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All Journal Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia PROSIDING SEMINAR KIMIA Jurnal Riset Kefarmasian Indonesia Bioscientist : Jurnal Ilmiah Biologi FASKES : Jurnal Farmasi, Kesehatan, dan Sains JI-KES (Jurnal Ilmu Kesehatan)
Warnida, Husnul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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PERBANDINGAN METODE EKSTRAKSI EKSTRAK UMBI BAWANG RAMBUT (Allium chinense G.Don.) MENGGUNAKAN PELARUT ETANOL 70% TERHADAP RENDEMEN DAN SKRINING FITOKIMIA Supomo, Supomo; Warnida, Husnul; Said, Bagus Moch
Jurnal Riset Kefarmasian Indonesia Vol 1 No 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.411 KB) | DOI: 10.33759/jrki.v1i1.15

Abstract

Allium chinense are plants that contain bioactive compounds such as alkaloids, flavonoids, and saponins. The rendement of an extract may be affected by the extraction mentod used. This study aims to determine the effect of maseration and digestion extraction method on rendemen and identification of secondary metabolite in the extract of the hair onion bulbs. Research conducted is an experimental study. The samples used were hair bulbs obtained in Kota Bangun, East Kalimantan, extracted wiyh 2 extraction methods of maceration and digestion using ethanol 70% solvent and done as much as 3 times replication. Identification of secondary metabolite compounds was performed by phytochemical screening including test of alkaloids, flavonoids, saponins, tannins, and steroids. From the test data is processed by statistical analysis. The result of rendement with 3 times replikation of digesti mentod obtained by 20,02 gram, 19,03 gram, and 19,17 gram. While the maseration method obtained for 12,38 grams, 12,45 grams, and 15,91 grams. So there are differences between the results of the results of digestion mentod and maseration mentod. Based on phytochemical screening tets showed that the thick extract of hair onion bulbs contain compounds alkaloids, flavonoids, and saponins.
AKTIVITAS DAN STABILITAS FISIK LOSION TABIR SURYA DARI EKSTRAK DAUN RAMBAI (Sonneratia caseolaris (L.)engl.) Warnida, Husnul; Ardita, Ardita; Nurhasnawati, Henny; Sukawaty, Yullia
PROSIDING SEMINAR KIMIA Vol 2 No 2 (2024): Prosiding SNKT III 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Long-term, intense sun exposure can cause erythema and sunburn, as well as premature aging and skin cancer. For generations, the people of the Banjar tribe of Borneo have applied a wet paste of Sonneratia caseolaris leaves mixture on the skin when undertaking tasks in the hot sun. The Sonneratia caseolaris tree is a mangrove plant that grows on river banks throughout the Borneo Island. The study aims to formulate Sonneratia caseolaris leaves ethanol extract into a stable lotion and test its efficacy as a sunscreen. Sonneratia caseolaris leaves were macerate with 70% ethanol, and the sunscreen activity of the extract was examined in vitro with a UV-visible spectrophotometer, and then formulated into a lotion dosage form. Organoleptic and homogeneity observations, pH measurements, viscosity measurements, and spreadability measurements were all performed on the lotion. Following that, the lotion sunscreen activity of was tested in vitro. The Sonneratia caseolaris extract sunscreen lotion has met the requirements of organoleptic, homogeneity, pH, viscosity, and spreadability tests. Sunscreen lotion with 2.5% Sonnerata caseolaris extract classified as standard suntan. Sonneratia caseolaris extract of Borneo has the potential to develop as a raw material for herbal cosmetics. Keywords : Sonneratia caseolaris, mangrove, lotion, sunscreen, suntan
Penetapan Kadar Flavonoid Total Ekstrak Etanol Kulit Buah Labu Kuning (Cucurbita moschata) Berdasarkan Perbedaan Konsentrasi Pelarut Secara Spektrofotometri UV-Vis ilham, ilham; Supriningrum, Risa; Warnida, Husnul
Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia Vol 25, No 1 (2024): CHEMICA
Publisher : Jurusan Kimia FMIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/chemica.v25i1.59074

