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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Soekardjo, Bambang
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dan Escherichia coli Pudjianto, Andreyanus Eko; Ervina, Martha; Caroline, Catherine; Soekardjo, Bambang; Foe, Kuncoro
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (819.005 KB) | DOI: 10.33508/jfst.v1i1.2342

Abstract

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methylpiperazin-N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoculated with Micrococcus luteus and Escherichia coli. Based on orientation studies, concentration of 4-methylpiperazin-N-carbonyl ampicillin and ampiCillin were 0.5 ppm against Micrococcus luteus and 500 ppm against Escherichia collin order to get visible zone of inhibition. The results showed that 4-methylpiperazin-Ncarbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coli.
Pemodelan Interaksi Turunan Potensial Asam Benzoilsalisilat dengan Reseptor Enzim Siklooksigenase-2 Natalia, Ongki; Caroline, Catherine; Soekardjo, Bambang
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2356.408 KB) | DOI: 10.33508/jfst.v1i1.2344

Abstract

The research of synthesize and quantitative structure activity relationship of benzoyl salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that O-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (EDso value was 15.7396 mg/kg) while the EDso value of acetyl salicylic acid was 3296 mg/kg. Therefore further studies were carried out to determine the interaction modelling of potential benzoy/saJicyJic acid derivatives with enzyme cyclooxygenase-2 receptor by using Glide (Schrodinger license). The result showed that the GScore of 0-(2-trifluoromethoxybenzoyl)salicylic acid: -9.97, 0-(2.4-dimethylbenzoyl)salicylic acid: -9.94, O-(2-fluorobenzoyl)saJicylic acid : -9.62 and 0-(2.3-dimethy/chlorobenzoyl)salicylic acid : -9.49 more active than O-(3-chloromethylbenzoyl)saJicylic acid (-9.48), which GScore of each compound less than 0-(3-chloromethylbenzoyl)salicylic acid that had been synthesized. 0-(2-trifluoromethoxybenzoyl)salicylic acid, 0-(2.4-dimethylbenzoyl)salicylic acid, O-(2-fluorobenzoyl) salicylic acid and O-(2.3-dimethylchlorobenzoyl) salicylic acid are compounds that have a good potency as an analgesic. Interaction of potential benzoy/salicy/lc acid derivatives with enzyme cyclooxygenase-2 receptor was on residues Tyrosine 385, Leusine 531, Tyrosine 355 dan Arginine 120.
Studi Hubungan Kuantitatif Sifat Lipofilik (πHANSCH), Elektronik (σHAMMET), dan Sterik (ES TAFT) dengan Aktivitas Antibakteri (Diameter Daerah Hambatan ) Pseudomonas aeruginosa ATCC 9027 dari Turunan N-Benzoil Sefaleksin Dipahayu, Damaranie; Soekardjo, Bambang; Susilowati, Ruly
Journal of Pharmacy and Science Vol. 1 No. 1 (2016): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v1i1.56

