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All Journal E-JOURNAL MANAJEMEN FE UNTAD Journal of Dentistry Indonesia As-syifaa Jurnal Farmasi Ad-Man-Pend (Jurnal Administarsi Manajemen Pendidikan) Makara Journal of Health Research
LESTARI, WIDYA
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Other

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PENGARUH AKTIVITAS, MINAT DAN OPINI TERHADAP KEPUTUSAN KONSUMEN MENGGUNAKAN JASA SALON CHIQUITA DI KOTA PALU LESTARI, WIDYA
JURNAL ILMU MANAJEMEN UNIVERSITAS TADULAKO Vol 1, No 1 (2015)
Publisher : Fakultas Ekonomi Universitas Tadulako

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Abstract

The purpose of the research is to find out the influence of activity, interest, and opinion on consumer decision in using Chiquita Salon in Palu City. There are 4 variables that used in this research; activity (X1), interest (X2), opinion (X3), and decision of the consumer (Y). Method of study is descriptive causal with a total sample of 60 respondents, who were selected by purposive sampling. Tool of analysis is multiple linear regressions with Software SPPS 17. The result finds that activity (X1), interest (X2), and opinion (X3) simultaneously influence the decision of the consumer in using Chiquita Salon in Palu City, with the level of significance of 0.000 < ? 0.05. Furthermore, activity (X1) with the t-sig. value of 0.042; interest (X2) has the t-sig. value of 0.022; opinion (X3) has the t-sig. value of 0.001. These values are < 0.05, which means that each variable partially influences the decision of the consumer in using Chiquita Salon in Palu City.
APLIKASI MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN HASIL BELAJAR SISWA MATERI ADMINISTRASI UMUM KELAS X AKL 1 SMK MUHAMMADIYAH 2 PALEMBANG Lestari, Widya; Petrossky, Rhyta
Ad-Man-Pend : Jurnal Administrasi Manajemen Pendidikan Vol 1, No 2 (2018): Ad-Man-Pend: Jurnal Administrasi Manajemen Pendidikan
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/amp.v1i2.1682

Abstract

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa kelas X AKL 1  SMK Muhammadiyah 2 Palembang tahun pelajaran 2018/2019 melalui penerapan model discovery learning.  Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam tiga siklus, masing-masing dua kali pertemuan untuk semua siklus.  Pengmpulan data dengan menggunakan lembar tes, lembar observasi dan kajian terhadap dokumen yang ada.  Hasil penelitian dapat disimpulkan bahwa hasil belajar administrasi umum meningkat setelah diterapkan dengan model pembelajaran discovery learning.  Ketercapaian hasil belajar pada siklus I sebesar 48,38%, pada siklus II 61,29% dan siklus III 100%. 
PROFIL KADAR GLUKOSA DARAH PASIEN DIABETES MELLITUS TIPE 2 YANG MENGGUNAKAN ATORVASTATIN 20 MG DI RUMAH SAKIT MADANI, ANUTAPURA DAN UNDATA PERIODE 2015-2019 Lestari, Widya; Mukaddas, Alwiyah
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.607

