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All Journal Journal of Dentistry Indonesia
Subhas Gogineni Babu, Subhas Gogineni
Prof & HOD Department of Oral Medicine And Radiology A B Shetty Memorial Institute Of Dental Sciences NitteUniversity Mangalore- 575018
Dentistry

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Status of Salivary Nitric Oxide Levels and Buccal Epithelial Cell DNA Damage in Potentially Malignant Disorders – A Biochemical Study KA, Fazil; Castelino, Renita Lorina; Babu, Subhas Gogineni; Madi, Medhini; Shetty, Shishir Ram; Balan, Preethi; Bhat, Supriya
Journal of Dentistry Indonesia Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Oral cancer is a progressive, multistage disease in which changes in genetic structure and cellular morphology occur from the normal to the premalignant state and then to the malignant state. Nitric oxide (NO.) is an uncharged molecule with an unpaired electron. It is highly reactive and interacts with DNA molecules, resulting in DNA damage. Objective: To evaluate the salivary nitric oxide levels and buccal epithelial cell DNA damage in patients with potentially malignant oral disorders. Methods: The salivary nitric oxide levels and buccal epithelial cell DNA damage were estimated in 20 healthy individuals without oral lesions, in 20 subjects having smoking and/or tobacco chewing habits without oral lesions, and 20 patients with a potentially malignant oral disorder. Results: The salivary nitric oxide levels were significantly greater in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Similarly, the extent of DNA damage was higher in the subjects with potentially malignant disorders and in the subjects with tobacco chewing and/or smoking habits without oral lesions than in the healthy controls. Conclusion: The encouraging results of the present study indicated the potential involvement of nitric oxide in the pathogenesis of potentially malignant oral disorders.
Atypical Presentation of Lateral Periodontal Cyst in an Elderly Female Patient – A Rare Case Report Castelino, Renita Lorina; Rao, Kumuda; Bhat, Supriya; Babu, Subhas Gogineni
Journal of Dentistry Indonesia Vol. 23, No. 1
Publisher : UI Scholars Hub

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elderly, lateral periodontal cyst, odontogenic cyst, residual cyst
Co-Authors Balan, Preethi KA, Fazil Kumuda Rao, Kumuda Madi, Medhini Renita Lorina Castelino, Renita Lorina Shetty, Shishir Ram Supriya Bhat, Supriya