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All Journal Majalah Kedokteran Bandung Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Public Health and Preventive Medicine Archive The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Riki Tenggara

Department Of Internal Medicine, Faculty Of Medicine, Atma Jaya Catholic University Of Indonesia, Jakarta

Author-ID : 402616

Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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DETEKSI ANTIGEN HELICOBACTER PYLORI PADA PASIEN GERD DAN NON-GERD DI RUMAH SAKIT ATMA JAYA Athalia Nofera Kurniawan; Riki Tenggara; Lucky Hartati Moehario
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v69i8.185

Pendahuluan: Helicobacter pylori adalah salah satu bakteri flora normal lambung dan sering diasosiasikan dengan dispepsia, tetapi keterkaitannya terhadap Gastroesophageal Reflux Disease (GERD) masih kontroversial. Diagnosis H. pylori paling sering ditegakkan melalui pemeriksaan histopatologi, tes urease yang invasif, dan urea breath test (UBT) yang relatif mahal. Salah satu uji serologi adalah stool antigen test (SAT) yang lebih murah, non-invasif dan lebih mudah pengerjannya. Penelitian ini bertujuan mendeteksi adanya antigen H. pylori pada pasien GERD dan non-GERD di Rumah Sakit Atma Jaya (RSAJ). Metode: Penelitian ini menggunakan studi potong lintang yang bersifat deskriptif. Inklusi penelitian mencakup pasien dewasa yang dirawat inap pada bulan Agustus 2018 ? November 2018 di RSAJ. Peserta diwawancara dengan kuesioner GERDQ. Sampel feses diperiksa menggunakan SAT (Biocare®). Hasil: Sebanyak 30 responden yang terdiri 22 perempuan dan 8 laki-laki, dengan usia terbanyak adalah kelompok usia dewasa (35?64 tahun). Sebanyak 40% responden termasuk kelompok GERD dengan 75% perempuan. Hasil uji SAT positif pada kelompok GERD 16,67%, non-GERD 11,11% dan hasil uji SAT negatif pada kelompok GERD 91,67%, non-GERD 77,78%. Kesimpulan: Keberadaan antigen H. pylori lebih banyak ditemukan pada perempuan, pada usia dewasa dan tidak ditemukan perbedaan antigen H. pylori pada pasien GERD dan non-GERD di RS Atma Jaya.

Correlation between Quality of Life and Gastroesophageal Reflux Disease Kevin Tandarto; Riki Tenggara; Febie Chriestya; Mario Steffanus
Majalah Kedokteran Bandung Vol 52, No 2 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n2.2003

Gastroesophageal reflux disease (GERD) is a disease characterized by the rise of stomach acid into the esophagus which leads to heartburn and regurgitation. The prevalence of adult GERD cases worldwide is 11-38.8%. This study aimed to determine the correlation between GERD and quality of life among patients affected by this disease. This was a cross-sectional study conducted on 92 GERD patients in Atma Jaya Hospital, Jakarta, Indonesia from April 2018 to June 2018. Two questionnaires, GERD-Q and GERD-HRQL were used in this study. A validation of the Indonesian version of the GERD-HRQL questionnaire was performed prior to this study. The Mann Whitney test was used to identify the correlation between GERD and the quality of life in patients with upper gastrointestinal symptoms. This study indicated that the GERD-HRQL questionnaire showed good validity and reliability. Results showed that there was a correlation between GERD and quality of life (p = 0.005) in patients with upper gastrointestinal symptoms. In conclusion, GERD affects the quality of life of patients affected by this disease. Korelasi antara Kualitas Hidup dan Penyakit Refluks GastroesofagusGastroesophageal reflux disease (GERD) atau penyakit refluks gastroesofagus adalah penyakit yang ditandai dengan naiknya asam lambung ke kerongkongan yang menyebabkan sensasi terbakar di dada dan regurgitasi. Prevalensi kasus GERD di seluruh dunia pada orang dewasa adalah 11–38,8%. Penelitian ini bertujuan mengetahui korelasi antara GERD dan kualitas hidup di antara pasien yang terkena penyakit ini. Penelitian dilakukan pada 92 pasien GERD di Rumah Sakit Atma Jaya, Jakarta, Indonesia dari April 2018 hingga Juni 2018. Dua kuesioner, GERD-Q dan GERD-HRQL digunakan dalam penelitian ini. Validasi kuesioner GERD-HRQL versi bahasa Indonesia dilakukan sebelum penelitian ini. Analisis uji Mann Whitney digunakan untuk mengidentifikasi korelasi antara GERD dan kualitas hidup pada pasien dengan gejala gastrointestinal bagian atas. Penelitian ini menunjukkan bahwa kuesioner GERD-HRQL memperlihatkan validitas dan reliabilitas yang baik. Hasil penelitian ini juga menunjukkan erdapat korelasi antara GERD dan kualitas hidup (p=0,005) pada pasien dengan gejala gastrointestinal atas. Simpulan, GERD mempengaruhi kualitas hidup pasien yang terkena penyakit ini.

