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Rational Antibiotic Use by Ordinary People in Jakarta Sherly Tandi Arrang; Fonny Cokro; Erlia Anggrainy Sianipar
MITRA: Jurnal Pemberdayaan Masyarakat Vol 3 No 1 (2019): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v3i1.502

Self-medication is defined as self treatment and self-diagnose for conditions such as cough, flu, fever, pain, stomach ulcers, worms, diarrhea, rash, and some other minor illnesses. Based on the data from Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI (2013), there were 103.860 of 294.959 households (35,2%) in Indonesia which store medicines for selfmedication (including 35,7% “Obat Keras” or “Gevaarlijk” and 27,8% antibiotics). DKI Jakarta (56,4%) is the highest province with respect to stored medicines. Some studies have found that 40-62% of antibiotics are not used properly. The inappropriate use of antibiotics can lead to antibiotic resistance risk and can be life-threatening for people in every part of the world. To address this problem, this community service was conducted to provide information about selfmedication of influenza and cough illness and to improve people’s knowledge in the proper use of antibiotics. Lecturing was chosen as the method for explaining the rational use of antibiotics and participants were requested to fill out a questionnaire. This activity was attended by 34 participants (and 32 participants filled out the questionnaire). About 13 participants (40,6%) provided correct answers to questions on the proper use of antibiotics. Twenty six participants (81,25%) said they had previously used antibiotics, 14 of them (53,85%) admitted to purchasing antibiotics without a prescription. Antibiotics are taken to treat symptoms such as runny nose, cough, sore throat, fever, and other conditions. A total of 7 participants (26,92%) admitted taking antibiotics with dosage modification and 8 participants (30,77%) switched one type of antibiotics with another type of antibiotics. Based on the results, we concluded that people did not have sufficient knowledge about the rational use of antibiotics. We suggested that counseling about the proper use of antibiotics should be improved.

Drug Information Service during Covid-19 Pandemic Sherly Tandi Arrang; Reynelda Juliani Sagala; Dion Notario; Erlia Anggrainy Sianipar; Fonny Cokro
MITRA: Jurnal Pemberdayaan Masyarakat Vol 5 No 1 (2021): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v5i1.1467

Pharmacists and pharmaceutical personnel need to support improving the people’s quality of life during the covid-19 outbreak by providing pharmaceutical services, one of which is the Drug Information Service (PIO). Many regions in Indonesia, including DKI Jakarta, have placed large-scale social restrictions since March 2020. In connection with that, the Department of Pharmacy of Atma Jaya Catholic University of Indonesia (PSFUAJ) organized an online PIO program. This program aimed to provide the service of Covid-19 drug-related information and education to the community. The PIO was carried out from April to July 2020 via whatsapp, email, and telephone. In addition, health education was provided through e-flyers, published on Instagram @pio_farmasi_uaj. Eighty percent of the questions were submitted via whatsapp, while the rest was sent via email. Most of the questions submitted (80%) were categorized into self-edication. Further examination shows that the common questions were related to drug choice (27.78%). These data indicate that most questioners tend to provide self-medication first and that they will only see a doctor if they have not recovered or experienced any improvement. PSFUAJ will continue running this program and disseminating this program to a broader audience.

PENGUJIAN AKTIVITAS ANTIOKSIDAN MAKRO ALGA SUMBAWA DALAM HUBUNGANNYA DENGAN KANDUNGAN SENYAWA BIOAKTIF DAN EFEK FARMAKOLOGI Erlia Anggrainy Sianipar; Natasha Satriawan; Juliana Sumartono; Pretty Falena Atmanda Kambira
Jurnal Riset Kesehatan Nasional Vol. 6 No. 2 (2022)
Publisher : Institute Teknologi dan Kesehatan (ITEKES) Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37294/jrkn.v6i2.457

