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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Poltekita: Jurnal Pengabdian Masyarakat Pharmaqueous Jurnal Ilmiah Nusantara
Septiyaningsih, Rochany
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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Formula Optimization of Propolis Transfersome Gel, Aloe Vera, Gotu Extract: Formula Design, Formulation Evaluation and Cell Regeneration Test in Diabetic Wounds Aji, Ajeng Puspo; Septiyaningsih, Rochany; Indratmoko, Septiana; Issusilaningtyas, Elisa; Nasikha, Solikhatun
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9283

Abstract

The study was conducted to determine the optimal formula of transfersome propolis gel, aloe vera extract and gotu gotu leaf extract and test it against diabetic wounds in male white rats (Rattus norvegicus). The gel was created with an optimal formulation resulting from the application of a Design Expert with Cutimed as a positive control of burns on the backs of male white rats (Rattus norvegicus). Formula optimization was carried out using a Simple Lattice Design with variations of carbopol, TEA and glycerin. Activity tests of propolis transferosome gel, aloe vera extract and gotu gotu extract were conducted on 20 rats. The data results were statistically analyzed using the SPSS One Way ANOVA method. Phytochemical screening on aloe vera and gotu gotu showed the presence of flavonoid compounds, tannins and saponins. Transfersome propolis has a particle size of 88.55 nm and a zeta potential of -24.13 mV. The optimal formula produces a clear preparation in white, a distinctive odour, a stable viscosity of 19980 cps, dispersion power of 6.67 cm, adhesion of 4.07 seconds and pH of 6.45. The burn activity test had the fastest effectiveness on day 12 but did not differ significantly from the customized control.
Co-Authors Ajeng Puspo Aji Elisa Issusilaningtyas Fitrianingsih, Rina Dwi Frisca Dewi Yunadi Kartiyani, Titin Kusumawati, Dhiah Dwi Nasikha, Solikhatun Susilawati Susilawati, Susilawati yunadi, frisca dewi