bone loss” OR “bone destruction” OR “bone resorption” OR “bone formation” OR “bone remodelling” OR “osteclast” OR “osteoblast” OR “osteocyte”. Only articles in English and research articles published within ten years were included. Results: In total, nine articles discussing alveolar bone destruction were included in the review. Most articles reported the virulence of A. actinomycetecomitans, lipopolysaccharide (LPS), and its target cells, osteoclast progenitors, osteoclasts, and osteoblasts. Conclusion: A. actinomycetecomitans induces alveolar bone destruction via various mechanisms, including osteoblast apoptosis, lowering osteoblast differentiation, increasing osteoclast activity and differentiation, and releasing inflammatory cytokines. The detailed interaction mechanisms between A. actinomycetecomitans and bone cells would provide valuable hints for further investigation toward constructing specific inhibitors to disrupt the interaction between A. actinomycetecomitans and bone cells that eventually protect the alveolar bone destruction.
The Role of Veillonella in The Pathogenesis of Periodontitis: Systematic Review Rohmah, Devi Kartika; Soekanto, Sri Angky; Djais, Ariadna Adisattya; Theodorea, Citra Fragrantia; Sastradipura, Dewi Fatma Suniarti
Cakradonya Dental Journal Vol 17, No 2 (2025): Agustus 2025
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v17i2.43973

Abstract

Veillonella is a common species found in the human oral cavity that plays a significant role in biofilm ecology. Veillonella is known to play a supporting role in colonizing other, more pathogenic species. Its abundant presence in supra- and sub-gingival biofilms is thought to have an associated relationship with red-complex bacterial species. These bacteria are known to be the causative of periodontal disease. Their ability to establish this mutualistic relationship is an important factor that we need to know to expand our understanding of their relationship to the pathogenesis of periodontal disease and to develop more effective treatments.
Co-Authors Ardiman, Karenina Raihani Amalia Djais, Ariadna Adisattya Erik Idrus LESTARI, WIDYA Mandasari, Masita Rohmah, Devi Kartika Sammy Fajar Nugraha Sastradipura, Dewi Fatma Suniarti Theodorea, Citra Fragrantia