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Formulasi, Evaluasi, dan Perbandingan Intensitas Kepedasan Granul Effervescent Jahe Lubis, Novriyanti; Prasetiawati, Riska; Rahmat, Gilang
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 1 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Telah dilakukan penelitian tentang formulasi, evaluasi, dan perbandingan intensitas kepedasan granul effervescent jahe putih (Zingiber officinale Roscoe) instan dan jahe merah (Zingiber officinale Var.Rubrum) instan yang menggunakan satu formulasi hasil dari estimasi. Metode yang digunakan ekstraksi panas yang digunakan untuk memperoleh ekstrak jahe instan dengan pengisi glukosa sebanyak 50% dari jumlah volum. Data pengamatan menunjukkan bahwa distribusi ukuran, bobot jenis benar, bobot jenis nyata, bobot jenis mampat, porositas, kompresibilitas, kadar air, kecepatan alir, dan sudut istirahat dari formula tetap stabil setelah penyimpanan selama 12 hari pada suhu ruangan. Hasil uji kepedasan dan kesukaan menyatakan bahwa granul effervescent jahe putih instan lebih pedas namun tidak memiliki aroma, warna yang kurang menarik, dibandingkan dengan granul effervescent jahe merah instan menurut para panelis relawan penguji.Â Kata kunci: Granul effervescent, intensitas kepedasan, jahe instan

IN SILICO STUDY: SECONDARY METABOLITES FROM JAMBOLAN (Syzygium Cumini L.) AS POTENTIAL BREAST CANCER TREATMENTS Suherman, Meilia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Purnamasari, Ade Rena
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3254

Breast cancer ranks second in world cancer incidence rates in 2020, contributing to 2,261,419 new cases, or 11.7% of all new cancer cases globally. The search for cancer drugs that work selectively continues to be encouraged to obtain safe and effective therapy, particularly those derived from medicinal plants. Jambolan is a plant that can thrive in both subtropical and tropical climates, including Indonesia. Jambolan (Syzygium cumini L.) has 89% antioxidant activity and 69% cytotoxic activity against T47D cells. Pharmacophore modelling and molecular docking were used to study the binding of 117 active jambolan drugs to alpha and beta estrogen receptors. Rutin was found to be potentially selective for ER-Beta receptors, with a fit score of 53.13. Molecular docking to ER-Beta revealed that rutin has breast cancer activity with a free bond energy value of -10.5 kcal/mol and better conformation and affinity than native ligands (genistein). It also binds to essential amino acids as an anticancer breast at ARG 346 and GLU 305. Lipinski's rule of five prediction results and in silico ADMET prediction from rutin yielded results that met the candidate drug's parameters. Rutin is a potential therapeutic option for treating breast cancer by targeting the ER-Beta receptor.

Determination of Vitamin C Red Guava (Psidium Guajava Linn) Fruit Juice, with Variation of Beverage Packaging Lubis, Novriyanti; Septiani, Wulan; Abdillah, Muhammad Nur; Prasetiawati, Riska; Junaedi, Effan Cahyati
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.42420

The quantitative analysis of vitamin C content from variations beverage packaging containing red guava (Psidium Guajava Linn) fruit juice had been done. In this study, 4 samples were obtained from the shopping center in Garut and Bandung City. Samples were tested quantitatively by 2,6-dichlorophenol indophenol titration method. The results showed different concentration of 4 samples consist of tetra pack packaging, tin, glass, and plastic bottles, such as; 17.99 mg/100 gr, 31.46 mg/100 gr, 13.00 mg/100 gr, and 12.01 mg/100 gr, respectively. These result indicated that the packaging variations affected to the level of vitamin C content which was characterized by decreased levels of vitamin C. It means the levels of vitamin C from this research were not in accordance to nutritional value information on the packaging. Tetra pack packaging was the most stable compared to other packaging even though it had a shorter expired date than with other.

