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Damayanti, Moretta
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Efek Penambahan Laktulosa Pada Susu Formula Bayi: Tinjauan Sistematik Damayanti, Moretta; Rusli Sjarif, Damayanti
Cermin Dunia Kedokteran Vol 45, No 11 (2018): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (519.075 KB) | DOI: 10.55175/cdk.v45i11.567

Abstract

Pendahuluan: Salah satu komponen terbesar dalam air susu ibu (ASI) adalah oligosakarida. Oligosakarida berperan penting pada saluran cerna bayi melalui efek prebiotiknya. Laktulosa sebagai salah satu oligosakarida sintetis, telah dikategorikan sebagai prebiotik dan memiliki efek menyerupai ASI dalam hal mengubah komposisi mikrobiota usus. Metode: Tinjauan sistematis efek penambahan laktulosa ke dalam susu formula bayi. Hasil: Laktulosa bisa memperbaiki konsistensi dan frekuensi tinja, hingga menyerupai tinja bayi yang mendapat ASI. Efek simpang campuran prebiotik yang sering ditemui adalah diare, kembung dan muntah. Simpulan: Masih diperlukan penelitian lebih lanjut untuk merekomendasikan penambahan laktulosa secara rutin pada susu formula bayi.Introduction. One of the largest components of breast milk is human milk oligosaccharides (HMO). These components play an important role in the infant gastrointestinal tract based on their prebiotic effect. Lactulose is one of synthetic oligosaccharides, categorized as prebiotic; its effect resembles breastmilk in altering intestinal microbiota composition. Method. A systematic review on the effects of lactulose addition to infant formula. Results. Our search indicates that lactulose can improve the consistency and frequency of feces to resemble the stools of breast-fed infants. Adverse effects of mixed prebiotics are diarrhea, bloating and vomiting. Conclusion. Further research is still needed. Routine addition of lactulose in infant formula is not yet recommended.
Quality of life in children with chronic kidney disease Fibrianto, Ari; Lestari, Hertanti Indah; Kesuma, Yudianita; Damayanti, Moretta; Fitriana, Eka Intan; Rismarini, Rismarini
Paediatrica Indonesiana Vol. 63 No. 5 (2023): September 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.5.2023.395-404

Abstract

Background Chronic kidney disease (CKD) has become a global burden on the healthcare system and significantly impacts the quality of life of children with the condition. Objective To assess quality of life in children with CKD as well as its relationship with sociodemographic, medical, and psychosocial factors. Methods This cross-sectional analytic study was conducted from June to November 2021 at Dr. Moh Hoesin Hospital, Palembang. Children with CKD aged 2–18 years were included by consecutive sampling. Parents and patients were asked to complete the PedsQL™ generic score scale version 4.0 questionnaire. Results We assessed quality of life in 112 children with CKD from parents’ and children’s reports in the PedsQL™ questionnaire. Physical and emotional parameters had the lowest scores. Based on parental reports, quality of life was significantly associated with disease severity (P=0.002), behavioral disorders (P=0.007), and sleep disturbances (P=0.001). Based on the children’s reports, the factors significantly associated with quality of life were anemia (P=0.044), sleep disturbances (P=0.024), and behavioral disorders (P=0.002). Almost one-third of children with CKD had general impairment of quality of life, both from parental reports (32.1%) and children’s reports (33.0%). Conclusion Disease severity, anemia, sleep disturbance, and behavioral disorders were all associated with poorer quality of life in children with CKD.
Hepcidin levels, markers of iron overload, and liver damage in children with beta-thalassemia major Sari, Indah; Sari, Dian Puspita; Damayanti, Moretta; Salwan, Hasri
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.412-8

Abstract

Background Thalassemia is a hemoglobin synthesis disorder that causes patients to need lifelong blood transfusions, leading to iron overload and alter organ function, including the liver. Hepcidin, produced by the liver, plays a role in iron homeostasis and should be increased in excess iron stores. However, the level decreases in thalassemia due to some factors, such as ineffective erythropoiesis and liver damage. Recent publications revealed that hepcidin could be associated with iron overload and also a marker of liver diseases. Objective To analyse the correlation between hepcidin level, markers of iron overload, and liver damage in beta-thalassemia major. Methods This cross-sectional study included all ?-thalassemia major age 2-18 years admitted to Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera, who underwent blood transfusions from March to August 2022. We measured the level of iron overload markers, hepcidin, liver function test (LFT), and performed liver ultrasonography (USG). Results Of 97 subjects, median hepcidin level was 10.01 ng/mL and 68% of the subjects showed a decrease. The iron overload parameters were evaluated from serum iron levels (P=0.13), ferritin levels (P=0.90), and transferrin saturation (P=0.29) and 24.7% had abnormal liver USG findings. Spearman’s correlation revealed that only direct bilirubin (DB) (r=0.35; P=0.001) and liver USG (r=0.20; P=0.05) had positive correlations with decreased levels of hepcidin. Also, it had 91.7% sensitivity in predicting liver damage from ultrasound. Conclusion The hepcidin level was not significantly associated with iron overload markers.
Differences in the Seroprevalence of SARS-CoV-2 in Children from Confirmed Covid-19 Healthworkers with or without Symptoms in RSUP Dr.Mohammad Hoesin Palembang Silitonga, Enggrajati; Iriani, Yulia; Kamila, Ariesti; Damayanti, Moretta
Journal of Social Research Vol. 5 No. 1 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i1.2919

Abstract

The surge of COVID-19 cases in June 2021 underscored the role of healthcare workers (HCWs) as potential sources of household transmission, including to their children. This study aimed to analyze the differences in SARS-CoV-2 seroprevalence among children of HCWs at RSUP Dr Mohammad Hoesin Hospital, Palembang, based on parental symptom status, and to identify influencing factors. A cross-sectional study was conducted involving 61 children of HCWs confirmed with COVID-19. SARS-CoV-2 IgG levels were measured using the Chemiluminescence Microparticle Immunoassay (CMIA). Statistical analyses included Chi-square/Fisher’s exact tests and logistic regression. Results showed that 86.8% of subjects had reactive IgG, with 54.1% being children of symptomatic HCWs. The mean age was 6.9 (±3.18) years, with a male-to-female ratio of 1.3:1. While seroprevalence did not differ significantly between groups (p=0.079), IgG levels were significantly higher in children of symptomatic HCWs (median 3112 AU/ml vs. 758.9 AU/ml, p=0.02). Symptomatic children also had higher median IgG levels (3270 AU/ml vs. 1324 AU/ml). A strong negative correlation was found between parental CT-value and child’s IgG level (r = -0.64, p=0.001). Multivariate analysis identified CT-value as the sole significant risk factor for seroprevalence (p=0.003, AUC=100%). In conclusion, although seroprevalence did not differ, IgG levels were significantly higher in children of symptomatic HCWs, with parental viral load (CT-value) being the key determinant of seropositivity.
Co-Authors Damayanti Rusli Sjarif Dian Puspita Sari Eka Intan Fitriana Fibrianto, Ari Hasri Salwan, Hasri Hertanti Indah Lestari, Hertanti Indah Kamila, Ariesti Rismarini Rismarini, Rismarini RR. Ella Evrita Hestiandari Silitonga, Enggrajati Yudianita Kesuma, Yudianita Yulia Iriani, Yulia