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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya MEDISAINS Biology, Medicine, & Natural Product Chemistry Science and Technology Indonesia Jurnal Penelitian Sains SRIWIJAYA JOURNAL OF MEDICINE Jurnal Pengabdian Masyarakat: Humanity and Medicine
Rasyid, Riana Sari Puspita
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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A Cytotoxic Activity of Tahongai (Kleinhovia hospita Linn.) Leaves Extracts Using Brine Shrimp Lethality Test Solihah, Indah; Herlina, Herlina; Rasyid, Riana Sari Puspita; Suciati, Tri; Khairunnisa, Khairunnisa
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1489.712 KB) | DOI: 10.26554/sti.2019.4.3.60-63

Abstract

Tahongai (Kleinhovia hospita Linn.) leaves had been known contain alkaloids, flavonoids, saponins, steroids, and tannins. At Komering, South Sumatera tribe, tahongai leaves had been known to treat tumor, cancer, polyps, acne, and dysmenorrhea. The study of cytotoxic activity of tahongai bark and stem were done. This study aims to determine the cytotoxic activity of tahongai leaves extracts using BSLT method. Tahongai leaves were extracted using gradual maceration with n-hexane, ethyl acetate, and ethanol 96%. Each extract was tested cytotoxic activity towards Artemia salina L. larvae. The yield of n-hexane, ethyl acetate, and ethanol extracts are 2,686%, 7,033%, and 7,933% respectively. Ethanol extract of tahongai leaves had the best cytotoxic activity with lethality value 76,667% at 500ppm. Statistical analysis with two way ANOVA showed extract and concentration had a significant (p<0,05) effect on larvae lethality percentage.
Prevalensi dan Faktor Risiko Persalinan Preterm di RSUP Dr. Mohammad Hoesin Palembang Trisa, Yusdela; Martadiansyah, Abarham; Rasyid, Riana Sari Puspita
Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.081 KB)

Abstract

Persalinan preterm adalah persalinan kurang dari 37 minggu usia kehamilan. Preterm menyumbang sekitar 50% dari semua kematian neonatal. Indonesia merupakan salah satu negara penyumbang persalinan preterm terbanyak pada tahun 2010. Penyebab persalinan preterm adalah kombinasi dari berbagai macam keadaan, seperti obstetrik, sosiodemografi, dan faktor medik. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan faktor risiko dengan persalinan preterm di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini adalah penelitian analitik observasional. Sebanyak 505 sampel ibu bersalin diambil dengan teknik simple random sampling. Data dicatat dan diobservasi dari rekam medik berupa usia, jarak kehamilan, riwayat persalinan preterm, tingkat pendidikan, kehamilan multipel, ketuban pecah dini, dan riwayat perdarahan antepartum. Lalu data dianalisis dengan uji chi square. Pada penelitian ini dijumpai angka kejadian persalinan preterm sebanyak 497 (20,7%) ditahun 2015, 687 (29,4%) ditahun 2016, dan 578 (26,9%) ditahun 2017. Secara statistik terdapat hubungan yang signifikan antara riwayat persalinan preterm, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum (p <0,05). Sedangkan variabel usia, jarak kehamilan, dan tingkat pendidikan tidak terdapat hubungan yang signifikan dengan kejadian persalinan preterm. Dari analisis mutivariat didapatkan variabel yang paling berpengaruh adalah kehamilan multipel. Terdapat hubungan yang signifikan antara variabel riwayat persalinan preterm sebelumnya, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum dengan kejadian persalinan preterm.
Skrining obesitas dan pemeriksaan kadar glukosa darah pada masyarakat di Posyandu Lansia Raflesia Kelurahan 20 Ilir Palembang Rasyid, Riana Sari Puspita; Susilawati, Susilawati; Diba, Masayu Farah; Syifa, Syifa; Hasbi, Alfian; Hidayatullah, Mohammad Wahyu; Syahranni, Dhanya
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 3 No 2 (2022): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V3I2.85

Abstract

Obesity is an excessive accumulation of fat due to an imbalance in energy intake (eating, drinking) with the energy used for a long time. Obesity is a modifiable risk of diabetes mellitus (DM). Screening for obesity and blood glucose in at-risk individuals is very important to prevent the incidence of DM. Routine nutritional status and blood glucose examinations for susceptible ages and people with DM still need to be carried out to monitor therapy and prevent severity. One way that can be used to determine obesity is through an abdominal circumference examination. The normal abdominal circumference for women is 80 cm for and for men 90 cm. This community service activity is aimed at the early detection of obesity and DM incidence by targeting the elderly and elderly in the 20 Ilir D-IV Village. The activity was carried out by lecturers and students of the Faculty of Medicine, Sriwijaya University, in collaboration with cadres of the Raflesia Elderly Posyandu, Kelurahan 20 Ilir D-IV, in the working area of ​​the Talang Ratu Health Center. The results of the examination showed that most of the participants were centrally obese, but only 2 people had blood glucose levels >200 mg/dL. It is necessary to periodically screen through the Raflesia Elderly Posyandu and creates a program to reduce the level of central obesity and increase blood glucose levels in the community of Kelurahan 20 Ilir D-IV.
Penyuluhan dan pelatihan pembuatan ekoenzim upaya pemanfaatan limbah organik rumah tangga di desa Tebedak 2 kecamatan Payaraman kabupaten Ogan ilir Sumatera Selatan Hermansyah, Hermansyah; Hasanudin; Yuliasari, Nova; Rasyid, Riana Sari Puspita; Susilawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 1 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I1.141

