Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Folia Medica Indonesiana CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal
Soebaktiningsih Soebaktiningsih
Universitas Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
PROBLEM OF MALARIA INFECTION ., Soebaktiningsih
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 7, No 2 (2011): Desember 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.186 KB) | DOI: 10.22219/sm.v7i2.4071

Abstract

Malaria is still Public Health Problem in tropical country. Failure of Mefloquine ? Artesunate combination treatment of uncomplicated Plasmodium falciparum beginning to fail is due to the delayed clearance times and elevated Artesunate IC50, suggest thatArtesunate resistance may be emerging on background of Mefloquine resistance ( Rogers et al 2009). Pathogenesis of malaria in pregnancy is related to the ability of Plasmodium falciparum intra erythrocyte to sequester in the placenta. Study to understand the molecular basis of susceptibility to malaria in pregnancy has been advanced through the discovery of Chondroitin Sulfat A (CSA) molecule that support the accumulation of infected erythrocytes (IE) by Plasmodium falciparum in the placenta
PENGARUH EKSTRAK BIJI NIMBA (Azadirachta indica) TERHADAP PENURUNAN DERAJAT PARASIT DAN JUMLAH HEMOZOINPADA KULTUR Plasmodium falciparum Aini, Noer; Soebaktiningsih, Soebaktiningsih; Fitri, Loeki Enggar; Kalsum, Umi; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.584 KB) | DOI: 10.21776/ub.jkb.2004.020.03.2

Abstract

Malaria infection is still one of world health’s problems that cause a high death rate (20.9% - 50%). One of the reason is Plasmodium falciparum resist to conventional anti-malarial drugs. Neem seeds extract had been reported has antimalarial effect by decreasing parasitemia, but there has not been any report on its effect in inhibition hemazoin formation. The aimof this research was to find the effect of Neem seeds extract on parasitemia and hemazoin level in Plasmodium falciparum culture. Laboratory experiment was done by using Papua isolate of Plasmodium falciparum (2300) from NAMRU 2 Jakarta. After synchronized, malarial culture was divided into 4 groups namely Control group (culture medium only), Chloroquine group, Artemisinin group, and Neem seeds extracts group. Each treatment group was devided into 5 drug doses of 6.25 µ/ml, 12.5 µ/ml, 25 µ/ml, 50 µ/ml and 100 µ/ml respectively. Parasitemia was measured by Pyridine-hemochrome methods using spectrophotometer  λ560 nm. Statistical analysis was done involving one-way-ANOVA followed by Tukey HSD and Pearson’s Correlation. A significant difference was found between control and treatment groups in parasitemia and hemozoin level. Different dose in treatment groups didn’t show any significant difference in both parasitemia (p=0.99) and hemozoin level (p=0.985). Tukey test between treatment groups didn’t show a significant difference decrease of hemazoin level and parasitemia (r=0.970). The conclusion was Neem deeds extract can inhibit P. falciparum growth by decreasing parasitemia and hemazoin level. Key words: Neem seeds extract, parasitemia, hemazoin level, P. falciparum
Problem of Malaria Infection Soebaktiningsih .
Saintika Medika Vol. 7 No. 2 (2011): Desember 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v7i2.4071

Abstract

Malaria is still Public Health Problem in tropical country. Failure of Mefloquine – Artesunate combination treatment of uncomplicated Plasmodium falciparum beginning to fail is due to the delayed clearance times and elevated Artesunate IC50, suggest thatArtesunate resistance may be emerging on background of Mefloquine resistance ( Rogers et al 2009). Pathogenesis of malaria in pregnancy is related to the ability of Plasmodium falciparum intra erythrocyte to sequester in the placenta. Study to understand the molecular basis of susceptibility to malaria in pregnancy has been advanced through the discovery of Chondroitin Sulfat A (CSA) molecule that support the accumulation of infected erythrocytes (IE) by Plasmodium falciparum in the placenta
Hookworm in Stray Cats (Felis silvestris catus) as Cutaneous Larva Migrant Agent (CLM) in Humans Fadhil Ihsan Mahendra; Soebaktiningsih Soebaktiningsih; Risma Karlina Prabawati
Folia Medica Indonesiana Vol. 58 No. 3 (2022): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.362 KB) | DOI: 10.20473/fmi.v58i3.28645