Abstract

ABSTRAKKulit labu kuning ( Cucurbita moschata ) yang selama ini dianggap sebagai limbah ternyata memiliki manfaat antara lain sebagai antibakteri, antioksidan, karena senyawa metabolit sekunder yang dikandungnya. Salah satu senyawa metabolit sekundernya adalah flavonoid. Penyarian senyawa aktif dalam bahan alam dapat dipengaruhi oleh konsentrasi pelarut. Tujuan penelitian ini adalah mengetahui kadar flavonoid total ekstrak etanol kulit buah labu kuning berdasarkan perbedaan konsentrasi pelarut etanol. Tahapan penelitian meliputi penentuan tanaman, pengumpulan bahan baku, pembuatan simplisia, penetapan kadar flavonoid total secara spektrofotometri UV-Vis. Variabel bebas pada penelitian ini adalah variasi konsentrasi etanol 70% dan 95%, variabel ikatan berupa kadar flavonoid total, variabel kontrol berupa metode ekstraksi, tempat pengambilan sampel. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menyatakan persen rendemen ekstrak etanol 70% dan 95%, masing-masing adalah 13,68% dan 15,54%. Kadar flavonoid total dari ekstrak etanol 70% dan 95%, masing-masing sebesar 1,1931% ± 0,0810; dan 1,2045% ± 0,0854. Sehingga dapat disimpulkan bahwa konsentrasi pelarut etanol berpengaruh terhadap kadar rendemen dan ekstrak flavonoid kulit buah labu kuning.Kata kunci : Cucurbita moschata , flavonoid, konsentrasi pelarut, spektrofotometri UV-Vis. ABSTRACTThe skin of pumpkin (Cucurbita moschata) which has been considered as waste so far has benefits such as antibacterial, and antioxidant, because of the secondary metabolites it contains. One of the secondary metabolites is flavonoids. The Extraction of active compounds in natural products can be affected by solvent concentration. The purpose of this study was to determine the total flavonoid content of the ethanol extract of pumpkin peel based on differences in ethanol solvent concentration. The stages of the research included plant determination, raw material collection, simplicia manufacture, extraction by maceration with variations in ethanol concentration, flavonoid phytochemical screening, and determination of total flavonoid content by UV-Vis spectrophotometry. The independent variable in this study was the variation of 70% and 95% ethanol concentration, the dependent variable was the total flavonoid content, and control variable was the extraction method, where the sample was taken. The data analysis used is descriptive analysis. The results of the study stated that the percent yield of 70% and 95% ethanol extract were 13.68% and 15.54%, respectively. The total flavonoid content of 70% and 95% ethanol extract, respectively, were 1.1931% ± 0.0810, 1.2045% ± 0.0854. So it can be concluded that the concentration of ethanol solvent affects the yield and flavonoid levels of pumpkin peel extract.Keywords : Cucurbita moschata, flavonoids, solvent concentration, UV-Vis spectrophotometry.
Aktivitas dan Stabilitas Fisik Lotion Tabir Surya dari Ekstrak Daun Rambai Warnida, Husnul; Nurhasnawati, Henny; Sukawaty, Yullia; Ardhita, Ardhita
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 3 No. 1 (2025): Bulan Juli 2025, FASKES : Jurnal Farmasi, Kesehatan, dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v3i1.3007

Abstract

Background: Long-term, intense sun exposure can cause erythema and sunburn, as well as premature aging and skin cancer. For generations, the people of the Banjar tribe of Borneo have applied a wet paste of Sonneratia caseolaris leaves mixture on the skin when undertaking tasks in the hot sun. The Sonneratia caseolaris tree is a mangrove plant that grows on river banks throughout the Borneo Island. Objectives: The study aims to formulate Sonneratia caseolaris leaves ethanol extract into a stable lotion and test its efficacy as a sunscreen. Methods: Sonneratia caseolaris leaves were macerate with 70% ethanol, and the sunscreen activity of the extract was examined in vitro with a UV-visible spectrophotometer, and then formulated into a lotion dosage form. Organoleptic and homogeneity observations, pH measurements, viscosity measurements, and spreadability measurements were all performed on the lotion. Following that, the lotion sunscreen activity of was tested in vitro. Results: The Sonneratia caseolaris extract sunscreen lotion has met the requirements of organoleptic, homogeneity, pH, viscosity, and spreadability tests. Conclusions and suggestions: Sunscreen lotion with 2.5% Sonnerata caseolaris extract classified as standard suntan. Sonneratia caseolaris extract of Borneo has the potential to develop as a raw material for herbal cosmetics.
Uji Aktivitas Antibakteri Ekstrak Metanol Propolis dari Lebah Kelulut (Heterotrigona itama) terhadap Bakteri Pseudomonas aeruginosa dan Staphylococcus aureus Wulandari, Dyah Tantri; Supomo, Supomo; Warnida, Husnul
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.9373