Abstract

Ecoenzymes are the result of fermentation of organic materials originating from kitchen waste in the form of fruit or vegetable peels which have many benefits for nature and humans, including as natural plant fertilizer, natural herbicides and pesticides, even in the field of human health. Utilizing fruit and vegetable waste is one of the 'zero waste' movements that can reduce the greenhouse effect. Community Service Program (PPM) activities by utilizing household waste into ecoenzymes were carried out in Tebedak 2 village, Payaraman, Ogan Ilir Regency. This activity is very simple and includes collecting and processing fruit or vegetable waste, mixing it with molasses and water in a ratio of 3: 1: 10, then fermenting or leaving it in a plastic container for 30 to 90 days until ecoenzymes are produced. The training participants were mostly attended by women, with the age range of participants being 20–50 years. The training material delivered, responses to the material delivered, how to implement the material, clarity of the counseling and training material, counseling on whether the information and knowledge provided will be applied, and satisfaction in delivering the counseling and training information were assessed by the majority as very good by the participants. The results of this questionnaire show that this activity is very beneficial for society.
In vivo study of the antioxidant test of ethanolic extract of Chromolaena odorata Linn. leaves Solihah, Indah; Herlina, Herlina; Munawwaroh, Inayatul; Rasyid, Riana Sari Puspita
MEDISAINS Vol 18, No 3 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i3.8307

Abstract

Background: Chromolaena odorata L. leaf was reported to contain phenolic group compounds, such as flavonoids. Flavonoid compounds have been reported to have antioxidant activity. Based on in vitro study, Chromolaena odorata L. leaves have potent antioxidant activity. However, in vivo, studies with dose variations have not been reported.Purpose: This study evaluates the antioxidant activity with various doses of ethanolic extract of Chromolaena odorata L. leaves against male Wistar rats induced by paracetamol.Methods: Flavonoid contents were measured spectrophotometrically based on the formation of a complex flavonoid-aluminum. Quercetin was used to make a calibration curve. In vivo test was used TBARS method carried out by measured malondialdehyde (MDA) level in male Wistar rats induced by paracetamol 2g/Kg BW. The test was carried out on extracts with doses of 125, 250, and 500 mg/Kg BW. Vitamin C with dose 6,5mg/Kg BW used as a positive control, and 1% of Na CMC used as the negative control. Histopathology assessment of liver used Hema-toxylin Eosin Stain.Results: Ethanolic extract of Chromolaena odorata L. leaves contain flavonoid 126.459±0.163 mg/g extract as quercetin equivalent. Intoxication paracetamol on rats increased MDA serum level significantly different (p-value < 0.005) with normal control. Treatment of ascorbic acid and extracts decreased MDA serum level significantly different (p-value < 0.005) with control negative and improved the histological structure of hepatocytes.Conclusion: Ethanolic extract of Chromolaena odorata Linn. dose 500 mg/Kg BW was the best treatment with exhibited 58.974% reduction of MDA serum level and better improve the histological structure hepatocytes than other doses
THE ASSOCIATION BETWEEN BODY MASS INDEX (BMI) AND GASTROESOPHAGEAL REFLUX DISEASE (GERD) INCIDENCE AMONG VISITORS AT THE GASTROENTEROLOGY CLINIC OF RSUP DR. MOHAMMAD HOESIN PALEMBANG Zuhdi, Kgs. Muhammad; Astoni, Muhamad Ayus; Rasyid, Riana Sari Puspita; Suprianto, Imam; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.626

