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Madi, Medhini
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Dentistry

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Status of Salivary Nitric Oxide Levels and Buccal Epithelial Cell DNA Damage in Potentially Malignant Disorders – A Biochemical Study KA, Fazil; Castelino, Renita Lorina; Babu, Subhas Gogineni; Madi, Medhini; Shetty, Shishir Ram; Balan, Preethi; Bhat, Supriya
Journal of Dentistry Indonesia Vol. 24, No. 2
Publisher : UI Scholars Hub

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Oral cancer is a progressive, multistage disease in which changes in genetic structure and cellular morphology occur from the normal to the premalignant state and then to the malignant state. Nitric oxide (NO.) is an uncharged molecule with an unpaired electron. It is highly reactive and interacts with DNA molecules, resulting in DNA damage. Objective: To evaluate the salivary nitric oxide levels and buccal epithelial cell DNA damage in patients with potentially malignant oral disorders. Methods: The salivary nitric oxide levels and buccal epithelial cell DNA damage were estimated in 20 healthy individuals without oral lesions, in 20 subjects having smoking and/or tobacco chewing habits without oral lesions, and 20 patients with a potentially malignant oral disorder. Results: The salivary nitric oxide levels were significantly greater in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Similarly, the extent of DNA damage was higher in the subjects with potentially malignant disorders and in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Conclusion: The encouraging results of the present study indicated the potential involvement of nitric oxide in the pathogenesis of potentially malignant oral disorders.
Binder’s Syndrome – An Unusual Craniofacial Anomaly Madiyal, Ananya; Babu, Subhas; Ajila, Vidya; Castelino, Renita Lorina; Rao, Kumuda; Madi, Medhini
Journal of Dentistry Indonesia Vol. 25, No. 1
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Binder’s syndrome or maxillonasal dysostosis is a rare congenital condition that primarily affects the mid-face and sometimes the vertebrae. It was named after von Binder who described three cases of hypoplastic maxilla-nasal complex in 1962. It can either occur as a sporadic mutation or may be inherited in an autosomal recessive pattern with incomplete penetrance. Decrease in the naso-labial angle, flat forehead, dish-shaped face, absence of protrusion of nasal tip, absence of nasal flare with triangular or semilunar nostrils, palpable depression in the nasal floor and a class III tendency are characteristic of the syndrome. Vertebral anomalies are seen in some patients owing to the parallel development of the nasal complex and vertebrae in the third month of intrauterine life. Prenatal diagnosis may be done using ultrasonography at 21 weeks of pregnancy. A multi-disciplinary approach towards planning of treatment for individuals with Binder’s syndrome includes orthodontic treatment along with osteotomies and grafting to correct the nasal and mid-face defects.
Assessment of Serum and Salivary Vitamin E Levels in Oral Potentially Malignant Disorders and Oral Cancer Bhat, Supriya; Babu, Subhas; Kumari, Suchetha; Shetty, Shishir Ram; Kamath, Vinayak; Bhat, Saidath; Areekat, Fazil K; Madi, Medhini; Achalli, Sonika; Madiyal, Ananya
Journal of Dentistry Indonesia Vol. 25, No. 1
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An increase in lipid peroxidation and a decrease in antioxidant activity have been reported in patients with cancer in comparison with normal subjects. Objective: To estimate the status of serum and saliva by assessing the serum and salivary vitamin E levels in patients with oral potentially malignant disorders and oral cancer. Methods: A total of 90 participants were enrolled in this study. 30 subjects with oral potentially malignant disorders, 30 sub¬jects with oral cancer, and 30 healthy subjects (controls). Serum and saliva samples were collected and vitamin E levels were assessed. The data were analyzed using ANOVA for between-group comparison. Post hoc Tukey analysis was used for comparing the two study groups with the control group. Pearson correlation coefficient was used to determine concordance between the groups. Results: Mean vitamin E levels in serum and saliva were sig¬nificantly decreased in oral potentially malignant disorders and oral cancer compared with controls. Conclusion: As significant reduction in vitamin E levels was observed in saliva, it was evident that salivary vitamin E levels potentially be used as a reliable, non invasive biomarker for diagnosing and managing oral potentially malignant disorders and oral cancer.
Co-Authors Achalli, Sonika Ajila, Vidya Areekat, Fazil K Babu, Subhas Balan, Preethi Bhat, Saidath KA, Fazil Kamath, Vinayak Kumari, Suchetha Kumuda Rao, Kumuda Madiyal, Ananya Renita Lorina Castelino, Renita Lorina Shetty, Shishir Ram Subhas Gogineni Babu, Subhas Gogineni Supriya Bhat, Supriya