Abstract A popular natural resource of Sumbawa Island is macroalgae. Chlorophyta, Phaeophyta, and Rhodophyta are types of macroalgae that have been cultivated and utilized by the local community. However, its potential to treat many diseases is still under-explored. Based on the content of bioactive compounds, macroalgae is believed to have antioxidant activity that could scavenge free radicals and thus potentially prevent and treat various diseases caused by excessive free radicals. This study aimed to analyze the antioxidant activity of Sumbawa macroalgae in various solvent fractions. Samples were macerated in n-hexane, ethyl acetate, and ethanol solvents. Antioxidant activity was tested using 1,1-Diphenyl-2-picryl Hydrazil (DPPH) method and ascorbic acid as a positive control. The percentage yield of extracts from various solvent fractions varied between 0.25% to 0.62%. The result of antioxidant activity testing showed that the IC50 (Inhibition Concentration) value of macroalgae extract was moderate to weak in the range of 108.1 ± 1.068 to 665.2 ± 0.479 g/mL and positive control was 6.156 ug/mL ±0.563g/mL. The relationship between antioxidant activity and the content of bioactive compounds and their pharmacological effects were discussed in this study. This study concluded that the ethyl acetate fraction of macroalgae had higher antioxidant activity than the n-hexane and ethanol fractions. Further analysis was needed to determine the composition of the bioactive compounds and identify their pharmacological effects at the molecular level. Keywords: Macroalgae, antioxidant, Sumbawa, bioactive compounds, pharmacological effects Abstrak Sumber daya alam yang populer di Pulau Sumbawa adalah makroalga. Chlorophyta, Phaeophyta dan Rhodophyta merupakan jenis makroalga yang telah dibudidayakan dan dimanfaatkan oleh masyarakat setempat. Namun, potensinya dalam hal pengobatan penyakit masih kurang tereksplorasi. Berdasarkan kandungan senyawa bioaktifnya, makroalga diyakini memiliki aktivitas antioksidan yang dapat menangkap radikal bebas sehingga berpotensi mencegah dan mengobati berbagai penyakit akibat radikal bebas yang berlebihan. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan makroalga Sumbawa dalam berbagai fraksi pelarut. Sampel dimaserasi dalam pelarut n-heksan, etil asetat, dan etanol. Aktivitas antioksidan diuji dengan metode 1,1-Diphenyl-2-picryl Hydrazil (DPPH) dan asam askorbat sebagai kontrol positif. Hasil persentase rendemen ekstrak dari berbagai fraksi pelarut cukup bervariasi berkisar antara 0,25% hingga 0,62%. Hasil pengujian aktivitas antioksidan menunjukkan nilai IC50 (Inhibition Concentration) ekstrak makroalga tergolong sedang hingga lemah yang berada dalam rentang 108,1 ± 1,068 hingga 665,2 ± 0,479 µg/mL dan kontrol positif sebesar 6,156 ug/mL ±0,563g/mL. Hubungan aktivitas antioksidan dengan kandungan senyawa bioaktif dan efek farmakologinya dibahas dalam penelitian ini. Penelitian ini menyimpulkan bahwa fraksi etil asetat makroalga memiliki aktivitas antioksidan yang lebih tinggi dibandingkan fraksi n-heksan dan etanol. Analisis lebih lanjut diperlukan untuk mengetahui komposisi senyawa bioaktif dan mengidentifikasi efek farmakologinya pada tingkat molekuler. Kata Kunci: Makroalga, Antioksidan, Sumbawa, Senyawa Bioaktif, Efek farmakologi

Pelayanan Informasi dan Edukasi Tentang Cara Kerja Obat Melalui Media Sosial Instagram Erlia Anggrainy Sianipar; Sherly Tandi Arrang; Fonny Cokro
Poltekita: Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2022): Oktober - Desember
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

