Rahmat, Rosita Dewi
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PENGEMBANGAN POTENSI RHODOMYRTONE SEBAGAI BAHAN AKTIF SEDIAAN TOPIKAL Fahmi, Rizal; Rullah, Kamal; Rahmat, Rosita Dewi; Lucida, Henny; Manjang, Yunazar; Hj. Lajisc, Nordin; Dachriyanus, .
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.93

Abstract

Rhodomyrtone, an antibacterial constituent was isolated from the active fraction of theleaves extract of Karamuntiang, Rhodomyrtus tomentosa (Aiton) Hassk. In this presentstudy, the topical cream formula of rhodomyrtone 2% in vanishing cream was evaluated byin vitro and in vivo preclinical test. The in vitro test was peformed against Staphylococcusaureus ATTC 6538 and Staphylococcus epidermidis ATTC 12228 by using disk agardiffusion method, while the in vivo test was evaluated on the surface of skin infection area ofthe rabbit caused by Staphylococcus aureus. Both these tests were guided bychloromphenicol 2% cream as a comparison. The topical cream of rhodomyrtone 2% invanishing cream showed diameters of inhibition zones of 15 mm and 26 mm towardStaphylococcus aureus and Staphylococcus epidermidis respectively. These diffusions werelower than inhibition zones of chloromphenicol 2% cream which has 30 mm and 32 mm forthe same bacterias in the same condition. The in vivo test showed that rhodomyrtone 2%topical cream can reduced that skin infection and did not caused irritation on the testedrabbits.ABSTRAKRhodomyrtone adalah suatu konstituen antibakteri fraksi aktif ekstrak daun karamuntiang,Rhodomyrtus tomentosa (Ait) Hassk. Pada penelitian ini telah dilakukan uji preklinisterhadap krim sediaan topikal Rhodomyrtone 2% dalam vanishing cream. Uji preklinissecara in vitro menggunakan media agar dan Staphylococcus aureus ATTC 6538 danStaphylococcus epidermidis 12228 sebagai bakteri uji, sedangkan secara in-vivo dilakukanterhadap kulit pada kelinci yang di infeksi dengan Staphylococcus aureus. Kedua uji inimenggunakan krim kloromfenikol 2% sebagai pembanding. Krim sediaan topikalrhodomyrtone 2% dengan basis vanishing cream memberikan diameter hambatan berturutturut15 mm dan 26 mm terhadap Staphylococcus aureus dan Staphylococcus epidermidis.Difusi ini lebih rendah dibanding sediaan krim kloromfenikol 2% yang memberikan diameterhambatan 30 mm dan 32 mm, masing-masing untuk Staphylococcus aureus danStaphylococcus epidermidis pada kondisi yang sama. Selanjutnya uji secara in vivomenunjukkan bahwa krim sediaan topikal rhodomyrtone 2% dapat mengurangi infeksi kulitdan tidak menimbulkan iritasi pada kelinci percobaan.
DAGUSIBU education and Beyond Use Date Medicine in the Community at the Rejosari Pekanbaru Community Health Center Agustini, Tiara Tri; Rahmat, Rosita Dewi; Tantrica, Monica Dora; Astari, Natasya; Fajriah, Nurul; Permata Sari, Poppy Wahyu
Research of Service Administration Health and Sains Healthys Vol 5, No 2 (2024): Research of Service Administration Health and Sains Healthys (Desember)
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/rehat.v5i2.7575

Abstract

Medicines are substances or combinations of substances, including biological products, which are used to influence or study physiological systems or pathological conditions in connection with the diagnosis, prevention, healing, recovery, improvement and prevention of health in humans. Medicines that can be used are medicines that meet certain quality standards. One of the parameters that influence the quality of medicines is the storage conditions of the medicine, the expiration date when the primary packaging is intact and the Beyond Use Date (BUD) or the deadline for using the medicine after it has been formulated or prepared or after the primary packaging is opened or damaged. The activity was carried out on April 3 2024 at the Rejosari Community Health Center, Pekanbaru city, Riau Province. The targets for this activity are people who come to the Rejosari Community Health Center, Pekanbaru City, Riau Province, totaling 25-30 people. Activities were carried out face to face using media in the form of educational leaflets about Beyond Use Date and DAGUSIBU at the Rejosari Community Health Center. This outreach activity was carried out by PKPA STIFAR Riau students which resulted in patient enthusiasm for following the rules that have been explained regarding Beyond use date and DAGUSIBU so that they do not use medicines carelessly and know what to do with medicines according to their needs.