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Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen Melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein: Curcumin Increased Breast Cancer Cells Sensitivity to Tamoxifen Through Inhibition of P-glycoprotein and Breast Cancer Resistance Protein Expressions Sianipar, Erlia Anggrainy; Louisa, Melva; Wanandi, Septelia Inawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

The decreasing of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. This study aim to know the effect of curcumin in increasing the cell sensitivity to tamoxifen through inhibition of P-gp and BCRP transporter efflux. MCF-7 breast cancer cell line was induced with tamoxifen 1 ÂµM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF-7(T) cells, curcumin was given at of 5/10/20 ÂµM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5th. As positive control, verapamil 50 ÂµM was used as P-gp inhibitor, ritonavir 15 ÂµM and nelfinavir 15 ÂµM were used as BCRP inhibitor. The results showed that MCF-7(T) cells sensitivity to tamoxifen decreased with 11.8 times, the cell viability increased 10.82 fold and mRNA expression of P-gp and BCRP increased 4.04 fold. Then after administration of curcumin with or without tamoxifen for 5 days, the cell viability and the mRNA expression of P-gp and BCRP decreased. As conclusion, curcumin increased the sensitivity of MCF-7(T) to tamoxifen characterized by the decreasing of cell viability and mRNA expression of P-gp and BCRP. However, the administration of combination of curcumin with tamoxifen was more potent than just curcumin. The increased sensitivity was estimated at least partly through the inhibition of P-gp and BCRP mRNA expression by curcumin

PENGECEKAN KADAR GLUKOSA DARAH SEWAKTU, TEKANAN DARAH, DAN GOLONGAN DARAH PADA MASYARAKAT DESA CIBOGO CISAUK TANGERANG Sianipar, Erlia Anggrainy; Arrang, Sherly Tandi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 1 No. 1 (2023)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v1i1.3913

Kesadaran masyarakat dalam melakukan cek kesehatan secara berkala masih kurang. Perubahan gaya hidup yang cenderung tidak sehat menjadi faktor memicu timbulnya berbagai penyakit. Saat ini, jumlah penderita penyakit hipertensi dan diabetes melitus masih cukup tinggi sehingga perlu dilakukan usaha pencegahan dan deteksi sedini mungkin. Pemeriksaan kesehatan seperti kadar glukosa darah sewaktu dan tekanan darah secara berkala perlu dilakukan. Selain itu, pemeriksaan golongan darah dan faktor rhesus juga penting dilakukan agar masyarakat mengetahui jenis golongan darahnya sehingga dapat digunakan sebagai alat informasi untuk menunjang kesehatannya di kemudian hari. Kegiatan ini diselenggarakan di desa Cibogo Kecamatan Cisauk Kabupaten Tangerang. Pemeriksaan kesehatan diikuti oleh 99 peserta yang merupakan warga desa Cibogo Kecamatan Cisauk dengan rentang usia 17 sampai dengan 84 tahun. Hasil menunjukkan bahwa persentase peserta yang bergolongan darah A, B, AB, dan O secara berturut-turut adalah 28,3%, 20,2%, 12,12%, dan 38,4%. Semua peserta memiliki rhesus positif (Rh+). Kemudian, berdasarkan hasil pemeriksaan kadar glukosa darah, terdapat 6 peserta (6,06%) dengan kadar glukosa darah tinggi yaitu lebih dari 200 mg/dL. Sedangkan pada pemeriksaan tekanan darah, ditemukan 31 orang peserta (31,3%) dengan tekanan darah tinggi yaitu lebih dari >120/80 mmHg.

PENGECEKAN KADAR GLUKOSA DARAH SEWAKTU, TEKANAN DARAH, DAN GOLONGAN DARAH PADA MASYARAKAT DESA CIBOGO CISAUK TANGERANG Sianipar, Erlia Anggrainy; Arrang, Sherly Tandi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 1 No. 1 (2023)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v1i1.3913

