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JANIN KEMBAR SIAM TIPE CEPHALOTHORACOOMPHALOPAGUS Sihotang, Christian Jonathan Marulitua; Andrian, Samuel Albert; Simanjuntak, Tigor Peniel
Majalah Kedokteran Indonesia Vol 68 No 4 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Kembar siam merupakan salah satu kelainan kongenital yang jarang terjadi. Insidensi tidak diketahui secara pasti, namun diperkirakan berkisar antara 1:50.000 sampai 1:250.000. Tipe kembar siam yang lebih jarang adalah cephalothoracoomphalopagus. Terdapat 11% kasus cephalothoracoomphalopagus dari total keseluruhan jenis kembar siam. Mekanisme perkembangan dari kembar siam tidak dapat dijelaskan secara pasti, diduga adanya perubahan dalam proses pembelahan normal pada kembar monozigot, yakni gagal berpisah satu sama lain. Diagnosis secara dini pada bayi kembar prenatal penting dilakukan untuk terminasi kehamilan jika diinginkan. Kami menyajikan kasus bayi kembar cephalothoracoomphalopagus yang dikonfirmasi pada usia kehamilan 14 minggu dengan menggunakan ultrasound 3 dimensi. Janin memiliki satu kepala, satu toraks, satu perut bagian atas. Janin juga memiliki satu jantung dan dua tulang belakang. Masing-masing dari janin memiliki dua ekstremitas atas dan bawah. Secara umum, tindakan pembedahan untuk pemisahan tidak direkomendasikan karena prognosis cephalothoracoomphalopagus sangat buruk.

Sindrom Turner Tigor P. Simanjuntak
Majalah Kedokteran UKI Vol. 27 No. 1 (2010): JANUARI – MARET
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstrak Sindrom Turner adalah kelainan kongenital yang terjadi karena masalah kromosom, yaitu hilangnya sebagianatau keseluruhan kromosom X (45, XO). Etiologi pasti belum diketahui. Insidensinya berkisar antara 2,5-5,5 per10.000 kelahiran hidup bayi perempuan. Diagnosis sindrom Turner dapat ditegakkan sejak intra uterin maupunpasca lahir. Diagnosis intra uterin dapat ditegakkan dengan USG, amniosintesis dan pemeriksaan kadar alfa-fetoprotein. Diagnosis pasca lahir dengan melihat karakteristik fisik dan pemeriksaan kromosom bayi. Tulisan inimelaporkan dua kasus sindrom Turner yang terdiagnosis saat antenatal di poliklinik spesialis Obstetri danGinekologi RSU. FK. UKI Jakarta. Kata Kunci: kromosom x, USG, amniosentesis, alfa-feto protein. Abstract Turner syndrome is a congenital disorder, due to partial or total loss of X chromosome (45, XO). The definitiveetiology is unknown. The incidence is 2.5- 5.5 per 10.000 female live birth. Diagnosis could be establishedsince intrauterine period to birth. The intrauterine diagnosis could be established by applying USG,amniocentesis, and by measuring the alpha feto protein level.1-4 At birth, diagnosis could be established byphysical characteristic examination and chromosome analysis. This paper reports two cases of Turner syndromediagnosed antenatally at the Obstetric and Ginecology’s clinic , FK. UKI Hospital, Jakarta. Kay words: chromosome x, USG, amniocentesis, alpha-feto protein

