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All Journal Majalah Kedokteran Bandung Majalah Kesehatan Pharmamedika Journal of Health and Nutrition Research Makara Journal of Science
Aryenti, Aryenti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Aktivitas Inhibitor α-Glukosidase Ekstrak Daun Toona sureni (Bl. ) Merr. sebagai Antihiperglikemik Permata Yuda, Indah; Aryenti, Aryenti; Juniarti, Juniarti
Majalah Kesehatan Pharmamedika Vol 10, No 2 (2018): DESEMBER 2018
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v10i2.724

Abstract

Telah dilakukan kajian aktivitas penghambatan α-glukosidase oleh ekstrak daun surian (Toona sureni (Bl.) Merr ). Daun surian diekstraksi menggunakan maserasi bertingkat dengan berbagai pelarut: n-heksana, etil asetat dan metanol. Hasil yang didapatkan ekstrak daun surian memiliki aktivitas yang potensial sebagai penghambat α-glukosidase. Ekstraksi dengan metanol menunjukkan aktivitas penghambatan paling baik dengan nilai IC50 sebesar 4,41 ppm, nilai ini sebanding dengan strandar nojiromycin yang memiliki nilai IC50 sebesar 4,98 ppm, selanjutnya ekstraksi dengan etil asetat (nilai IC50 sebesar 7,21 ppm). Hasil ini menunjukkan ekstrak daun surian dapat digunakan untuk mengontrol glukosa darah dan pencegahan hiperglikemia.
Effects of Methanolic Jatropha multifida L. Extract in Wound Healing Assessed by the Total Number of PMN Leukocytes and Fibroblasts Juniarti, Juniarti; Aryenti, Aryenti; Yuhernita, Yuhernita; Poerwaningsih, Ernie Ernie
Makara Journal of Science Vol. 16, No. 3
Publisher : UI Scholars Hub

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Abstract

The aim of this study was to evaluate the effects of methanol extract of Jatropha multifida leaves on the wound healing process and to investigate the wound healing activity based on reduced numbers of PMN (polymorpho nuclear) leukocytes and increased numbers of fibroblasts. Methanol extract of dried leaves of J. multifida was used in the wound healing activity studies. The study subjects were 36 white male Sprague Dawlay rats aged 2 months with 150-200 gram body weight. The subjects were divided into 4 groups and experimentally injured: Group I (negative control) underwent injury without subsequent treatment; group II (positive control) received topical treatment with Bethasone-N after injury; group III (solvent control) was treated with 70% methanol; group IV (treatment group) was treated with 10 mg methanol extract of J. multifida Each group consisted of 3 rats, which were decapitated on days 3, 6, and 13 after the start of treatment. Histological preparation was stained with hematoxyline-eosin (HE) and was continuously examined by counting the numbers of PMN leukocytes and fibroblasts as indicators of wound healing on days 3, 6, and 13 of treatment. The study showed lower numbers of PMN leukocytes in subjects treated with the extract of J. multifida as compared to the other groups. The numbers of fibroblasts were significantly higher on days 6 and 13 of treatment. The treatment of injuries with methanol extract of leaves from J. multifida provided better results compared to the other groups in our study.
PMN Leukocytes and Fibroblasts Numbers on Wound Burn Healing on the Skin of White Rat after Administration of Ambonese Plantain Banana Aryenti, Aryenti; Suryadi, Suryadi; Harijadi, Harijadi; Yuhernita, Yuhernita
Makara Journal of Science Vol. 16, No. 1
Publisher : UI Scholars Hub

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Abstract

A study of ambonese plantain banana (Musa paradisiaca var sapientum Lamb) treatment in burn wound healing on the skin of white rats (Rattus novergicus) has been conducted. The wound healing of burn injuries was evaluated by counting the number of PMN leukocytes and fibroblasts at the 7th, 14th, and 21st days following the treatment. The study showed that the decrease in number of PMN leukocytes of subjects treated with ambonese plantain banana was relatively more significant compared to both negative and positive control (Bioplacenton ®). In contrast, an increasing number of fibroblasts was significantly demonstrated at the 14th and 21st days after treatment. In conclusion, ambonese plantain banana treatment in burn injuries will provide better results compared to both positive and negative controls.
Antioxidant and Antiaging Properties of Ethanolic Ripe Sesoot Fruit Extract Utami, Sri; Sosiawan, Insan; Nurul, Dewi; Purnamasari, Endah; Batubara, Lilian; Sachrowardi, Qomariyah Romadhiyani; Damayanti, Ndaru Andri; Aryenti, Aryenti; Dewi, Intan Keumala; Nafik, Said; Arrahmani, Betharie Cendera; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Utomo, Herry S
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3472