Counseling on the Dangers of Repeated Use of Cooking Oil and Training on the Valorization of Used Cooking Oil for Dorokdok Cracker Producer in Suci Village Fauziah, Nenden; Prasetiawati, Riska; Senania, Astri; Apriani, Riza; Annisa Rahmasari Kanto, Dhini
Jurnal Inovasi Sains dan Teknologi untuk Masyarakat Vol. 2 No. 2 (2024): November
Publisher : Faculty of Mathematics and Natural Sciences, University of Jember. Jl. Kalimantan No.37, Krajan Timur, Jemberlor, Kec. Sumbersari, Jember Regency, East Java 68121

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/instem.v2i2.1574

Producers of cowhide crackers (dorokdok) in Suci Village have the potential to produce cooking oil waste of more than 1 ton/week. In addition, cooking oil is often used repeatedly to reduce production costs. From situation analysis and field observations, the people of Suci Village do not yet know the dangers of using used cooking oil repeatedly and how to process used cooking oil into biodiesel. This service activity aims to educate the public about the dangers of repeated use of used cooking oil and the valorization of used cooking oil into biodiesel. It is hoped that the step of valorizing used cooking oil can prevent repeated use of cooking oil without having an impact on increasing dorokdok production costs. The method of implementing service is counselling and training. Changes in community knowledge are evaluated through the implementation of pretests and posttests. The evaluation results show an increase in public knowledge about the dangers of repeated use of cooking oil and steps to valorize used cooking oil reaching 66.20%. It is hoped that the step to valorize used cooking oil will be a way to create a healthy environment and food as well as realize economic independence in Suci Village.

In Silico Study of Compounds in Noni (Morinda citrifolia L.) against Main-Protease in SARS-CoV-2 Lestyawan, Samuel; Fakhirah, Maitsa Alya; Prasetiawati, Riska; Anggraeni, Diyani Sovia; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.58058

Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a contagious illness transmitted from person to person. The main protease (Mpro) of SARS-CoV-2 is a promising target for therapeutic intervention. Noni (Morinda citrifolia L.), a plant commonly used in traditional medicine in Indonesia for treating COVID-19, has been investigated for its potential anti-SARS-CoV-2 compounds. However, the specific bioactive compounds targeting SARS-CoV-2 remain unidentified. This study aimed to identify and predict the activity of compounds in Noni against Mpro through pharmacophore modeling, molecular docking, drug-likeness, and pharmacokinetic analysis using LigandScout®, Discovery Studio Visualizer®, AutoDock®, SwissADME, Pre-ADMET, and Toxtree®. Among the 40 compounds analyzed, quercetin emerged as the most promising candidate, with a pharmacophore fit score of 41.05, a binding energy (ΔG) of -7.79 kcal/mol, and interactions with amino acid residues GLY143A and MET165A, similar to the native ligand. These findings suggest that quercetin from M. citrifolia has the potential to be developed as a novel anti-SARS-CoV-2 therapeutic agent.

IN SILICO STUDY: SECONDARY METABOLITES FROM JAMBOLAN (Syzygium Cumini L.) AS POTENTIAL BREAST CANCER TREATMENTS Suherman, Meilia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Purnamasari, Ade Rena
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3254

Breast cancer ranks second in world cancer incidence rates in 2020, contributing to 2,261,419 new cases, or 11.7% of all new cancer cases globally. The search for cancer drugs that work selectively continues to be encouraged to obtain safe and effective therapy, particularly those derived from medicinal plants. Jambolan is a plant that can thrive in both subtropical and tropical climates, including Indonesia. Jambolan (Syzygium cumini L.) has 89% antioxidant activity and 69% cytotoxic activity against T47D cells. Pharmacophore modelling and molecular docking were used to study the binding of 117 active jambolan drugs to alpha and beta estrogen receptors. Rutin was found to be potentially selective for ER-Beta receptors, with a fit score of 53.13. Molecular docking to ER-Beta revealed that rutin has breast cancer activity with a free bond energy value of -10.5 kcal/mol and better conformation and affinity than native ligands (genistein). It also binds to essential amino acids as an anticancer breast at ARG 346 and GLU 305. Lipinski's rule of five prediction results and in silico ADMET prediction from rutin yielded results that met the candidate drug's parameters. Rutin is a potential therapeutic option for treating breast cancer by targeting the ER-Beta receptor.