The limited knowledge of community regarding drugs is still become a root cause in irrationality treatment. Information and education services about drug action is an important thing that should be known by the community as drug consumers so the rational treatment will be realized and misuse and errors in using drugs can be avoided. The aims of this program are to increase public knowledge about drug action and to find out the most favourite educational topic. Education is provided through the Instagram social media account @pioheal.fkikuaj which is easily accessible by social media users. Knowledge is presented on e-flyer and posted once a week for eight consecutive weeks from May to July 2021. The activities were evaluated through a questionnaire by the e-flyer readers. The results showed that 100% of the readers stated that their knowledge had increased after reading the e-flyer with an average increase ranging from 50-75% and as many as 80% of readers get a score of 70-100 (good). The most favorite educational topic was the drug action on the autonomic nervous system. Based on these results, we concluded that this information and educational services have succeeded in increasing the knowledge of social media users, especially about how drugs work. However, the evaluation of behavioral changes in the community regarding rational drug use needs further investigation. ABSTRAK Keterbatasan pengetahuan masyarakat terkait obat masih menjadi akar masalah dalam ketidakrasionalan pengobatan. Pelayanan informasi dan edukasi tentang cara kerja obat merupakan hal penting yang hendaknya diketahui oleh masyarakat sebagai konsumen obat sehingga pengobatan yang rasional dapat terwujud dan penyalahgunaan serta penggunaan yang salah terhadap obat dapat dihindari. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan masyarakat tentang cara kerja obat dan mengetahui topik edukasi yang paling diminati. Pemberian edukasi dilakukan melalui akun media sosial Instagram @pioheal.fkikuaj yang mudah diakses oleh para pengguna media sosial. Pengetahuan disajikan dalam bentuk e-flyer dan diposting setiap satu minggu sekali selama delapan minggu berturut-turut mulai pada bulan Mei hingga bulan Juli 2021. Kegiatan dievaluasi melalui kuesioner oleh pembaca e-flyer. Hasil kuesioner menunjukkan bahwa 100% pembaca menyatakan pengetahuannya meningkat setelah membaca e-flyer dengan rata-rata peningkatan berkisar antara 50-75% dan sebanyak 80% pembaca mendapatkan nilai 70-100 (baik). Topik edukasi yang paling diminati adalah tentang obat-obat yang bekerja pada sistem saraf otonom. Berdasarkan hasil tersebut, kami menyimpulkan bahwa pelayanan informasi dan edukasi ini berhasil meningkatkan pengetahuan pengguna media sosial terutama mengenai cara kerja obat. Namun, evaluasi terhadap perubahan perilaku di masyarakat terkait penggunaan obat yang rasional perlu diteliti lebih lanjut.

Review: Potensi Resin Kemenyan (Styrax benzoin) dan Senyawa Aktifnya Dalam Pengobatan Penyakit Erlia Anggrainy Sianipar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30202

Studies on drug discovery from natural ingredients are important to determine the pharmacological effects of the compound’s content so that it can be used to treat diseases. Kemenyan (Styrax benzoin) resin has been widely used by the local community for various purposes, including medicine. This review article aims to provide a comprehensive view of the potency of Kemenyan resin and its active compounds so that they could be used and developed to treat diseases in the future. The method used was based on searching for scientific literature in national and international journals. The results showed that the Kemenyan resin contains active compounds, including cinnamic acid, benzoic acid, benzaldehyde, benzyl benzoate, vanillin, styrene, styracin, coniferyl benzoate, benziresinol resin, resinotannol, sterols, phthalic acid, and sumaresorcinol. These compounds are known to have various pharmacological effects, including antibacterial, anesthetic, anti-inflammatory, antispasmodic, antimutagenic, fungicidal, herbicidal, tyrosinase inhibitory, and LDL synthesis inhibitory effects. Based on these studies, it can be concluded that the Kemenyan resin has great potential for the treatment of various diseases.

