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All Journal Indonesian Journal of Pharmaceutical Science and Technology JFIOnline Medika Kartika : Jurnal Kedokteran dan Kesehatan
Gladdis Kamilah Pratiwi
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Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Veterinary

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Studi Prevalensi Penggunaan Alat dan Obat Kontrasepsi di Masyarakat Kabupaten Bandung Weking, J. M.; Sutrisno, Entries; Kamilla, Gladdis
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.349 KB) | DOI: 10.35617/jfi.v7i3.307

Abstract

Governmentâ??s efforts in controlling the populationâ??s family planning program (KB) is using contraception. Contraception is a devices or a drug that is used to prevent conception (pregnancy). The purpose of this study was to determine the prevalence use of contraceptive drugs and devices (Alokon) in the community of Bandung Regency in July-August of 2013. This research uses the observation method with the cross sectional eksional questionnaire contain- ing questions related to knowledge, attitudes, and behaviors of 290 respondents about the use of Alokon. Results of the study showed that 87% of respondents know the Government program in terms of the number of children is recommended (two children). Respondents understand Alokon as a means of pregnancy prevention (78%) and can be used as requirements (42%). This type of contraception is the most known and used by the respondents are: Implants (5%), IUD (19%), birth control pills (20%) and injection (23%). In addition, respondents believed that it is not effective to delay pregnancy (82%). The existence of the respondentâ??s concern with respect to side effects(56%), Alokon among others obesity(42%). Alokon used more by women (75%) than men (4%). Alokon more chosen (43%) compared to devices (19%). Based on the results of the study it can be concluded that the respondents have a good knowledge in terms of Alokon and its use. Considering the type of medication Alokon (birth control pills) are chosen by many respondents, the required role of pharmacists in pharmaceutical care in giving right information about how to use to achieve their effectiveness as contraceptives (prevention of pregnancy).
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
EFEK PENAMBAHAN EKSTRAK AIR KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP AKTIVITAS TABIR SURYA ETILHEKSIL METOKSISINAMAT Gladdis Kamilah Pratiwi; Fikri Alatas; Dessy Adriani Putri
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 4 No 2 (2021): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.822 KB)

Abstract

Etilheksil metoksisinamat atau oktil metoksisinamat merupakan senyawa yang sering digunakan sebagai bahan tabir surya. Namun demikian bahan tabir surya ini memiliki kelemahan karena mudah teroksidasi sehingga aktivitasnya sebagai tabir suryanya menurun. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan ekstrak air kulit buah naga merah (Hylocereus polyrhizus) sebagai antioksidan terhadap aktivitas krim tabir surya yang mengandung zat aktif etilheksil metoksisinamat. Ekstrak air kulit buah naga merah dibuat dengan cara maserasi, dan dilanjutkan dengan penentuan konsentrasi penangkal radikal bebas sebanyak 50% (IC 50) dengan metode difenilpikril hidrazil (DPPH). Ekstrak kulit buah naga merah mempunyai nilai IC50 64,0 μg/mL. Formulasi krim dibuat dengan konsentrasi ekstrak kulit buah naga merah10xIC50 (F1), 50xIC50 (F2), dan 100xIC50 (F3) serta dibandingkan dengan formula tanpa ekstrak kulit buah naga merah. Efektivitas tabir surya dilakukan dengan menentukan nilai sun protecting factor (SPF), transmisi eritema (%Te), dan transmisi pigmentasi (%Tp) sebelum dan setelah penyinaran selama lima jam dibawah sinar ultraviolet. Nilai SPF F0; F1; F2; dan F3 berturut-turut adalah 8,2; 13,0; 16,0 dan 17,0 dan menurun sebanyak 35,4; 14,7; 6,9; dan 2,9% setelah penyinaran selama 5 jam. Ekstrak air kulit buah naga merah (Hylocereus polyrhizus) dengan konsentrasi 10xIC50, 50xIC50, dan 100xIC50 efektif meningkatkan nilai SPF. Formula 3 memiliki kemampuan mempertahankan nilai SPF paling baik setelah penyinaran sinar ultraviolet selama lima jam. DOI : 10.35990/mk.v4n2.p122-131
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36513

Abstract

The combination formulation of TB drugs may cause interactions if these drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR test showed that the microcapsules didn’t change the chemical composition of isoniazid or the coating on the microencapsulation so that it was concluded that no chemical reaction or decomposition occurred before and after the formation of the microcapsules. Scanning Electron Microscopy (SEM) showed a spherical microcapsule surface morphology and the active substance was well coated for INH: HPMCP HP-50 (2:3), while for INH: HPMCP HP-55 (2:3) the surface of the microcapsules was round but hollow. This study produces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCP HP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.
PENGARUH KOMBINASI HIDROKSIPROPIL METIL SELULOSA DAN CARBOPOL® 940 TERHADAP SIFAT FISIK DAN STABILITAS ANTIOKSIDAN GEL SLEEPING MASK EKSTRAK KAYU SECANG Nur Achsan Al-Hakim; Gladdis Kamilah Pratiwi; Fikri Alatas; Novitri Sri Rahayu
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 1 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Perawatan kulit menjadi salah satu upaya dalam mencegah penuaan dini, diantaranya dengan memanfaatkan bahan alami sebagai sumber antioksidan. Kayu secang (Caesalpinia sappan L.) merupakan salah satu tumbuhan yang mengandung antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kombinasi bahan pembentuk gel hidroksipropil metil selulosa (HPMC) dan Carbopol® 940 pada formulasi gel sleeping mask ekstrak kayu secang terhadap sifat fisik dan stabilitas antioksidannya. Sediaan gel sleeping mask dibuat dengan lima variasi rasio HPMC dan Carbopol® 940, yaitu 5:0 (F1), 0:5 (F2), 2,5:2,5 (F3), 3:2 (F4), dan 3,5:1,5 (F5). Evaluasi fisik sediaan meliputi organoleptik, pengukuran pH dan viskositas, homogenitas, uji daya sebar, serta penentuan stabilitas fisik aktivitas antioksidan sediaan gel sleeping mask. Aktivitas antioksidan ditetapkan menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil evaluasi fisik sediaan gel sleeping mask menunjukkan bahwa F5 merupakan formula yang terbaik dan stabil selama penyimpanan 28 hari, dan memenuhi parameter ideal sediaan kosmetik topikal, serta memiliki aktivitas antioksidan yang stabil. Penelitian ini menunjukkan bahwa ekstrak kayu secang dapat diformulasikan menjadi sediaan gel sleeping mask dan dengan memodifikasi agen pengental dalam formulasi menghasilkan sediaan yang baik dan stabil, serta penelitian ini menjadi pertimbangan ilmiah sebagai terapi alternatif dalam upaya mencegah penuaan dini. Kata kunci : antioksidan, Carbopol® 940, ekstrak kayu secang, HPMC, gel sleeping mask DOI : 10.35990/mk.v7n1.p45-56
Co-Authors Bella Dewinta Saraswati Dessy Adriani Putri Fikri Alatas Hestiary Ratih Mia Agustin Novitri Sri Rahayu Nur Achsan Al-Hakim Sutrisno, Entries Weking, J. M.