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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication Journal of Epidemiology and Public Health Indonesian Journal of Medicine Jurnal Respirologi Indonesia YARSI Medical Journal Jurnal Respirasi (JR) Narra J Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Reviono Reviono
Bagian Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sebelas Maret
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Relationship Risk Factors and Laten Tuberculosis Infection (LTBI) in HIV Patients Irwandi, Delvan; Harsini, Harsini; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 39, No 2 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

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Abstract

Introduction: In 2014 globally 9.6 million people are infected with TB, including 1.2 million people living with HIV. HIV positive patients have a risk of Tuberculosis (TB), infection or latent TB infection (LTBI) about 5-8% per year and the risk of developing active TB 3 times higher than the immunocompetent individuals. The impact of HIV infection on the immune system is the destruction of lymphocyte T CD4 and declining nutritional status. Nutritional status can be assessed by clinical signs, anthropometry and biochemical indicators such as serum albumin levels. Methods: Cross-sectional observational epidemiological research in RS Dr. Moewardi, Surakarta, to patients with HIV, from April to May 2017 to observe the association of risk factors with LTBI in HIV patients. The first step is patient and family anamnesis, history of past and family illness, duration of antiretroviral therapy, Cluster of Differentiation 4 (CD4) count, BMI count, serum albumin concentration, immunologic Tuberculin Skin Test (TST) for LTBI diagnosis. Results: Total of 93 people meet the criteria. There was no association close contact history with active tuberculosis patients with ITBL in HIV (p = 0.5, OR 1.268; 95% CI 1.139-1.411); no association of BMI classification with LTBI in HIV (P=1.000; OR=0.894; 95%CI=0.326-2.457), no association of serum albumin grade with ITBL in HIV (P=0.19; OR=1.284; 95%CI=1.147-1.436); there was a significant association of CD4 classification with LTBI in HIV (P=0.033; OR=3.560; 95%CI=1.214-10.433), there was no association between duration of antiretroviral therapy with LTBI in HIV (P=0.636; OR=0.969; 95% CI=0.244-3.848). Conclusions: HIV patients with advanced CD4 and severe immunosuppressive CD4 classification (CD4+
Factors Associated with Success Rate for Tuberculosis Treatment in Hospital: A Directly Observed Treatment Short Tuberculosis Prevention Strategy in Central Java Reviono, Reviono; Ramadhiana, Yusniar; Probandari, Ari N; Setianingsih, Wahyu
Journal of Epidemiology and Public Health Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Tuberculosis (TB) is a major health problem throughout the world. Hospitals and pulmonary clinics contribute significantly to the number of patients from all positive smear cases. Hospital performance in TB control is assessed using treatment success rates. The purpose of this study is to find out an overview of hospital performance factors that influence the success of hospitals in TB control in Central Java.Subjects and Method: The study design was a descriptive analytical epidemiology with a retro­spective cohort design. The samples were taken in total sampling. The subjects were 158 hospitals in Central Java Province that used the DOTS strategy. The variable assessment instrument from the 2010 TB Sub-Directorate of the Ministry of Health's checklist was taken in January-February 2018. The data were linked to TB data from the Central Java Provincial Health Office in 2013 and 2016. Treatment success rates were stated to be good if the value was %85%Results: There were 110 hospitals with complete data in 2013 and 2016. Good success rates (>85%) in 2013 were achieved by 59 (53.60%) hospitals in 2013, in 2016 it decreased, only 43 (39.10%) hospitals were achieved. There was no significant relationship between the commitment and organization of the DOTS Hospital team, treatment, medical supervision, internal/external networks, and health facilities with the success rate of TB treatment, in which in this study, the value of p > 0.05. The type of hospital was significantly associated with treatment success rates in 2013, in which the lower type of hospital, the better the success rate of TB treatment.Conclusion: Because of the low number of hospitals that achieve good success rates (>85%), more detailed identification of risk factors is needed. Keywords: tuberculosis, success rate, hospitals Correspondence: Reviono. Department of Pulmonology and Medical Respiration, Universitas Sebelas Maret Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: reviono@staff.uns.ac.id. Mobile: +6281­847­4671.Journal of Epidemiology and Public Health (2019), 4(4): 283-295https://doi.org/10.26911/jepublichealth.2019.04.04.03 
Para-aortic and Meningitis Tuberculosis: A Case Report Reviono, Reviono; R, Sari Apriliana; Sutanto, Yusup Subagio; Soetejo, FX; Subandrio, Subandrio
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: In 2018, Indonesia was in third place as the country with the highest incidence of tuberculosis (TB) in the world. In addition to pulmonary TB, extrapulmonary TB cases are also quite large. Lymphadenitis of the aortic TB can cause a fatal risk if not treated immediately. This study aimed to explore the para-aortic and meningitis tuberculosis case in Klaten Hospital, Central Java.Case presentation: There was a 24-year-old woman with complaints of missing chest pain for 2 months, fear of seeing light (photophobia), and decreased consciousness. The patient was a referral from Klaten Hospital with a diagnosis of a mediastinal tumor. The chest radiograph shows a picture of homogeneous opacity in the anterior mediastinum. Bronchoscopy results show compression stenosis in 1/3 distal and blunt carina. After a sternotomy, it was obtained pus (pus) and tissue granuloma in the area of the aorta. After the rapid molecular test was carried out, the results showed that M tuberculosis detected. The results of histopathology of anatomical pathology show epitheloid tubercle and Datia Langhans cells that suggest an infection with M. tuberculosis. Therapy was done by giving a standard anti-tuberculosis drug, namely Rifampicin 450 mg, INH 300 mg, Ethambutol 1000 mg, and Pyrazinamide 1000 mg. The patient's condition improved marked by weight gain in 2 months.Conclusion: In the case of pulmonary masses (mediastinal tumors), we need to be aware of the possibility of cases of TB lymphadenitis because Indonesia is a country with a high prevalence of TB. This is because a slow diagnosis can lead to life-threatening conditions Keywords: Tuberculosis, para aorta lymphadenitis, meningitis TB, tumor mediastinum, sternotomyCorrespondence: Reviono. Department of Pulmonology and Medical Respiration, Universitas Sebelas Maret Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: reviono@staff.uns.ac.id. Mobile: +6281­8474671.Indonesian Journal of Medicine (2019), 4(3): 201-210https://doi.org/10.26911/theijmed.2019.04.03.02
The Agreement Compatibility Level of Tuberculin Skin Test (TST) and POT.TB in Detecting Latent Tuberculosis Infection (LTBI) in Diabetic Mellitus (DM) Sebayang, Pribadi M; Reviono, Reviono; Kartodarsono, Supriyanto
Jurnal Respirologi Indonesia Vol 39, No 4 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i4.78