Abstract

One of the causes of infection is influenced by the occurrence of wounds. Treatment of infected wounds using antibiotics. But antibiotics causes resistance. Then another alternative material from natural ingredients is used, is Propolis from Heterotrigona itama bees. This study aims to determine the inhibition, MIC and MBC of Propolis methanol extract with concentrations of 10%,20%30%,40%,50% against Pseudomonas aeruginosa and Staphylococcus aureus. Research uses experimental research with a non-probability sampling technique, purposive sampling. The extraction method uses methanol solvent maceration. Antibacterial test was carried out by disc diffusion method, positive control of 0.1% clindamycin, negative control of DMSO. The independent variable is the concentration of propolis methanol extract and the dependent variable is the inhibition zone formed and the MIC and MBC values. Analyzed statistically using the ANOVA. Propolis methanol extract inhibited Pseudomonas aeruginosa bacteria at concentrations of 10%:7.74mm, 20%:8.05mm, 30%:10.00mm, 40%:10.05mm, 50%:12,25mm, and can inhibit the growth of Staphylococcus aureus bacteria at concentrations of 10%:7,05mm, 20%:8.00mm, 30%:10.20mm, 40%:11.15mm, 50%:12,05mm. MIC and MBC methanol extract of propolis on the bacteria Pseudomonas aeruginosa and Staphylococcus aureus of 100 mg/ml. Statistical test results showed that all concentrations of propolis methanol extract had a significant difference with the positive control of Clindamycin 0.1%.
Aktivitas Anti Jamur Fraksi Aktif Ekstrak Etanol Umbi Bawang Rambut (Allium Chinense G.Don) terhadap Jamur Candida Albicans Supomo, Supomo; Idriana, Idriana; Eka, Audinah; Indra, Indra; Huda, Miftahul; Warnida, Husnul
JI-KES (Jurnal Ilmu Kesehatan) Vol. 4 No. 2 (2021): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v4i2.188

Abstract

AbstrakTumbuhan umbi bawang rambut (Allium chinense G.Don) memiliki efek sebagai antijamur karena mengandung metabolit sekunder seperti flavanoid, alkaloid dan saponin. Tujuan penelitian ini adalah mengetahui aktivitas antijamur ekstrak umbi bawang rambut melalui proses fraksinasi menggunakan pelarut N-heksan, etil asetat, kloroform dan etanol-air. Penelitian yang dilakukan adalah penelitian eksperimental. Sampel yang digunakan adalah umbi bawang rambut yang diperoleh di kampung Kelasan kecamatann Sungai Payang Kutai Kartanegara. Penelitian ini menggunakan metode maserasi dengan pelarut etanol 70%, metode uji aktivitas antijamur berdasarkan metode difusi cakram terhadap jamur Candida albicans dengan konsentrasi 5%, 10%, 25%, dan 50%, dengan kontrol negatif DMSO 50%. Hasil penelitian menunjukkan bahwa semua fraksi dari ekstrak etanol umbi bawang rambut memiliki aktivitas antijamur. Aktivitas antijamur fraksi etil asetat memberikan daya hambat yang paling besar terhadap Candida albicans diantara fraksi lainnya. Kata kunci:  candida albicans; Allium chinense G. Don; antijamur; fraksi AbstractAllium chinense has an antifungal effect because it contains secondary metabolites such as flavonoids, alkaloids and saponins. The purpose of this research is to investigate the antifungal activity of Allium chinense extract through fractionation process using N-hexane solvent, ethyl acetate, chloroform and ethanol-water. The research is experimental research. Samples used are the Allium chinense found in  Kelasan Sungai Payang  Kutai Kartanegara. Using maseration method with 70% ethanol solvent, antifungal activity test method based on disc diffusion method on Candida albicans fungi with concentration of 5%, 10%, 25%, and 50%, with negative control of DMSO 50%. The results showed that all fractions of Allium chinense ethanol extract had antifungal activity. The antifungal activity of the ethyl acetate fraction provides the greatest resistance to Candida albicans among other fractions. Keywords:  candida albicans, allium chinense G. Don, antifungal, fraction
Uji Aktivitas Antioksidan Ekstrak Baccaurea Lanceolata Fructus dengan Metode ABTS dan DPPH Rahman, Rauli Dimas Nur; Supomo, Supomo; Warnida, Husnul
JI-KES (Jurnal Ilmu Kesehatan) Vol. 6 No. 2 (2023): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/jikes.v6i2.546

