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All Journal Althea Medical Journal Damianus Journal of Medicine Nusantara Medical Science Journal Indonesian Journal of Cancer Jurnal Kedokteran Meditek Jurnal Lentera Kesehatan Masyarakat (JLKM)
Sudiarta, Ketut Edy
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Expression of HMGB1 and NF-κB in Fetal Membranes of Premature Rupture of Membranes Sudiarta, Ketut Edy; Khan, Joan; Aldinasyah, Monicha Zalzabilla; Garianto, Efyluk; Budiarti, Retno
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2911

Abstract

Background: Inflammation, either sterile or infection-related, may lead to premature rupture of membranes (PROM). The non-histone nuclear proteins, high mobility group box-1 (HMGB1), and nuclear factor kappa-B (NF-κB) transcription factors have been extensively investigated in many disorders involving inflammatory reactions. This study aimed to determine the expression of HMGB1 and NF-κB in fetal membranes of PROM compared with non-PROM.Methods: This study was an analytical observational study with a case-control design, performed from November 2021 to January 2022, including 40 fetal membrane samples (20 PROM and 20 non-PROM), which were obtained from pregnant women treated in the emergency unit of a hospital in Surabaya from August to November 2019 using the non-probability sampling method. The HMGB1 and NF-κB expressions were examined using the immunohistochemical method and further viewed under a light microscope (400x magnification), then assessed by Image-J software. The values were then compared between PROM and non-PROM, and analyzed using the Mann-Whitney U test.Results: There was a significant difference (p<0.001) in the expression of HMGB1 and NF-κB in PROM and non-PROM for HMGB1 45.86± 14.21% vs. 8.50± 5.66% expression/mm2; and NF-κB 33.47±5.45% vs. 7.29±4.90% expression/mm2, respectively.Conclusions: PROM groups have significantly higher expression of HMGB1 and NF-κB s, indicating their higher activity and contribution to PROM.
Upaya peningkatan kesadaran ancaman kanker serviks melalui konseling skrining berbasis inspeksi visual asam asetat (IVA) Al Hasan, Hafidz Ramadhan; Adiwinoto, Ronald Pratama; Ariewibawa, Fariz Atiqi; Sianipar, Habel Ryan Annerico; Sudiarta, Ketut Edy; Herdiyantini, Mita
Jurnal Lentera Kesehatan Masyarakat Vol. 4 No. 2 (2025): Jurnal Lentera Kesehatan Masyarakat
Publisher : PT. Lentera Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69883/fgp8pp39

Abstract

Kanker serviks masih menjadi masalah kesehatan masyarakat yang signifikan, terutama di negara berpenghasilan rendah dan menengah, sehingga upaya skrining (deteksi dini) risiko kanker serviks, salah satunya berupa IVA(Inspeksi Visual Asam asetat) penting untuk upaya. Penelitian ini bertujuan mengevaluasi dampak intervensi konseling berbasis Model Keyakinan Kesehatan (Health Belief Model) dalam meningkatkan pengetahuan dan kemauan guru serta staf sekolah untuk menjalani skrining kanker serviks dengan metode Inspeksi Visual Asam Asetat (IVA). Intervensi berupa sesi konseling dilaksanakan di delapan sekolah, dan pengetahuan serta sikap peserta diukur sebelum dan sesudah edukasi. Data hasil penelitian disajikan dalam bentuk tabel, diagram dan dianalisis dengan uji statistik paired-student's T test. Hasil menunjukkan adanya peningkatan skor pengetahuan yang signifikan secara statistik, dari 65,2 ± 12,4 menjadi 84,7 ± 9,8 (p < 0,001). Persentase peserta yang menyatakan kesediaan untuk menjalani skrining IVA juga meningkat dari 58,3% menjadi 87,5% (p = 0,003). Namun demikian, cakupan skrining aktual hanya naik dari 12% menjadi 14% (p = 0,08), masih jauh dari target partisipasi sebesar 70%. Kesimpulan penelitian ini adalah diperlukan strategi komprehensif yang tidak hanya fokus pada peningkatan pengetahuan, tetapi juga mengatasi hambatan psikologis, budaya, dan akses pelayanan. Pendekatan multifaset yang melibatkan edukasi berkelanjutan, dukungan sosial, peran aktif tenaga kesehatan masyarakat, serta peningkatan aksesibilitas layanan skrining diyakini dapat mendorong partisipasi lebih luas. Kesimpulannya, intervensi konseling dapat meningkatkan kesadaran dan kemauan, namun dampaknya terhadap cakupan skrining masih terbatas sehingga perlu didukung langkah strategis yang lebih menyeluruh.
The Characteristics of Sociodemography, Histopathologic Features, Stage, and Management of Ovarian Cancer in Dr. Ramelan Navy Hospital Surabaya Rahmalia, Karina; Sudiarta, Ketut Edy; Setianingsih, Herin; Diarsvitri, Wienta
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1050