Malaria in Pregnancy: A Holistic Review and Approach to Laboratory Findings, Management and Outcomes Tigor P. Simanjuntak; Giovanni A. Simbolon; Novita Hermanus; Nadya R. Permata; Clarissa Agdelina
Majalah Kedokteran UKI Vol. 35 No. 1 (2019): JANUARI - MARET
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract Malaria is an infectious disease caused by protozoa of the genus Plasmodium, transmitted by the bite of female mosquitoes Anopheles. Malaria can infect various populations including pregnant women. The incidence of malaria in pregnancy is quite high especially in tropical - endemic regions such as Indonesia, Papua New Guinea, Nigeria, West Africa and Sudan. It happens because there is no enhanced control activities such as two prevention approaches advocated by the WHO, as well prevention intermittently with sulfadoxine- pyrimethamine (SP) and the treatment of malaria during pregnancy. There are several factors that influence the high prevalence of malaria such as mosquito vectors, malaria parasites, human hosts and environment. As a result of the presence of malarial parasites in the placenta appear serious adverse outcomes to the mother, fetus and newborn. Malaria can be diagnosed with microscopy, rapid diagnostic test (RDT), and polymerase chain reaction (PCR).The firstline treatments recommended by the WHO in the second and third trimester of pregnancy are artemisinin-based combination treatments (ACT).Keywords: Malaria, pregnancy, laboratory findings, management, outcomes Abstrak Penyakit malaria merupakan infeksi yang disebabkan oleh genus Plasmodium, yang ditularkan melalui gigitan nyamuk Anopheles betina. Malaria dapat menginfeksi berbagai populasi termasuk perempuan hamil. Insidens malaria dalam kehamilan cukup tinggi terutama di wilayah tropis - endemik seperti Indonesia, Papua Nugini, Nigeria, Afrika Barat, dan Sudan. Hal itu terjadi karena ketiadaan penanggulangan/pencegahan seperti yang dianjurkan WHO yaitu pemberian sulfadoxine- pyrimethamine (SP) intermiten dan pengobatan malaria dalam kehamilan. Ada banyak faktor yang berperan terhadap kejadian malaria yakni nyamuk sebagai vektor, parasit malaria, manusia sebagai pejamu dan lingkungan yang juga berperan terhadap kejadian malaria dalam kehamilan. Malaria dalam kehamilan berakibat serius trehadap ibu, janin dan neonatus. Diagnosis dapat ditegakkan secara mikroskopi, rapid diagnostic test (RDT), dan polymerase chain reaction (PCR). Pengobatan lini pertama yang direkomendasikan oleh WHO pada trimester ke dua dan ketiga kehamilan adalah kombinasi artemisinin (artemisinin-based combination treatments - ACT).Kata kunci: Malaria, kehamilan, pemeriksaan laboratorium, tatalaksana, luaran

Operasi Seksio Sesarea pada Ibu Hamil dengan Gagal Jantung Tigor P. Simanjuntak
Majalah Kedokteran UKI Vol. 28 No. 3 (2012): JULI-SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

AbstrakTindakan operasi seksio sesarea adalah persalinan buatan untuk melahirkan bayi melalui operasi dinding perut dan uterus. Tindakan itu dilakukan atas indikasi obstetri atau indikasi medis. Tindakan seksio sesarea pada kehamilan dengan kelainan jantung kelas 4/ gagal jantung/ dekompensasi kordis merupakan indikasi medis yang bersifat selektif dan harus dilakukan di rumah sakit dengan fasilitas memadai. Tulisan ini akan melaporkan kasus seorang ibu berumur 37 tahun, gravida tujuh, paritas tiga, abortus tiga (G7P3A3), hamil 35-36 minggu, gemeli, anak pertama letak kepala, dan anak kedua letak sungsang, menderita kelainan jantung kelas 4 dan hipertensi gestasional. Kehamilan di terminasi dengan tindakan seksio sesarea karena pasien semakin sesak. Pasca operasi hari ke-10 ibu dan bayi pulang dengan keadaan umum baik.Kata kunci: seksio sesarea, gagal jantung, indikasi AbstractCesarean section is an artificial labor of a fetus through incisions on the abdominal and the uterine wall. The surgery was performed based on medical or obstetric indication. Cesarean section in grade 4 heart disease/ heart failure/cardiac decompensation during pregnancy is a selective medical indication, and should be performed in hospital with appropriate facility. This paper reports a case of a female, 37 years old, seventh gravid, three parities, and three abortions (G7P3A3). She was pregnant for 35- 36 weeks, twin pregnancy, and the first baby was head presentation, the second baby was breech presentation, and the mother having grade 4 heart disease, and had gestational hypertension. Pregnancy was terminated by cesarean section because the patient was getting more dyspneic. Ten days after surgery the mother and the babies were released from the hospital in a good condition.Key word: cesarean section, heart failure, indication

Hubungan Antara Pengetahuan, Sikap dan Praktik Personal Hygiene Organ Genitalia Eksterna Terhadap Kejadian Keputihan Patologis Widia A. A. Cahyaningtyas; Sudung Nainggolan; Tigor P. Simanjuntak
Majalah Kedokteran UKI Vol. 36 No. 2 (2020): MEI - AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v36i2.3091

