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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Journal of International Surgery and Clinical Medicine Indonesian Journal of Biomedicine and Clinical Sciences
Hakim, Fikar Arsyad
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Social Sciences Other

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Juvenile ossifying fibroma accompanied with low-grade central osteosarcoma in sinonasal: a rare case report Solichin, Muchamad Ridotu; Hakim, Fikar Arsyad; Dwianingsih, Ery Kus
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.15911

Abstract

Sinonasal osteosarcoma is comparatively rare and accounts for 6.5% of all osteosarcomas. The five-year survival rate is less than 25% and may be improved to 60% when chemotherapy is initiated earlier. The diagnosis of low-grade central osteosarcoma requires a meticulous histopathological examination because histopathologically the tumor may mimic fibro-osseus neoplasm. We report a 12 y.o. male patient who complained of a lump on the face for 4 yr with symptoms of nasal discharge, congestion, epistaxis, and a feeling of fullness in the ears. Sinonasal biopsy was later performed and revealed an inverted papilloma. Two months after the biopsy procedure, mass extirpation and medial maxillectomy were performed. Histopathology examination confirms the diagnosis of ossifying fibroma accompanied by low-grade central osteosarcoma. Low-grade central osteosarcoma is an exceptionally rare variant, and the diagnosis is occasionally difficult. It can be misdiagnosed as a benign lesion, especially fibrous dysplasia or ossifying fibroma. Histomorphological, the discovery of atypical tumor cells producing osteoid matrix can be used to confirm that the lesion is a malignant lesion of low-grade central osteosarcoma. As demonstrated in our case, the tumor can consist of a trabecular and curvilinear arrangement of immature bone, at the edges of which there is an osteoblastic rimming appearance with a background of connective tissue stroma which is a histopathological feature of ossifying fibroma.
Bovine nucleus pulposus decellularization using freeze drying technique to form a biological scaffold Romaniyanto; Prijosedjati, Raden Andhi; Ermawan, Rieva; Hakim, Fikar Arsyad; Saddalqous
Journal of International Surgery and Clinical Medicine Vol. 4 No. 1 (2024): (Available online: 1 June 2024)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v4i1.54

Abstract

Introduction: As much as 40% of low back pain patients are caused by degenerative disc disease. The current treatments are fusion stabilization and total disc replacement, which have a risk for adjacent segment disease. These suboptimal results have become the beginning of the development of regenerative therapy. The success of this therapy will increase if the scaffold meets the ideal conditions. Biological scaffolds provide a cell growth environment that resembles the original tissue. Bovine intervertebral nucleus pulposus can become promising scaffolds. Objective: This research describes the proper freeze-drying approach for decellularizing bovine nucleus pulposus to create a biological scaffold. Methods: We conducted an experimental post-test control design study using bovine coccygeal nucleus pulposus material. All treatment groups underwent freeze-drying with Buchi Lyovapor™ L-200/L-200 Pro. All groups were evaluated for the level of decellularization using the Quick-DNA™ Miniprep Plus Kit (Zymo Research®) and remaining glycosaminoglycan levels by Alcian Blue staining. Results: Comparison of DNA concentrations obtained p-values respectively <0.0001 (p <0.05), which means that all the treatments showed a decrease in DNA concentration compared to the control group. The comparison of the glycosaminoglycan percentage between the P1 vs. Control group obtained a value of p=0.381 (p>0.05), which means that the glycosaminoglycan percentage results for the P1 group were not significantly different from the control group. Conclusion: This study of group P1 showed that decellularization of the bovine nucleus pulposus by freeze-drying technique can form an excellent biological scaffold.
Ekstrak Etanolik Daun kelor (Moringa oleifera, L) Menurunkan Kadar SGOT dan SGPT pada Tikus Wistar Model Sindroma Metabolik Budiani, Dyah Ratna; Subandono, Jarot; Hermawan, Danus; Hakim, Fikar Arsyad
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i10.50099

Abstract

Sindrom metabolik ditandai oleh hipertensi, obesitas sentral, resistensi insulin, dan dislipidemia, dan dapat meningkatkan risiko stroke serta penyakit jantung koroner. Kehadiran dan tingginya kadar enzim SGPT dan SGOT dalam darah menunjukkan adanya gangguan fungsi hati. Pemberian ekstrak daun Moringa berdampak pada penurunan nilai serum SGPT dan SGOT pada tikus Wistar dalam model sindrom metabolik. Penelitian eksperimental laboratorium dengan desain pretest-posttest dan kontrol posttest hanya. Sebanyak 30 tikus Wistar dibagi menjadi 5 kelompok sampel, yaitu: P1 sebagai kontrol normal, P2 sebagai kontrol sindrom metabolik tanpa pemberian ekstrak etanol daun Moringa, P3, P4, dan P5 sebagai kelompok sindrom metabolik yang diberikan ekstrak etanol daun Moringa selama 28 hari (mulai dari hari ke-28 hingga ke-56) dengan dosis bertingkat 150 mg/KgBB, 250 mg/KgBB, dan 350 mg/KgBB per hari. Induksi sindrom metabolik dilakukan dengan pakan tinggi lemak selama 28 hari pertama dan injeksi STZ-NA dilakukan pada hari ke-25. Analisis statistik yang akan digunakan adalah ANOVA satu arah dan post-hoc Tukey HSD untuk data yang terdistribusi normal, serta menggunakan uji Kruskal-Wallis untuk data yang tidak terdistribusi normal diikuti oleh uji Mann-Whitney. Data penelitian adalah data kuantitatif deskriptif. Pemberian ekstrak etanol daun Moringa 150 mg/kg BB/hari (kelompok P3); 250 mg/kg BB/hari (kelompok P4) dan 350 mg/kg BB/hari (kelompok P5) menghasilkan penurunan kadar SGPT dan SGOT, dan dosis 350 mg/kg BB/hari memberikan hasil terbaik. Pemberian ekstrak etanol daun Moringa dapat menurunkan kadar SGPT dan SGOT dalam plasma darah.
Co-Authors Dyah Ratna Budiani Ermawan, Rieva Ery Kus Dwianingsih Hermawan, Danus Jarot Subandono Prijosedjati, Raden Andhi Romaniyanto Saddalqous Solichin, Muchamad Ridotu