Abstract

Background: Ovarian cancer is considered a silent killer disease, mainly due to the late diagnosis. It is often diagnosed at an advanced stage, thus increasing the mortality rate. Ovarian cancer can happen to any age, with different characteristics according to the age group, the most often being the epithelial type.Methods: This research is a descriptive study with a quantitative method. This study aims to determine the characteristics and histopathological features of ovarian cancer in Dr. Ramelan Navy Hospital from January 2019 to December 2021. There were 155 samples out of 635 patients, with the information acquired through medical records.Results: The highest incidence of ovarian cancer occurs in the 40-60-year-old group at 52.9%. Among all participants, 85.8% of patients were not employed. Of most histopathological features in epithelial ovarian cancer, 34.8% were the serous carcinoma subtype. The majority of these cases were diagnosed at stage IIIC at 21.3%, and the most prevalent treatment for ovarian cancer was surgery and chemotherapy at 49.7%.Conclusions: The most common type of ovarian cancer is epithelial ovarian cancer, a subtype of serous carcinoma, with histopathological features of round nucleated anaptic cells, prominent nucleoli, forming acini, papillae, and thin connective tissue stroma. 
Histopathological Difference of Inflammatory Cells Infiltration into Fetal Membranes of PROM and Non-PROM SUDIARTA, KETUT EDY; FABIOLLA, FABIOLLA; HERDIYANTINI, MITA
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.36072

Abstract

Introduction: Premature rupture of membranes (PROM) remains one of several causes of premature birth that increases both maternal mortality ratio and neonatal mortality rate. Inflammation of fetal membranes leads to release of inflammatory mediators and resulting in weakness of fetal membranes, particularly the amniotic membrane. The amniotic membrane in PROM has a focal weakness, which differs from the membrane in non-premature rupture of membrane (non-PROM) that has a generalized weakness. This research aimed to determine histopathological difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM.   Methods:  Quantitative observation was applied to this research. Cross-sectional design was used for analyzing data. Primary data was collected from the delivery room and operating theater of Emergency Department in dr. Ramelan Central Naval Hospital (RSPAL dr. Ramelan) Surabaya. Data collection started from August to November 2019 using total population sampling technique. Results: A total of 40 samples histopathologically examined showed that 11 out of 20 (55%) fetal membranes in PROM had polymorphonuclear (PMN) cells infiltration and 9 (45%) did not have PMN cells infiltration, 1 out of 20 (5%) fetal membranes in non-PROM had PMN cells infiltration and 19 (95%) did not have PMN cells infiltration. The prevalence ratio (PR) of PROM based upon the presence of PMN cells infiltration into fetal membranes was 2.85 (PR>1). The significance level of Chi-square test was 0.001 (ρ>0.05). Conclusions: The difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM was statistically significant.
Perbedaan Rasio Trombosit Limfosit Pre dan Post Terapi Kemoradiasi Kanker Serviks di Rumah Sakit Pusat Angkatan Laut dr. Ramelan Surabaya Marbentan, Purwo Diva Nadib; Sudiarta, Ketut Edy; Purwaningsari, Diah; Puspita, Angela
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3105

