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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Diah Rini Handjari
Department of Pathology, Faculty of Medicine,University of Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Medicine & Pharmacology

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Relationship between Clinicopathological Profile and Tumor Budding Status in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General National Hospital: A Retrospective Study Dhuhani, Ika; Handjari, Diah Rini; Rahadiani, Nur; Krisnuhoni, Ening; Stephanie, Marini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022193-199

Abstract

Background: Colorectal adenocarcinoma (CA) is one of the most common malignancies. Tumor budding (TB) status is associated with poor prognosis in patients. Prognosis is influenced by the clinicopathological profile. This study aims to determine the relationship between the clinicopathological profile with TB status in CA at Dr. Cipto Mangunkusumo General National Hospital.Method: A cross-sectional retrospective analytic study using secondary data in the form of cases in large bowel malignancy resection preparations at the Department of Anatomical Pathology in 2019-2021. A total of 213 samples were taken from all cases according to the inclusion and exclusion criteria. Chi square statistical analysis was performed to see the clinicopathological relationship with TB status.Results: Most common TB status were low grade with 92 cases. Most cases were ≥ 50 years old (64.3%), male (50.7%), located in the left colon (77.5%), histopathological degree low grade (85.9%), depth of invasion on pT3 (61.5%), lymphovascular invasion (LVI) (50.2%), lymph node metastasis (52.6%), stage 3 American Joint Committee on Cancer (AJCC (42.3%), without perineural invasion (PNI) (79.3%) and without distant metastases (82.6%). Statistical analysis test showed that there was a significant relationship between the degree of histopathology, depth of invasion, LVI, lymph node metastasis, and AJCC stage (p 0.001) and tumor location (p = 0.036).Conclusion: TB status was significantly related histopathological degree, LVI, lymph node metastasis, depth of invasion, AJCC stage, and tumor location. TB status was not associated with PNI and distant organ metastases. 
Diagnostic Challenge in Distinguishing Crohn’s Disease from Lupus Enteritis in Systemic Lupus Erythematosus Patient: A Case Report Layadi, Eka Benhardi; Pribadi, Rabbinu Rangga; Ariane, Anna; Kartika, Emiliana; Handjari, Diah Rini; Idzni, Irsalina; Ichsan, Oemar; Putri, Megawati Ananda Hasbi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202389-97

Abstract

Diagnosing Crohn’s disease in systemic lupus erythematosus patients with gastrointestinal symptoms poses a great challenge, due to its rare occurrence and similarity of clinical characteristics between its differential diagnosis. We herein present a rare case of a patient diagnosed with systemic lupus erythematosus, complicated by renal involvement and conspicuous gastrointestinal manifestations. The non-specific gastrointestinal findings in this patient led to challenge in differentiating lupus enteritis from Crohn's disease, as they share many similar aspects in clinical manifestations, endoscopic findings, and histopathological findings. We herein provide the clinical judgement in reaching Crohn's disease in concurrence with systemic lupus erythematosus as the final working diagnosis through scrutinizing and comparing data from similar case studies in the past. 
Co-Authors Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi Ahmar Abyadh Anna Ariane, Anna Ari Fahrial Syam Budiningsih Siregar Dadang Makmun Daldiyono Daldiyono Darmawan Kartono David Handojo Muljono Dewantoro, Okto Dhuhani, Ika Dolly Dolven Kansera Ening Krisnuhoni Fransiska Hardi Ichsan, Oemar Idzni, Irsalina Iskandar, Rizka Puteri Jane Estherina Kartika, Emiliana Layadi, Eka Benhardi Marcellus Simadibrata Marini Stephanie Murdani Abdullah Nata Pratama Nikko Darnindro Nunung Ainur Rahmah Nur Rahadiani Pamela Abineno Pamela Abineno Damaledo Pamela Damaledo Abineno Putri, Megawati Ananda Hasbi Rabbinu Rangga Pribadi Raden Nur Ista Rahadiani, Nur Rizki Yaruntradhani Sufangga, Fili Tjahjadi Robert Tedjasaputra Velma Herwanto Vera Yuwono Wirasmi Marwoto Yonathan, I Wayan Murna