Abstract

Background: The lifetime risk of TB reactivation develops within the first 5 years after initial infection. Good LTBI management helps in preventing the progression of the disease to be active. It is recommended in countries with a low prevalence of TB infection and high risk populations such as DM patients. The diagnosis of LTBI is done by examining TST and T-SPOT.TB. This study aimed to determine the correspondence between TST and T-SPOT.TB in detecting LTBI in DM patients. Methods: This cross-sectional study was conducted in DM patients treated in Dr. Moewardi Hospital Surakarta in September 2018. The study subjects received TST by injecting intradermal PPD RT 23 2TU intradermally, and T-SPOT.TB by taking 6 ml of venous blood examined with ELISPOT method. Statistical analysis used SPSS21 for windows. Results: There were 30 subjects. The prevalence of LTBI was 20%. The correspondence between TST and T-SPOT.TB was substantial (K=0.667, p
Pengaruh Faktor Risiko terhadap Waktu Timbulnya Efek Samping Kanamisin pada Tuberkulosis Resistan Obat Wati, Martha Ratna; Reviono, Reviono; Putranto, Wachid; Sutanto, Yusup Subagio; Harsini, Harsini
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.161 KB) | DOI: 10.15395/mkb.v50n2.1297

Abstract

Kanamisin adalah obat untuk terapi tuberkulosis resistan obat (TB RO) yang menimbulkan efek samping gangguan pendengaran, gangguan fungsi ginjal, dan gangguan elektrolit terutama hipokalemia. Penelitian bertujuan menilai kesintasan waktu timbulnya efek samping dan pengaruh faktor risiko usia, riwayat terapi streptomisin serta berat badan terhadap efek samping akibat pemberian kanamisin pasien TB RO. Penelitian kohort retrospektif dari data rekam medis pasien TB RO dari Januari 2011 sampai April 2017 di RSUD Dr. Moewardi Surakarta. Analisis pengaruh faktor risiko terhadap efek samping menggunakan uji cox regression. Dari 238 pasien didapatkan gangguan pendengaran 143 pasien, gangguan fungsi ginjal 147 pasien, dan hipokalemia 169 pasien. Usia lebih dari 40 tahun hazard ratio (HR) 2,419 (IK: 95%; 1,716–3,409; p= 0,000) dan jenis kelamin perempuan HR: 1,549 (IK: 95%; 1,089–2,202; p= 0,015) berisiko terjadi gangguan pendengaran. Usia lebih dari 40 tahun HR: 1,892 (IK: 95%; 1,353–2,646; p= 0,000) dan jenis kelamin perempuan HR: 1,667 (IK: 95%; 1,179–2,357; p= 0,004) berisiko terjadi gangguan fungsi ginjal. Riwayat streptomisin sebelumnya dan indeks massa tubuh (IMT) tidak berisiko timbul efek samping akibat pemberian kanamisin. Pengawasan ketat timbulnya efek samping gangguan pendengaran dan gangguan fungsi ginjal pasien usia lebih dari 40 tahun dan perempuan pada pengobatan TB RO.Kata kunci: Efek samping, gangguan fungsi ginjal, gangguan pendengaran, kanamisin, TB resistan obat Effects of Risk Factors on the Onset of Kanamycin’s Adverse Events in Drug Resistant TuberculosisKanamycin is a therapy for drug-resistant tuberculosis (TB) which may cause hearing loss, impaired kidney function, and electrolyte disorders, especially hypokalemia. The objective of this study was to assess patient survival and the effects of risk factors such as age, previous history of streptomycin therapy, and weight on adverse events due to kanamycin administration in patients with drug resistant TB. A retrospective cohort study was conducted in TB patients by using medical records from January 2011 to April 2017 in Dr. Moewardi Hospital Surakarta. Cox regression analysis was used to analyze the relation between risk factors and adverse events. Of 238 patients, 143 patients experienced hearing loss, 147 patients experienced impaired kidney function, and 169 patients had hypokalemia. Age over 40 and female gender had higher risks for hearing loss and impaired kidney function (HR: 2.419 (95% CI: 1.716–3.409; p= 0,000) and HR: 1,892 (95% CI: 1.353–2.646; p=0,000); HR: 1.549 (95%CI: 1.089–2.202; p=0,015), and HR: 1.667 (95% CI: 1.179–2.357; p=0.004)), respectively. History of streptomycin and body mass index (BMI) were not risk factors for  kanamycin’s adverse events. Therefore, closed monitoring on hearing loss and impaired kidney function is necessary for drug resistant TB patients aged over 40, and female patients. Key words: Adverse events, drug resistant tuberculosis, hearing loss, impaired kidney function, kanamycin
MODAL SOSIAL KADER KESEHATAN DAN KEPEMIMPINAN TOKOH MASYARAKAT DALAM PENEMUAN PENDERITA TUBERKULOSIS Sutisna, Endang; Reviono, Reviono; Setyowati, Arry
Jurnal Kedokteran YARSI Vol 24, No 1 (2016): JANUARI - APRIL 2016
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.286 KB) | DOI: 10.33476/jky.v24i1.125

Abstract

Tuberkulosis (TB) merupakan kedaruratan global bagi kemanusiaan. WHO menggulirkan Strategi DOTS (Directly Observed Treatment Short-course) dan Strategi Stop TB Partnership bertujuan untuk menjangkau semua penderita TB. Kedua strategi tersebut belum mampu mencapai target CDR (Case Detection Rate) secara konsisten. Penelitian ini bertujuan menganalisis pengaruh dan peran modal sosial kader kesehatan dan kepemimpinan tokoh masyarakat dalam penemuan TB paru BTA positif (CDR). Metode yang digunakan adalah survei dan studi kasus. Sasaran penelitian adalah Tim Penanggulangan TB di Puskesmas dan Dinas Kesehatan Kabupaten, serta kader kesehatan, tokoh masyarakat, penderita TB, dan mantan penderita TB di Kabupaten Sukoharjo, Jawa Tengah. Hasil penelitian survei dengan analisis jalur menunjukkan, besaran pengaruh langsung modal sosial kader kesehatan terhadap CDR adalah 8,64%; pengaruh langsung kepemimpinan tokoh masyarakat terhadap CDR adalah 33%; dan pengaruh modal sosial kader kesehatan dan kepemimpinan tokoh masyarakat secara simultan terhadap CDR adalah 27,7%. Hasil penelitian studi kasus menyimpulkan, peran modal sosial kader kesehatan dalam CDR terdiri dari dimensi kognitif, relasional dan struktural. Dimensi kognitif meliputi kepedulian, saling percaya dan rasa memiliki antar anggota keluarga, warga masyarakat, serta kader dan petugas kesehatan. Dimensi relasional meliputi kerjasama dan komunikasi yang dilandasi nilai-nilai bersama. Dimensi struktural meliputi jaringan sosial, perkumpulan dan persatuan masyarakat. Peran kepemimpinan tokoh masyarakat dalam CDR adalah memberikan motivasi, tempat bertanya dan konsultasi, mengadakan pertemuan rutin, serta mengelola kegiatan dan menggalang donasi.Tuberculosis (TB) is a global emergency for humanity. WHO launches DOTS (Directly Observed Treatment Short-Course) and Stop TB Partnership strategies aiming to reach all people with TB. Both strategies have not been able to reach the target of CDR (case detection rate) consistently. This research aimed to analyze the effect and the role of health cadres? social capital and community figures? leadership in finding the people with positive-BTA pulmonary tuberculosis (CDR). The methods employed were survey and case study. The target of research was TB management team in Puskesmas (Public Health Centre) and Regency Health Service, and health cadres, community figures, people with TB, and people with TB previously in Sukoharjo Regency, Central Java. The result of research with path analysis showed that the size of direct effect of health cadres? social capital on CDR was 8.64%; that of community figures? leadership on CDR was 33%; and that of health cadres? social capital and community figures? leadership simultaneously on CDR was 27.7%. The result of case study research concluded that the role of health cadres? social capital in CDR consisted of cognitive, relational and structural dimensions. Cognitive dimension included care, mutual trust, and sense of belonging among the members of family, members of society, and health cadres and workers. Relational dimension included cooperation and communication based on commonness value. Structural dimension included social network, community association and unity. The role of community figures? leadership in CDR was that it provided motivation, served as the one to which any one asking question and consulting, conducted routine meeting, and managed activity and raised donation.
Determinants of Delay in Diagnosis and Treatment in Multi Drug-Resistant Tuberculosis Patients in Health Facilities Sutanto, Yusup Subagio; Murti, Paulus Wisnu Kuncoro; Reviono, Reviono; Probandari, Ari Natalia; Kurniawan, Hendra
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Multidrug-resistant tubercu­lo­sis (MDR-TB) is a serious threat to global TB control programs. According to WHO, there are 23,000 cases of TB multidrug-/rifampicin-resistant (MDR/RR-TB) in Indonesia. In 2017, there were 442,000 of TB cases. There were 8,600 - 15,000 MDR/RR-TB cases, of which 2.4% were new cases and 13% were previously treated TB cases. This study aims to determine the factors that influence the delay in diagnosis and treatment of MDR-TB patients.Subjects and Method: This study was a cross-sectional study conducted at Dr. Moe­wardi hospital, from Sep­tem­ber to October 2017, Surakarta, Central Java. A sample of 73 MDR-TB patients with disabilities on medical records was selected for this study. The depen­dent variables were delay in diagnosis and delay in therapy of MDR-TB cases. The inde­pendent variables were age, gender, distance to health facilities, and type of health facilities. Data were collected from medical records of MDR-TB patients who were treated from March 2012 to March 2017. Data were analyzed using the chi-square model.Results: Median delay in diagnosis = 4 days. Median treatment delay = 12 days. The average patient who had delayed MDR-TB therapy (≥4 days) was 44 years old (Mean= 44.19; SD= 12.64). Delay in MDR-TB diagnosis was not significantly associated with gender (OR= 0.53; 95% CI= 0.18 to 1.57; p= 0.264), distance to health facility (OR= 1.56; 95% CI= 0.58 to 4.21; p= 0.389), and type of health facility (OR= 0.60; 95% CI= 0.26 to 1.41; p= 0.983). The average of patient who had delayed MDR-TB therapy (≥12 days) was 41 years old (Mean= 41.39; SD= 12.69). Treatment delay was not significantly related to gender (OR= 0.45; 95% CI= 0.16 to 1.26; p= 0.137), distance to health facility (OR=1.44; 95% CI= 0.55 to 3.78; p= 0.466), and type of health facility (OR= 2.31; 95% CI= 1.03 to 5.21; p= 2.967).Conclusion: There was no statistically sig­nificant relationship between gender, dis­tance from the patient's home to health facilities, and type of health facility with the delay in diag­nosis and treatment of MDR-TB patients.Keywords: diagnosis, treatment, TB-MDRCorrespondence: Yusup Subagio Sutanto. Department of Pulmo­nology and Respiratory Medicine, Faculty of Medicine Universitas Sebelas Maret/ Dr. Moe­wardi Hospital, Surakarta. Jl. Kolonel Sutarto No.132, Jebres, Surakarta, Central Java 57126. Email: dr_yusupsubagio@yahoo.com. Mobile: 0811284165.Indonesian Journal of Medicine (2021), 06(01): 14-22https://doi.org/10.26911/theijmed.2021.06.01.02
Effectiveness of Zingiber officinale to reduce inflammation markers and the length of stay of patients with community-acquired pneumonia: An open-label clinical trial Reviono, Reviono; Hapsari, Brigitta DA.; Sutanto, Yusup S.; Adhiputri, Artrien; Harsini, Harsini; Suryawati, Betty; Marwoto, Marwoto; Syaikhu, Akhmad
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.142