Abstract

Atorvastatin is one of the lipophilic statins that can cause diabetes through some mechanisms, such as liphophilic properties, it’s activities to insulin secretion, insulin signaling, and adiponectin levels. The purpose of this research is to know demographic data, profile of when blood sugar levels, and the time needed for atorvastatin to increase blood sugar when type 2 diabetes mellitus patients use atorvastatin for 20 mg. This research is observational descriptive research with retrospective data collection approach by looking at the usage of atorvastatin, with total samples 22 patients obtained from medical record data at Madani hospital, Anutapura and Undata in Palu in the period of 2015-2019. This research result shows that the demographic data of the average age of type 2 diabetes mellitus patients in which complications of dysplidemia that uses atorvastatin for 20 mg are in the age of 45-56 years old, female gender (57.14%), with the last education of Senior High School (38.09%) and occupation as Government Employees (33.33%), the time needed for atorvastatin 20 mg to increase blood sugar is 2 months (the difference is 26.38 mg/dl; percentage 19.52%) and the percentage of highest blood sugar increase is one year, which is 93.91%.
Gene expression of selected apoptotic markers in human oral squamous carcinoma HSC-3 cell line treated with Myrmecodia pendans plant extract Lestari, Widya; Yusry, Wan N A W; Iskandar, Siti H; Ichwan, Solachuddin J A; Irfan, Nining I; Suriyah, Wastuti H
Makara Journal of Health Research Vol. 23, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Myrmecodia pendans (M. pendans), or Sarang Semut, is an epiphyte with anticancer potential. It was recently reported that it induces apoptotic activity in the human oral squamous carcinoma (HSC-3) cell line. This study aimed to investigate the effect of M. pendans treated samples on the expression of apoptotic markers, Bax and Bcl-2. Methods: M. pendans was purchased from West Papua, Indonesia. The hypocotyl was dried thoroughly and then extracted aqueously. The apoptotic activity was detected via flow cytometry. Bax and Bcl-2 expression was analyzed by quantitative real-time polymerase chain reaction. Results: Results of our cell cycle analysis reveal that aqueous extract of M. pendans induced apoptosis in 2.5 and 5 mg/mL but no change between these two concentrations. Apoptosis was observed at 24 h but not at 48 h. Bax and Bcl-2 expression in HSC-3 cells was affected by M. pendans. At 24 h, upregulation of Bax was observed at 2.5 mg/mL. However, after 48 h, Bax expression showed no changes at any concentration. Bcl-2 was significantly downregulated after 48 h of treatment. Conclusions: M. pendans extract induced apoptosis in HSC-3 cells, which might occur via the proapoptotic (Bax) and antiapoptotic (Bcl-2) pathways
Effects of Flaxseed (Linum usitatissimum) Extract on the Osteoblast Differentiation Potential of Stem Cells Derived from Human Exfoliated Deciduous Teeth Nordin, Nur Sazwi; Mokhtar, Khairani Idah; Mustafa, Basma Ezzat; Lestari, Widya; Ichwan, Solachuddin JA Ichwan Jauhari Ichwan; Darnis, Deny Susanti; Kannan, Thirumulu Ponnuraj; Ahmad, Azlina
Makara Journal of Health Research Vol. 25, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Flaxseed promotes bone health and possibly induces bone regeneration. However, the capacity of flaxseed to induce the differentiation of stem cells into osteoblasts remains unreported. Accordingly, this study aimed to determine the effects of flaxseed extract on the osteoblast differentiation potential of stem cells derived from human exfoliated deciduous teeth (SHED). Methods: SHED cultured in osteoblast induction media (OIM) were treated with 4 mg/mL flaxseed extract. RNA was collected and extracted with Total RNA Mini Kit (Geneaid) from cells cultured at days 1, 3, 7, 14, and 21 and subjected to reverse-transcriptase PCR for osteoblast markers (OSX, OCN, and DMP1). Alkaline phosphatase (ALP) activity was determined by ALP assay, and Alizarin Red-S staining was performed to evaluate calcium deposition in SHED. Results: All osteoblast markers were expressed in all samples analyzed. OSX expression was reduced in the SHED treated with flaxseed extract. In addition, the SHED treated with flaxseed extract had lower ALP activity than the control (p < 0.05). Calcium deposition was positive in the SHED cultured in OIM only. Conclusions: Flaxseed can reduce the expression of osteoblast markers, ALP activity, and calcium deposition in SHED. Thus, flaxseed potentially inhibits the osteoblast differentiation of SHED.
Analysis of Bone Destruction Mechanism by Aggregatibacter Actinomycetemcomitans: A Systematic Review Idrus, Erik; Ardiman, Karenina Raihani Amalia; Lestari, Widya; Mandasari, Masita; Soekanto, Sri Angky
Journal of Dentistry Indonesia Vol. 31, No. 2
Publisher : UI Scholars Hub

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Abstract

Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor. Objective : To systematically review the mechanism of bone destruction by A. actinomycetecomitans based on its interaction with bone cells and its precursors. Methods: A comprehensive search was performed in two database (Scopus, PubMed) from September 2021 to June 2022, according to the Preferred Reporting Items for SystematicvReviews and Meta-Analyses (PRISMA) protocol. The terms used in the search were ”Aggregatibacter actinomycetemcomitans” OR “A. actinomycetemcomitans” AN” bone”OR “bone loss” OR “bone destruction” OR “bone resorption” OR “bone formation” OR “bone remodelling” OR “osteclast” OR “osteoblast” OR “osteocyte”. Only articles in English and research articles published within ten years were included. Results: In total, nine articles discussing alveolar bone destruction were included in the review. Most articles reported the virulence of A. actinomycetecomitans, lipopolysaccharide (LPS), and its target cells, osteoclast progenitors, osteoclasts, and osteoblasts. Conclusion: A. actinomycetecomitans induces alveolar bone destruction via various mechanisms, including osteoblast apoptosis, lowering osteoblast differentiation, increasing osteoclast activity and differentiation, and releasing inflammatory cytokines. The detailed interaction mechanisms between A. actinomycetecomitans and bone cells would provide valuable hints for further investigation toward constructing specific inhibitors to disrupt the interaction between A. actinomycetecomitans and bone cells that eventually protect the alveolar bone destruction.
Co-Authors Alwiyah Mukaddas Ardiman, Karenina Raihani Amalia Azlina Ahmad, Azlina Daniel Happy Putra Erik Idrus Ichwan, Solachuddin J A Ichwan, Solachuddin JA Ichwan Jauhari Ichwan Irfan, Nining I Iskandar, Siti H Kannan, Thirumulu Ponnuraj Mandasari, Masita Mokhtar, Khairani Idah Mustafa, Basma Ezzat Nordin, Nur Sazwi Petrossky, Rhyta Sri Angky Soekanto Suriyah, Wastuti H Yusry, Wan N A W