Abstract

Introduction: Cervical cancer is caused by persistent infection with HPV transmitted through sexual intercourse. Chemoradiation is often used in the treatment of cervical cancer because it can reduce recurrence and further cell growth and can increase survival. Increased Platelet Lymphocyte Ratio (RTL) can be used to track the progression of cervical cancer and the degree of differentiation of cancer cells. High RTL indicates a worse degree of cell differentiation and vice versa. Purpose: The aim of this study was to determine the difference in RTL in cervical cancer patients pre and post chemoradiation therapy. Methods: The research design is cross-sectional with total sampling. Data was taken from medical records of cervical cancer patients at the Department of Obstetrics and Gynaecology, RSPAL dr. Ramelan Surabaya in year 2000 - 2023. Results: The average RTL for cervical cancer patients before chemoradiation was 193.1293; and after chemoradiation 169.5459. The results of the Wilcoxon signed rank test showed a significant decrease (p < 0.001). This research proves that there is a significant difference in the Platelet Lymphocyte Ratio (RTL) of stage ≥ IIB cervical cancer patients pre- and post-chemoradiation therapy. Statistical tests show significant results. Conclusion: Chemoradiation has been proven to significantly reduce RTL, and it can be concluded that giving chemoradiation to cervical cancer stage IIIB and above provides good results.
Relationship between Risk of Malignancy Index (RMI) and Histopathology of Ovarian Tumors at RSPAL dr. Ramelan Surabaya Thetrawan, Daisy Maurent; Sudiarta, Ketut Edy; Biutifasari, Verna
Bahasa Indonesia Vol 24 No 3 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i3.5179

Abstract

Pendahuluan: Massa adneksa mengindikasikan berbagai kelainan baik yang berasal dari ginekologi atau non ginekologi dan dapat bersifat jinak maupun ganas, seperti kanker ovarium. Kanker ovarium merupakan kanker ginekologi yang memiliki prognosis terburuk dan menempati peringkat kedelapan penyebab kematian wanita di dunia. Lebih dari 70% pasien datang terdiagnosis pada stadium lanjut akibat tidak adanya keluhan penyerta.  Hal ini disebabkan oleh keterbatasan infrastruktur kesehatan seperti skrining deteksi dini, sehingga mendorong banyak peneliti menciptakan sebuah prediktor sederhana, salah satunya Risk of Malignancy Index  (RMI). Tujuan penelitian ini adalah untuk memberikan wawasan yang lebih dalam mengenai RMI yang berkorelasi dengan histopatologi jaringan tumor untuk memprediksi keganasan tumor ovarium. Metode: Penelitian ini merupakan penelitian potong lintang dengan teknik consecutive sampling. Besar sampel yang memenuhi kriteria inklusi dan eksklusi berjumlah 42 sampel yang di peroleh dari data rekam medis pasien Departemen Obstetri dan Ginekologi RSPAL dr. Ramelan Surabaya periode Januari 2021 sampai Oktober 2023. Hasil: Pasien dengan kanker ovarium didominasi wanita postmenopause berusia 50–59 tahun. Risk of Malignancy Index dengan nilai cut-off <200 memiliki korelasi yang signifikan (p=0,026) dengan hasil histopatologi jaringan tumor ovarium. Hasil perhitungan statistik menunjukkan nilai sensitivitas RMI <200 sebesar 80% dan spesifisitas sebesar 55%. Nilai cut–off RMI di bawah area kurva (AUC) ROC sebesar 322 dengan sensitivitas sebesar 66,7% dan spesifisitas sebesar 59,3%. Hasil uji korelasi RMI dengan cut-off 322 memiliki p=0,107 yang menunjukkan korelasi tidak signifikan. Simpulan: Risk of Malignancy Index <200 memiliki korelasi signifikan dengan histopatologi tumor ovarium dengan sensitivitas 80% dan spesifisitas 55% dalam memprediksi keganasan tumor ovarium.
Co-Authors Al Hasan, Hafidz Ramadhan Aldinasyah, Monicha Zalzabilla Ariewibawa, Fariz Atiqi Biutifasari, Verna Diah Purwaningsari FABIOLLA, FABIOLLA Garianto, Efyluk Herdiyantini, Mita Khan, Joan Marbentan, Purwo Diva Nadib Puspita, Angela Rahmalia, Karina Retno Budiarti Ronald Pratama Adiwinoto Setianingsih, Herin Sianipar, Habel Ryan Annerico Thetrawan, Daisy Maurent Wienta Diarsvitri