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Shetty, Shishir Ram
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Dentistry

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Status of Salivary Nitric Oxide Levels and Buccal Epithelial Cell DNA Damage in Potentially Malignant Disorders – A Biochemical Study KA, Fazil; Castelino, Renita Lorina; Babu, Subhas Gogineni; Madi, Medhini; Shetty, Shishir Ram; Balan, Preethi; Bhat, Supriya
Journal of Dentistry Indonesia Vol. 24, No. 2
Publisher : UI Scholars Hub

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Oral cancer is a progressive, multistage disease in which changes in genetic structure and cellular morphology occur from the normal to the premalignant state and then to the malignant state. Nitric oxide (NO.) is an uncharged molecule with an unpaired electron. It is highly reactive and interacts with DNA molecules, resulting in DNA damage. Objective: To evaluate the salivary nitric oxide levels and buccal epithelial cell DNA damage in patients with potentially malignant oral disorders. Methods: The salivary nitric oxide levels and buccal epithelial cell DNA damage were estimated in 20 healthy individuals without oral lesions, in 20 subjects having smoking and/or tobacco chewing habits without oral lesions, and 20 patients with a potentially malignant oral disorder. Results: The salivary nitric oxide levels were significantly greater in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Similarly, the extent of DNA damage was higher in the subjects with potentially malignant disorders and in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Conclusion: The encouraging results of the present study indicated the potential involvement of nitric oxide in the pathogenesis of potentially malignant oral disorders.
Assessment of Serum and Salivary Vitamin E Levels in Oral Potentially Malignant Disorders and Oral Cancer Bhat, Supriya; Babu, Subhas; Kumari, Suchetha; Shetty, Shishir Ram; Kamath, Vinayak; Bhat, Saidath; Areekat, Fazil K; Madi, Medhini; Achalli, Sonika; Madiyal, Ananya
Journal of Dentistry Indonesia Vol. 25, No. 1
Publisher : UI Scholars Hub

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An increase in lipid peroxidation and a decrease in antioxidant activity have been reported in patients with cancer in comparison with normal subjects. Objective: To estimate the status of serum and saliva by assessing the serum and salivary vitamin E levels in patients with oral potentially malignant disorders and oral cancer. Methods: A total of 90 participants were enrolled in this study. 30 subjects with oral potentially malignant disorders, 30 sub¬jects with oral cancer, and 30 healthy subjects (controls). Serum and saliva samples were collected and vitamin E levels were assessed. The data were analyzed using ANOVA for between-group comparison. Post hoc Tukey analysis was used for comparing the two study groups with the control group. Pearson correlation coefficient was used to determine concordance between the groups. Results: Mean vitamin E levels in serum and saliva were sig¬nificantly decreased in oral potentially malignant disorders and oral cancer compared with controls. Conclusion: As significant reduction in vitamin E levels was observed in saliva, it was evident that salivary vitamin E levels potentially be used as a reliable, non invasive biomarker for diagnosing and managing oral potentially malignant disorders and oral cancer.
Co-Authors Achalli, Sonika Areekat, Fazil K Babu, Subhas Balan, Preethi Bhat, Saidath KA, Fazil Kamath, Vinayak Kumari, Suchetha Madi, Medhini Madiyal, Ananya Renita Lorina Castelino, Renita Lorina Subhas Gogineni Babu, Subhas Gogineni Supriya Bhat, Supriya