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All Journal Majalah Kedokteran Indonesian Journal of Obstetrics & Gynecology Science Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal ComunitA Servizio Cermin Dunia Kedokteran
Tigor P. Simanjuntak
Department Of Obstetrics And Gynecology Medicine Faculty Of Universitas Kristen Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences

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The Efficacy of Emergency Contraception to Prevent Pregnancy: A Systematic Review and Meta-Analysis Simanjuntak, Tigor Peniel; Sihaloho, Resilia; Sirait, Batara Imanuel
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.574

Abstract

Objective: A systematic review and meta-analysis to determine the effectiveness of various emergency contraceptive methods to prevent pregnancy.Method: This study followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) protocol. Data search used four databases, namely Pubmed, Google Scholar, Science Direct, and Wiley. Data that met the inclusion criteria were subjected to meta-analysis to analyze the combined proportion of data using MedCalc 20.012 software, calculation of a percentage of 95% Confidence Intervals (CI) and P<0.05, and heterogeneity test between studies.Results: There were 6 journals that met the criteria. Some of the contraceptives used as emergency contraception are: the copper IUD (CuIUD) with effectiveness reaching 100% in preventing pregnancy, levonorgestrel (LNG) 52-mg IUS with effectiveness reaching 99.95%, the levonorgestrel (LNG) 52-mg IUD with effectiveness reaching 99.7%, mifepristone 10 mg with effectiveness reaching 99.3%, mifepristone 5 mg with effectiveness reaching 98.8%, ulipristal acetate (UPA) 30 mg in pre-ovulatory women with effectiveness reaching 98.6%, levonorgestrel (LNG) 0.75 mg with effectiveness reaching 98.3%, yuzpe regimen with effectiveness reaching 98.2%, and ulipristal acetate (UPA) 30 mg in post-ovulatory women with effectiveness reaching 97.9%. The results of the proportion meta-analysis showed the proportion of pregnancies after the use of emergency contraceptive, which was 0.231% (95% CI 0.116–0.384) from 4,927 samples in 6 studies, and the results of the heterogeneity test between studies were found to be not meaningful (I2 = 0%). Conclusion: The emergency contraception used to prevent pregnancy is very effective with the results of a meta-analysis of the proportion of 0.231% (95% CI 0.116–0.384). This suggests that the percentage of pregnancies after emergency contraceptive use is quite low.Efektivitas Kontrasepsi Darurat untuk Mencegah Kehamilan: Tinjauan Sistematis dan Meta-AnalisisAbstrakTujuan: Tinjauan sistematis dan meta-analisis untuk mengetahui efektivitas berbagai metode kontrasepsi darurat untuk mencegah kehamilan.Metode: Penelitian ini mengikuti protokol Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Pencarian data menggunakan empat database yaitu Pubmed, Google Scholar, Science Direct, dan Wiley. Data yang memenuhi kriteria inklusi dilakukan meta analisis dengan analisis proporsi gabungan data menggunakan software MeldCalc 20.012, dilakukan perhitungan persentase 95% CI dan P<0.05, serta dilakukan uji heterogenitas antar studi.Hasil: Terdapat 6 jurnal yang memenuhi kriteria. Beberapa alat kontrasepsi yang digunakan sebagai kontrasepsi darurat yaitu: AKDR tembaga (CuIUD) dengan efektivitas mencapai 100% dalam mencegah kehamilan, levonorgestrel (LNG) 52-mg IUS dengan efektivitas mencapai 99,95%, levonorgestrel (LNG) 52-mg IUD dengan efektivitas mencapai 99,7%, mifepristone 10 mg dengan efektivitas mencapai 99,3%, mifepristone 5 mg dengan efektivitas mencapai 98,8%, ulipristal asetat (UPA) 30 mg pada wanita pre-ovulasi dengan efektivitas mencapai 98,6%, levonorgestrel (LNG) 0,75 mg dengan efektivitas mencapai 98,3%, yuzpe regimen dengan efektivitas mencapai 98,2%, dan ulipristal asetat (UPA) 30 mg pada wanita post-ovulasi dengan efektivitas mencapai 97,9%. Hasil meta analisis proporsi menunjukkan proporsi kehamilan setelah penggunaan kontrasepsi darurat yaitu 0,231% (95% CI 0,116–0,384) dari 4.927 sampel, serta hasil uji heterogenitas antar studi ditemukan tidak bermakna (I2 = 0%).Kesimpulan: Penggunaan kontrasepsi darurat sangat efektif dalam mencegah kehamilan dengan hasil meta analisis proporsi yaitu 0,231% (95%CI 0,116–0,384). Hasil tersebut menunjukkan bahwa persentase kehamilan setelah penggunaan kontrasepsi darurat cukup rendah.Kata kunci: Efektivitas, Kontrasepsi Darurat
Effectiveness of Aspirin Dose in Preventing Preeclampsia in High-Risk Group: A Meta-Analysis Simanjuntak, Tigor Peniel; Elena, Elena; Sirait, Batara Imanuel
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.848

