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HUBUNGAN ANTARA AKTIVITAS BELAJAR KELOMPOK DENGAN INDEKS PRESTASI MAHASISWA SEMESTER 6 FAKULTAS KEDOKTERAN UNIVERSITAS HANG TUAH SURABAYA TAHUN AJARAN 2017/2018 Handajani, Fitri; Hapsari, Kinanti; Garianto, Efyluk
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1070

One of the active learning methods is to do a study group. Researcher is interested in research on the correlation between study group activities and student?s grade, so that students can find learning methods which may influence academic outcomes and facilitate learning, especially the medical students. This observational analytic study was carried out with a cross sectional design. The data of this study were obtained from the answers to the respondent's questionnaire in the Medical Faculty of Hang Tuah University, Surabaya. The sample in this study were semester 6 students of the 2017/2018 academic year at the Faculty of Medicine, University of Hang Tuah Surabaya (130 respondents). Based on the Spearman correlation statistical test between study group activities with the 6th semester students grade point, the significance of the correlation between study group activities and the 6th semester students grade point is 0.687. With a value of ? = 0.05, means p> ?, it can be concluded that the correlation between the two variables is not significant so that H0 accepts and H1 is rejected. So, there is no correlation between study group activities with 6th semester grade point. There is no correlation between study group activities and the 6th semester students grade point in the Faculty of Medicine, Hang Tuah University Surabaya.

Potential Effect of Phlorotannins in Brown Algae for Antidiabetic Therapy: Molecular Docking Approach Renagupita, Melani Sinastri; Rahadianto, Rahadianto; Garianto, Efyluk; Setianingsih, Herin
Makara Journal of Science Vol. 27, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

This study aims to manifest the effect of the active compound phlorotannins in brown algae on decreasing insulin resistance by analyzing the predicted interaction between phlorotannins and protein tyrosine phosphatase 1B (PTP 1B) and estimating the pharmacokinetics and toxicity of the active compound for type 2 diabetes mellitus (DM) therapy. This type of research uses an in silico study to test the effect of using phlorotannins as an active compound in brown algae against PTP 1B inhibition. Starting from preparing materials, i.e., downloading the three-dimensional structure of phlorotannins via PubChem and PTP 1B via RSCB PDB (PDB 1A5Y), molecular docking using Molegro Virtual Docker 5, molecular visualization using PyMol and Discovery Studio, and predicting pharmacokinetics and toxicity via pkCSM have been conducted. Here, the phlorotannins include phloroglucinol, dioxinodehydroeckol, eckol, phlorofucofuroeckol-A, dieckol, 7-phloroeckol, and 6,6′-bieckol. In addition, Ertiprotafib and S-phosphocysteine are used here as the comparison controls for docking validation. All phlorotannins can bind to PTP 1B at the same binding site with drug control. Experimental results revealed that phlorotannins–PTP 1B produces lower energy than complex S-phosphocysteine–PTP 1B (−266.8 kJ/mol), which acts as a control here. However, phloroglucinol–PTP 1B produces (−208 kJ/mol) under the same condition. Compared with the drug control Ertiprotafib (−322.8 kJ/mol), the lower bond energy is owned by phlorofucofuroeckol-A (−370.6 kJ/mol), 7-phloroeckol (−328 kJ/mol), dieckol (−331.8 kJ/mol), and 6.6'-bieckol (−341 kJ/mol). Furthermore, phlorotannins are very well absorbed in the intestine. According to Lipinski’s rule, active compounds, such as phloroglucinol, eckol, and dioxinodehydroeckol have high potential as a drug. Phlorotannins are nontoxic against hepatocytes and have fewer side effects than drug control. Based on the obtained data, use of the active compound phlorotannins in brown algae can decrease insulin resistance, which can be employed as adjunctive therapy in type 2 DM.

HUBUNGAN ANTARA AKTIVITAS BELAJAR KELOMPOK DENGAN INDEKS PRESTASI MAHASISWA SEMESTER 6 FAKULTAS KEDOKTERAN UNIVERSITAS HANG TUAH SURABAYA TAHUN AJARAN 2017/2018 Handajani, Fitri; Hapsari, Kinanti; Garianto, Efyluk
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1070

One of the active learning methods is to do a study group. Researcher is interested in research on the correlation between study group activities and student’s grade, so that students can find learning methods which may influence academic outcomes and facilitate learning, especially the medical students. This observational analytic study was carried out with a cross sectional design. The data of this study were obtained from the answers to the respondent's questionnaire in the Medical Faculty of Hang Tuah University, Surabaya. The sample in this study were semester 6 students of the 2017/2018 academic year at the Faculty of Medicine, University of Hang Tuah Surabaya (130 respondents). Based on the Spearman correlation statistical test between study group activities with the 6th semester students grade point, the significance of the correlation between study group activities and the 6th semester students grade point is 0.687. With a value of α = 0.05, means p> α, it can be concluded that the correlation between the two variables is not significant so that H0 accepts and H1 is rejected. So, there is no correlation between study group activities with 6th semester grade point. There is no correlation between study group activities and the 6th semester students grade point in the Faculty of Medicine, Hang Tuah University Surabaya.

Expression of HMGB1 and NF-κB in Fetal Membranes of Premature Rupture of Membranes Sudiarta, Ketut Edy; Khan, Joan; Aldinasyah, Monicha Zalzabilla; Garianto, Efyluk; Budiarti, Retno
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2911

Background: Inflammation, either sterile or infection-related, may lead to premature rupture of membranes (PROM). The non-histone nuclear proteins, high mobility group box-1 (HMGB1), and nuclear factor kappa-B (NF-κB) transcription factors have been extensively investigated in many disorders involving inflammatory reactions. This study aimed to determine the expression of HMGB1 and NF-κB in fetal membranes of PROM compared with non-PROM.Methods: This study was an analytical observational study with a case-control design, performed from November 2021 to January 2022, including 40 fetal membrane samples (20 PROM and 20 non-PROM), which were obtained from pregnant women treated in the emergency unit of a hospital in Surabaya from August to November 2019 using the non-probability sampling method. The HMGB1 and NF-κB expressions were examined using the immunohistochemical method and further viewed under a light microscope (400x magnification), then assessed by Image-J software. The values were then compared between PROM and non-PROM, and analyzed using the Mann-Whitney U test.Results: There was a significant difference (p<0.001) in the expression of HMGB1 and NF-κB in PROM and non-PROM for HMGB1 45.86± 14.21% vs. 8.50± 5.66% expression/mm2; and NF-κB 33.47±5.45% vs. 7.29±4.90% expression/mm2, respectively.Conclusions: PROM groups have significantly higher expression of HMGB1 and NF-κB s, indicating their higher activity and contribution to PROM.

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