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All Journal Journal of Dentistry Indonesia
Renita Lorina Castelino, Renita Lorina
Senior Lecturer MDS Department of Oral Medicine and Radiology A B Shetty Memorial Institute of Dental Sciences NitteUniversity Mangalore- 575018
Dentistry

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Status of Salivary Nitric Oxide Levels and Buccal Epithelial Cell DNA Damage in Potentially Malignant Disorders – A Biochemical Study KA, Fazil; Castelino, Renita Lorina; Babu, Subhas Gogineni; Madi, Medhini; Shetty, Shishir Ram; Balan, Preethi; Bhat, Supriya
Journal of Dentistry Indonesia Vol. 24, No. 2
Publisher : UI Scholars Hub

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Oral cancer is a progressive, multistage disease in which changes in genetic structure and cellular morphology occur from the normal to the premalignant state and then to the malignant state. Nitric oxide (NO.) is an uncharged molecule with an unpaired electron. It is highly reactive and interacts with DNA molecules, resulting in DNA damage. Objective: To evaluate the salivary nitric oxide levels and buccal epithelial cell DNA damage in patients with potentially malignant oral disorders. Methods: The salivary nitric oxide levels and buccal epithelial cell DNA damage were estimated in 20 healthy individuals without oral lesions, in 20 subjects having smoking and/or tobacco chewing habits without oral lesions, and 20 patients with a potentially malignant oral disorder. Results: The salivary nitric oxide levels were significantly greater in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Similarly, the extent of DNA damage was higher in the subjects with potentially malignant disorders and in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Conclusion: The encouraging results of the present study indicated the potential involvement of nitric oxide in the pathogenesis of potentially malignant oral disorders.
A Rare Case of Oral Erythema Multiforme: A Case Report with a Literature Review Buch, Sajad Ahmad; Babu, Subhas G; Castelino, Renita Lorina; Rao, Shruthi; Rao, Kumuda; Pillai, Devika S
Journal of Dentistry Indonesia Vol. 24, No. 2
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Erythema multiforme (EM) is an acute mucocutaneous hypersensitivity reaction characterized by skin eruptions with or without oral or other mucous membrane lesions. The main two variants are erythema minor and erythema major. Oral disease with typical EM lesions has been suggested as a third variant of EM. Known as oral EM, it is reported less and has no target lesions unlike the other two types, in its primary presentation. Objective: To report a manifestation of a rare case of oral EM and discuss various forms of EM including its management. Case report: A 22-year-old male patient reported with a complaint of oral and lip ulcers and severe pain for the past 7 days. The patient reported spontaneous onset of the lesions in the form of vesicles after consuming unknown artificially colored food items. The vesicles ruptured within two days leaving ulcers on the lips and the intraoral mucosa, with blood encrustations. The patient was unable to take food, was admitted for hydration, and was kept on corticosteroids. It took around three weeks for the patient to completely recover. Conclusion: The positive his¬tory of artificially colored food intake followed by the sudden onset of lesions and eruptions on the lips and oral mucosa led us to the diagnosis of oral EM. Early recognition and timely intervention benefits patients because the lesions associated with EM and related disorders can compromise life.
Binder’s Syndrome – An Unusual Craniofacial Anomaly Madiyal, Ananya; Babu, Subhas; Ajila, Vidya; Castelino, Renita Lorina; Rao, Kumuda; Madi, Medhini
Journal of Dentistry Indonesia Vol. 25, No. 1
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Binder’s syndrome or maxillonasal dysostosis is a rare congenital condition that primarily affects the mid-face and sometimes the vertebrae. It was named after von Binder who described three cases of hypoplastic maxilla-nasal complex in 1962. It can either occur as a sporadic mutation or may be inherited in an autosomal recessive pattern with incomplete penetrance. Decrease in the naso-labial angle, flat forehead, dish-shaped face, absence of protrusion of nasal tip, absence of nasal flare with triangular or semilunar nostrils, palpable depression in the nasal floor and a class III tendency are characteristic of the syndrome. Vertebral anomalies are seen in some patients owing to the parallel development of the nasal complex and vertebrae in the third month of intrauterine life. Prenatal diagnosis may be done using ultrasonography at 21 weeks of pregnancy. A multi-disciplinary approach towards planning of treatment for individuals with Binder’s syndrome includes orthodontic treatment along with osteotomies and grafting to correct the nasal and mid-face defects.
Atypical Presentation of Lateral Periodontal Cyst in an Elderly Female Patient – A Rare Case Report Castelino, Renita Lorina; Rao, Kumuda; Bhat, Supriya; Babu, Subhas Gogineni
Journal of Dentistry Indonesia Vol. 23, No. 1
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elderly, lateral periodontal cyst, odontogenic cyst, residual cyst
Co-Authors Ajila, Vidya Babu, Subhas Babu, Subhas G Balan, Preethi Buch, Sajad Ahmad KA, Fazil Kumuda Rao, Kumuda Madi, Medhini Madiyal, Ananya Pillai, Devika S Rao, Shruthi Shetty, Shishir Ram Subhas Gogineni Babu, Subhas Gogineni Supriya Bhat, Supriya