Abstrak Keputihan (leukorea, flour albus, vaginal discharge) adalah sekret berlebihan dari vagina selain darah haid, dan tidak disebabkan neoplasma atau penyakit sistemik. Keputihan merupakan masalah kesehatan reproduksi dialami hampir 75% perempuan didunia, paling tidak sekali selama hidupnya. Kurangnya pengetahuan, sikap, dan praktik dalam perawatan vagina diyakini berpengaruh terhadap kejadian keputihan patologis tersebut. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap, dan praktik personal hygiene organ genital eksterna terhadap kejadian keputihan patologis pada mahasiswi Fakultas Kedokteran Universitas Kristen Indonesia. Penelitian ini menggunakan desain penelitian analitik korelasional pada 98 mahasiswi. Terdapathubungan yang bermakna (p= 0,000) dan korelasi positif antara tingkat pengetahuan, sikap dan praktik personal hygiene dengan kejadian keputihan patologis. Kata Kunci : keputihan, pengetahuan, sikap, praktik, personal hygiene. Relationship Between Knowledge, Attitudes and Personal Practices of External Genitalia Hygiene Against Pathological Leucorrhoea Abstract Vaginal discharge (leukorrhea, flour albus, vaginal discharge) is excessive discharge from the vagina other than menstrual blood, and is not caused by neoplasms or systemic disease. Leucorrhoea is a reproductive health problem that affects nearly 75% of women in the world, at least once in their lifetime. Lack of knowledge, attitude, and practice in vaginal care is believed to have an effect on the incidence of pathological vaginal discharge. This study aims to determine the relationship between knowledge, attitudes, and personal hygiene practices of external genital organs on the incidence of pathological vaginal discharge in students of the Faculty of Medicine, Christian University of Indonesia. This study used a correlational analytical research design on 98 female students of the Faculty of Medicine, Christian University of Indonesia. It was found a significant relationship (p = 0.000) and a positive correlation between the level of knowledge, attitudes and personal hygiene practices with the incidence of pathological vaginal discharge. Keywords: leucorrhoea, knowledge, attitude, practice, personal hygiene.

Effectiveness Curcuma Longa to Prevent Cells Damage in Early Pregnant Mice with Acute Toxoplasmosis Tigor Peniel Simanjuntak; Mochammad Hatta; Syahrul Rauf; Andi Mardiah Tahir; Irawan Yusuf; Nurpudi Astuti Taslim; Robert Hotman Sirait; Silvia Arin Prabandari
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 2 September 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Objective: To prove the effectiveness of Curcuma longa to prevent damage cells by analyzing FOXP3 gene expression, TNF-α level, and histopathology of placental tissue. Method: This study was conducted in 20 early pregnant mice, divided in 5 groups (K1-K5). K1-K4 were injected with tachyzoites. K1 and K2 were intervened with Curcuma longa 125 and 500 mg/kg/day. K3 were intervened with spiramycin 60 mg/kg/day, K4 were intervened with 0,2 distilled water, and K5 was not injected and intervened. IgG-IgM levels, FOXP3 mRNA expression, TNF-α level was examined serially, and placental mice were taken for histopathology examination 7 days after intervention.Result: FOXP3 mRNA expression in K1 and K2 increased significantly 7 days after intervention compared to K4 (p < 0.05), however the increased of expression in two groups has no significant difference. TNF-α level in K1 and K2 decreased significantly 7 days after intervention compared to K4 (p < 0.05), however the decrease of level in two groups has no significant difference. Hemorrhagic and necrotic cells were not found in K1 and K2, but were found in K3 (75%) and K4 (100%). Conclusion: Curcuma longa 125 mg is effective to prevent cells damage in early pregnant mice with acute toxoplasmosis. Efektivitas Ekstrak Curcuma Longa Mencegah Kerusakan Sel Pada Mencit Hamil Muda dengan Toksoplasmosis Akut.AbstrakTujuan: Membuktikan efektivitas Curcuma longa mencegah kerusakan sel dengan menganalisis ekspresi gen FOXP3, kadar TNF-α, dan histopatologi jaringan plasenta.Metode: Penelitian dilakukan pada 20 tikus hamil muda, dibagi dalam 5 kelompok (K1-K5). K1-K4 diinjeksi 10 takizoid toksoplasma intra abdominal. Tiga hari pasca injeksi takizoid, K1 dan K2 diintervensi dengan Curcuma longa 125 dan 500 mg / kg / hari. K3 diintervensi dengan spiramisin 60 mg / kg / hari, K4 diintervensi dengan 0,2 ml air suling dan K5 tidak diinjeksi dan tidak diintervensi. Kadar IgG-IgM, ekspresi mRNA FOXP3, kadar TNF-α diperiksa secara serial dan plasenta tikus diambil untuk pemeriksaan histopatologi 7 hari pasca intervensi.Hasil: Ekspresi mRNA FOXP3 pada K1 dan K2 meningkat bermakna (p< 0.05) 7 hari pasca intervensi dibandingkan dengan K4 (p <0,05), tetapi peningkatan ekspresi pada kedua kelompok tidak terdapat perbedaan bermakna. Kadar TNF-α pada K1 dan K2 menurun bermakna 7 hari pasca intervensi dibandingkan dengan K4 (p <0,05), tetapi penurunan kadar pada dua kelompok tidak terdapat perbedaan bermakna. Hemoragik dan nekrotik sel tidak ditemukan pada K1 dan K2, tetapi ditemukan pada K3 (75%) dan K4 (100%).Kesimpulan: Curcuma longa 125 mg efektif untuk mencegah kerusakan sel pada tikus hamil muda dengan toksoplasmosis akut.Key words: Curcuma longa, kerusakan sel, hamil muda, gene FOXP3, TNF-α, toxoplasmosis

