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All Journal Medical Journal of Indonesia Public Health and Preventive Medicine Archive The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Riki Tenggara

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Unika Atma Jaya

Author-ID : 402616

Medicine & Pharmacology Public Health

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Articles

The effect of oxygenated water in Diabetes Mellitus Handajani, Yvonne S.; Tenggara, Riki; Suyatna, Fransiscus D.; Surjadi, Charles; Widjaja, Nelly T.
Medical Journal of Indonesia Vol 18, No 2 (2009): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Aim To examine those claims, i.e the effects of oxygenated water on hypertension and Diabetes Mellitus (DM).Methods In this clinical trial, 108 subjects of Diabetes Mellitus were recruited. Each group was divided randomly into 2 subgroups. One subgroup was given oxygenated water and the other subgroup was given non-oxygenated water for 2 period of intervention, 45 days and 90 days. Measured variables were, blood sugar and malondialdehyde (MDA).Results The study showed that oxygenated water could reduce post-prandial glucose in DM subjects. DM subjects with normal nutritional states, also had greater tendency of MDA reduction after consuming oxygenated water for 45 days. Most of subjects felt healthier after consuming oxygenated water.Conclusion The consumption of oxygenated water could improve the healing process for patients with diabetes mellitus. (Med J Indones 2009; 18: 102-7)Key words: oxygenated water, diabetes mellitus, MDA, free radicals

Association between Stress, Depression and Anxiety with Body Fat Percentage among Medical Students of Faculty of Medicine and Health Sciences of Atma Jaya Catholic University Dewi, Sheilla; Tenggara, Riki; Hasan, Surilena
Public Health and Preventive Medicine Archive Vol. 9 No. 1 (2021)
Publisher : Universitas Udayana

Background and purpose: Medical students have higher rate of stress, depression and anxiety compared to the general population of the same age and are at risk of having high level of body fat percentage. The objective of this study is to determine the association between stress, depression and anxiety with body fat percentage among medical students. Methods: This is a cross sectional study carried out among 90 undergraduate medical students of Faculty of Medicine and Health Sciences of Atma Jaya Catholic University, North Jakarta, from January to March 2019. Sampling was performed by using the stratified proportional random sampling method. Stress, depression and anxiety were measured with Depression Anxiety Stress Scale 42 and body fat percentage was measured with Bioelectrical Impedance Analysis. Data analysis was performed by using Spearman correlation. Results: Based on sociodemographic characteristics, the respondents were mostly 19 years old, female and 1st year students. This study shows that 34.4% of respondents had stress, 22.2% had depression and 48.9% had anxiety. This study shows that 62.1% of the male respondents and 32.8% of the female respondents had high body fat percentage. Spearman analysis showed moderate positive correlation between stress (r=0.505), depression (r=0,403) and anxiety (r=0,485) with body fat percentage among the respondents. Conclusion: There is a significant association between stress, depression and anxiety with body fat percentage among medical students. This study intends to be an input for educational institutions to screen for mental health problems (stress, depression and anxiety) as well as body fat percentage in students that may affect their well-being and learning process so that they can be diagnosed and intervened as early as possible.

Urinary Gluten Immunogenic Peptides Correlation with Celiac Disease: A Systematic Review Prasetya, Alver; Yonatan, Eric Ricardo; Subagya, Jonathan Christianto; Tansil, Naomi Juwita; Lee, Yeong Yeh; Tenggara, Riki
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024280

