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All Journal Jurnal Kebidanan Window of Health : Jurnal Kesehatan Media Ilmu Kesehatan Indonesian Journal of Medicine Jurnal Masyarakat Merdeka (JMM) Indonesian of Health Information Management Journal (INOHIM) Jurnal Review Pendidikan dan Pengajaran (JRPP) PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Midwifery Care Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Lentera Perawat Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC)
Barokah, Liberty
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Medicine

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Correlation between Obesity and Contraceptive Method on Estrogen and Progesterone Receptors and Human Epidermal Growth Factor Receptor–2 Expression among Breast Cancer Patients in Dr. Moewardi Hospital, Surakarta Agustina, Silvia Ari; Barokah, Liberty
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the number 2 cancer in Indonesia after cervical cancer. Breast cancer increases every year. The formation of breast cancer is stimulated by various factors such as obesity and a history of family planning. In breast cancer, there are three important receptors, namely estrogen (ER) receptors, progesterone receptors (PR), and HER-2/Neu. The purpose of this study was to determine the association of obesity and history of family planning with the estrogen hormone receptor (ER), progesterone hormone receptor (PR), and HER-2/Neu expression in breast cancer patients in the dr. Moewardi Hospital in Surakarta, Central Java.Subjects and Method: This was an analytic observational study carried out at Dr. Moewardi Hospital, Surakarta, Central Java. A sample of 117 pre- and post-menopausal women who performed examinations at the oncology surgical clinic at Dr. Moewardi hospital, Surakarta was selected by total sampling. The dependent variables were estrogen and progesterone receptors and HER-2/Neu expressions. The independent variables were obesity and history of contraceptive method. Data were obtained from the medical record and analyzed by multiple logistic regression.Results: Obesity (OR= 0.29; 95% CI= 0.13 to 0.68; p= 0.004) reduced estrogen hormone receptors and it was statistically significant. History of contraceptive method (OR= 1.18; 95% CI= 0.55 to 2.52; p= 0.680) increased estrogen hormone receptors but it was not statistically signi­ficant. Obesity (OR=0.41; 95% CI= 0.18 to 0.96; p= 0.040) and history of contraceptive method (OR= 0.41; 95% CI= 0.19 to 0.88; p= 0.022) reduced progesterone hormone receptors. Obesity and history of contraceptive method increased Her-2/Neu expression.Conclusion: Obesity reduces estrogen hormone receptors. History of the contraceptive method increases estrogen hormone receptors. Obesity and history of contraceptive method reduce pro­gesterone hormone receptors. Obesity and history of contraceptive method increase Her-2/Neu expression.Keywords: Obesity, contraceptive method, estrogen, progesterone hormones, Her-2/neuCorrespondence: Silvia Ari Agustina. Study Program in Midwifery, School of Health Sciences Achmad Yani, Yogya­karta. Jl. Ringroad Barat Ambarketawang, Gamping, Sleman, Yogyakarta. Phone: (0274) 4342000. Email: silvia_ari99@yahoo.com. Indonesian Journal of Medicine (2019), 4(3): 259-265https://doi.org/10.26911/theijmed.2019.04.03.09
Co-Authors Anggraini, Tyas Ning Yuni Astuti Budi Rahayu, Budi Dewi Zolekhah Elvika Fit Ari Shanti, Elvika Fit Ari Fit Ari Shanti, Elvika Ika Fitria Ayuningtyas Kusumawardani, Arum Margi Laili Rahmatul Ilmi laili rahmatul ilmi Mahmudah, Happy Purbobinuko, Zakharias Kurnia Rukmi, Dwi Kartika Setyawati, Anik Silvia Ari Agustina Sugiyono Sugiyono Sujono Riyadi Tyas Ning Yuni Astuti A Yuli Astuti Zolekhah, Dewi