This study was prompted by the widespread phenomenon of homesickness among female boarders (mahasantri) at Ma'had Al-Jami'ah UIN Sjech M. Djamil Djambek Bukittinggi, manifesting in nostalgia for family life, emotional despondency, social alienation, and adjustment hurdles within a novel residential setting. The primary objective was to evaluate the distinct (partial) and combined (simultaneous) impacts of locus of control and social support on homesickness among these female students. Employing a quantitative approach with a descriptive-associative framework, the research surveyed a representative sample of 212 respondents drawn from a total population of 453 using proportional random sampling. Data were gathered via structured instruments assessing locus of control, social support, and homesickness, followed by analytical processing through simple and multiple linear regressions executed on SPSS software. Statistical outcomes validated that locus of control independently exerts a significant effect on homesickness. Specifically, the internal dimension demonstrated a inverse, statistically significant association (p = 0.000 < 0.05) accounting for a 14.9% contribution, signifying that reinforced internal locus of control corresponds to a diminished degree of homesickness. Conversely, the external dimension revealed a direct, significant correlation (p = 0.000 < 0.05) with a 16.9\% influence, suggesting that a strong external orientation intensifies homesickness. Additionally, social support independently exhibited a negative, significant effect (p = 0.000 < 0.05) contributing 13.1\%, proving that augmented social support effectively mitigates the severity of homesickness. Collectively, locus of control and social support exerted a significant joint impact on homesickness (p = 0.000 < 0.05), jointly explaining 23.4% of the variance, whereas the remaining 76.6% was governed by extraneous factors beyond the scope of this model. In conclusion, both internal dynamics and social assistance serve as pivotal determinants of homesickness in this demographic, highlighting the need for future studies to incorporate additional extraneous variables for a more holistic perspective.