ABSTRACTBackground: Celiac disease (CD) is a condition caused by an abnormal immune response to gluten products. The mainstay of treatment is the gluten-free diet (GFD), but despite patients' efforts to avoid gluten products, some inevitably consume gluten. As current methods for monitoring are limited, a better marker is urgently needed. Urinary gluten immunogenic peptide (UGIP) has been shown to correlate with gluten intake and mucosal damage in CD patients. Therefore, the aim of this systematic review is to summarize the evidence on UGIP as a biomarker in CD patients.Method: This systematic review was conducted in accordance with the PRISMA statement guidelines. The literature search was done using PubMed, ProQuest, EBSCOHost, and Google Scholar for relevant journals published up to March 2023. Newcastle Ottawa Scale and Cochrane Risk of Bias were utilized in the quality assessment of the studies. Result: The literature search identified 85 studies. After eliminating irrelevant and duplicated studies, eight studies were included. Detectable UGIP concentration in the urine correlates with the degree of mucosal damage of CD patients (Marsh II-III). Although three observational studies concluded that there is a correlation between gluten intake and UGIP detection, two randomized controlled trials (RCTs) found that UGIP is not reliable for determining adherence to GFD. Furthermore, UGIP concentrations did not correlate with antibody titers and clinical symptoms. Conclusion: UGIP may be a helpful biomarker for predicting the severity of mucosal damage in CD patients. However, further studies are needed to evaluate its role in predicting adherence to GFD.ABSTRAKLatar belakang: Penyakit Celiac (CD) adalah suatu kondisi yang disebabkan oleh respon imun yang tidak normal terhadap produk gluten. Pengobatan utama adalah dengan diet bebas gluten (GFD). Meskipun pasien berupaya untuk menghindari produk gluten, beberapa pasien dapat secara tidak sengaja mengkonsumsi gluten. Karena pemeriksaan untuk memantau konsumsi gluten masih terbatas, modalitas pemeriksaan yang dapat diandalkan sangat dibutuhkan. Beberapa bukti mengatakan terdapat korelasi antara peptida imunogenik gluten urin (UGIP) dengan asupan gluten serta kerusakan mukosa pada pasien CD. Oleh karena itu, tinjauan sistematis ini bertujuan untuk merangkum bukti tentang UGIP sebagai modalitas pemeriksaan pada pasien CD.Metode: Tinjauan sistematis ini dilakukan sesuai dengan pedoman pernyataan PRISMA. Pencarian literatur dilakukan menggunakan PubMed, ProQuest, EBSCOHost, dan Google Scholar untuk jurnal relevan yang diterbitkan hingga Maret 2023. Newcastle Ottawa Scale dan Cochrane Risk of Bias digunakan dalam penilaian kualitas studi.Hasil: Pencarian literatur mengidentifikasi 85 penelitian. Setelah mengeliminasi studi yang tidak relevan dan duplikat, delapan studi dimasukkan. Konsentrasi UGIP yang terdeteksi dalam urin berkorelasi dengan tingkat kerusakan mukosa pasien CD (Marsh II-III). Meskipun tiga studi observasi menyimpulkan bahwa ada korelasi antara asupan gluten dan deteksi UGIP, dua uji randomized controlled trials (RCT) menemukan bahwa UGIP tidak dapat diandalkan untuk menentukan kepatuhan terhadap GFD. Selain itu, konsentrasi UGIP tidak berkorelasi dengan titer antibodi dan gejala klinis. Kesimpulan: UGIP dapat dipertimbangkan untuk membantu untuk memprediksi tingkat keparahan kerusakan mukosa pada pasien CD. Namun, studi lebih lanjut diperlukan untuk mengevaluasi perannya dalam memprediksi kepatuhan terhadap GFD.

The Effects Between Black Coffee and Mixed Coffee Consumption Towards Gastroesophageal Reflux Disease (GERD) Symptomps Arsanti, Nabila Mayori; Dewi, Rita; Tenggara, Riki; Rensa, Agnes
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024288

Background: Gastroesophageal Reflux Disease (GERD) is a disease characterized by regurgitation of stomach contents into the esophagus. Signs and symptoms of GERD are regurgitation and heartburn. One of the triggers for GERD is coffee consumption.Aims: This study aims to determine differences in the effect of coffee consumption on black coffee drinkers and mixed coffee drinkers on symptoms of GERD.Methods: A cross-sectional study was conducted in Bekasi City and DKI Jakarta using a demographic questionnaire and consumption of black coffee and mixed coffee and the Gastroesophageal Reflux Disease Questionnaire (GERDQ) in Indonesian language. Data analysis used the Mann-Whitney test to test the percentage difference between the dependent variable and the independent variable.Results: This study obtained 195 participants who were analyzed. As much as 50.8% (99 people) consumed mixed coffee and 52.8% (19 people) had GERD and 50.3% (80 people) did not experience GERD. As many as 49.2% (96 people) consumed black coffee and 47.2% (17 people) had GERD and 49.7% (79 people) did not have GERD. The Mann-Whitney test did not show a significant change (Asymp. Sig. 0.790).Conclusion: There is no significant comparison between the effects of coffee consumption on black coffee drinkers and mixed coffee drinkers on GERD symptoms.Keywords: Gastroesophageal Reflux Disease, GERD, Black Coffee, Mixed Coffee

Association between Anxiety and Dyspepsia among Outpatients at Atma Jaya Hospital Heryadi, Samantha Yaffa; Tenggara, Riki; Suryani, Eva; Widjaja, Nelly Tina; Hardi, Nicholas
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 1 (2024): VOLUME 25, NUMBER 1, April, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/251202421-26

