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All Journal MEDISAINS Science and Technology Indonesia Jurnal Penelitian Sains Jurnal Fitofarmaka Indonesia Jurnal Pengabdian Masyarakat Indonesia
Solihah, Indah
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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A Cytotoxic Activity of Tahongai (Kleinhovia hospita Linn.) Leaves Extracts Using Brine Shrimp Lethality Test Solihah, Indah; Herlina, Herlina; Rasyid, Riana Sari Puspita; Suciati, Tri; Khairunnisa, Khairunnisa
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1489.712 KB) | DOI: 10.26554/sti.2019.4.3.60-63

Abstract

Tahongai (Kleinhovia hospita Linn.) leaves had been known contain alkaloids, flavonoids, saponins, steroids, and tannins. At Komering, South Sumatera tribe, tahongai leaves had been known to treat tumor, cancer, polyps, acne, and dysmenorrhea. The study of cytotoxic activity of tahongai bark and stem were done. This study aims to determine the cytotoxic activity of tahongai leaves extracts using BSLT method. Tahongai leaves were extracted using gradual maceration with n-hexane, ethyl acetate, and ethanol 96%. Each extract was tested cytotoxic activity towards Artemia salina L. larvae. The yield of n-hexane, ethyl acetate, and ethanol extracts are 2,686%, 7,033%, and 7,933% respectively. Ethanol extract of tahongai leaves had the best cytotoxic activity with lethality value 76,667% at 500ppm. Statistical analysis with two way ANOVA showed extract and concentration had a significant (p<0,05) effect on larvae lethality percentage.
In vivo study of the antioxidant test of ethanolic extract of Chromolaena odorata Linn. leaves Solihah, Indah; Herlina, Herlina; Munawwaroh, Inayatul; Rasyid, Riana Sari Puspita
MEDISAINS Vol 18, No 3 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i3.8307

Abstract

Background: Chromolaena odorata L. leaf was reported to contain phenolic group compounds, such as flavonoids. Flavonoid compounds have been reported to have antioxidant activity. Based on in vitro study, Chromolaena odorata L. leaves have potent antioxidant activity. However, in vivo, studies with dose variations have not been reported.Purpose: This study evaluates the antioxidant activity with various doses of ethanolic extract of Chromolaena odorata L. leaves against male Wistar rats induced by paracetamol.Methods: Flavonoid contents were measured spectrophotometrically based on the formation of a complex flavonoid-aluminum. Quercetin was used to make a calibration curve. In vivo test was used TBARS method carried out by measured malondialdehyde (MDA) level in male Wistar rats induced by paracetamol 2g/Kg BW. The test was carried out on extracts with doses of 125, 250, and 500 mg/Kg BW. Vitamin C with dose 6,5mg/Kg BW used as a positive control, and 1% of Na CMC used as the negative control. Histopathology assessment of liver used Hema-toxylin Eosin Stain.Results: Ethanolic extract of Chromolaena odorata L. leaves contain flavonoid 126.459±0.163 mg/g extract as quercetin equivalent. Intoxication paracetamol on rats increased MDA serum level significantly different (p-value < 0.005) with normal control. Treatment of ascorbic acid and extracts decreased MDA serum level significantly different (p-value < 0.005) with control negative and improved the histological structure of hepatocytes.Conclusion: Ethanolic extract of Chromolaena odorata Linn. dose 500 mg/Kg BW was the best treatment with exhibited 58.974% reduction of MDA serum level and better improve the histological structure hepatocytes than other doses
Burn Wound Healing Activity of Ethanol Extract of Jackfruit Leaves (Artocarpus heterophyllus Lmk.) in Sprague Dawley Male Rats Solihah, Indah; Herlina, Herlina; Mareta, Fauzia
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.978

Abstract

Burn wounds have the potential to become infection, dehydration, and serious complications if not treated properly. Jackfruit leaves (Artocarpus heterophyllus Lmk.) contain secondary metabolites such as flavonoids, tannins, saponins, and steroids which has big potential to accelerate of burn wound's healing. The purpose of this study is to learn more about the effect of jackfruit leaves ethanol extract application on the burn wound healing. The experimental animals were 25 Sprague Dawley rats separated into five groups: negative control group, positive control group, and test groups G1 (94 mg/Kg BW), G2 (188 mg/Kg BW), and G3 (376 mg/Kg BW). The wound area, wound recovery (%), and wound healing time were all measured. To determine the difference on a given day of observation, wound area data were evaluated using a one-way ANOVA test. The ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lmk.) was found to have an effect on burn healing. On the 14th day, the percent recovery values for burns in the positive control, negative control, G1, G2, and G3 groups were 89.9%, 76.5%, 88.8%, 87.2%, and 100%, respectively. Treatment group 3 had the quickest burn healing time and the highest percentage of recovery.
The Antioxidant Potential of Kecombrang (Etlingera elatior) Solihah, Indah; Syarif, Nirwan; Resmiyani, Ubbadah; Rasyid, Riana Sari Puspita; Suciati, Tri
Jurnal Penelitian Sains Vol 26, No 2 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i2.1028