Abstract

Examination of the interleukin 6 (IL-6) and procalcitonin levels, and neutrophil-lymphocyte ratio (NLR) might could help to diagnosis and predict the duration of therapy and prognosis of pneumonia cases. Zingiber officinale var rubrum could be used as an adjunct therapy in infectious diseases as it has anti-inflammatory activity. The aim of study was to assess the effect of Z. officinale on levels of IL-6 dan procalcitonin, NLR, and the length of hospitalization of patients with community-acquired pneumonia (CAP). An open-label clinical trial was conducted among CAP cases regardless of the etiology at Dr Moewardi Hospital and Universitas Sebelas Maret Hospital, Surakarta, Indonesia from July to September 2022. A total of 30 inpatient CAP cases were recruited and were randomly divided into two groups: (1) received Z. officinale capsule 300 mg daily for five days in addition to CAP standard therapy; and (2) received CAP standard therapy only, as control group. The data were compared using a paired Student t-test, Chi-squared test, Mann-Whitney test and Wilcoxon signed-rank test as appropriate. In Z. officinale group, the mean difference between post- and pre-treatment as follow: IL-6 level was 9.93 pg/mL, procalcitonin level -471.31 ng/mL, and NLR value -4.01. In control group, the difference was 18.94 pg/mL for IL-6, 339.39 ng/mL for procalcitonin, and 1.56 for NLR. The change of IL-6 was not statistically significant between treatment and control groups with p=0.917. The changes of procalcitonin level and NLR were significant between treatment and control group with p=0.024 and p=0.007, respectively, of which the treatment had better improvement. In addition, our data indicated that the length of stay was not statistically significant between the treatment and control groups (4.13 vs 4.47 days, p=0.361). In conclusion, Z. officinale could reduce serum inflammatory markers such as procalcitonin and NLR but it has little impact in reducing IL-16 level and the length of hospitalization of CAP patients.
Effects of secretome supplementation on interleukin-6, tumor necrosis factor-α, procalcitonin, and the length of stay in acute exacerbation COPD patients Fahlevie, Fahlevie; Apriningsih, Hendrastutik; Sutanto, Yusup S.; Reviono, Reviono; Adhiputri, Artrien; Aphridasari, Jatu; Prasetyo, Windu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.171

Abstract

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it has the potential to be an additional therapy for AECOPD. Its potential is associated with its secretome since it has anti-inflammatory and immunomodulator activities. The aim of this study was to determine the effect of the secretome as an adjuvant therapy in reducing the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, and the length of stay in AECOPD patients. A clinical control trial study was conducted among 28 moderate and severe AECOPD patients who were hospitalized from January to February 2023. The control group (n=14) received standard therapy of AECOPD while the treatment group (n=14) received standard therapy plus secretome 1 ml twice daily for three days. The levels of IL-6, TNF-α, and procalcitonin were measured at admission and on the fourth day of treatment. The length of stay was calculated from the time the patient was admitted until the patient was discharged from hospital. The data were compared using a paired Student t-test, chi-squared test and Mann-Whitney test as appropriate. In the treatment group, the levels of IL-6, TNF-α and procalcitonin after the treatment reduced 13.09 pg/mL, 5.00 pg/mL and 751.26 pg/mL, respectively compared to pre-treatment. In contrast, the levels of IL-6, TNF-α and procalcitonin increased 48.56 pg/mL, 44.48 pg/mL and 346.96 pg/mL, respectively after four days of treatment. There was a significant reduction of IL-6, TNF-α and procalcitonin in treatment group compared to the control group with p=0.022, p=0.009 and p=0.001, respectively. However, there was no significant reduction of the length of stay (p=0.072). In conclusion, administration of secretome to AECOPD patients could reduce the levels of IL-6, TNF-α and procalcitonin.
Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis Asrial, An A.; Reviono, Reviono; Soetrisno, Soetrisno; Setianto, Budi Y.; Widyaningsih, Vitri; Nurwati, Ida; Wasita, Brian; Pudjiastuti, Anggit
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.293

