Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal E-Jurnal Medika Udayana
Arijana, IGK Nyoman
Unknown Affiliation
Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH PEMBERIAN THE EUPHORBIA MILII DAN PROPOLIS TERHADAP GAMBARAN HISTOLOGIS GINJAL TIKUS WISTAR JANTAN Wicaksana, I Dewa Agung Gede Oka Dwi; Linawati, Ni Made; Arijana, IGK Nyoman; Ratnayanti, I Gusti Ayu Dewi
E-Jurnal Medika Udayana Vol 11 No 3 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i03.P03

Abstract

ABSTRACT Introduction: There are various kinds of traditional medicine in Indonesia, either derived from animals or from plants. One of kind traditional medicine that can be found in Indonesia are Euphorbia milii and propolis which has benefits as an immunomodulator and as an antioxidant. The use of traditional medicine with uncertain doses and time intervals may cause some adverse effects. The main purpose of the study is to know the effect of tea which made from Euphorbia milii and propolis on the histological appearance of the kidney of male wistar rats. Methods: This study used a randomized post test only controlled group. There are 4 groups of rats were taken from total 24 male wistar rats with an age range 2-3 months and a bodyweight ± 200 grams. The controlled group (K) was given aquabidest, the intervention group (P1-P3) was given the tea of Euphorbia milii and propolis, then terminated and continued with histological examination by measuring the diameter of the glomerulus. Data analysis technique is One Way Anova and Post Hoc with LSD test. Result: Based on the result of data analysis, the difference between the controlled group (K) and the intervention group (P1-P3) was not significant. Conclusion: Based on the result, the conclusion is that the tea of Euphorbia milii and propolis did not cause significant damage to the kidneys of male wistar rats. Keywords : Euphorbia milii, propolis, glomerulal diameter
PENGARUH PEMBERIAN EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI FITOESTROGEN TERHADAP STEATOSIS HEPAR TIKUS MODEL MENOPAUSE Hernowo, Elliana Freya; Arijana, IGK Nyoman; Sugiritama, I Wayan; Ratnayanti, IGA Dewi
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P17

Abstract

Latar belakang: Wanita menopause akan mengalami penurunan hormon estrogen. Hormon estrogen diketahui memiliki sifat hepatoprotektif yang mampu mencegah terjadinya perlemakan pada hepar. Penurunan kadar estrogen bisa digantikan dengan senyawa fitoestrogen. Kulit buah naga merah (Hylocereus polyrhizus) diketahui memiliki banyak kandungan antosianin yang terbukti memiliki aktivitas sebagai fitoestrogen. Tujuan: Mengetahui adakah perubahan steatosis hepar tikus model menopause dengan pemberian ekstrak etanol kulit buah Hylocereus Polyrhizus. Metode: Penelitian ini merupakan penelitian randomized post-test control group design dengan menggunakan tiga kelompok sampel yang sudah melalui prosedur ovariektomi. Ketiga kelompok adalah kelompok P0 sebagai kontrol tanpa intervensi, P1 dengan intervensi ekstrak etanol kulit buah naga merah dosis 60mg/200grBB, dan P2 dengan intervensi ekstrak etanol kulit buah naga merah dosis 90mg/200grBB. Hasil: Didapatkan rerata jumlah sel steatosis per 100 sel hepar tikus model menopause pada kelompok P0, P1, dan P2 adalah 59,1259 ± 10,0087; 53,0435 ± 14,0674; 41,5001 ± 10,5814. Hasil One Way ANOVA menemukan adanya perbedaan yang bermakna dengan nilai p = 0,013. Hasil uji Post Hoc LSD menemukan perbedaan rerata antara kelompok P2 dengan P0 ditemukan bermakna (p = 0,004) dan P2 dengan P1 juga bermakna (p = 0,047). Sedangkan P0 dan P1 tidak bermakna (p = 0,247). Simpulan: Ekstrak etanol kulit buah Hylocereus Polyrhizus memiliki pengaruh terhadap steatosis hepar tikus model menopause. Didapatkan steatosis hepar terendah pada kelompok intervensi 90mg/200grBB. Kata kunci : Hylocereus polyrhizus, steatosis, menopause, fitoestrogen
Co-Authors Hernowo, Elliana Freya I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Wayan Sugiritama Ni Made Linawati Wicaksana, I Dewa Agung Gede Oka Dwi