Abstract

Skin aging can be characterized by changes in skin, such as the appearance of wrinkles and loss of skin moisture. Some elements that might lead to cell damages and aging are free radicals through the increase of the activities of hyaluronidase and tyrosinase. Bioactive compounds found in sesoot (Garcinia picrorhiza Miq.) are known for their antioxidant properties, which may reduce excessive amounts of free radicals in the body and act as an antiaging agent by inhibiting hyaluronidase and tyrosinase activities. This study aimed to examine the antioxidant, anti-hyaluronidase, and anti-tyrosinase properties found in Ethanolic Extract Ripe Sesoot (EERS). The ethanol extract of ripe sesoot fruit obtained from LIPI, Bogor Botanical Garden was used for the antioxidant and antiaging assays conducted at PT Aretha Medika Utama in December 2016. The activity of antioxidants was measured as the Ferric Reducing Antioxidant Power (FRAP) of the EERS, while the antiaging assays were performed through the inhibition activity of hyaluronidase and tyrosinase. Results indicated that the EERS has a higher FRAP activity (17.58 μM Fe (II)/μg) than xanthone (2.54 μM Fe (II)/μg) at the highest concentration of sample of 5,000 µg/mL. The anti-hyaluronidase of the EERS exhibited lower activity (IC50 of 619.21±12.15 µg/mL) than xanthone (IC50 of 365.55±25.10 µg/mL) and the tyrosinase inhibitory assay demonstrated a lower activity of EERS (IC50 of 1060.68±12.81 µg/mL) compared to xanthone (IC50 of 218.33±9.73 µg/mL). To conclude, EERS shows antioxidant and antiaging properties.
How Osteoporosis Looks Like in CT Scan Images: An Alternative Osteoporosis Assessment Genisa, Maya; Abdullah, Johari Yap; MD Yusoff, Bazli Bin; Aryenti, Aryenti; Juniarti, Juniarti
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.393

Abstract

Osteoporosis is a silent degenerative disease that commonly affects the elderly, leading to decreased bone density and increased risk of fractures. Dual-Energy X-ray Absorptiometry (DEXA) is the standard tool for assessing Bone Mineral Density (BMD), but its limited availability and high cost in many healthcare facilities, especially in developing countries like Indonesia, necessitate alternative diagnostic methods. This study aims to assess the potential use of Computed Tomography (CT) scan images as a substitute for DEXA in detecting osteoporosis. The objective is to analyze bone texture attributes from CT images to differentiate between normal and osteoporotic bone structures. The method involved collecting CT scan data from patients at Hospital Universiti Sains Malaysia (HUSM). The vertebrae regions were segmented from the abdominal CT images using image processing techniques to isolate bone tissue. Four image-derived texture attributes—Roughness, Contrast, Greyscale, and Phase—were then extracted using MATLAB-based analysis. The results showed that osteoporotic bones had higher values in Roughness and Contrast, and lower values in Greyscale and Phase compared to normal bones. Among these, Roughness was identified as the most sensitive attribute in detecting changes associated with osteoporosis. These findings indicate that CT scan images, when analyzed through proper segmentation and texture evaluation, have the potential to serve as a viable alternative for osteoporosis screening, particularly in settings where DEXA is unavailable.
Co-Authors Abdullah, Johari Yap Arrahmani, Betharie Cendera Batubara, Lilian Damayanti, Ndaru Andri Dewi Nurul, Dewi Dewi, Intan Keumala Endah Purnamasari Hanna Sari Widya Kusuma, Hanna Sari Widya Harijadi Harijadi Juniarti . Juniarti Juniarti Maya Genisa MD Yusoff, Bazli Bin Nafik, Said Permata Yuda, Indah Poerwaningsih, Ernie Ernie Sachrowardi, Qomariyah Romadhiyani Sosiawan, Insan Sri Utami Suryadi Suryadi Utomo, Herry S WAHYU WIDOWATI Yuhernita, Yuhernita