Abstract

Highlights : Risk factors that can increase the incidence of CLM in humans include male sex, children aged <15 years, low-income people, and daily behaviour of walking outdoors without using footwear, especially on the sand. Risk factors that play the most role in increasing the incidence of CLM in humans are walking outdoors without using footwear, especially on the sand.   Abstract : Cats arethe host of a wide variety of microorganisms including ectoparasites and endoparasites.One of theendoparasites that infect cats is hookworm. The hookworms consists of two groups, the animal hookworms, and the human hookworms. The manifestation that can be caused by animal hookworms to humans is Cutaneous Larva Migrant (CLM). This study aimed to discover whether hookworm in stray cats (Felis silvestris catus) can cause CLM in humans. We performed a systematic search in Pubmed/Medline and Cochrane published between 2016 and 2021 with no restrictions by language, research country, or type of research design . The results of the analysis showed that the high level of hookworms infection in stray cats could increase the risk of CLM in humans. Based on the study, we could conclude that the high prevalence of hookworm infection in cats plays an important role in the increased risk of zoonoses in humans which in turn could also increase the prevalence of CLM in humans.
Telur Trichuris trichiura pada Bagian Luar Tubuh Lalat Musca domestica sebagai Penyebab Penyakit Trichuriasis pada Manusia Kinsay Maura Larasati; Soebaktiningsih Soebaktiningsih; Bahrudin Bahrudin; Febri Endra Budi Setyawan
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 1 (2022): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i1.45

Abstract

Background: Musca domestica is the most common fly species and spreading around the world also act as mechanical vectors various pathogenic agent (virus, bakteri, parasite, one of them is Trichuris trichiura). Human will suffer from Trichuriasis if they ingest food ordrinks contaminating Trichuris trichiura eggs. The prevalence of Trichuriasis is still high and it affects children more often because lack of hygiene. Purpose: to determine the role of Trichuris trichiura eggs on the body surfaces of Musca domestica thatcauses Trichuriasis in humans.Methods: Literature review by retrieving library resources from 39 journals and 2textbooksselected by using the criteria of accredited national journals sintaand reputable international journals and indexed scopus and non-scopus published by 2016.Results: From some experimental studies, Musca domestica carried Trichuris trichiura eggs on the outer body surfaces, as mechanical vectors potential for spreading Trichuriasis.Conclusion: Trichuris trichiura eggs carried by outer body surfaces of Musca domestica can causes serious health problem in humans, has potential cause Trichuriasis disease. Good control and education are needed to prevent Trichuriasis disease
Pengaruh Pemberian Kalsium terhadap Pertumbuhan Plasmodium falciparum in Vitro Verry Asfirizal; Soebaktiningsih Soebaktiningsih; Sudjari Sudjari; Sumarno Sumarno; Loeki Enggar Fitri
The Journal of Experimental Life Science Vol. 1 No. 1 (2011)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (735.63 KB) | DOI: 10.21776/ub.jels.2011.001.01.03

Abstract

Peningkatan permeabilitas sel eritrosit yang terinfeksi Plasmodium falciparum terhadap ion dan makromolekul diketahui sebagai mekanisme parasit untuk memenuhi nutrisi dalam proses pertumbuhan. Peningkatan permeabilitas terhadap kalsium masih merupakan hal yang kontradiktif dalam peranannya meningkatkan pertumbuhan Plasmodium falciparum dalam sel eritrosit. Tujuan dari penelitian ini adalah mengetahui peningkatan pertumbuhan Plasmodium falciparum dalam sel eritrosit pasca pemberian kalsium. Biakan primer Plasmodium falciparum dalam medium biakan RPMI 1640 yang menghasilkan parasitemia 15%, dilakukan inokulasi untuk pembuatan subkultur yang menghasilkan parasitemia 2% dan dilakukan pembagian untuk kelompok perlakuan pemberian kalsium dan kontrol (ML 10%) dengan replikasi 3 kali. Pengamatan dilakukan hari pertama sampai hari ke-6 setelah perlakuan. Pengamatan pertumbuhan dilakukan dengan parameter parasitemia, bentuk skizon, hemolisis dan kalsium intraseluler. Hasil penelitian menunjukkan bahwa pemberian kalsium menghasilkan peningkatan tertinggi jumlah total rerata parasitemia (11,09 ± 4,01) (Rerata ± SD), bentuk skizon (23,52 ± 10,83), hemolisis (0,278 ± 0,03) dan kalsium intraseluler (6,55 ± 1,88), dibandingkan dengan media biakan kontrol (ML 10%). Analisis T-test (α= 0,05) menghasilkan perbedaan yang signifikan pada parameter parasitemia, bentuk skizon, hemolisis tetapi tidak memberikan perberbedaan yang signifikan pada parameter kalsium intraseluler. Kata kunci: glukosa, hemolisis, kalsium, kalsium intraseluler, parasitemia, skizon
Co-Authors A.A. Ketut Agung Cahyawan W Bahrudin Bahrudin Fadhil Ihsan Mahendra Febri Endra Budi Setyawan Kinsay Maura Larasati Loeki Enggar Fitri Noer Aini Risma Karlina Prabawati Sudjari Sudjari Sumarno . Sumarno Sumarno Verry Asfirizal