Education and Early Detection of Diabetes Mellitus Risk in North Jakarta Office Environment Erlia Anggrainy Sianipar; Monica Fransiska; Marisa Felicia; Alnardo Tuamain; Monika Angelina; Maria Gracia Mutiara Misesha; Sherly Tandi Arrang
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.386-392.2024

A low level of knowledge related to the causative factors, signs and symptoms, dangers, prevention, and treatment of diabetes mellitus (DM) causes an increasing number of DM sufferers worldwide, including in Indonesia. This community service activity aims to increase public knowledge, especially in the office environment, about DM disease and conduct early detection of DM. Participants in the community service activities consisted of 90 employees of an Accountant's office in North Jakarta. The community service activities included education about DM disease, tests of blood sugar, and question-and-answer discussions about DM. The results showed an increase in knowledge by 20.3% based on the score obtained from the pretest compared to the posttest. Based on the blood sugar test results, 98.9% of participants had blood sugar levels within normal limits, 1.1% were below average (hypoglycemia), and 1.1% were at risk of DM. This activity concludes that educational activities can increase participants' knowledge about DM disease, so it is hoped that the community can implement a healthy lifestyle to prevent DM disease and reduce the number of DM sufferers.

Education and Early Detection of Diabetes Mellitus Risk in North Jakarta Office Environment Erlia Anggrainy Sianipar; Monica Fransiska; Marisa Felicia; Alnardo Tuamain; Monika Angelina; Maria Gracia Mutiara Misesha; Sherly Tandi Arrang
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.386-392.2024

A low level of knowledge related to the causative factors, signs and symptoms, dangers, prevention, and treatment of diabetes mellitus (DM) causes an increasing number of DM sufferers worldwide, including in Indonesia. This community service activity aims to increase public knowledge, especially in the office environment, about DM disease and conduct early detection of DM. Participants in the community service activities consisted of 90 employees of an Accountant's office in North Jakarta. The community service activities included education about DM disease, tests of blood sugar, and question-and-answer discussions about DM. The results showed an increase in knowledge by 20.3% based on the score obtained from the pretest compared to the posttest. Based on the blood sugar test results, 98.9% of participants had blood sugar levels within normal limits, 1.1% were below average (hypoglycemia), and 1.1% were at risk of DM. This activity concludes that educational activities can increase participants' knowledge about DM disease, so it is hoped that the community can implement a healthy lifestyle to prevent DM disease and reduce the number of DM sufferers.

Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen Melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein: Curcumin Increased Breast Cancer Cells Sensitivity to Tamoxifen Through Inhibition of P-glycoprotein and Breast Cancer Resistance Protein Expressions Sianipar, Erlia Anggrainy; Louisa, Melva; Wanandi, Septelia Inawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

The decreasing of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. This study aim to know the effect of curcumin in increasing the cell sensitivity to tamoxifen through inhibition of P-gp and BCRP transporter efflux. MCF-7 breast cancer cell line was induced with tamoxifen 1 ÂµM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF-7(T) cells, curcumin was given at of 5/10/20 ÂµM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5th. As positive control, verapamil 50 ÂµM was used as P-gp inhibitor, ritonavir 15 ÂµM and nelfinavir 15 ÂµM were used as BCRP inhibitor. The results showed that MCF-7(T) cells sensitivity to tamoxifen decreased with 11.8 times, the cell viability increased 10.82 fold and mRNA expression of P-gp and BCRP increased 4.04 fold. Then after administration of curcumin with or without tamoxifen for 5 days, the cell viability and the mRNA expression of P-gp and BCRP decreased. As conclusion, curcumin increased the sensitivity of MCF-7(T) to tamoxifen characterized by the decreasing of cell viability and mRNA expression of P-gp and BCRP. However, the administration of combination of curcumin with tamoxifen was more potent than just curcumin. The increased sensitivity was estimated at least partly through the inhibition of P-gp and BCRP mRNA expression by curcumin

PENGECEKAN KADAR GLUKOSA DARAH SEWAKTU, TEKANAN DARAH, DAN GOLONGAN DARAH PADA MASYARAKAT DESA CIBOGO CISAUK TANGERANG Sianipar, Erlia Anggrainy; Arrang, Sherly Tandi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 1 No. 1 (2023)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v1i1.3913