ACE2 Receptors Finding in Placenta with Intrauterine Fetal COVID-19 Infection: A Meta-Analysis Tigor Peniel Simanjuntak; Hanny Hadinata Wiranegara; Temmy Hadinata Wiranegara
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.412

Objective: Association between ACE2 receptors in the placenta and the incidence of intrauterine COVID-19 infection in pregnant women infected with COVID-19 Methods: Systematic review and meta-analysis of placenta in pregnant women with COVID-19 infection, ACE2 receptor in placenta, and RT-PCR of neonates from COVID-19 pregnant women. This study followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) protocol. Results: 6 journals meet the inclusion criteria. ACE2 receptors were found in syncytiotrophoblasts 72/72 (100%), cytotrophoblasts 41/72 (56.9%), extravillous trophoblasts 24/72 (33.3%), decidual cells 2/72 (2.7%), villous stromal cells 1/72 (1.3%), and 1/72 stromal cells (1.3%) with the incidence of neonates infected with SARS-CoV-2 from pregnant women with COVID-19 10.5%, odds ratio (OR) between ACE2 receptors and neonates infected with COVID-19 is 1.97 (95%CI 0.05–81.09), the pooled proportion of ACE2 receptor findings in 72 placentas in pregnant women with COVID-19 infection, syncytiotrophoblast 98.3 (95% CI 94.3–99.9), cytotrophoblast 40.3 (95% CI 2.3–88.9), and extravillous trophoblast 35.2 (95% CI 0.2–88.5). Conclusion: Expression of ACE2 receptors is always present in the placenta of pregnant women, and there is an association but non-significant between ACE2 receptors in the placenta and the incidence of COVID-19 intrauterine infection with an odds ratio of 1.97 (95%CI 0.05-81.09).Reseptor ACE2 Pada Plasenta dengan Kejadian Infeksi COVID-19 Intrauterine Pada Fetus: A Meta-AnalysisAbstrakTujuan: Hubungan antara reseptor ACE2 di plasenta dengan angka kejadian infeksi COVID-19 intrauterine pada ibu hamil yang terinfeksi COVID-19. Metode: Tinjauan sistematis dan meta-analisis plasenta pada ibu hamil COVID-19, reseptor ACE2 pada plasenta, dan hasil uji RT-PCR neonatus dari ibu hamil COVID-19. Penelitian ini mengikuti protokol Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Hasil: 6 jurnal memenuhi kriteria. Reseptor ACE2 ditemukan di sinsitiotrofoblas 72/72 (100%), 41/72 sitotrofoblas (56.9%), trofoblas ekstravili 24/72 (33.3%), sel desidua 2/72 (2.7%), sel stroma vili 1/72 (1.3%), dan sel stroma 1/72 (1.3%) dengan insidensi neonatus yang terinfeksi SARS-CoV-2 dari ibu hamil dengan COVID-19 sebanyak 10.5%, odds ratio (OR) antara reseptor ACE2 dan neonatus terinfeksi COVID-19 adalah 1.97 (95%CI 0.05–81.09), proporsi gabungan penemuan reseptor ACE2 pada 72 plasenta ibu hamil COVID-19, sintiotrofoblas 98.3 (95%CI 94.3 – 99.9), sitotrofoblas 40.3 (95%CI 2.3 – 88.9), dan trofoblas ekstravili 35.2 (95%CI 0.2 – 88.5). Kesimpulan: Ekspresi reseptor ACE2 selalu ditemukan di plasenta ibu hamil, dan terdapat hubungan yang tidak bermakna antara reseptor ACE2 di plasenta dengan kejadian infeksi intrauterine COVID-19 yaitu odds ratio 1.97 (95%CI 0.05-81.09).Kata kunci : Infeksi COVID-19, Intrauterine, reseptor ACE2 plasenta.

