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All Journal E-Jurnal Medika Udayana Bali Dermatology Venereology and Aesthetic Journal
Hernowo, Elliana Freya
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI FITOESTROGEN TERHADAP STEATOSIS HEPAR TIKUS MODEL MENOPAUSE Hernowo, Elliana Freya; Arijana, IGK Nyoman; Sugiritama, I Wayan; Ratnayanti, IGA Dewi
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P17

Abstract

Latar belakang: Wanita menopause akan mengalami penurunan hormon estrogen. Hormon estrogen diketahui memiliki sifat hepatoprotektif yang mampu mencegah terjadinya perlemakan pada hepar. Penurunan kadar estrogen bisa digantikan dengan senyawa fitoestrogen. Kulit buah naga merah (Hylocereus polyrhizus) diketahui memiliki banyak kandungan antosianin yang terbukti memiliki aktivitas sebagai fitoestrogen. Tujuan: Mengetahui adakah perubahan steatosis hepar tikus model menopause dengan pemberian ekstrak etanol kulit buah Hylocereus Polyrhizus. Metode: Penelitian ini merupakan penelitian randomized post-test control group design dengan menggunakan tiga kelompok sampel yang sudah melalui prosedur ovariektomi. Ketiga kelompok adalah kelompok P0 sebagai kontrol tanpa intervensi, P1 dengan intervensi ekstrak etanol kulit buah naga merah dosis 60mg/200grBB, dan P2 dengan intervensi ekstrak etanol kulit buah naga merah dosis 90mg/200grBB. Hasil: Didapatkan rerata jumlah sel steatosis per 100 sel hepar tikus model menopause pada kelompok P0, P1, dan P2 adalah 59,1259 ± 10,0087; 53,0435 ± 14,0674; 41,5001 ± 10,5814. Hasil One Way ANOVA menemukan adanya perbedaan yang bermakna dengan nilai p = 0,013. Hasil uji Post Hoc LSD menemukan perbedaan rerata antara kelompok P2 dengan P0 ditemukan bermakna (p = 0,004) dan P2 dengan P1 juga bermakna (p = 0,047). Sedangkan P0 dan P1 tidak bermakna (p = 0,247). Simpulan: Ekstrak etanol kulit buah Hylocereus Polyrhizus memiliki pengaruh terhadap steatosis hepar tikus model menopause. Didapatkan steatosis hepar terendah pada kelompok intervensi 90mg/200grBB. Kata kunci : Hylocereus polyrhizus, steatosis, menopause, fitoestrogen
Effectiveness and tolerability of bakuchiol (Psolarea corylifolia) as a dermal anti-aging modality: A systematic review on skin wellness and harmony Limanda, Claudia Felicia; Els, Vanessa; Hernowo, Elliana Freya; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 8, Issue 1 (2025)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v8i1.116

Abstract

Skin aging is a natural phenomenon caused by a decline in collagen production that leads to skin thinning, dry and pale skin, wrinkles, and sagging. Skin aging may not contribute to the mortality rate. However, people tend to connect their symbol of inner self to external appearance. Therefore, psychosocial effects such as social anxiety, low self-esteem, and low satisfaction in life will affect their personal and social life. Anti-aging procedures focus on the prevention of damage, replacement of tissues, and skin rejuvenation. Bakuchiol (Psolarea corylifolia) is a novel anti-aging product with antioxidant, anti-inflammatory, and anti-aging properties that is deemed effective and tolerable in skin rejuvenation. This comprehensive review aims to further examine the effectiveness and tolerability of bakuchiol based on previous studies in order to provide new insights into delaying skin aging. A comprehensive literature search was conducted to assess the effectiveness and tolerability of bakuchiol as a dermal anti-aging modality from search engines, PubMed, Google Scholar, CORE, Science Direct, and Cochrane using search terms (“Bakuchiol” OR “Psolarea corylifolia”) AND (“Dermal Aging” OR “Skin Aging”). Bakuchiol proved to have anti-inflammatory and antioxidant properties to maintain youthfulness and skin appearance. Regarding tolerability, bakuchiol has fewer side effects compared to other commonly used modalities. Therefore, bakuchiol (Psolarea corylifolia) is an effective and tolerable modality in the treatment of aging skin.
Co-Authors Arijana, IGK Nyoman Els, Vanessa I Gusti Ayu Dewi Ratnayanti I Wayan Sugiritama Limanda, Claudia Felicia Winaya, Ketut Kwartantaya