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All Journal Majalah Kesehatan Pharmamedika Makara Journal of Science
Yuhernita, Yuhernita
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Uji Aktivitas Antidiabetes Infusa Beras Hitam (Oryza sativa L. indica) dengan Metode Toleransi Glukosa dan Inhibisi ?-Glukosidase Yuda, Indah Permata; Juniarti, Juniarti; Yuhernita, Yuhernita; Ferlianti, Rika; Taufik Nasrullah, Taufik
Majalah Kesehatan Pharmamedika Vol 11, No 2 (2019): DESEMBER 2019
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v11i2.1326

Abstract

Diabetes Melitus merupakan penyakit metabolik dengan karakteristik kadar gula darah tinggi akibat kelainan sekresi dan atau kerja insulin. Beras hitam (Oryza sativa L. indica) secara empiris dipercaya dapat mengendalikan kadar glukosa darah. Tujuan penelitian ini adalah untuk mengetahui aktivitas antidiabetes dari infusa beras hitam dengan menggunakan metode uji toleransi glukosa dan inhibisi ?-glukosidase. Uji toleransi glukosa dilakukan secara oral menggunakan 15 ekor tikus (Rattus novergicus) yang dibagi menjadi 5 kelompok, yaitu Na-CMC, glibenklamid dan infusa O. sativa dengan konsentrasi 10, 50 dan 100%. Tiga puluh menit setelah semua kelompok diberikan perlakuan, semua hewan uji diberikan glukosa 50%. Kadar glukosa darah diukur pada menit ke-0, 30, 60, 90 dan 120 dengan menggunakan glukometer. Aktivitas inhibitor ?-glukosidase diuji secara in vitro dengan menggunakan substrat p-nitrofenil-?-D-glukopiranosida dan enzim ?-glukosidase. Hasil penelitian menunjukkan infusa O. sativa dapat mempengaruhi toleransi glukosa darah pada konsentrasi infusa beras hitam 50% dan inhibisi ?-glukosidase diuji secara in vitro didapatkan niai IC50 sebesar 77,92 µg/mL. Nilai ini lebih baik dibanding acarbose yang hanya memberikan  dengan nilai IC50 sebesar 421,55 µg/mL. Hasil ini menunjukkan O. sativa berpotensi menurunkan kadar glukosa darah dan inhibisi ?-glukosidase.
Effects of Methanolic Jatropha multifida L. Extract in Wound Healing Assessed by the Total Number of PMN Leukocytes and Fibroblasts Juniarti, Juniarti; Aryenti, Aryenti; Yuhernita, Yuhernita; Poerwaningsih, Ernie Ernie
Makara Journal of Science Vol. 16, No. 3
Publisher : UI Scholars Hub

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Abstract

The aim of this study was to evaluate the effects of methanol extract of Jatropha multifida leaves on the wound healing process and to investigate the wound healing activity based on reduced numbers of PMN (polymorpho nuclear) leukocytes and increased numbers of fibroblasts. Methanol extract of dried leaves of J. multifida was used in the wound healing activity studies. The study subjects were 36 white male Sprague Dawlay rats aged 2 months with 150-200 gram body weight. The subjects were divided into 4 groups and experimentally injured: Group I (negative control) underwent injury without subsequent treatment; group II (positive control) received topical treatment with Bethasone-N after injury; group III (solvent control) was treated with 70% methanol; group IV (treatment group) was treated with 10 mg methanol extract of J. multifida Each group consisted of 3 rats, which were decapitated on days 3, 6, and 13 after the start of treatment. Histological preparation was stained with hematoxyline-eosin (HE) and was continuously examined by counting the numbers of PMN leukocytes and fibroblasts as indicators of wound healing on days 3, 6, and 13 of treatment. The study showed lower numbers of PMN leukocytes in subjects treated with the extract of J. multifida as compared to the other groups. The numbers of fibroblasts were significantly higher on days 6 and 13 of treatment. The treatment of injuries with methanol extract of leaves from J. multifida provided better results compared to the other groups in our study.
PMN Leukocytes and Fibroblasts Numbers on Wound Burn Healing on the Skin of White Rat after Administration of Ambonese Plantain Banana Aryenti, Aryenti; Suryadi, Suryadi; Harijadi, Harijadi; Yuhernita, Yuhernita
Makara Journal of Science Vol. 16, No. 1
Publisher : UI Scholars Hub

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Abstract

A study of ambonese plantain banana (Musa paradisiaca var sapientum Lamb) treatment in burn wound healing on the skin of white rats (Rattus novergicus) has been conducted. The wound healing of burn injuries was evaluated by counting the number of PMN leukocytes and fibroblasts at the 7th, 14th, and 21st days following the treatment. The study showed that the decrease in number of PMN leukocytes of subjects treated with ambonese plantain banana was relatively more significant compared to both negative and positive control (Bioplacenton ®). In contrast, an increasing number of fibroblasts was significantly demonstrated at the 14th and 21st days after treatment. In conclusion, ambonese plantain banana treatment in burn injuries will provide better results compared to both positive and negative controls.
KANDUNGAN SENYAWA KIMIA, UJI TOKSISITAS (Brine Shrimp Lethality Test) DAN ANTIOKSIDAN (1,1-diphenyl-2-pikrilhydrazyl) DARI EKSTRAK DAUN SAGA (Abrus precatorius L.) Juniarti, Juniarti; Osmeli, Delvi; Yuhernita, Yuhernita
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

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Abstract

Chemical Compound Gynecology, ToxinTest (Brine Shrimp Lethality Test) and Antioxidants (1,1-Diphenyl-2- Pikrilhydrazyl) from Saga Leaf Extract (Abrus Precatorius L.). Cytotoxicity effects and antioxidant activities of saga (Abrus precatorius L.) extract were studied by using Brine Shrimp Lethality Test and 1,1-diphenyl-2-pikrilhydrazyl assays. Saga was extracted with different solvents i.e n-hexane, ethyl acetate and methanol. Result showed that the methanolic extract of saga had been potential to be cytotoxic againts Brine Shrimp with LC50 value of 606.736 ppm. However, all the extract of saga did not have antioxidant activities.
ANALISIS SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL DAUN SURIAN YANG BERPOTENSI SEBAGAI ANTIOKSIDAN Yuhernita, Yuhernita; Juniarti, Juniarti
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Secondary Metabolites Analysis of Methanol Extract of Surian (Toona sureni (Bl.) Merr) Leaf as Antioxidant Potential. The study of performed secondary metabolites from the methanol extract of Surian (Toona sureni (Bl.) Merr) leaves have been done by thin-layer chromatography (TLC) method. The result showed that methanol extract of Surian leaves consist of alkaloid, flavonoid, polyphenol and terpenoid. All of them positively have the ability to scavenge 2,2- diphenyl-1-picrylhydrazyl (DPPH). It has IC50 (4.80) are smaller than the ascorbat acid standard (IC50 = 9.23).
DESTILASI MINYAK ATSIRI DAUN SURIAN SEBAGAI KRIM PENCEGAH GIGITAN NYAMUK Aedes aegypty L. Juniarti, Juniarti; Yuhernita, Yuhernita; Endrini, Susi
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Distillation of Essential Oil from Surian Leaf (Toona sureni (Bl.) Merr.) as Repellent Cream for Protection Aedes aegypty L. Bites. Isolation of volatile oil of leaf surian (Toona sureni (Bl.) Merr.) have been done by distillation aqueous vapour method. Distillation result had the chocolate colored and stinging aroma, and rendement was 0.23%. GC-MS analysis shown of some compound of terpenoid (naftalen derivated) which correspondence to mass spectrum. One of them is copaene (C15H24), m/z = 204. Cream based of Rajin et al. formula giving stable cream, white coloured and neutral pH. Volatile oil of surian leaf in cream based cause color and aroma cream were changed. Cream stability also was annoyed at oil of atsiri 10%.
Co-Authors A.A. Ketut Agung Cahyawan W Aryenti, Aryenti Ferlianti, Rika Harijadi Harijadi Juniarti . Juniarti Juniarti Osmeli, Delvi Poerwaningsih, Ernie Ernie Suryadi Suryadi Susi Endrini Taufik Nasrullah, Taufik Yuda, Indah Permata