Abstract

Introduction: Preeclampsia is hypertension that occurs after 20 weeks of pregnancy and is accompanied by impaired function of the mother’s organs or the uteroplacental unit. Purpose: To evaluate the efficacy of aspirin doses in preventing preeclampsia in high-risk populations. Method: This study follows the PRISMA protocol. The reviewers examined all the findings and selected studies that met the inclusion criteria and PICO analysis. Statistical analysis was performed using Review Manager 5.4 software. A total of 14 journals met the inclusion criteria with searches in four databases (PubMed, Science Direct, Google Scholar, and Plos One). Result: Aspirin significantly reduced the incidence of preeclampsia in the high-risk group (RR 0.83 [95% CI: 0.78, 0.88], P<0.00001), reducing the incidence of preeclampsia by 50 mg/day (RR 0.56 [95% CI: 0.36, 0.86] P=0.008), 60 mg/day (RR 0.87 [95% CI: 0.81, 0.93] P <0.0001), 75 mg/day (RR 0.54 [95% CI: 0.40, 0.73] P<0.0001), 80-81 mg/day (RR 0.72 [95% CI: 0.56, 0.94] P=0.02), and 150 mg/day, reduced the incidence of PE (P<0.00001). Conclusion: The results of the study show that the best dose of aspirin to prevent PE in high-risk groups is 75 mg/day.Efektivitas Dosis Aspirin untuk Mencegah Preeklamsia pada Kelompok Risiko Tinggi: Sebuah MetaanalisisAbstrakPendahuluan: Preeklamsia adalah hipertensi yang terjadi setelah usia kehamilan 20 minggu dan disertai dengan gangguan fungsi organ ibu atau uteroplasenta. Tujuan: Untuk mengetahui efektivitas dosis aspirin untuk mencegah preeklamsia pada kelompok risiko tinggi. Metode: Penelitian ini mengikuti protokol PRISMA. Para peninjau memeriksa semua temuan dan memilih penelitian yang memenuhi kriteria inklusi dan analisis PICO. Analisis statistik dilakukan dengan menggunakan perangkat lunak Review Manager 5.4. Terdapat 14 jurnal yang memenuhi kriteria inklusi dengan pencarian di 4 database (PubMed, Science Direct, Google Scholar, dan Plos One). Hasil: Aspirin secara signifikan menurunkan kejadian preeklampsia pada kelompok risiko tinggi (RR 0,83 [95% CI: 0,78, 0,88], P<0,00001), menurunkan kejadian preeklamsia sebesar 50 mg/hari (RR 0.56 [95% CI: 0.36, 0.86] P=0.008), 60 mg/hari (RR 0.87 [95% CI: 0,81, 0.93] P <0,0001), 75 mg/hari (RR 0,54 [95% CI: 0,40, 0,73] P<0,0001), 80-81 mg/hari (RR 0,72 [95% CI: 0,56, 0,94] P=0,02), dan 150 mg/hari, mengurangi kejadian PE (P<0,00001). Kesimpulan: Hasil penelitian menunjukan bahwa dosis aspirin terbaik untuk mencegah PE pada kelompok risiko tinggi adalah 75 mg/hari.
Janin Kembar Siam Tipe Cephalothoracoomphalopagus Sihotang, Christian Jonathan Marulitua; Andrian, Samuel Albert; Simanjuntak, Tigor Peniel
Majalah Kedokteran Indonesia Vol 68 No 4 (2018): Journal of the Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.4-2018-83

