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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan
Ruslin, R
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

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Pemodelan Homologi Protein Receptor Orphan Receptor-1 (ROR-1) Sebagai Target Terapi Chronic Lymphocytic Leukemia (CLL Ruslin, R; Putri, Suci Rahmawati; Arba, Muhammad
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 5, No 1 (2019): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v5i1.8992

Abstract

Receptor Orphan Reseptor-1 (ROR-1) is a trans-membrane protein consists of 937 amino acid residues located on 1p31.3 chomosome. ROR-1 has an important role in leukemogenesis of CLL cells. Co-expressions of ROR-1 and TCL enhance leukemogenesis and caused AKT’s phosphorylation, cell’s proliferations, and resistances to apoptosis. This study had done physicochemical characteristics analysis, secondary structure and tertiary structure prediction of ROR-1 Protein using few types of bioinformation tools. The physicochemical characteristics analysis was done by using Expasy Protparam server and the prediction of secondary structure was using Sopma and Psipred. The prediction of ROR-1’s tertiary structure was done by using Modeller 9.19 software  and resulting five ROR-1’s tertiary structures predicted model. The accuration of the results then evaluated using Ramachandran’s plot analysis and it was showed Model 3 is the best models wich percentage is 82%.Keywords: ROR-1, Choronic Lymphocytic Leukemia (CLL), homology modeling, Modeller, Ramachandran plot
Skrining Fitokimia dan Evaluasi Sediaan Sabun Cair Ekstrak Etanol 96% Kulit Buah Salak Pondoh (Salacca zalacca (Gaertn.) Voss.) Sebagai Antioksidan Adjeng, Andi Nafisah Tendri; Hairah, Sania; Herman, Syahlan; Ruslin, R; Fitrawan, La Ode Muhammad; Sartinah, Ari; Ali, Nur Fitriana Muhammad; Sabarudin, S
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 5, No 2 (2019): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v5i2.10170

Abstract

Pemanfaatan kulit buah Salacca zalacca (Gaertn.) Voss.) sebagai sumber antioksidan alami dalam sediaan sabun cair merupakan salah satu cara untuk mencegah efek buruk radikal bebas terhadap kesehatan kulit. Tujuan penelitian ini adalah melakukan skrining fitokimia terhadap senyawa metabolit sekunder yang terdapat dalam ekstrak etanol 96% kulit buah Salacca zalacca (Gaertn.) Voss.) dan memformulasi serta mengevaluasi sediaan sabun cair dari ekstrak tersebut.  Skrining fitokimia ekstrak dilakukan dengan menggunakan metode tabung. Penentuan variabel evaluasi sediaan sabun cair meliputi uji organoleptik, uji pH, tinggi busa dan viskositas. Hasil penelitian menunjukkan bahwa ekstrak etanol 96% kulit buah Salacca zalacca (Gaertn.) Voss.) mengandung Flavonoid, Saponin, Tanin, dan Alkaloid. Sediaan sabun cair memilki karakteristik yaitu konsistensi yang cair, berwarna kuning kecoklatan, aroma rose. Tingkat keasaman (pH) adalah 10,46 dengan viskositas adalah 600 cPs dan Kestabilan busa mencapai 85% dimana semua hasil evaluasi karakteristik sediaan sabun cair ekstrak Salacca zalacca (Gaertn.) Voss.) sesuai dengan parameter Standar Nasional Indonesia (SNI)Kata kunci: ekstrak, etanol, sabun, Salacca zalacca, antioksidan
The Test of Improvement Activity on Kidney Function by Etanolic Extract of Lansau from Muna Regency on Male Wistar Rat Ruslin, R; Kasmawati, Henny; Suryani, S; Ihsan, Sunandar; Soleman, Imelda Sarda
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 6, No 1 (2020): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v6i1.11655

Abstract

Lansau is one of the traditional ingredients that consist of 44 types of plants that are believed by the local society as a nutritious herb to treat various diseases that exist in the society of Muna Southeast Sulawesi Province that has been used for hundreds of years for generations. The study was conducted to determine the effect of ethanol extract of Lansau on the improvement activity of kidney function that induced gentamicin-piroxicam. A total of 24 rats were used in which 20 ratswere modeled with damage of renal function using gentamicin-piroxicam drug which was then grouped into 5 groups. The first group was treated using a Lansau extract with doseI , the second group was treated with aLansauextract dose II, the third group was treated with the Lansau extract dose III, the fourth group was treated with ketosteryl, the fifth group was no treatment only given Na. 1% CMC and the sixth group is the normal group. The Modeling was performed for 7 days and on the eighth day blood sampling was taken to measure creatinine and urea levels. As for therapy performed for 4 weeks and every end of the week also made blood taking for measurement of creatinine and urea. The highest percentage of creatinin decrease for each group was negative group -8.92%,positive group control was 84.21%,dose group I 74.75%, dose group II 80.07%, and dose group III 84.08%. For the highest percentage of decrease of ureum level for each group that is negative group -31.l49%,positive control group 49.59%,dose group I 40.53%, dose group II 26.79%, and dose group III 43.32%. The results showed that Lansau ethanol extract has the potential and effectiveness in the repair of kidney function damage.
Co-Authors Ali, Nur Fitriana Muhammad Arba, Muhammad Ari Sartinah, Ari Fitrawan, La Ode Muhammad Hairah, Sania Herman, Syahlan Kasmawati, Henny Mallarangeng, Andi Nafisah Tendri Adjeng Putri, Suci Rahmawati Sabarudin, S Soleman, Imelda Sarda Sunandar Ihsan, Sunandar Suryani, S