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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Farmako Bahari Journal of halal product and research (JHPR)
Junaedi, Effan Cahyati
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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IN SILICO STUDY: SECONDARY METABOLITES FROM JAMBOLAN (Syzygium Cumini L.) AS POTENTIAL BREAST CANCER TREATMENTS Suherman, Meilia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Purnamasari, Ade Rena
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3254

Abstract

Breast cancer ranks second in world cancer incidence rates in 2020, contributing to 2,261,419 new cases, or 11.7% of all new cancer cases globally. The search for cancer drugs that work selectively continues to be encouraged to obtain safe and effective therapy, particularly those derived from medicinal plants. Jambolan is a plant that can thrive in both subtropical and tropical climates, including Indonesia. Jambolan (Syzygium cumini L.) has 89% antioxidant activity and 69% cytotoxic activity against T47D cells. Pharmacophore modelling and molecular docking were used to study the binding of 117 active jambolan drugs to alpha and beta estrogen receptors. Rutin was found to be potentially selective for ER-Beta receptors, with a fit score of 53.13. Molecular docking to ER-Beta revealed that rutin has breast cancer activity with a free bond energy value of -10.5 kcal/mol and better conformation and affinity than native ligands (genistein). It also binds to essential amino acids as an anticancer breast at ARG 346 and GLU 305. Lipinski's rule of five prediction results and in silico ADMET prediction from rutin yielded results that met the candidate drug's parameters. Rutin is a potential therapeutic option for treating breast cancer by targeting the ER-Beta receptor.
Determination of Vitamin C Red Guava (Psidium Guajava Linn) Fruit Juice, with Variation of Beverage Packaging Lubis, Novriyanti; Septiani, Wulan; Abdillah, Muhammad Nur; Prasetiawati, Riska; Junaedi, Effan Cahyati
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.42420

Abstract

The quantitative analysis of vitamin C content from variations beverage  packaging  containing red guava (Psidium Guajava Linn) fruit juice had been done. In this study, 4 samples were obtained from the shopping center in Garut and Bandung City. Samples were tested quantitatively by 2,6-dichlorophenol indophenol titration method. The results showed different concentration of 4 samples consist of  tetra pack packaging, tin, glass, and plastic bottles, such as; 17.99 mg/100 gr, 31.46 mg/100 gr, 13.00 mg/100 gr, and 12.01 mg/100 gr, respectively. These result indicated that the packaging variations affected to the level of vitamin C content which was characterized by decreased levels of vitamin C. It means the levels of vitamin C from this research were not in accordance to nutritional value information on the packaging. Tetra pack packaging was the most stable compared to other packaging even though it had a shorter expired date than with other. 
Definition of halal analysis of formulation of kombucha drink from simplicia of malay apple fruit (Syzygium malaccense) Lubis, Novriyanti; Mubarok, Anwar; Junaedi, Effan Cahyati; Soni, Dang
Journal of Halal Product and Research (JHPR) Vol. 7 No. 1 (2024): Driving Global Halal Value Chain, What Should We Do?
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jhpr.vol.7-issue.1.30-39

Abstract

The wealth of biodiversity and the abundance of native Indonesian germplasm resources have not been optimally utilized domestically. Malay apple, which belongs to the myrtaceae family, has various health benefits. However, its utilization is still limited, thus requiring ideas to increase public interest in this fruit. Therefore, innovation is carried out by transforming malay apple  into kombucha fermentation beverages as a step to optimize its utilization. The research aimed to measure the total alcohol content, total acid, and total sugar in the formulation of kombucha beverages derived from malay apple  fruit juice, with the goal of developing it into a functional beverage. The research process involved testing alcohol content using gas chromatography, measuring total acid by alkalimetric titration method, and measuring total sugar content by anthrone method. The research results showed that the malay apple  kombucha sample  the level  of alcohol content was 0.0213%, the total acid was 1.38% (<2 g/L), and the total sugar was 0.807 µg. The kombucha malay apple which category halal kombucha.
IN SILICO STUDY: SECONDARY METABOLITES FROM JAMBOLAN (Syzygium Cumini L.) AS POTENTIAL BREAST CANCER TREATMENTS Suherman, Meilia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Purnamasari, Ade Rena
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3254

Abstract

Breast cancer ranks second in world cancer incidence rates in 2020, contributing to 2,261,419 new cases, or 11.7% of all new cancer cases globally. The search for cancer drugs that work selectively continues to be encouraged to obtain safe and effective therapy, particularly those derived from medicinal plants. Jambolan is a plant that can thrive in both subtropical and tropical climates, including Indonesia. Jambolan (Syzygium cumini L.) has 89% antioxidant activity and 69% cytotoxic activity against T47D cells. Pharmacophore modelling and molecular docking were used to study the binding of 117 active jambolan drugs to alpha and beta estrogen receptors. Rutin was found to be potentially selective for ER-Beta receptors, with a fit score of 53.13. Molecular docking to ER-Beta revealed that rutin has breast cancer activity with a free bond energy value of -10.5 kcal/mol and better conformation and affinity than native ligands (genistein). It also binds to essential amino acids as an anticancer breast at ARG 346 and GLU 305. Lipinski's rule of five prediction results and in silico ADMET prediction from rutin yielded results that met the candidate drug's parameters. Rutin is a potential therapeutic option for treating breast cancer by targeting the ER-Beta receptor.
THE EFFECT OF SUGAR CONCENTRATION IN KOMBUCHA, KEJEK TEA AND ASAM KANDIS (Garciniaxanthochymus) ON ANTIOXIDANT ACTIVITY, TOTAL ALCOHOL AND TOTAL ACID Soni, M.Farm., Dang; Abdillah, Muhammad Nur; Junaedi, Effan Cahyati; Panjaitan, Destrien Resmita
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41942

Abstract

This study aims to determine the effect of sugar concentration and the addition of asam kandis on antioxidant activity, total alcohol and total acid in kombucha drinks. The test began with a test of the characteristics of the simplicia phytochemical screening. The antioxidant activity was then examined using the DPPH method, the total alcohol content was determined using gas chromatography, and the total acid test was performed using titration. The results of the simplicia characteristic test showed that the simplicia used had met the standards of the Indonesian herbal pharmacopoeia, and the results of the phytochemical screening test showed that only saponins did not show their presence, both kejek tea, asam kandis and a combination of both. The results of the DPPH test showed that the sample with optimal antioxidant activity was in Formula 4 with a percentage inhibition value of 82% ± 0.08, total alcohol of 0.09% ± 0.12 and total acid of 1.57% ± 0.17. This study also proves that the combination of kejek tea, kandis acid and higher sugar content can increase antioxidant activity, total alcohol and total acid, but the total alcohol and total acid are still below the safe limit. Nikmati pengalaman bermain slot, grafis epik dan fitur bonus hadir untuk meningkatkan peluang kemenangan.
Co-Authors Abdillah, Muhammad Nur Anwar Mubarok Meilia Suherman, Meilia Novriyanti Lubis, Novriyanti Panjaitan, Destrien Resmita Purnamasari, Ade Rena Riska Prasetiawati, Riska Soni, Dang Soni, M.Farm., Dang Wulan Septiani, Wulan