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All Journal Indonesian Journal of Chemistry Indonesian Journal of Pharmaceutical and Clinical Research Bivalen: Chemical Studies Journal
Anita Apriliana, Anita
Akademi Farmasi Samarinda
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Karakterisasi simplisia kulit batang selutui puka (Tabernaemontana macrocarpa Jack.) Handayani, Fitri; Apriliana, Anita; Arlanda, Desi
Bivalen: Chemical Studies Journal Vol. 5 No. 2 (2022)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v5i2.1235

Abstract

Penelitian ini bertujuan untuk mengetahui karakteristik spesifik dan non spesifik simplisia kulit batang selutui puka. Penelitian merupakan penelitian eksperimental yang dimulai dari determinasi tumbuhan, pembuatan simplisia, karakterisasi spesifik yang meliputi pengujian makroskopik dan mikroskopik, penentuan kadar ekstrak larut etanol dan air, dan skrining fitokimia, karakterisasi non spesifik meliputi penentuan kadar air, kadar abu, dan kadar abu tidak larut asam. Data dianalisis dengan metode deskriptif. Hasil karakterisasi menunjukan bahwa simplisia memiliki permukaan luar kasar dan bercak putih, permukaan dalam halus, memiliki tekstur keras dan rapuh, berwarna coklat muda, beraroma khas dan berasa pahit, memiliki fragmen pengenal seperti sel gabus tangesial, serabut, sel batu, hablur kalsium oksalat dan butir pati, memiliki kadar ekstrak larut air dan etanol secara berurutan adalah 7% (b/b) dan 4% (b/b), dan mengandung alkaloid, flavonoid, saponin dan steroid. Kadar air, abu, dan abu tidak larut asam dari simplisia berturut-turut adalah 8% (b/b), 5,08% (b/b) dan 0,68% (b/b). Dapat disimpulkan bahwa kulit batang selutui puka memiliki karakteristik spesifik dan non spesifik yang berpotensi sebagai obat tradisional dan acuan penelitian selanjutnya mengenai aktivitas senyawa bioaktif.
Formulation of Antiacne Cream Dosage Form Containing Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract Supomo; Apriliana, Anita; Purnawati, Titin; Risqi, Ainur
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (860.169 KB) | DOI: 10.32734/idjpcr.v1i1.207

Abstract

Abstract. The aim of this study was to formulate ethanolic extract of mangosteen (Garcinia mangostana L.) pericarp (EEMP) in the antiacne cream dosage form. The formulae were made with 3 varied concentrations of 0.5%, 1.5% and 4.5%. The tests carried out in this study were organoleptic cream preparations (odor, color, texture), homogeneity, pH, determination of the type of cream, spreadability, and the antibacterial activity against Staphylococcus epidermidis. The results of physical property evaluations showed that the EEMP indicated the pH value of 6, the spredability of the cream increased along with the increasing length of storage time. Duncan Test on the measurement of diameter dispersibility based on storage time showed that there were significant differences between the spreadability of the cream B and C. The cream produced was easy to wash indicating oil in water (o/w) type. The results of antibacterial activity test applying agar diffusion method using Mueller Hinton medium Agar (MHA) indicated that the inhibition zones of formulae II and III were 5.2 and 6 mm, respectively. Whereas, the formula I as well as the negative control showed no inhibition zones. It can be concluded that the EEMP can be formulated as an antiacne cream. The best cream formula was the formula II with the results of physical properties test were quite stable and able to produce inhibition zone against Staphylococcus epidermidis. Keywords: Garcinia mangostana, cream, antiacne, antibacterial, Staphylococcus epidermidis.
Phytochemical Analysis and Anti-Thrombocytopenic Activity of Dayak Onion (Eleutherine palmifolia (L.) Merr) Extract and Fractions with HR-LCMS Profiling of Active Compounds Apriliana, Anita; Milanda, Tiana; Susilawati, Yasmiwar; Wilar, Gofarana
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104534

Abstract

Thrombocytopenia, characterized by a low platelet count, poses significant clinical challenges and can arise from various etiologies. This study investigates the anti-thrombocytopenic effects of Dayak onion (Eleutherine palmifolia (L.) Merr) extracts and their fractions in Wistar rats. Ethanolic extracts and fractions were evaluated for their efficacy in enhancing platelet production. Male Wistar rats were administered doses of 100, 200, and 300 mg/kg, and platelet counts were measured at 24, 48, and 72 h post-treatment. Results indicated that all doses of the ethanolic extract significantly increased platelet counts over time, with the ethyl acetate fraction demonstrating the highest efficacy at a dose of 24.087 mg/kg, achieving significant increases as early as 24 h post-administration. Phytochemical analysis revealed substantial levels of phenolics (318.80 mg GAE/g) and flavonoids (45.63 mg QE/g) in the ethyl acetate fraction, with quercetin identified as a prominent compound via HR-LCMS. These findings suggest that Dayak onion possesses promising anti-thrombocytopenic properties, warranting further exploration as a therapeutic agent for accelerating platelet recovery in conditions such as dengue fever.
Co-Authors Arlanda, Desi Fitri Handayani Gofarana Wilar Khatimah, Khusnul Kusumawati, Eko Medi Hendra, Medi Purnawati, Titin Risqi, Ainur Sapitri, Atila Selvitawati, Selvitawati Sukawaty, Yullia Sukawaty, Yullia Supomo TIANA MILANDA Warnida, Husnul Warnida, Husnul Yasmiwar Susilawati