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All Journal SYUKUR (Jurnal Inovasi Sosial dan Pengabdian Masyarakat) Jurnal Ilmu dan Teknologi Kesehatan Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Pengabdian Masyarakat (Jupemas)
Merizka, Engla
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Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KESADARAN PENGETAHUAN TERHADAP GOLONGAN DARAH BERDASARKAN STATUS EKONOMI KELUARGA DI SMA MUHAMMADIYAH 23 DAN SMUN 44 JAKARTA Merizka, Engla; Herlina, Herlina; Suzane, Meri
SYUKUR (Jurnal Inovasi Sosial dan Pengabdian Masyarakat) Vol 2 No 1 (2019): April
Publisher : Faculty of Economics and Business, University of Muhammadiyah Prof. DR. HAMKA

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Abstract

Saat ini, dikalangan masyarakat awam pengetahuan mengenai jenis golongan darah belum terlalu dikenal. Banyak dari masyarakat di Indonesia yang belum mengetahui golongan darah apa yang dimilikinya. Dikalangan masyarakat awam, golongan darah yang dikenal hanya golongan darah A,B,O dan AB. Pemeriksaan golongan darah sebaiknya dilakukan sejak dini, hal ini bertujuan agar memudahkan pencarian donor apabila suatu saat membutuhkan transfusi darah. Hal lain, pemeriksaan golongan darah berguna untuk meningkatkan pengetahuan masyarakat terhadap jenis-jenis golongan darah. Pada tinggak ekonomi keluarga menengah keatas, melakukan medical check-up adalah suatu hal yang rutin dilakukan satu tahun sekali. Oleh karena itu, biasanya siswa dari kalangan menengah keatas sebahagian besar telah megetahui jenis golongan darah yang ia miliki. Berbanding terbalik dengan siswa dengan tingkat ekonomi menengah ke bawah. Sebahagian besar dari mereka tidak mengetahui jenis golongan darah yang ia miliki. Setelah dilakukan pengabdian masyarakat di dua SMA diatas dapat disimpulkan bahwa faktor utama yang menjadi penyebab ketidaktahuan mereka adalah karna kurangnya ajakan dari orang tua ke fasilitas kesehatan dan kurang pedulinya keluarga terhadap pengetahuan kesehatan.  Kata kunci: status ekonomi, kesehatan, golongan darah, kurang pengetahuan
The Effectiveness of Citrus Limon Extract as A Substitute for Glacial Acetic Acid Solution in The Turks Solution Merizka, Engla; Harun, Hamdan Bin
jitek Vol 10 No 2 (2023): Maret 2023
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v10i2.1093

Abstract

In basic clinical laboratories, the availability of chemicals to create a test solution (reagent) is frequently limited or non-existent, delaying the sample inspection procedure. In medical laboratories, the inability to create a test solution with a certain chemical compound is a common constraint. The components of Turk's reagent are glacial acetic acid, gentian violet, and distilled water. The chemical glacial acetic acid, which is required to prepare Turk's reagent for leukocyte count testing, is frequently unavailable. To confirm that the counting of leukocytes may still be performed, it is required to find a readily available replacement to glacial acetic acid solution in turk solution that serves the same purpose. This study was done to investigate the viability of substituting extract Citrus limon for glacial acetic acid in the production of Turk's solution for the measurement of leukocyte counts. The study was developed as an experiment and conducted at Prof. Dr. Hamka's Medical Laboratory Technology Laboratory at Muhammadiyah University in Jakarta. In this investigation, a total of 30 blood samples containing the anticoagulant Ethylenediaminetetraacetic acid (EDTA) were utilized. The samples were separated into three treatment groups, each containing 10 samples: lemon treatments with concentrations of 2%, 3%, and 4%. Comparing the results of the study with those of controls using Turk solution revealed that lemon juice can be substituted for glacial acetic acid in Turk solution for determining the number of leukocytes, with a concentration of 2% being optimal.
Prediction of Structure and Function of a Novel β-Lactamase Protein in Gram-Negative Bacteria Using Homology Modeling and Molecular Docking Kiranasari, Ariyani; Dwira, Surya; Merizka, Engla
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