PENYULUHAN VITAMIN DAN SUPPLEMEN YANG DIBUTUHKAN TUBUH LANSIA DI KELURAHAN TIDUNG, PULAU SERIBU 17-19 JUNI 2022 Fransiska Sitompul; Romauli Lumbantobing; Tjio Ie Wei; Tigor P Simanjuntak
JURNAL ComunitÃ Servizio : Jurnal Terkait Kegiatan Pengabdian kepada Masyarakat, terkhusus bidang Teknologi, Kewirausahaan dan Sosial Kemasyarakatan Vol. 4 No. 2 (2022): OKTOBER
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM), Univesitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/cs.v4i2.4090

Abstract The COVID-19 (coronavirus) pandemic has caused many changes in daily life. Good nutrition is very important before, during and after infection. Adequate nutrition, especially vitamins and minerals, is needed in maintaining an optimal immune system, vegetables and fruits are the best sources of various vitamins, minerals and fiber. According to the World Health Organization (WHO), the elderly is someone who has entered the age of 60 years and over. In Indonesia, the number of elderly people increased from 18 million people (7.56%) in 2010 to 25.9 million people (9.7%) in 2019 and can be expected to continue to increase where in 2035 to 48.2 million people (15,77%). The elderly need a variety of foods to maintain a nutritional balance, one of which is to avoid infectious diseases (eg infections) and non-communicable diseases (eg hypertension). In principle, the elderly really need protection and the provision of correct information during a pandemic, especially regarding mental and physical health care. According to statistical data, the Thousand Islands Regency in 2021 consists of 2 sub-districts and 6 urban villages. During the period of 1 year (2019 – 2020), the population of the Thousand Islands experienced an increase of 1.56 percent. If we look at the population by age group, it can be seen that the composition of productive age (15-64 years) is almost double the unproductive age (> 64 years/elderly) which is 66.82 percent. Therefore, in community service activities (PKM), we want to do Vitamin and Food Supplement Counseling for the elderly (over 60 years old) in P. Tidung Village, Pulau Seribu on 17-19 June 2022. Keywords: Community Service; Vitamin and Supplement; elderly; The Covid-19 Pandemic.

Vulvovaginitis: Karakteristik Klinis, Diagnosis, dan Tatalaksana Syefi, Monica; Simanjuntak, Tigor P.
Majalah Kedokteran UKI Vol. 39 No. 2 (2023): MEI - AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v39i2.5902