Multiple Primary Malignancy of Esophageal and Gastric Synchronous and Colon Metachronous Riki Tenggara; Lauretta Ariella Sugondo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Multiple primary cancer is an incidence when a patient has multiple malignancy in two or more organs without possibility of metastatic lesion. There have been many reports on mutiple primary cancer since Billroth reported it for the first time in 1879. Patients who have been diagnosed with a cancer have higher risk for developing another cancer, thereby physician and the patients should raise more awareness toward possibility of developing a new metachronous or synchronous cancer. We report a patient who has three histologically distinct cancers. Resected primary colon adenocarcinoma and 3 years after came with hematemesis and diagnosed to have a metachronous squamous cell carcinoma of the oesophagus synchronous with gastric adenocarcinoma. This case is interesting due to the clustering of three primary cancers (synchronous and metachronous) which is a rare occurrence in a single patient.

Diagnosis and Management Pancolitis in Patient with Ulcerative Colitis Cindy Cindy; Riki Tenggara; Yudistira Panji Santoso; Mario Steffanus
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/112201096-99

ABSTRACT Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) that usually affects the rectum and part of the colon, which spreads continuously with no skip area. Pancolitis occurs in 20% of patients with UC. Patients with chronic UC, especially pancolitis, have a higher risk of colon cancer. In patients with pancolitis, the risk of cancer increases by 0.5-1% per year after having 8-10 years of disease. A 72-year-old man came with complaint of bloody-mucus diarrhea associated with abdominal cramps. The colonoscopic appearance of colitis was observed in whole lumen throughout colon. Histopathological analysis demonstrated dense infiltrates of granulocytes and macrophages formed by severe inflammation. Normal appearances were observed in the remaining epithelial cells. No parasites, specific process, or malignancy were found. Moreover, no acid-resistant bacteria were found. However, atypical cells were found in one of the biopsy specimens. The patient was diagnosed with extensive type of severe UC. The initial management of treatment included improvement of his general condition along with antibacterial therapy of metronidazole and ciprofloxacin. Specific treatment of sulphasalazine and prednisone were given after pancolitis appearance was revealed, which has similar clinical manifestations in accordance with UC. Keywords: pancolitis, ulcerative colitis, chronic diarrhea, inflammatory bowel disease

The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection Riki Tenggara; Visakha Revana Irawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Helicobacter pylori (H. pylori) infection is the main cause of peptic ulcer disease, gastric mucosa metaplasia, and gastric malignancy. The hypothesis of this study is whether there’s an association between metaplasia and gastric malignancy with H. pylori infection.Method: We conducted a retrospective study on 1.127 dyspepsia subjects who performed endoscopy between 2001 to 2011 at a hospital in North Jakarta. Data is obtained based on endoscopy and histopathology data. Investigation of H. pylori in this study using histopathology examination.Results: Of the 1.127 dyspepsia subjects who performed endoscopy and biopsy, there were 130 (11,54%) H. pylori-positive subjects. Gender proportion was composed of 55,37% men and 44,63% women, with median age was 47 years. On the histopathology examination, we obtained 45 metaplasia subjects with median age of 45 years and 7 malignancy subjects with median age of 64 years. Metaplasia was found in 33 of 997 (3,31%) H. pylori-negative subjects and 12 of 130 (9.23%) H. pylori-positive subjects. All gastric malignancy subjects had H. pylori-negative results.Conclusion: There was an association between metaplasia and H. pylori infection, but no association between gastric malignancy and H. pylori infection.

Association between Stress, Depression and Anxiety with Body Fat Percentage among Medical Students of Faculty of Medicine and Health Sciences of Atma Jaya Catholic University Dewi, Sheilla; Tenggara, Riki; Hasan, Surilena
Public Health and Preventive Medicine Archive Vol. 9 No. 1 (2021)
Publisher : Universitas Udayana

Background and purpose: Medical students have higher rate of stress, depression and anxiety compared to the general population of the same age and are at risk of having high level of body fat percentage. The objective of this study is to determine the association between stress, depression and anxiety with body fat percentage among medical students. Methods: This is a cross sectional study carried out among 90 undergraduate medical students of Faculty of Medicine and Health Sciences of Atma Jaya Catholic University, North Jakarta, from January to March 2019. Sampling was performed by using the stratified proportional random sampling method. Stress, depression and anxiety were measured with Depression Anxiety Stress Scale 42 and body fat percentage was measured with Bioelectrical Impedance Analysis. Data analysis was performed by using Spearman correlation. Results: Based on sociodemographic characteristics, the respondents were mostly 19 years old, female and 1st year students. This study shows that 34.4% of respondents had stress, 22.2% had depression and 48.9% had anxiety. This study shows that 62.1% of the male respondents and 32.8% of the female respondents had high body fat percentage. Spearman analysis showed moderate positive correlation between stress (r=0.505), depression (r=0,403) and anxiety (r=0,485) with body fat percentage among the respondents. Conclusion: There is a significant association between stress, depression and anxiety with body fat percentage among medical students. This study intends to be an input for educational institutions to screen for mental health problems (stress, depression and anxiety) as well as body fat percentage in students that may affect their well-being and learning process so that they can be diagnosed and intervened as early as possible.

Urinary Gluten Immunogenic Peptides Correlation with Celiac Disease: A Systematic Review Prasetya, Alver; Yonatan, Eric Ricardo; Subagya, Jonathan Christianto; Tansil, Naomi Juwita; Lee, Yeong Yeh; Tenggara, Riki
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024280

ABSTRACTBackground: Celiac disease (CD) is a condition caused by an abnormal immune response to gluten products. The mainstay of treatment is the gluten-free diet (GFD), but despite patients' efforts to avoid gluten products, some inevitably consume gluten. As current methods for monitoring are limited, a better marker is urgently needed. Urinary gluten immunogenic peptide (UGIP) has been shown to correlate with gluten intake and mucosal damage in CD patients. Therefore, the aim of this systematic review is to summarize the evidence on UGIP as a biomarker in CD patients.Method: This systematic review was conducted in accordance with the PRISMA statement guidelines. The literature search was done using PubMed, ProQuest, EBSCOHost, and Google Scholar for relevant journals published up to March 2023. Newcastle Ottawa Scale and Cochrane Risk of Bias were utilized in the quality assessment of the studies. Result: The literature search identified 85 studies. After eliminating irrelevant and duplicated studies, eight studies were included. Detectable UGIP concentration in the urine correlates with the degree of mucosal damage of CD patients (Marsh II-III). Although three observational studies concluded that there is a correlation between gluten intake and UGIP detection, two randomized controlled trials (RCTs) found that UGIP is not reliable for determining adherence to GFD. Furthermore, UGIP concentrations did not correlate with antibody titers and clinical symptoms. Conclusion: UGIP may be a helpful biomarker for predicting the severity of mucosal damage in CD patients. However, further studies are needed to evaluate its role in predicting adherence to GFD.ABSTRAKLatar belakang: Penyakit Celiac (CD) adalah suatu kondisi yang disebabkan oleh respon imun yang tidak normal terhadap produk gluten. Pengobatan utama adalah dengan diet bebas gluten (GFD). Meskipun pasien berupaya untuk menghindari produk gluten, beberapa pasien dapat secara tidak sengaja mengkonsumsi gluten. Karena pemeriksaan untuk memantau konsumsi gluten masih terbatas, modalitas pemeriksaan yang dapat diandalkan sangat dibutuhkan. Beberapa bukti mengatakan terdapat korelasi antara peptida imunogenik gluten urin (UGIP) dengan asupan gluten serta kerusakan mukosa pada pasien CD. Oleh karena itu, tinjauan sistematis ini bertujuan untuk merangkum bukti tentang UGIP sebagai modalitas pemeriksaan pada pasien CD.Metode: Tinjauan sistematis ini dilakukan sesuai dengan pedoman pernyataan PRISMA. Pencarian literatur dilakukan menggunakan PubMed, ProQuest, EBSCOHost, dan Google Scholar untuk jurnal relevan yang diterbitkan hingga Maret 2023. Newcastle Ottawa Scale dan Cochrane Risk of Bias digunakan dalam penilaian kualitas studi.Hasil: Pencarian literatur mengidentifikasi 85 penelitian. Setelah mengeliminasi studi yang tidak relevan dan duplikat, delapan studi dimasukkan. Konsentrasi UGIP yang terdeteksi dalam urin berkorelasi dengan tingkat kerusakan mukosa pasien CD (Marsh II-III). Meskipun tiga studi observasi menyimpulkan bahwa ada korelasi antara asupan gluten dan deteksi UGIP, dua uji randomized controlled trials (RCT) menemukan bahwa UGIP tidak dapat diandalkan untuk menentukan kepatuhan terhadap GFD. Selain itu, konsentrasi UGIP tidak berkorelasi dengan titer antibodi dan gejala klinis. Kesimpulan: UGIP dapat dipertimbangkan untuk membantu untuk memprediksi tingkat keparahan kerusakan mukosa pada pasien CD. Namun, studi lebih lanjut diperlukan untuk mengevaluasi perannya dalam memprediksi kepatuhan terhadap GFD.

The Effects Between Black Coffee and Mixed Coffee Consumption Towards Gastroesophageal Reflux Disease (GERD) Symptomps Arsanti, Nabila Mayori; Dewi, Rita; Tenggara, Riki; Rensa, Agnes
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024288

Background: Gastroesophageal Reflux Disease (GERD) is a disease characterized by regurgitation of stomach contents into the esophagus. Signs and symptoms of GERD are regurgitation and heartburn. One of the triggers for GERD is coffee consumption.Aims: This study aims to determine differences in the effect of coffee consumption on black coffee drinkers and mixed coffee drinkers on symptoms of GERD.Methods: A cross-sectional study was conducted in Bekasi City and DKI Jakarta using a demographic questionnaire and consumption of black coffee and mixed coffee and the Gastroesophageal Reflux Disease Questionnaire (GERDQ) in Indonesian language. Data analysis used the Mann-Whitney test to test the percentage difference between the dependent variable and the independent variable.Results: This study obtained 195 participants who were analyzed. As much as 50.8% (99 people) consumed mixed coffee and 52.8% (19 people) had GERD and 50.3% (80 people) did not experience GERD. As many as 49.2% (96 people) consumed black coffee and 47.2% (17 people) had GERD and 49.7% (79 people) did not have GERD. The Mann-Whitney test did not show a significant change (Asymp. Sig. 0.790).Conclusion: There is no significant comparison between the effects of coffee consumption on black coffee drinkers and mixed coffee drinkers on GERD symptoms.Keywords: Gastroesophageal Reflux Disease, GERD, Black Coffee, Mixed Coffee