Abstract

Kecombrang (Etlingera elatior) is one of the native plants of Indonesia.E.elatioris used as a condiment, food, medicine, and ornament. The antioxidant properties of rhizomes, leaves, and flowers ofE.elatiorhas not been reported. This study aimed to explore the antioxidant capacity of the rhizome, leaves, and flowers ofE.elatiorin extracts and fractions. The rhizome, leaves, and flower ofE.elatiorwere macerated by ethanol 96% to generate crude extract. The crude extract was fractionated by n-hexane, ethyl acetate, and ethanol 96% to generate n-hexane, ethyl acetate, and ethanol fraction. The total phenolic compound was determined spectrophotometrically using the follin-ciocalteau color complex. The antioxidant effect of extracts and fractions ofE.elatiorwas evaluated using DPPH scavenging activity. The largest total phenolic compound ofE.elatiorwas in the ethanolic fraction of flower (298.47mgGAE/100g), and the lowest was in a crude extract of rhizome (61.80mgGAE/100g). The very strong antioxidant capacity (IC50value <50ppm) was in crude extract, n-hexane fraction of rhizome, and an ethanolic fraction of leaves. The strong antioxidant capacity (IC50value: 50-100 ppm) was crude extract and all fractions of flower; ethyl acetate and an ethanolic fraction of rhizome; crude extract, n-hexane, and ethyl acetate fraction of leaf.The conclusion of this study is that, depending on the type of solvent, the type of antioxidant compounds being extracted and antioxidant capacity also vary.
Submikro Partikel Gelasi Ionik Pembawa Ekstrak Etanol Daun Inai (Lawsonia Inermis Linn.) Menggunakan Biopolimer Kitosan-Alginat Dan Kalsium Klorida Mardiyanto, Mardiyanto; Solihah, Indah; Shiyan, Shaum; Sari, Familia Maya
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1199

Abstract

Ekstrak daun inai memiliki senyawa aktif turunan dari flavonoid yang menunjukkan aktivitas antioksidan. Penelitian ini bertujuan untuk menjadikan ekstrak etanol daun inai menjadi submikropartikel dengan metode gelasi ionic: menginteraksikan ekstrak inai dengan kitosan selanjutnya pengikatan oleh natrium alginat dibantu CaCl2 sebagai agen sambung-silang. Jumlah total flavonoid pada ekstrak inai adalah 41,419 mg/g. Hasil pengamatan terhadap plat KLT mengindikasikan bahwa ekstrak inai memiliki senyawa flavonoid yang ditandai oleh angka Rf 0,77. Harga %efisiensi enkapsulasi (%EE) masing-masing formula F1, F2, dan F3 adalah 96,280%, 93,456%, dan 92,117%. Data property fisik produk: size, keseragaman, dan perbedaan potensial dari produk sebesar 593 nm, 0,248, dan +35,07 mV yang diukur dengan PSA. Hasil pengujian penyimpanan pada 6 siklus terhadap produk secara pengulangan panas-dingin terjadi penurunan kadar terbesar pada F3 yaitu sebesar 8,75% pada siklus ke 5.
Pemberdayaan Masyarakat Desa Ulak Kerbau Baru dalam Penyusunan Program Toga melalui Perkuliahan Terintegrasi Solihah, Indah; Shiyan, Shaum; Puspita Rasyid, Rianasari; Fertilita, Soilia
Jurnal Pengabdian Masyarakat Indonesia Vol 5 No 4 (2025): JPMI - Agustus 2025
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.3736

Abstract

Pengetahuan masyarakat desa Ulak Kerbau Baru, kecamatan Tanjung Raja, kabupaten Ogan Ilir, Sumatera Selatan masih rendah. Peningkatan keilmuan masyarakat terkait cara penggunaan tanaman obat yang benar, dari segi ketepatan bahan, takaran, cara penggunaan, khasiat, dan keamanannya perlu dilakukan. Metode yang digunakan dapat melalui kegiatan perkuliahan terintegrasi pada mata kuliah Obat Tradisional yang ada di Jurusan Farmasi FMIPA UNSRI. Penggunaan lahan kosong yang tidak produktif sebagai lahan TOGA yang diinisiasi melalui Kepala Desa dan perangkatnya. Lahan yang telah disepakati selanjutnya akan diolah menjadi lahan TOGA dengan penanaman beberapa tanaman obat dengan variasi penggunaan tanaman yang dimanfaatkan bagian daun, bunga, buah, dan rimpang. Penunjukkan kader TOGA melalui musyawarah dengan masyarakat dan perangkat desa untuk menjaga dan merawat TOGA yang sudah dibentuk. Proses penanaman dan pemeliharaan tanaman obat pada TOGA melibatkan mahasiswa dan kader TOGA yang telah ditunjuk. Pasca kegiatan penyuluhan terlihat adanya peningkatan pengetahuan masyarakat setelah diberikan penyuluhan terkait TOGA, budidaya tanaman obat, serta manfaat tanaman obat.
Co-Authors Fertilita, Soilia Herlina Herlina Khairunnisa Khairunnisa Mardiyanto Mardiyanto Mareta, Fauzia Munawwaroh, Inayatul Nirwan Syarif, Nirwan Puspita Rasyid, Rianasari Rasyid, Riana Sari Puspita Resmiyani, Ubbadah Sari, Familia Maya Shaum Shiyan Tri Suciati