Abstract

Kembar siam merupakan salah satu kelainan kongenital yang jarang terjadi. Insidensi tidak diketahui secara pasti, namun diperkirakan berkisar antara 1:50.000 sampai 1:250.000. Tipe kembar siam yang lebih jarang adalah cephalothoracoomphalopagus. Terdapat 11% kasus cephalothoracoomphalopagus dari total keseluruhan jenis kembar siam. Mekanisme perkembangan dari kembar siam tidak dapat dijelaskan secara pasti, diduga adanya perubahan dalam proses pembelahan normal pada kembar monozigot, yakni gagal berpisah satu sama lain. Diagnosis secara dini pada bayi kembar prenatal penting dilakukan untuk terminasi kehamilan jika diinginkan. Kami menyajikan kasus bayi kembar cephalothoracoomphalopagus yang dikonfirmasi pada usia kehamilan 14 minggu dengan menggunakan ultrasound 3 dimensi. Janin memiliki satu kepala, satu toraks, satu perut bagian atas. Janin juga memiliki satu jantung dan dua tulang belakang. Masing-masing dari janin memiliki dua ekstremitas atas dan bawah. Secara umum, tindakan pembedahan untuk pemisahan tidak direkomendasikan karena prognosis cephalothoracoomphalopagus sangat buruk.
Hasil Luaran Janin pada Kehamilan yang Terinfeksi Sifilis yang Diobati dengan Penicillin G: Tinjauan Sistematis: Analisis Nathaniel, Joshua; Simanjuntak, Tigor Peniel
Cermin Dunia Kedokteran Vol 52 No 1 (2025): Obstetri & Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i1.1297

Abstract

Background: Syphilis infection during pregnancy can cause congenital syphilis. Syphilis in pregnant women is treated with penicillin to prevent fetal infection and congenital syphilis. A systematic literature review is conducted to determine the efficacy of penicillin G by reviewing outcome parameters. Methods: A systematic literature review following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Results: Through searches on PubMed, Science Direct, and Cochrane using keywords ‘Antibiotics’, ‘Pregnancy’, ‘Syphilis’, and ‘Treatment’, 230 articles were found. Twenty-five articles were duplicates, 135 articles did not meet the inclusion criteria, 75 articles were literature reviews, and 58 articles were not related to pregnant women, resulting in 6 journals that met the inclusion criteria. Conclusion: Penicillin G benzathine is the most common antibiotic used to treat syphilis in pregnancy. A total of 1,190 cases (26.26%) of congenital syphilis were found among 4,531 pregnant women infected with syphilis and receiving penicillin G benzathine therapy. The incidence of congenital syphilis was 2.4% in pregnant women who received therapy since the first trimester. The incidence of congenital syphilis increased 12 times if therapy was given in the second trimester and 33 times if given in the third trimester.
Co-Authors Andi Mardiah Tahir Andrian, Samuel Albert Andrian, Samuel Albert Batara Sirait Clarissa Agdelina Elena, Elena Fransiska Sitompul Giovanni A. Simbolon Hanny Hadinata Wiranegara Irawan Yusuf Kakerissa, Angela Putri Kurniawan, Grady Ivan Mochammad Hatta Nadya R. Permata Nathaniel, Joshua Novita Hermanus Nurpudi Astuti Taslim Robert Hotman Sirait Romauli Lumbantobing Sihaloho, Resilia Sihotang, Christian Jonathan Marulitua Sihotang, Christian Jonathan Marulitua Silvia Arin Prabandari Sudung Nainggolan Syahrul Rauf Syefi, Monica Temmy Hadinata Wiranegara Tjio Ie Wei Widia A. A. Cahyaningtyas