Background: Anxiety is a psychological condition characterized by excessive fear and worry that occurs continuously and is difficult to control. Anxiety play a significant role in causing dyspepsia through the Brain-Gut Axis mechanism. Although, there are many cases of anxiety and dyspepsia in Indonesia, there is still a lack of research on the relationship between anxiety and dyspepsia in Indonesia, especially in the clinic. Therefore, this study aimed to determine the relationship between anxiety and dyspepsia among outpatients at Atma Jaya Hospital.Method: This cross-sectional study was conducted on outpatients at Atma Jaya Hospital to investigate the relationship between anxiety and dyspepsia. The demographic and patient characteristic data, including gender, age, highest level of education, and habits, such as eating spicy food, drinking coffee, alcohol consumption, smoking, and NSAID used were collected. The GAD-7 and SF-LDQ questionnaires, which have been validated in Indonesian, were used in this study. Spearman correlation test was used to analyze the data to find the relationship between anxiety and dyspepsia.Results: This study obtained 158 participants. The age range of participants who experienced dyspepsia the most is 19-44 years(77.53%). The majority of those who experienced dyspepsia are female (79.12%). The highest education level of the participants who experienced dyspepsia is a Master’s degree (100%). Participants who consumed spicy food accounted for 61.39% while 54.43% consumed coffee, 6.96% consumed alcohol, 12.66% smoked, and 1.90% used NSAIDs. Additionally, 105 participants (66.46%) experienced both anxiety and dyspepsia. The Spearman correlation test results showed a significant relationship between anxiety and dyspepsia (p-value = 0.000) and a moderate correlation (rs = 0.450). Conclusion: There is a moderate correlation between anxiety and dyspepsia. Keywords: Anxiety, Dyspepsia, GAD-7, Heartburn, SF-LDQ.

Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model Blandina, Maria Bernadetta Nadya; ., Vetinly; Djuartina, Tena; Tenggara, Riki; Budianto, Iskandar R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202536-42

Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats. Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole). Results: It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent.Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract.Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells

Association Between Coffee Consumption and Gastroesophageal Reflux Disease (GERD): A Cross-Sectional Analysis Hartoyo, Farrell ZR; Tandarto, Kevin; Sidharta, Veronika; Tenggara, Riki
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Gastroesophageal reflux disease (GERD) is a condition in which stomach contents flow back into the esophagus, leading to various symptoms and complications. In Indonesia, the prevalence of GERD has been reported at 57.6%. Coffee consumption is often suspected to be closely linked to the occurrence of GERD. This study aims to determine the association between coffee consumption and the incidence of GERD.Methods: This study used a cross-sectional approach to conduct observational analytical research. The sample included individuals aged 18 to 65 years residing in Jakarta, selected using a consecutive sampling method. Data were collected using the Indonesian version of the Gastroesophageal Reflux Disease Questionnaire (GERD-Q). To assess the association between coffee consumption and GERD, the Chi-square test of independence was applied.Results: Out of 105 respondents, 26 were identified as having GERD. Among those, 84.6% reported consuming coffee at moderate to high frequencies, while 15.3% consumed little to no coffee. The Chi-square test of independence revealed a statistically significant association between coffee consumption and GERD among Jakarta residents aged 18 to 65 years (p = 0.006).Conclusion: There is a significant association between coffee consumption and the incidence of gastroesophageal reflux disease (GERD) among Jakarta residents aged 18 to 65 years.

Co-Authors ., Vetinly Arsanti, Nabila Mayori Blandina, Maria Bernadetta Nadya Budianto, Iskandar R. Charles Surjadi CINDY CINDY Dewi, Sheilla Eva Suryani Fransiscus D. Suyatna Hardi, Nicholas Hartoyo, Farrell ZR Heryadi, Samantha Yaffa Irawan, Visakha Revana Irawan, Visakha Revana Lee, Yeong Yeh Mario Steffanus Nelly T. Widjaja Nelly Tina Widjaja Prasetya, Alver Rensa, Agnes Rita Dewi Sidharta, Veronika Subagya, Jonathan Christianto Sugondo, Lauretta Ariella Surilena Hasan Tandarto, Kevin Tansil, Naomi Juwita Tena Djuartina, Tena Yonatan, Eric Ricardo Yudistira Panji Santoso Yvonne S. Handajani

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