Abstract

This study aimed to determine the association between BMI and the incidence of GERD in visitors to the Gastroclinic of RSUP Dr. Mohammad Hoesin Palembang. A total of 153 samples met the eligibility requirements, this study used a random sampling technique and collected primary data through a questionnaire instrument. Data were analyzed using SPSS Statistic V27 in univariate, bivariate (chi-square test) and multivariate (logistic regression enter method) analysis. The majority of GERD patients were aged 36-65 years (46.7%), male sex (46.2%) and BMI in the obese category (65.9%). The results of this research showed no significant association among age and sex in the incidence of GERD, but there was a significant association between BMI on the incidence of GERD (p=0.003) thus being the most significant variable in this research (p=0.012). In conclusion, there is a significant association between BMI and the incidence of GERD while there is no significant association among age and sex in the incidence of GERD.
The Antioxidant Potential of Kecombrang (Etlingera elatior) Solihah, Indah; Syarif, Nirwan; Resmiyani, Ubbadah; Rasyid, Riana Sari Puspita; Suciati, Tri
Jurnal Penelitian Sains Vol 26, No 2 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i2.1028

Abstract

Kecombrang (Etlingera elatior) is one of the native plants of Indonesia.E.elatioris used as a condiment, food, medicine, and ornament. The antioxidant properties of rhizomes, leaves, and flowers ofE.elatiorhas not been reported. This study aimed to explore the antioxidant capacity of the rhizome, leaves, and flowers ofE.elatiorin extracts and fractions. The rhizome, leaves, and flower ofE.elatiorwere macerated by ethanol 96% to generate crude extract. The crude extract was fractionated by n-hexane, ethyl acetate, and ethanol 96% to generate n-hexane, ethyl acetate, and ethanol fraction. The total phenolic compound was determined spectrophotometrically using the follin-ciocalteau color complex. The antioxidant effect of extracts and fractions ofE.elatiorwas evaluated using DPPH scavenging activity. The largest total phenolic compound ofE.elatiorwas in the ethanolic fraction of flower (298.47mgGAE/100g), and the lowest was in a crude extract of rhizome (61.80mgGAE/100g). The very strong antioxidant capacity (IC50value <50ppm) was in crude extract, n-hexane fraction of rhizome, and an ethanolic fraction of leaves. The strong antioxidant capacity (IC50value: 50-100 ppm) was crude extract and all fractions of flower; ethyl acetate and an ethanolic fraction of rhizome; crude extract, n-hexane, and ethyl acetate fraction of leaf.The conclusion of this study is that, depending on the type of solvent, the type of antioxidant compounds being extracted and antioxidant capacity also vary.
Effectiveness of Cherry Tomato Extract in Gel Form to Accelerate the Healing Process of Excision Wounds in Wistar White Rats Fertilita, Soilia; Zulfadli, Muhammad; Larasati, Veny; Rasyid, Riana Sari Puspita; Argentina, Fifa; Tanta, Yudhi; Athiah, Medina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.427-434

Abstract

Cherry tomatoes (Solanum lycopersicum L. var. cerasiforme) are rich in antioxidants, particularly flavonoids and lycopene, which help reduce free radicals and promote wound healing. Flavonoids exhibit anti-inflammatory, antioxidant, antibacterial, and antidiabetic properties. They enhance wound contraction, collagen deposition, granulation tissue formation, and epithelialization in wound healing. This study evaluates the efficacy of cherry tomato extract gel in accelerating excision wound healing in Wistar rats. This in vivo experimental study used a post-test control group design. Twenty-five 2–3-month-old Wistar rats with excision wounds were treated with cherry tomato extract gel or controls. The five groups included a positive control (NaCl), a negative control (CMC-Na gel), and treatment groups receiving 8%, 12%, or 16% extract gel. Wound size was measured on days 3, 5, 7, and 9, with data analyzed using One-Way ANOVA and post hoc tests. The extract-treated groups exhibited nearly complete wound closure by day 9. The wound size of the treatment groups significantly differed from the control groups (p<0.05). Cherry tomato extract gel significantly accelerates wound closure at 8%, 12%, and 16% concentrations, with the best results observed at 16% (p<0.05), surpassing even the positive control. The 16% extract gel group demonstrated the most effective wound healing. Cherry tomato extract gel significantly enhances wound healing, with the 16% concentration demonstrating the most effective acceleration of wound closure. These findings suggest that cherry tomato extract gel, particularly at 16%, holds promise as a potent wound-healing agent.
Co-Authors Athiah, Medina Chodijah, Nyimas Daniel Happy Putra Diba, Masayu Farah Fertilita, Soilia Fifa Argentina Gita Dwi Prasasty Hasanudin Hasbi, Alfian Herlina Herlina Hermansyah Hermansyah Hidayatullah, Mohammad Wahyu Khairunnisa Khairunnisa Krisna Murti Larasati, Veny Martadiansyah, Abarham Muhamad Ayus Astoni Munawwaroh, Inayatul Nirwan Syarif, Nirwan Nova Yuliasari Resmiyani, Ubbadah Solihah, Indah Suprianto, Imam Susilawati, Susilawati Syahranni, Dhanya Syifa, Syifa Tanta, Yudhi Tri Suciati Trisa, Yusdela Zuhdi, Kgs. Muhammad Zulfadli, Muhammad