UPAYA PENINGKATAN PENGETAHUAN KESEHATAN MENTAL PADA REMAJA DALAM MEWUJUDKAN GENERASI Z YANG BERIMAN Lubis, Novriyanti; Annafiah, Salma; Wibowo, Diki Prayugo; Fadhilah, Salma Firyal; Sudrajat, Awang; Prasetiawati, Riska
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 3 (2025): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i3.30365

Abstrak: Generasi Z atau Gen Z merupakan generasi yang lahir pada 1997-2012. Perkembangan pola pikir kritis adalah pada saat usia remaja. WHO menyebutkan penduduk dengan rentan usia 10-19 tahun menyumbangkan sebanyak 16% beban penyakit, cedera, dan gangguan mental emosional. Hal ini disebabkan oleh kurangnya edukasi dan kesadaran masyarakat terhadap penanggulangan kesehatan mental pada anak dan remaja. Kasus-kasus ini disebabkan oleh ketidaktahuan dan dan kurangnya kesadaran mengenai kesehatan mental. Penyuluhan ini dilakukan agar kondisi kesehatan mental remaja di MTS Babussalam yang berlokasi di Desa Barusuda Kecamatan Cigedug, Kabupaten Garut, Jawa Barat lebih baik lagi dan adanya peningkatan pengetahuan mengenai kesehatan mental. Metode penyuluhan dilakukan melalui presentasi langsung. Total siswa yang berpartisipasi dalam peenyuluhan ini sebanyak 57 siswa. Instrumen yang digunakan dalam metode ini adalah lembar kuisioner. Hasil penyuluhan menunjukkan sebanyak 77,2% siswa yang mengikuti kegiatan sosialisasi diketahui telah paham terhadap pentingnya kesehatan mental pada remaja. Selain itu, pemahaman responden terhadap perilaku tidak baik bagi kesehatan mental yakni sebanyak 82,5% siswa dan sebanyak 75,4% siswa paham akan kondisi ketika kesehatan mental tidak baik. Diharapkan penyuluhan ini dapat menjadi landasan untuk mengetahui cara penanganan dalam kesehatan mental secara preventif dan promotif pada kesehatan jiwa remaja yang di dalamnya melibatkan di lingkungan sekolah termasuk guru dan teman sebaya sehingga remaja mampu memiliki faktor protektor yang baik dan mampu mengatasi masalah yang terjadi dengan adaptif.Abstract: The development of critical thinking is during adolescence. WHO states that the vulnerable population aged 10-19 years contributes as much as 16% of the burden of disease, injury and mental-emotional disorders. This is caused by a lack of education and public awareness of mental health management in children and adolescents. These cases are caused by ignorance and lack of awareness regarding mental health. This counseling was carried out to find out how students know about adolescent mental health at MTS Babussalam which is located in Barusuda Village, Cigedug District, Garut Regency, Total participating in this counseling were 57 students. The instrument used in this method is a questionnaire sheet. Data were analyzed with descriptive analysis techniques. The results of the counseling showed that 77.2% of the students who took part in the socialization activities were known to have understood the importance of mental health in adolescents. In addition, respondents' understanding of behavior that is not good for mental health, namely as many as 82.5% of students and as many as 75.4% of students understand the conditions when mental health is not good. It is hoped that this counseling can become the basis for knowing how to deal with preventive and promotive mental health in adolescent mental health which involves the school environment including teachers and peers so that adolescents are able to have good protective factors and are able to overcome problems that occur adaptively.

Studi Karakteristik Edible Film Dari Pektin Buah Pandan Laut (Pandanus ordorifer): Study of Edible Film Physicochemical Characteristics of Pandan Laut Fruit (Pandanus ordorifer) Pectin Lubis, Novriyanti; Nuraeni, Ai Resna Fitri; Mahmudah, Rahma; Abdillah, Muhammad Nur; Prasetiawati, Riska
Jurnal Teknologi dan Mutu Pangan Vol. 4 No. 1 (2025): JTMP: Jurnal Teknologi dan Mutu Pangan
Publisher : Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/jtmp.v4i1.4805