Abstract

Mitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes. A cross-sectional study was conducted at Panti Rahayu Hospital and Permata Bunda Hospital, Purwodadi, Central Java, with a total of 40 RHD patients with severe mitral stenosis. The ELISA was used to measure the levels of carboxy-terminal propeptide of type I procollagen (PICP), matrix metalloproteinase I (MMP-1), tissue inhibitor matrix metalloproteinase 1 (TIMP-1), and transforming growth factor-β1 (TGF-β1). The left atrial function was assessed by measuring Cn, and the LAVI parameters were measured to assess left atrium structure/size. The mean levels of circulating fibrosis biomarkers were as follows: PICP 153.96±89.12 ng/mL; MMP-1 1.44±2.12 ng/mL; MMP-1/TIMP-1 ratio 0.38±0.54 and TGF-β1 2.66±1.96 pg/mL. From the echocardiographic evaluation, the mean Cn was 5.24±1.93 mL/mmHg and the mean LAVI was 152.55±79.36 mL/m2. There were significant correlation between MMP-1 and MMP-1/TIMP-1 ratio with Cn (r=0.345 and r=0.333, respectively; both had p<0.05). PICP and TGF-β1 biomarkers did not significantly correlate with Cn (p>0.05). Meanwhile, none of the biomarkers had a significant correlation with LAVI (p>0.05). This study highlights that MMP-1 and MMP-1/TIMP-1 ratio are potentially to be used as markers to determine the Cn in RHD patients with severe mitral stenosis. However, further studies with a higher sample size are needed to confirm this finding.
Co-Authors Adhiputri, Artrien Akhmad Syaikhu Alfarizi, Aditya Ana Rima Setijadi Anindita, Brigitta Devi Apriningsih, Hendrastutik Ari N Probandari Ari Natalia Probandari Asrial, An A. Atmojo, Anang Purwoko Bambang Purwanto Bhisma Murti Brian Wasita Damayanti, Raninditya Dhani Redhono, Dhani Endang Sutisna Endang Sutisna Sulaeman Fahlevie, Fahlevie Hapsari, Brigitta Anindita Devi Hapsari, Brigitta DA. Hapsari, Brigitta Devi Anindita Harsini Harsini Hermansah, Muhamad Lukman Hermawati, Berty Denny Ida Nurwati Irwandi, Delvan Jatu Aphridasari Kartodarsono, Supriyanto Laqif, Abdurrahman Leli Saptawati Lestari, Anggraini Dwi Lilik Lestari marwoto marwoto Mochammad Imron Awalludin Murti, Paulus Wisnu Kuncoro Myrtha, Risalina Nur Hafidha Hikmayani Prabowo, Nurhasan Agung Pudjiastuti, Anggit Putranto, Wachid Putri, Desy Puspa Putro, Prasetyo Sarwono R, Sari Apriliana Raharjo, A Farih Rahayu, Nur Indah Ramadhiana, Yusniar Roxanne, Olivia Geraldine Sebayang, Pribadi M Septiawan, Debree Setianingsih, Wahyu Setianto, Budi Y. Setyowati, Arry Soetejo, FX Soetrisno Soetrisno Soewondo, Widiastuti Subandrio, Subandrio SURYAWATI, BETTY Sutanto, Yusup S. Vagheggini, Guido Vitri Widyaningsih Wati, Martha Ratna Widyasanti, Diana Windu Prasetyo, Windu Wulandari, Eka T. Yudhi Prasetyo, Yudhi Yundari, Yundari Yusup Subagio Sutanto