Background & Objective: Fever is a condition of an increase in body temperature. Fever is a condition ofbody temperature above 37.5 ° C. Fever is part of the immune process that is fighting infections caused byviruses, bacteria, or parasites. The aim is to determine the relationship between knowledge and attitudes ofmothers about fever with treatment of fever in children at the shanty clinic.Material and Method: The studydesign used analytical survey research using cross sectional. Technique in this study was accidentalsampling, as many as 47 respondents, and analysis data with Chi-Square statistical test. Result: Knowledgedistribution with a good majority of 20 people (42.6%), Distribution of attitudes with a positive majority of18 people (38.2%). The majority of the handling categories were 32 people (68.1%). Poor 12 respondents(37.5%) with the category of handling The results of the study showed a significant relationship betweenmaternal knowledge of fever and treatment of fever in children with p-value = 0.000, attitude categories withhandling fever in children related to p-value = 0.001. Conclusion: There is a relationship betweenknowledge and attitudes about fever with treatment of fever in children at the Shanty Medan Clinic. Toincrease maternal knowledge about fever by treating fever in children so that the mother is not too worried ifher child has a fever. By monitoring the child's body temperature, compressing the child on the forehead,armpits and folds of the thighs and giving the child plenty to drink.