Abstract

Abstrak Radikal bebas dapat menyebabkan kerusakan pada tubuh yang berlanjut kepada penyakit kronis seperti kanker, penyakit neurodegeneratif dan diabetes. Antioksidan merupakan suatu zat yang memiliki kemampuan untuk memperlambat proses oksidasi yang disebabkan radikal bebas. Ekstrak buah limpasu (Baccaurea lanceolata) memiliki kandungan senyawa flavonoid dan tannin. Metabolit sekunder seperti flavonoid dan tanin ini memiliki aktivitas antioksidan.  Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan ekstrak buah limpasu menggunakan metode ABTS (2,2-azinobis-3-Ethylbenzothiazoline-6-Sulfonic Acid) dan DPPH (1,1-difenil-2-pikrilhidrazil) melalui nilai IC50. Penelitian yang dilakukan bersifat eksperimental. Objek penelitian ini adalah aktivitas antioksidan dari metode ABTS dan DPPH. Konsentrasi ekstrak etanol buah limpasu diukur menggunakan spektrofotometri UV-Vis untuk mendapatkan persen inhibisi dari sampel. Persen inhibisi dimasukkan ke dalam persamaan regresi linear untuk mendapatkan nilai IC50 dari kedua metode uji. Berdasarkan hasil penelitian diperoleh nilai IC50 sebesar 721,19 ppm pada metode DPPH yang termasuk kategori antioksidan tidak aktif, sedangkan pada uji ABTS didapatkan nilai IC50 sebesar 118,70 ppm yang termasuk kategori antioksidan sedang. Keywords: antioksidan, buah limpasu, ABTS, DPPH, IC50    Abstract Free radicals can harm the body and cause chronic diseases such as cancer, neurodegenerative diseases, and diabetes. Antioxidants are substances that have the ability to slow the oxidation process caused by free radicals. Limpasu fruit extract (Baccaurea lanceolata) contains flavonoid and tannin. Flavonoids and tannins have antioxidant activity. The goal of this study was to determine the antioxidant activity of limpasu fruit extract using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazil) methods using the IC50 value. This study is an experiment. The antioxidant activity of the ABTS and DPPH methods is the focus of this study. Independent variables of this study were limpasu fruit extract with concentration of 100; 200; 300; 400 500 ppm in DPPH and 30; 40; 50; 60; 70 ppm in ABTS, dependent variable is the antioxidant activity of limpasu fruit extract. The concentration of limpasu fruit extract measured using UV-Vis spectrophotometry to obtain the inhibition percentage of sample. The inhibition percentage was then entered into a linear regression equation to calculate the IC50 value for both methods. According to the study's findings, the IC50 value in the DPPH method was 721.19 ppm, indicating that it was an inactive antioxidant, whereas the IC50 value in the ABTS test was 118.70 ppm, indicating that it was a moderate antioxidant. Keywords: antioxidants, limpasu fruit, ABTS, DPPH, IC50
Co-Authors Anita Apriliana, Anita Ardhita, Ardhita Ardhita, Fazri Wisnu Ardita, Ardita Eka, Audinah Henny Nurhasnawati Idriana, Idriana Ilham Ilham Indra Indra Masliyana, Agustiani Mega, Mega Miftahul Huda Mursyidin, Musyidin Rahman, Rauli Dimas Nur Risa Supriningrum Said, Bagus Moch sapri sapri Sukawaty, Yullia Supomo Supomo Wulandari, Dyah Tantri