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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biomedika MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Medica Arteriana (Med-Art) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Dian Yuliartha Lestari
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga.

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Cardioprotectant Effect Of Bay Leaf Extract (Syzygiumpolyanthum) On Myocardium Thickness Of Rat Heart Dian Yuliartha Lestari; Rizky Trimaulidia
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.15803

Abstract

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids which can lower blood pressure and decrease left ventricular thickening. To determine the effect of bay leaf extract (Syzygiumpolyanthum) on the left ventricle thickening of rat heart (Rattus norvegicus wistar strain) in hypertensive model.  True experimental post-test only controls group design with simple random sampling technique. The subjects of this study were 25 male Wistar rats aged 2-3 months weighing 150-200 grams. Rats were induced with prednisone 1.5 mg/ KgBW / day in 2% NaCl for 6 weeks followed by administration of bay leaf extract at a dose of 70 mg/ KgBW, a dose of 140 mg/ KgBW, and a dose of 280 mg/ KgBW. Data analyzed by One Way ANOVA, Post Hoc Bonferroni, followed by Linear: One Way ANOVA test showed significant differences between treatments (p = 0.000). The Bonferroni Post Hoc test concluded that there were significant differences in the treatment of the P2 and P3 groups. Linear regression test obtained R square 0.663 and obtained the equation Y = 1965.838 - 1.275X. The extract of bay leaf (Syzygiumpolyanthum) has an effect on decreasing the left ventricle thickening of the white male rat heart (Rattus norvegicus wistar strain) hypertension model.
The Effect Of Family Support On Stress Level In Muhammadiyah High School 1 Malang Students With Acne Vulgaris Dwi Nurwulan Pravitasari; Anung Putri Illahika; Dian Yuliartha lestari; Febriana Nur Layli; Siska Fitriana
Saintika Medika Vol. 17 No. 2 (2021): December 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM2.18001

Abstract

Adolescence is a stage that has relatively not reached maturity both emotionally and mentally so that in achieving good development, it is necessary to have positive support in life from the family. Stress that occurs identified as one of the triggering factors for acne vulgaris. To determine the effect of family support on stress levels in Muhammadiyah High School 1 Malang students with acne vulgaris complaints. This research an analytic observational study with a cross-sectional approach. Sampling by purposive sampling and a sample of 52 respondents. Analyzed with Spearman correlation followed by ordinal regression analysis. The results of the ordinal regression test of the effect of family support on stress levels showed a value of p = 0.000 (p<0.05), which means that there is an effect of family support on the stress level of students who have acne vulgaris complaints, with the magnitude of the OR being exp (3.323) = 27.743. The magnitude of the influence of family support in predicting the stress level of students with acne vulgaris complaints is 46.7% There is an effect of family support on stress levels in students of Muhammadiyah High School 1 Malang with acne vulgaris complaints.
Effectiveness Of Watermelon (Citrullus lanatus) Red Flesh Extract On Reducing Coronary Artery Foam Cells and Thinning Of The Aortical Intima In Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Bahrudin, Mochamad; Dian Yuliartha Lestari; Nabila Risma Anjana; Tiara Lastari
Saintika Medika Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.32403

Abstract

Introduction: Atherosclerosis (AS) is a process of narrowing of the lumen of arteries due to progressive plaque buildup. Foam Cell and plaque appear as a result of lipoprotein metabolism disorders which result in inflammatory reactions. The incidence of AS in the world is increasing, resulting in various complications that can lead to death. Lycopene is contained in the red flesh of watermelon, which is an antioxidant that can control free radicals and can reduce the risk of AS. Objective: To determine the effectiveness of watermelon (Cittrulus lanatus) red flesh extract on reducing coronary artery foam cells and thinning of the aortic intima in Wistar rats (Rattus norvegicus strain Wistar) atherosclerosis model. Method: This research was an experimental study (true experimental) using the Post Test Only Control Group Design method, which measures the number of coronary artery foam cells and the thickness of the aortic intima in Wistar rats (five groups) after administration of a hypercholesterolemic diet and watermelon red flesh extract at a dose of 250,500,750 mg /kgBW. Data analysis was carried out using One-Way ANOVA and Post Hoc Bonferroni tests. Results: The One-Way ANOVA statistical test showed results of 0.020 for foam cells and 0.008 for thickness of the intimal tunica, which means that there was a real influence of watermelon red flesh extract on decreasing foam cells and significant thinning of the intimal tunica in the treatment group. Furthermore, the Post Hoc Bonferroni test showed that the dose of 750 mg/kgBW had the most effect on reducing foam cells (p=0.046) and thinning the intima (p=0.015). Conclusion: Watermelon (Citrullus lanatus) red flesh extract at a dose of 750 mg/kgBW has a significant effect on reducing the number of foam cells and thinning of the aorta of the Wistar rat model of atherosclerosis.
Effectiveness of Petai (Parkia speciosa) Ethanol Extract in Controlling Foam Cell Numbers in Atherosclerosis-Induced Male Wistar Rats Handirosiyanto, Ikhwan; Indra setiawan; Nisa, Seftiana Khaerun; Lestari, Dian Yuliartha
Saintika Medika Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38652

Abstract

Atherosclerosis is a chronic inflammatory disease that causes the narrowing of the arterial lumen, and it is considered the primary cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease is the leading of death globally. Atherosclerosis has a complex pathophysiology, such as endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. After that process, foam cells will form, which is the key to the development of atherosclerosis. Petai ethanol extract contains antioxidants, which are flavonoids, saponins, and tannins, that can reduce the number of Low-Density lipoproteins (LDL). The purpose of this study was to evaluate the effect of petai ethanol extract on the number of atherosclerotic foam cells in male white rats (Rattus norvegicus strain wistar) induced by lard. The method of this study was a genuinely experimental and post-test-only control group design with 25 rats divided into five control groups, which are one negative control group, one positive control group, and three treatment groups with extract doses of 100mg/kgBW, 200mg/kgBW and 400mg/kgBW. Observation of foam cells was carried out using a microscope with 400x magnification. Data were analyzed using Oneway ANOVA and Post Hoc Tamhane's test. The results of the study using the Oneway ANOVA test showed that there were significant differences between groups (p: 0.000). Post Hoc Tamhane's test between the positive control group and treatment groups 1, 2, and 3 can be seen that there is a significant difference between the formation of foam cells due to the administration of petai ethanol extract compared to positive control (p <0.05). This study concludes that Petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Co-Authors Abi Noerwahjono Afif Wafiq Waliyuddin Anak Agung Istri Sri Wiadnyani Anung Putri Illahika Cindy Savira Dwi Nurwulan Pravitasari DYAH FAUZIAH, DYAH Fathiyah Safithri Febriana Nur Layli Gita Sekar Prihanti Handirosiyanto, Ikhwan Ilham Niawan Saputra Indra Setiawan KUSUMASTUTI, ETTY HARY Lilik Yusetyani Lilik Yusetyani Lucky Dimas Abimanyu Mochamad Bahrudin Mohammad Saifur Rahman Nabila Risma Anjana Nisa, Seftiana Khaerun Radya Kusuma Ardianto Rahman, Mohammad Saifur Risky Amalia Rizky Trimaulidia Saputra, Ilham Niawan Savira, Cindy Setyawati Soeharto Setyawati Soeharto, Setyawati Siska Fitriana Siti Rofida Tiara Lastari Wafiyah Hasanah Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono