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All Journal Journal of the Indonesian Tropical Animal Agriculture Tropical Animal Science Journal
Harahap, M. A.
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Energy

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Nitrogen degradation of the limestone-urea mixtures in the rumen of goats Harahap, M. A.; Nuswantara, L. K.; Pangestu, E.; Wahyono, F.; Achmadi, J.
Journal of the Indonesian Tropical Animal Agriculture Vol 43, No 3 (2018): September
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jitaa.43.3.282-288

Abstract

This experiment was aimed to study the degradation kinetics of limestone-urea mixtures in the goats rumen using the nylon bag technique. Samples of limestone were obtained from two limestone mountains, Pamotan Subdistrict of Central Java Province and Wonosari Subdistrict of Yogyakarta Province. The mixtures were created by combining urea at levels 25, 50, 75and 100%; respectively with two limestones on the basis of their Ca contents: L0U100, LP25U75, LP50U50; LP75U25, LW25U75; LW50U50; and LW75U25. The soluble fraction, potentially degradable fraction, the degradation rate of potentially degradable fraction, and effective degradation of respective dry matter (DM) and nitrogen (N) ruminal degradation kinetics were measured in each mixture. The mixture of LP75U25 had lowest effective and degradation rate of potentially degradable fraction (P<0.05) respectively for DM and N compared with those of other mixtures. In conclusion, the limestone-urea mixture of LP75U25 could be suggested as a dietary supplement of ruminal N slow release.
In Vitro Anthelmintic Evaluation of Acanthophora spicifera Macroalgal Extract Against Haemonchus contortus in Sheep Sakti, A. A.; Kustantinah; Suwignyo, B.; Sofyan, A.; Panjono; Nurcahyo, R. W.; Baihaqi, Z. A.; Harahap, M. A.; Wulandari; Prasetyo
Tropical Animal Science Journal Vol. 48 No. 6 (2025): Tropical Animal Science Journal
Publisher : Faculty of Animal Science, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5398/tasj.2025.48.6.508

Abstract

This study investigated the chemical composition and anthelmintic activity of Acanthophora spicifera against Haemonchus contortus from sheep in vitro. Fresh macroalgae were collected from Sepanjang Beach, Gunungkidul, Indonesia. Proximate analysis, fiber fractions, mineral composition, and color profile analysis were conducted to determine chemical profile of the macroalga. It was extracted by maceration with 96% ethanol (1:5) and ultrasonication. Secondary metabolites analyzed from the extract included total flavonoids, phenols, tannins, and saponins. The anthelmintic activity was tested in vitro through H. contortus adult worm motility and egg hatch inhibition tests. Extract treatments included P0: 0.9% physiological NaCl (negative control); P1: 0.5 mg/mL macroalgal extract; P2: 1 mg/mL macroalgal extract; P3: 1.5 mg/mL macroalgal extract; and Palb: 0.5 mg/mL albendazole (positive control). Motility test results showed that the use of macroalgae at levels of 0.5, 1, and 1.5 mg/mL significantly reduced H. contortus motility (p<0.05). However, effective LD₅₀ was reached in 1 and 1.5 mg/mL within the first 10 hours, and LD₁₀₀ after 21 hours (p<0.05). None of the extract levels matched the efficacy of albendazole (p<0.05). The egg hatch inhibition test revealed that the use of macroalgae at levels of 0.5, 1, and 1.5 mg/mL significantly inhibited H. contortus egg hatching by more than 85.73% after 24 hours (p<0.01), demonstrating comparable efficacy to albendazole. Based on these findings, A. spicifera extract contains various secondary metabolites with anthelmintic activity, inhibiting both H. contortus adult worm motility and egg hatching. This suggests that A. spicifera has potential for further development as a bioanthelmintic for ruminant parasite control, although further in vivo studies are needed.
Co-Authors A. A. Sakti, A. A. A. Sofyan B. Suwignyo, B. Baihaqi, Z. A. E. Pangestu F. Wahyono J. Achmadi Kustantinah L. K. Nuswantara Nurcahyo, R. W. Panjono Prasetyo WULANDARI