Kesadaran masyarakat dalam melakukan cek kesehatan secara berkala masih kurang. Perubahan gaya hidup yang cenderung tidak sehat menjadi faktor memicu timbulnya berbagai penyakit. Saat ini, jumlah penderita penyakit hipertensi dan diabetes melitus masih cukup tinggi sehingga perlu dilakukan usaha pencegahan dan deteksi sedini mungkin. Pemeriksaan kesehatan seperti kadar glukosa darah sewaktu dan tekanan darah secara berkala perlu dilakukan. Selain itu, pemeriksaan golongan darah dan faktor rhesus juga penting dilakukan agar masyarakat mengetahui jenis golongan darahnya sehingga dapat digunakan sebagai alat informasi untuk menunjang kesehatannya di kemudian hari. Kegiatan ini diselenggarakan di desa Cibogo Kecamatan Cisauk Kabupaten Tangerang. Pemeriksaan kesehatan diikuti oleh 99 peserta yang merupakan warga desa Cibogo Kecamatan Cisauk dengan rentang usia 17 sampai dengan 84 tahun. Hasil menunjukkan bahwa persentase peserta yang bergolongan darah A, B, AB, dan O secara berturut-turut adalah 28,3%, 20,2%, 12,12%, dan 38,4%. Semua peserta memiliki rhesus positif (Rh+). Kemudian, berdasarkan hasil pemeriksaan kadar glukosa darah, terdapat 6 peserta (6,06%) dengan kadar glukosa darah tinggi yaitu lebih dari 200 mg/dL. Sedangkan pada pemeriksaan tekanan darah, ditemukan 31 orang peserta (31,3%) dengan tekanan darah tinggi yaitu lebih dari >120/80 mmHg.

PENGECEKAN KADAR GLUKOSA DARAH SEWAKTU, TEKANAN DARAH, DAN GOLONGAN DARAH PADA MASYARAKAT DESA CIBOGO CISAUK TANGERANG Sianipar, Erlia Anggrainy; Arrang, Sherly Tandi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 1 No. 1 (2023)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v1i1.3913

Kesadaran masyarakat dalam melakukan cek kesehatan secara berkala masih kurang. Perubahan gaya hidup yang cenderung tidak sehat menjadi faktor memicu timbulnya berbagai penyakit. Saat ini, jumlah penderita penyakit hipertensi dan diabetes melitus masih cukup tinggi sehingga perlu dilakukan usaha pencegahan dan deteksi sedini mungkin. Pemeriksaan kesehatan seperti kadar glukosa darah sewaktu dan tekanan darah secara berkala perlu dilakukan. Selain itu, pemeriksaan golongan darah dan faktor rhesus juga penting dilakukan agar masyarakat mengetahui jenis golongan darahnya sehingga dapat digunakan sebagai alat informasi untuk menunjang kesehatannya di kemudian hari. Kegiatan ini diselenggarakan di desa Cibogo Kecamatan Cisauk Kabupaten Tangerang. Pemeriksaan kesehatan diikuti oleh 99 peserta yang merupakan warga desa Cibogo Kecamatan Cisauk dengan rentang usia 17 sampai dengan 84 tahun. Hasil menunjukkan bahwa persentase peserta yang bergolongan darah A, B, AB, dan O secara berturut-turut adalah 28,3%, 20,2%, 12,12%, dan 38,4%. Semua peserta memiliki rhesus positif (Rh+). Kemudian, berdasarkan hasil pemeriksaan kadar glukosa darah, terdapat 6 peserta (6,06%) dengan kadar glukosa darah tinggi yaitu lebih dari 200 mg/dL. Sedangkan pada pemeriksaan tekanan darah, ditemukan 31 orang peserta (31,3%) dengan tekanan darah tinggi yaitu lebih dari >120/80 mmHg.

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