Edible film is a thin layer used to protect food ingredients (as a coating) that comes from food-grade components and can be consumed directly. Pandanus sea fruit has the potential to be a source of pectin. This study aims to determine the characteristics of edible film from Pandanus sea fruit pectin (Pandanus ordorifer). The method used was laboratory experimental research with a simple one-factor experimental design. The pectin extraction formula consists of Pandanus sea simplicia, distilled water, and H2SO4, with variations in pH conditions at 2, 3, and 4. The results showed that pectin with pH 4 met the requirements according to the Japanese Industrial standard consisting of a yield of 2.60%, water content of 8.1%, ash content of 9.2%, methoxyl content of 6.2%, equivalent weight of 631 mg, galacturonic acid content of 253% and degree of esterification of 13.9%. The edible film making formula is Pandanus sea pectin, distilled water, with variations of sorbitol added at 5%, 10%, and 15%. The results showed that a concentration of 5% sorbitol produced the best edible film, meeting the requirements of a water content of 6.5%, a thickness of 0.13 mm, and a solubility of 59%. The organoleptic test of the edible film with a 5% sorbitol concentration was the most preferred by the panelists.This research is expected to be an innovation in the use of Pandan Laut fruit as an alternative food packaging.

Improving Elderly Knowledge on Hypertension through Health Education in Parakan Village, Garut Sadino, Asman; Lubis, Novriyanti; Suryana, Shendi; Prasetiawati, Riska; Hermawan, Belya Anindia; Cahyati, Effan; Apriani, Riza; Karina, Karina; Rena, Rena
Indonesian Journal of Community Empowerment (IJCE) Vol 6 No 2 (2025): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v6i2.1034

Hypertension is a non-communicable disease often referred to as a "silent killer" because it may develop without noticeable symptoms and can lead to serious complications if left untreated. Elderly individuals are among the high-risk groups who require special attention in efforts to prevent and control hypertension. This community service activity aimed to improve the knowledge of elderly residents regarding hypertension through health education as a preventive measure against further complications. The program was conducted in Parakan Village, Garut Regency, involving 30 elderly participants. The method used was health education combined with pre-test and post-test assessments to evaluate knowledge improvement. The results showed a significant increase in understanding after the session, particularly regarding the symptoms and prevention of hypertension. Another notable finding was that most participants had only elementary-level education, which influenced their receptiveness to health information. In conclusion, health education proved effective in enhancing the elderly's knowledge of hypertension and its potential complications. Periodic follow-up education and collaboration with local health services are recommended to sustain the impact.

In silico study: secondary metabolites from malay apple (Syzygium malaccense (L.) Merr. & L.M. Perry) as potential breast cancer treatments Prasetiawati, Riska; Fauzan, Nawadhir; Suherman, Meilia
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26537

Breast cancer has the highest prevalence of all cancers. Breast cancer has overtaken lung cancer as the leading cause of global cancer incidence in 2020, accounting for 2,261,419 new cases, or 11.7% of all new cancer cases worldwide. Among the efforts that can be done are efforts to find breast cancer medications that are safe and selective for the treatment and prevention of cancer, particularly those derived from medicinal plants. The Malay apple (Syzygium malaccense (L.) Merr. and L.M. Perry) is one plant that has been extensively examined and proved to have an antiproliferative effect. The pharmacophore modelling, molecular docking, and molecular dynamic approach was conducted on 155 active compounds of Malay apple to alpha and beta estrogen receptors. According on the results of ER-lamda docking, numerous substances have binding free energy values less than 4-OHT yet are not bound to important amino acids, as the result, it is not continued to the next test. On other side, with a fit score of 45.81, rutin was potentially selective for ER-beta receptors, molecular docking to ER-beta obtained that rutin was predicted to have breast cancer activity with a free binding energy value of -10.6 kcal /mol with better conformation and affinity compared to native ligand (genistein), and bound to essential amino acids as anticancer breast at ARG 346, GLU 305, and molecular dynamics simulations show that the compound has good stability when binding to the receptor. In silico toxicity prediction from rutin showed outcomes that match the requirements for the candidate drug. However, because it does not match the ADME prediction and Lipinsky's rule of five, rutin must be optimalization to improve its pharmacokinetic and pharmacological profile before it can be further explored as a therapeutic option for the treatment of breast cancer that targets the ER- receptor.

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