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All Journal Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Kartodarsono, Supriyanto
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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The Agreement Compatibility Level of Tuberculin Skin Test (TST) and POT.TB in Detecting Latent Tuberculosis Infection (LTBI) in Diabetic Mellitus (DM) Sebayang, Pribadi M; Reviono, Reviono; Kartodarsono, Supriyanto
Jurnal Respirologi Indonesia Vol 39, No 4 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i4.78

Abstract

Background: The lifetime risk of TB reactivation develops within the first 5 years after initial infection. Good LTBI management helps in preventing the progression of the disease to be active. It is recommended in countries with a low prevalence of TB infection and high risk populations such as DM patients. The diagnosis of LTBI is done by examining TST and T-SPOT.TB. This study aimed to determine the correspondence between TST and T-SPOT.TB in detecting LTBI in DM patients. Methods: This cross-sectional study was conducted in DM patients treated in Dr. Moewardi Hospital Surakarta in September 2018. The study subjects received TST by injecting intradermal PPD RT 23 2TU intradermally, and T-SPOT.TB by taking 6 ml of venous blood examined with ELISPOT method. Statistical analysis used SPSS21 for windows. Results: There were 30 subjects. The prevalence of LTBI was 20%. The correspondence between TST and T-SPOT.TB was substantial (K=0.667, p
Aspek Psikoendokrinoneuroimunologi pada Patogenesis Diabetes Mellitus Tipe 2 Setiani, Ariana; Maharatih, Gusti Ayu; Kartodarsono, Supriyanto
Majalah Kedokteran Indonesia Vol 72 No 5 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.5-2022-860

Abstract

Diabetes is a chronic disease which included in the 10 major leading causes of death globally. Pathogenesis of DM 2 involves complex mechanisms in various organs. Psychological conditions including stress, anxiety, and depression considered to be reciprocally related to impaired glucose regulation. On the other hand, hyperglycaemia in DM 2 may triggers some psychological disorder. Chronic psychological disorders activate the HPA axis, causing cortisol level elevation and disrupt its negative feedback mechanism. Other factors involved in disturbance of glucose regulation due to psychological distress were sympathetic nervous system, inflammatory and oxidative stress pathways, tryptophan metabolism and gut microbiota dysbiosis. These factors were interrelated to form a vicious cycle causing progression and complications in DM 2.
Co-Authors Ariana Setiani Maharatih, Gusti Ayu Reviono Reviono Sebayang, Pribadi M