Vulvovaginitis adalah infeksi pada vulva dan vagina yang sering terjadi. Diperkirakan 70% perempuan di dunia pernah mengalami vulvovaginitis. Vulvovaginitis sering ditemukan pada remaja dan perempuan usia produktif. Penyebab tersering adalah bakteri, jamur Candida, dan Trichomonas vaginalis. Vaginosis bakterial dialami oleh 22-50% perempuan, kandidiasis vagina 17-39%, dan trikomoniasis 4-35%, Pada vaginosis bakterial ditemukan sekret berwarna putih abu-abu, berbau, gatal, dan pH vagina meningkat. Diagnosis vaginosis bakterial ditegakkan berdasarkan kriteria klinis dan kriteria Amsal yang dibuat berdasarkan pewarnaan Gram. Pada kandidiasis trikomoniasis ditemukan sekret berwarna putih seperti yoghurt, gatal, nyeri, bengkak, sensasi terbakar, dan kemerahan vulva pada pemeriksaan fisik. Pemeriksaan laboratorium dilakukan dengan memeriksa pH vagina dan pemeriksaan mikroskopis sediaan KOH 10%. Pada trikomoniasis, keluhan pasien berupa keputihan berwarna kuning kehijauan, berbusa, berbau, gatal, disuria, dan rasa terbakar pada vulva. Diagnosis ditegakkan dengan memeriksa pH, pemeriksaan sediaan basah vagina, dan metode berbasis molekular NAAT. Kata kunci: vaginosis bakterial, kandidiasis trikomoniasis, trikomoniasis, keputihan, pemeriksaan laboratorium Vulvovaginitis is a common infection of the vulva and vagina. It is estimated that 70% of women in the world have experienced vulvovaginitis. Vulvovaginitis is often found in teenagers and women of reproductive age. The most common causes are bacteria, Candida fungi, and Trichomonas vaginalis. Bacterial vaginosis is experienced by 22-50% of women, vaginal candidiasis 17-39%, and trichomoniasis 4-35%. In bacterial vaginosis, white-grey discharge is found, smelly, itchy, and the vaginal pH increases. The diagnosis of bacterial vaginosis is made based on clinical criteria and Proverbs criteria based on Gram staining. In vaginal candidiasis, white discharge like yoghurt is found, itching, pain, swelling, burning sensation, and redness of the vulva on physical examination. Laboratory examination is carried out by checking vaginal pH and microscopic examination of 10% KOH preparations. In trichomoniasis, patient complaints include greenish-yellow vaginal discharge, foamy, smelly, itchy, dysuria, and a burning sensation in the vulva. The diagnosis is made by checking the pH, vaginal wet preparation examination, and NAAT molecular-based methods. Keywords: bacterial vaginosis, vulvovaginal kandidiasis, trichomoniasis, vaginal discharge

Antiviral Treatment on Pregnancy with COVID-19 Infection : A Systematic Review Simanjuntak, Tigor Peniel; Kakerissa, Angela Putri; Kurniawan, Grady Ivan
Indonesian Journal of Obstetrics & Gynecology Science Special Issue: Article Review
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v4i2s.329

Objective to evaluate antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Method: a systematic review of antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement. Result 948 papers accessed through Pubmed, Scopus, Science Direct, Cohcrane, and other with keywords “Antiviral”, “Pregnancy” “Pregnant” “Coronavirus” “COVID-19” “SARS-CoV-2”. Duplicate papers were excluded (n=302), topics and abstracts that do not meet the criteria (n=612), and 25 papers that did not meet the inclusion criteria. 9 papers that meet the inclusion criteria (case reports and cohort retrospective case study) discussed 20 pregnant women with COVID-19 infection (16 moderate and severe cases received Remdesivir, 3 moderate and mild cases received Lopinavir-ritonavir combination, and 1 moderate case received Arbidol). Conclusion, remdesivir is an antiviral frequently used in pregnancy on trimester II and III with severe COVID-19 infection with a duration of treatment of 5-10 days. Remdesivir should be monitored because some show side effects of increasing liver function.Pengobatan Ibu Hamil yang Terinfeksi COVID−19 dengan AntivirusAbstrakTujuan untuk mengevaluasi penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan derajat keparahan. Metode tinjauan literatur sistematis tentang penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan tingkat keparahan. Tinjauan sistematis mengikuti pedoman dari Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil terdapat 948 jurnal yang diakses melalui Pubmed, Scopus, Science Direct, Cohcrane dan lainya dengan kata kunci : Antiviral, Pregnancy, Pregnant, Coronavirus, COVID-19, SARS-CoV-2. Terdapat jurnal yang terduplikasi (n=302), topik dan abstrak yang tidak sesuai kriteria (n=612), dan 25 jurnal yang tidak sesuai kriteria inklusi. Terdapat 9 jurnal yang memenuhi kriteria inklusi (laporan kasus dan studi retrosepktif kohort) yang membahas 20 wanita hamil dengan infeksi COVID-19 (16 kasus dengan derajat sedang dan berat menerima Remdesivir, 3 kasus derajat sedang dan ringan menerima kombinasi Lopinavir-ritonavir, dan 1 kasus derajat sedang menerima Arbidol). Kesimpulan, remdesivir adalah antivirus yang sering digunakan pada wanita hamil trisemester II dan III dengan infeksi COVID-19 derajat berat, lama pengobatan 5-10 hari. Remdesivir harus diwaspadai karena dapat menimbulkan efek samping seperti peningkatan fungsi hati. Kata kunci: Antivirus, Hamil, COVID-19

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