Association between Anxiety and Dyspepsia among Outpatients at Atma Jaya Hospital Heryadi, Samantha Yaffa; Tenggara, Riki; Suryani, Eva; Widjaja, Nelly Tina; Hardi, Nicholas
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 1 (2024): VOLUME 25, NUMBER 1, April, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/251202421-26

Background: Anxiety is a psychological condition characterized by excessive fear and worry that occurs continuously and is difficult to control. Anxiety play a significant role in causing dyspepsia through the Brain-Gut Axis mechanism. Although, there are many cases of anxiety and dyspepsia in Indonesia, there is still a lack of research on the relationship between anxiety and dyspepsia in Indonesia, especially in the clinic. Therefore, this study aimed to determine the relationship between anxiety and dyspepsia among outpatients at Atma Jaya Hospital.Method: This cross-sectional study was conducted on outpatients at Atma Jaya Hospital to investigate the relationship between anxiety and dyspepsia. The demographic and patient characteristic data, including gender, age, highest level of education, and habits, such as eating spicy food, drinking coffee, alcohol consumption, smoking, and NSAID used were collected. The GAD-7 and SF-LDQ questionnaires, which have been validated in Indonesian, were used in this study. Spearman correlation test was used to analyze the data to find the relationship between anxiety and dyspepsia.Results: This study obtained 158 participants. The age range of participants who experienced dyspepsia the most is 19-44 years(77.53%). The majority of those who experienced dyspepsia are female (79.12%). The highest education level of the participants who experienced dyspepsia is a Master’s degree (100%). Participants who consumed spicy food accounted for 61.39% while 54.43% consumed coffee, 6.96% consumed alcohol, 12.66% smoked, and 1.90% used NSAIDs. Additionally, 105 participants (66.46%) experienced both anxiety and dyspepsia. The Spearman correlation test results showed a significant relationship between anxiety and dyspepsia (p-value = 0.000) and a moderate correlation (rs = 0.450). Conclusion: There is a moderate correlation between anxiety and dyspepsia. Keywords: Anxiety, Dyspepsia, GAD-7, Heartburn, SF-LDQ.

Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model Blandina, Maria Bernadetta Nadya; ., Vetinly; Djuartina, Tena; Tenggara, Riki; Budianto, Iskandar R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202536-42

Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats. Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole). Results: It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent.Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract.Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells

Co-Authors Arsanti, Nabila Mayori Athalia Nofera Kurniawan Athalia Nofera Kurniawan Blandina, Maria Bernadetta Nadya Budianto, Iskandar R. Charles Surjadi Cindy Cindy CINDY CINDY Dewi, Sheilla Eva Suryani Febie Chriestya Fransiscus D. Suyatna Hartoyo, Farrell ZR Heryadi, Samantha Yaffa Irawan, Visakha Revana Irawan, Visakha Revana Kevin Tandarto Lauretta Ariella Sugondo Lee, Yeong Yeh Lucky Hartati Moehario Luse Loe Mario Steffanus Nelly T. Widjaja Nelly Tina Widjaja Nicholas Hardi Prasetya, Alver Purwoko, Agus Rensa, Agnes Rita Dewi Subagya, Jonathan Christianto Sugondo, Lauretta Ariella Surilena Tandarto, Kevin Tanjaya, Hendri Tansil, Naomi Juwita Tena Djuartina, Tena Tobian, Nikolaus Veronika Maria Sidharta Vetinly Visakha Revana Irawan Yonatan, Eric Ricardo Yudistira Panji Santoso Yvonne S. Handajani

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