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All Journal Universa Medicina The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rahadiani, Nur
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Comprehensive analysis of the role of NLRC5 in gastrointestinal cancer: a systematic review Rahadiani, Nur; Ghozali, Mohammad; Dewi, Dyah Laksmi
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.229-239

Abstract

BackgroundGastrointestinal (GI) cancer is affecting millions of people globally, leading to high incidence and mortality rates and a heavy economic burden. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic pattern recognition receptors that regulate host defense responses against microorganisms. Among these, NLR family CARD domain-containing 5 (NLRC5) is assumed to function as a regulator of proinflammatory responses to intracellular pathogens. NLRC5 has been known to regulate immune responses, although its association with cancer remains controversial. This systematic review aimed to explore the roles and functions of NLRC5 in GI cancers. MethodsThree electronic databases, PubMed, Scopus, and ProQuest, were used for literature searching on March 18, 2024. From 921 articles found, 157 duplicates were removed, 671 were excluded based on title and abstract screening, and 84 were excluded based on full-text assessment, resulting in 19 articles included in this review. ResultsElevated NLRC5 levels have been observed in tumor tissues compared to normal tissues across esophageal, gastric, colorectal, and liver cancers. NLRC5 is also associated with increased tumor cell proliferation, migration, and invasion. Cancer cell sensitivity to 5-fluorouracil chemotherapy was found to be negatively correlated with NLRC5 expression. NLRC5 expression levels and genetic variations were also associated with cancer susceptibility to chemotherapeutic drugs and cancer survival. ConclusionNLRC5 potentially exhibits diverse functions in GI cancers, acting as a biomarker for diagnosis, disease progression, prognostic assessment, and determining therapeutic implications. Further investigations are warranted to explore these mechanisms and their potentials for the development of effective treatment of GI cancers.
Relationship between Clinicopathological Profile and Tumor Budding Status in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General National Hospital: A Retrospective Study Dhuhani, Ika; Handjari, Diah Rini; Rahadiani, Nur; Krisnuhoni, Ening; Stephanie, Marini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022193-199

Abstract

Background: Colorectal adenocarcinoma (CA) is one of the most common malignancies. Tumor budding (TB) status is associated with poor prognosis in patients. Prognosis is influenced by the clinicopathological profile. This study aims to determine the relationship between the clinicopathological profile with TB status in CA at Dr. Cipto Mangunkusumo General National Hospital.Method: A cross-sectional retrospective analytic study using secondary data in the form of cases in large bowel malignancy resection preparations at the Department of Anatomical Pathology in 2019-2021. A total of 213 samples were taken from all cases according to the inclusion and exclusion criteria. Chi square statistical analysis was performed to see the clinicopathological relationship with TB status.Results: Most common TB status were low grade with 92 cases. Most cases were ≥ 50 years old (64.3%), male (50.7%), located in the left colon (77.5%), histopathological degree low grade (85.9%), depth of invasion on pT3 (61.5%), lymphovascular invasion (LVI) (50.2%), lymph node metastasis (52.6%), stage 3 American Joint Committee on Cancer (AJCC (42.3%), without perineural invasion (PNI) (79.3%) and without distant metastases (82.6%). Statistical analysis test showed that there was a significant relationship between the degree of histopathology, depth of invasion, LVI, lymph node metastasis, and AJCC stage (p 0.001) and tumor location (p = 0.036).Conclusion: TB status was significantly related histopathological degree, LVI, lymph node metastasis, depth of invasion, AJCC stage, and tumor location. TB status was not associated with PNI and distant organ metastases. 
The Plausible Use of Mango (Mangifera indica) Peel Isoquercitrin as Adjuvant Therapy for Colorectal Cancer: Translating Research from Bench to Bedside Habiburrahman, Muhammad; Sutopo, Stefanus; Rahadiani, Nur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202354-62

Abstract

A deadly and debilitating disease, colorectal cancer (CRC), is rapidly becoming a significant threat to public health. However, current therapeutic approaches are still hampered by various side effects. Due to its benefits and remarkable apoptotic impact on cancer cells, plant-derived flavonoids now garner interest as candidates for cancer therapy. Isoquercitrin, a flavonoid commonly found in fruit plants, especially mangoes, is notable due to its ability to inhibit cancer development through various mechanisms. This review aims to highlight the use of isoquercitrin extracted from mango peels in inhibiting CRC carcinogenesis. A literature search was done on Pubmed, Proquest, and Google Scholar using inclusion and exclusion criteria, and a narrative review was synthesised using the evidence gathered. Validity assessment was done through the the Office of Health Assessment and Translation (OHAT) and Oxford Center for Evidence-Based Medicine (CEBM) critical assessment tools. Evidence suggested that isoquercitrin is promising as adjuvant therapy in CRC. It may inhibit overaccumulation of cytoplasmic β-catenin and its translocation into the nucleus, thus downregulating the expression of target proto-oncogenes leading to carcinogenesis of colon crypts. Isoquercitrin concentration in mango peel is abundant, 557.7 mg/kg in dried mango peel and 31.0 mg/kg in pure extracts. A pharmacology study approved that a daily intake of 5.4 mg/kgBW of isoquercitrin has an effective anticancer effect. This substance has good oral bioavailability and is well-tolerated but inhibits the metabolising enzymes CYP1A1 and CYP1B1. In conclusion, isoquercitrin is a potential adjuvant in inhibiting CRC growth with minimum costs and side effects.
Co-Authors Dhuhani, Ika Diah Rini Handjari Dyah Laksmi Dewi Ening Krisnuhoni Manatar, Amelia Fossetta Marini Stephanie Mohammad Ghozali, Mohammad Muhammad Habiburrahman, Muhammad Prisscila, Jessica Sutopo, Stefanus