Abstract

ABSTRAKPenelitian ini bertujuan untuk mencari hubungan kuantitatif antara parameter sifat lipofilik ((π Hansch), elektronik (σ Hammet) dan sterik (ES Taft) dengan aktivitas antibakteri yang ditunjukkan dengan diameter daerah hambatan Pseudomonas aeroginosa ATCC 90277 dari turunan N-Benzoil Sefaleksin. Turunan N-Benzoil Sefaleksin yang digunakan dalam penelitian ini adalah N- Benzoil sefaleksin; N-[4- metilbenzoil] sefaleksin; N-[4- klorobenzoil] sefaleksin and N-[3,4- diklorobenzoil] sefaleksin. Aktivitas antibakteri dilakukan secara uji mikrobiologi menggunakan difusi silinder logam pada media Antibiotika-1. Data penelitian dianalisa secara regresi dengan derajat kepercayaan (α = 0,05). Hasil penelitian menunjukkan bahwa terdapat hubungan yang liner antara variabelbebas yaitu parameter sifat lipofilik ((π Hansch), elektronik (σ Hammet) dan sterik (ES Taft) dari turunan NBenzoil Sefaleksin dengan variabel tergantung yaitu diameter daerah hambatan pertumbuhan bakteriPseudomonas aeroginosa ATCC 90277. Hubungan tersebut dinyatakan dengan suatu persamaan.Kata kunci : turunan N-Benzoil Sefaleksin, lipofilik (π Hansch), elektronik (σ Hammet),sterik (ES Taft), hubungan kuantitatif struktur dan aktivitas, diameter zona hambatABSTRACTThe aims of this research are to studies the quantitative relationship between lipophilicity (π Hansch); electronicity (σ Hammet); stericity (ES Taft) parameters and antibacterial activity of N- Benzoil cephalexin derivate (inhibit area diameter) on Pseudomonas aeroginosa ATCC 90277. The N- Benzoil cephalexin derivate which used in this research are N- Benzoil cephalexin; N-[4- methylbenzoil] cephalexin; N-[4- chlorobenzoil] cephalexin and N- [3,4- dichlorobenzoil] cephalexin. Antibacterial activity was done through assessment microbiological using metal cylinder diffusion on antibiotic-1 media.The experimental data was carried out by regression analyzed with α = 0.05. The result showed that there are linier relationship between lipophilicity (π Hansch); electronicity (σ Hammet); stericity (ES Taft) parameters of N- Benzoil cephalexin derivate (as independent variable) and inhibitation zone (diameter against Pseudomonas aeroginosa ATCC 90277 as dependent variable). The relationship are represented by equation.Keywords : N- Benzoil cephalexin derivate (lipophilicity (π Hansch), electronicity (σ Hammet) and stericity (ES Taft) parameter); quantitative structure activity relationship; antibacterial activity (inhibit area diameter)
Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dan Escherichia coli Pudjianto, Andreyanus Eko; Ervina, Martha; Caroline, Catherine; Soekardjo, Bambang; Foe, Kuncoro
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2342

Abstract

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methylpiperazin-N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoculated with Micrococcus luteus and Escherichia coli. Based on orientation studies, concentration of 4-methylpiperazin-N-carbonyl ampicillin and ampiCillin were 0.5 ppm against Micrococcus luteus and 500 ppm against Escherichia collin order to get visible zone of inhibition. The results showed that 4-methylpiperazin-Ncarbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coli.
Pemodelan Interaksi Turunan Potensial Asam Benzoilsalisilat dengan Reseptor Enzim Siklooksigenase-2 Natalia, Ongki; Caroline, Catherine; Soekardjo, Bambang
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2344

Abstract

The research of synthesize and quantitative structure activity relationship of benzoyl salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that O-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (EDso value was 15.7396 mg/kg) while the EDso value of acetyl salicylic acid was 3296 mg/kg. Therefore further studies were carried out to determine the interaction modelling of potential benzoy/saJicyJic acid derivatives with enzyme cyclooxygenase-2 receptor by using Glide (Schrodinger license). The result showed that the GScore of 0-(2-trifluoromethoxybenzoyl)salicylic acid: -9.97, 0-(2.4-dimethylbenzoyl)salicylic acid: -9.94, O-(2-fluorobenzoyl)saJicylic acid : -9.62 and 0-(2.3-dimethy/chlorobenzoyl)salicylic acid : -9.49 more active than O-(3-chloromethylbenzoyl)saJicylic acid (-9.48), which GScore of each compound less than 0-(3-chloromethylbenzoyl)salicylic acid that had been synthesized. 0-(2-trifluoromethoxybenzoyl)salicylic acid, 0-(2.4-dimethylbenzoyl)salicylic acid, O-(2-fluorobenzoyl) salicylic acid and O-(2.3-dimethylchlorobenzoyl) salicylic acid are compounds that have a good potency as an analgesic. Interaction of potential benzoy/salicy/lc acid derivatives with enzyme cyclooxygenase-2 receptor was on residues Tyrosine 385, Leusine 531, Tyrosine 355 dan Arginine 120.
Co-Authors Catherine Caroline Damaranie Dipahayu, Damaranie Foe, Kuncoro Martha Ervina Natalia, Ongki Pudjianto, Andreyanus Eko Susilowati, Ruly