Kesadaran masyarakat dalam melakukan cek kesehatan secara berkala masih kurang. Perubahan gaya hidup yang cenderung tidak sehat menjadi faktor memicu timbulnya berbagai penyakit. Saat ini, jumlah penderita penyakit hipertensi dan diabetes melitus masih cukup tinggi sehingga perlu dilakukan usaha pencegahan dan deteksi sedini mungkin. Pemeriksaan kesehatan seperti kadar glukosa darah sewaktu dan tekanan darah secara berkala perlu dilakukan. Selain itu, pemeriksaan golongan darah dan faktor rhesus juga penting dilakukan agar masyarakat mengetahui jenis golongan darahnya sehingga dapat digunakan sebagai alat informasi untuk menunjang kesehatannya di kemudian hari. Kegiatan ini diselenggarakan di desa Cibogo Kecamatan Cisauk Kabupaten Tangerang. Pemeriksaan kesehatan diikuti oleh 99 peserta yang merupakan warga desa Cibogo Kecamatan Cisauk dengan rentang usia 17 sampai dengan 84 tahun. Hasil menunjukkan bahwa persentase peserta yang bergolongan darah A, B, AB, dan O secara berturut-turut adalah 28,3%, 20,2%, 12,12%, dan 38,4%. Semua peserta memiliki rhesus positif (Rh+). Kemudian, berdasarkan hasil pemeriksaan kadar glukosa darah, terdapat 6 peserta (6,06%) dengan kadar glukosa darah tinggi yaitu lebih dari 200 mg/dL. Sedangkan pada pemeriksaan tekanan darah, ditemukan 31 orang peserta (31,3%) dengan tekanan darah tinggi yaitu lebih dari >120/80 mmHg.

Terapkan Perilaku “CERDIK” untuk Hidup Sehat & Bebas dari Penyakit Kardiovaskular Arrang, Sherly Tandi; Jerrycho, Jerrycho; Then, Julia; Suhanto, Jessica; Nidya, Joyce; Benneditha, Lasmaria; Sianipar, Erlia Anggrainy
Poltekita: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2024)
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v5i2.3073

Cardiovascular disease is the main cause of death throughout the world. Prevention of cardiovascular disease can reduce mortality rate. Some of the main risk factors for cardiovascular disease in office employees are smoking habits, lack of physical activity, unbalanced diet, obesity, high blood pressure, diabetes, stress and lack of sleep. Considering the importance of changing people's behavior to be more aware of risk factors that lead to cardiovascular disease, education and health checks are carried out targeting office employees. Health promotion programs can reduce the risk of disease in company employees. Educational activities “CERDIK” and blood pressure and cholesterol checks were carried out at one of the accounting offices in North Jakarta. The number of participants who took part in this activity was 87 people. Participants with a good level of knowledge before education were 71.9% and after education 96.9%. The majority of participants had abnormal cholesterol levels (36.8%) and blood pressure in the pre-hypertension (40.2%) and grade 1 hypertension (36.8%) categories. Respondents need to have regular medical check-up because most of them have risk factors for cardiovascular disease, and implement "CERDIK" behavior. Examination of LDL, HDL, glucose levels, measurements body weight and body height, should also be carried out to calculated the risk level of cardiovascular disease. The Company plans to carry out routine medical check-up for employees.

Edukasi tentang Potensi Daun Sambiloto sebagai Penguat Sistem Imun Tubuh terhadap Covid-19 Sianipar, Erlia Anggrainy; Marcella, Sherleen; Liliana, Merry; Tiono, Yovita viona; Edyson, Dino Claudio Signory Putra; Buntoro, Leonardo; Nanda, Karmill Tri; Siswandi, Alodia Jeconiah
Poltekita: Jurnal Pengabdian Masyarakat Vol. 4 No. 3 (2023): Juli-September
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v4i3.1812

The immune system greatly influences the increasing positive cases and death of Covid 19. In order to increase public knowledge about the use of herbal plants as a booster for the immune system, the Pharmacy Study Program at the Atma Jaya Catholic University of Indonesia was holding activities for community dedication by providing education about the potential of Sambiloto leaves in preventing Covid-19 infection. This education was aimed at social media users, given a seven-minute video shared on Youtube. The video link was shared through social media Instagram, WhatsApp, and Line. The video was uploaded to Youtube on April 18, 2021, then after two weeks, followed by filling out a questionnaire by the viewers using a Google form until May 2, 2021. The results show that 1,929 viewers, 354 likers, and 305 respondents filled out the questionnaire. The questionnaire results also showed that over 90% of respondents increased their knowledge after watching the video and could answer all the questions correctly. Thus, it can be concluded that this educational activity has succeeded in increasing the knowledge of social media users significantly and had a positive impact on changing people's behavior for using sambiloto leaves as immune boosters for the prevention and treatment of covid 19.

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