The emergence of β-lactamase–producing Gram-negative bacteria represents a major global challenge due to increasing resistance to β-lactam antibiotics. In this study, we performed in silico structural and functional prediction of a newly identified β-lactamase protein sequence obtained from a Gram-negative bacterial isolate. Homology modeling was used to construct a reliable 3D model of the protein based on structurally resolved β-lactamases. The model was further evaluated using stereochemical validation parameters. Molecular docking was conducted to assess binding affinity and interaction patterns between the predicted β-lactamase and clinically relevant β-lactam antibiotics, including ampicillin, cefotaxime, and imipenem. The results revealed conserved catalytic residues typical of class A β-lactamases, strong binding affinities toward penicillin and cephalosporin substrates, and key hydrogen bond interactions within the active site. This study provides a structural framework for understanding the function of the new β-lactamase and offers insights for developing β-lactamase inhibitors targeting resistant Gram-negative pathogens.
Edukasi Penyakit Hiperglikemia, Hiperurisemia Dan Pengujiannya Pada Anggota Ranting Aisyiyah Duren Seribu, Jawa Barat Nisma, Fatimah; Suzana, Meri; Merizka, Engla
Jurnal Pengabdian Masyarakat (Jupemas) Vol. 7 No. 1 (2026): Maret
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v7i1.1907

Abstract

Pimpinan Ranting Aisyiyah (PRA) Duren Seribu, Depok Jawa Barat adalah salah satu PRA yang ada di bawah Pimpinan Cabang Aisyiyah (PCA) Duren Seribu. PRA banyak melakukan kegiatan organisasi untuk meningkatkan kualitas anggotanya seperti pendidikan, dakwah, kegiatan sosial dan pemberdayaan wanita. PRA Duren Seribu telah melaksanakan edukasi tentang penyakit hiperglikemia, hiperurisemia serta melakukan pengukuran kadar glukosa dan asam urat dalam darah pada anggotanya dan kaum dhuafa yang ada di sekitarnya yang berjumlah 92 orang. Edukasi bertujuan untuk mencegah penyakit tersebut secara dini dengan menerapkan pola makan sehat sehari-hari. Pengujian meliputi pemeriksaan tekanan darah, kadar glukosa dan asam urat dalam darah setiap warga yang datang. Hasil yang diperoleh adalah pengetahuan warga sebelum dan sesudah edukasi terlihat meningkat, hal ini diketahui dari nilai pretest sebelum dan postes sesudah edukasi diberikan. Tekanan darah peserta umumnya normal tetapi ada beberapa orang yang tinggi, begitu juga dengan kadar glukosa dan asam urat dalam darah warga secara umum normal.
In Silico Analysis of Vaginal Microbiota in Female Reproductive Health Using NCBI Database and BLAST Bustami, Arleni; Kiranasari, Ariyani; Merizka, Engla
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Abstract

Background: The vaginal microbiota plays a critical role in maintaining female reproductive health. Beneficial bacteria, particularly Lactobacillus species, contribute to vaginal homeostasis, whereas dysbiosis-associated bacteria such as Gardnerella vaginalis and Prevotella bivia have been linked to bacterial vaginosis and reproductive tract disorders. Publicly available nucleotide databases and bioinformatic tools provide accessible resources for studying microbial species associated with vaginal health. Objective: This study aimed to perform a simple in silico analysis of representative vaginal microbiota using publicly available 16S rRNA gene sequences retrieved from the NCBI database and analyzed using BLAST and phylogenetic approaches. Methods: Representative 16S rRNA gene sequences of Lactobacillus crispatus (NR_041857.1), Gardnerella vaginalis (NR_026079.1), and Prevotella bivia(NR_113598.1) were retrieved from the NCBI Nucleotide Database. Sequence identification was performed using NCBI BLASTn against the Nucleotide Collection (nr/nt) database. Phylogenetic analysis was conducted using MUSCLE sequence alignment and the Neighbor-Joining method implemented in MEGA11 with 1,000 bootstrap replicates. Biological interpretation was supported by a literature review of the selected bacterial species. Results: BLAST analysis demonstrated high sequence similarity (>98%), high query coverage, and E-values approaching zero for all retrieved sequences, confirming accurate species identification. Comparative analysis indicated that Lactobacillus crispatus is associated with maintenance of vaginal homeostasis through lactic acid production and protection against pathogen colonization. In contrast, Gardnerella vaginalis and Prevotella bivia are commonly associated with vaginal dysbiosis, bacterial vaginosis, and inflammatory reproductive conditions. Phylogenetic analysis revealed a clear separation between L. crispatus and the dysbiosis-associated bacterial species, reflecting their distinct taxonomic relationships. Conclusion:This study demonstrates the usefulness of publicly available sequence databases and basic bioinformatic tools for the identification and characterization of representative vaginal microbiota associated with female reproductive health. The findings highlight the contrasting biological roles of beneficial and dysbiosis-associated bacteria and provide a simple framework for introductory studies in reproductive microbiology and bioinformatics.
Co-Authors Ariyani Kiranasari Arleni Bustami Fatimah Nisma Harun, Hamdan Bin Herlina Herlina Surya Dwira Suzana, Meri Suzane, Meri