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All Journal Journal Pharmaceutical Science and Application (JPSA) Jurnal Ilmiah Medicamento Jurnal Edukasi Citra Olahraga
Nugraha, Iwan Saka
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Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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ROLE OF PROBIOTICS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH HYPERTENSION: A REVIEW Nugraha, Iwan Saka; Suastini, Ni Made; Santi, Made Dwike Swari
Journal Pharmaceutical Science and Application Vol 5 No 2 (2023): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i02.p03

Abstract

Background: Type 2 Diabetes Mellitus (DM) is one of a global health problem. One of the comorbidities that often occurs in patients with type 2 DM is hypertension. Hypertension can increase the risk of cardiovascular complications. One of the causes of type 2 DM and hypertension is gut dysbiosis. An imbalance of gastrointestinal microbiota contributes to chronic inflammation and effects on the insulin action, increases insulin resistance, and leads to endothelial dysfunction. The role of this inflammatory mediator is a new therapeutic target in type 2 DM patients with hypertension. Objective: to describe how probiotic effect in type 2 diabetic patients with hypertension. Methods: All articles were obtained by conducting an electronic search through Pubmed and Google Scholar. Results: Probiotics help to restore the balance of the gastrointestinal microbiota, produce anti-inflammatory mediators, and suppress the pro-inflammatory mediators to control the glycemic profile and blood pressure of patients with type 2 DM with hypertension. All the clinical trial showed that probiotic help to maintaining clinical outcome in diabetic patients with hypertension. Conclusion: Probiotic effective for glycemic control and blood pressure in type 2 DM with hypertension. Keywords: Diabetes; Hypertension; Gut dysbiosis; Probiotics; Inflammation mediators
PENGARUH PEMBERIAN ELEKTROLIT BUAH NANAS TERHADAP DENYUT NADI SISWA SMK SAAT MELAKUKAN OLAHRAGA Nugraha, Iwan Saka; Udayani, Ni Wayan; Adiama, I Gede Agus Sindhu
Jurnal Edukasi Citra Olahraga Vol. 5 No. 1 (2025): Jurnal Edukasi Citra Olahraga
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jor.v5i1.4796

Abstract

Penelitian ini bertujuan mengetahui pengaruh minuman isotonik buah nanas terhadap efektifitas denyut nadi siswa SMK di Denpasar. Penelitian ini merupakan penelitian eksperimental menggunakan randomized pretest – posttest control group design dengan satu kelompok kontrol. Kelompok kontrol mengkonsumsi air mineral, sedangkan kelompok perlakuan mengkonsumsi minuman isotonik buah nanas. Setelah itu, atlet diukur intensitas denyut nadinya, sebanyak 3 kali, masing selama 1 menit. Pengukuran denyut nadi dilakukan sebelum latihan, sesaat latihan selama 60-90 menit dan setelah jeda istirahat 10 menit dari selesai latihan. Analisis data dengan menggunakan uji man-whitney. Hasil pengukuran denyut nasi pemberian minuman isotonic buah nanas terhadap denyut nadi siswa SMK baik sebelum olahraga, sesaat setelah olahraga, dan jedah 10 menit setelah latihan (p>0,05). Kesimpulan penelitian ini adalah konsumsi minuman isotonik tidak terlihat meningkatkan efektifitas denyut nadi atlet.
Analisis Bibliometrik Formulasi Poliherbal sebagai Afrodisiak: Tinjauan Tren Penelitian Terkini Kartika, I Gusti Agung Ayu; Nugraha, Iwan Saka; Mahardika, Ida Bagus Putra; Suryani, Suryani
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11418

Abstract

In recent years, the therapeutic potential of polyherbal formulations as aphrodisiacs, particularly as natural alternatives to synthetic treatments for sexual health disorders, has garnered significant attention. Polyherbal formulations are believed to enhance efficacy through synergistic effects, making them a preferred option in both traditional and modern therapeutic practices. This review aims to provide a comprehensive analysis of research trends relating to the use of polyherbal formulations for aphrodisiac purposes. A bibliometric analysis was conducted using the Scopus database, extracting relevant articles with the keywords 'Aphrodisiac AND Polyherbal OR Combination.' From an initial pool of 88 articles, 16 were selected for in-depth analysis. VOSviewer software was used to visualize collaboration networks, co-authorship patterns, and keyword trends, highlighting the increasing research interest in polyherbal formulations for sexual health enhancement. The narrative review supplements these findings by exploring study methodologies, sources of herbal ingredients, formulation compositions, and commonly used herbs. Results indicate that while polyherbal aphrodisiac formulations show promising therapeutic potential, research in this field remains fragmented, with limited clinical trials evaluating safety and efficacy. The most frequently studied herbs include Tribulus terrestris, Mucuna pruriens, and Withania somnifera, known for their effects on testosterone levels, vascular function, and libido enhancement. Future studies should focus on clinical validation, standardization, and pharmacokinetic assessments to facilitate their integration into modern medical practice. These findings provide valuable insights for researchers and industries developing polyherbal-based nutraceutical and pharmaceutical products.
Co-Authors Adiama, I Gede Agus Sindhu I Gusti Agung Ayu Kartika Made Dwike Swari Santi Mahardika, Ida Bagus Putra Ni Made Suastini, Ni Made Suryani Suryani Udayani, Ni Wayan