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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN ASPIRATOR Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Jurnal ABDINUS : Jurnal Pengabdian Nusantara Keluwih: Jurnal Kesehatan dan Kedokteran Indonesian Journal of Pharmaceutical Education Prominentia Medical Journal Jurnal Pengabdian Masyarakat dan aplikasi Teknologi Jurnal Medika: Medika Holistik Jurnal Kesehatan ASPIRATOR - Journal of Vector-Borne Diseases Studies
Arief Gunawan Darmanto
Universitas Ciputra Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Daya Predasi Ikan Lemon (Labidochromis caeruleus) dan Ikan Kapiat (Barbonymus schwanenfeldii) terhadap Larva Nyamuk Aedes aegypti: Predation Capacity of Electric Yellow Cichlid Fish (Labidochromis caeruleus) and Tinfoil Barb Fish (Barbonymus schwanenfeldii) on Aedes aegypti Larvae Andriani, Nathania Disa Ariesta; Adrianto, Hebert; Darmanto, Arief Gunawan
Aspirator Vol 13 No 1 (2021): Jurnal Aspirator Volume 13 Nomor 1 2021
Publisher : Perkumpulan Entomologi Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/asp.v13i1.3854

Abstract

Dengue hemorrhagic fever (DHF) is a vector-borne disease that still happens every year in Indonesia. This disease is caused by the dengue virus and transmitted by the Aedes aegypti as its vector. One of the biological vector controls that can be implemented is using fish as a predator of mosquito larvae, such as using Electric Yellow Cichlid fish (Labidochromis caeruleus) and Tinfoil Barb fish (Barbonymus schwanenfeldii). This study aimed to determine the difference in predation capacities of Electric Yellow Cichlid and Tinfoil Barb on Ae. aegypti larvae. This research is quasiexperimental with a completely randomized design (CRD) with Post Test Only research design. One aquarium with three liters of water containing one fish is given 25 Ae. aegypti larvae. Testing of each fish species is carried out in five replications. Fish predation was observed every 30 seconds until all larvae were eaten. The result showed that Electric Yellow Cichlid could prey on 25 larvae in an average time of 5.7 minutes, while Tinfoil Barb spent 11.6 minutes. The results of the Friedman test showed that there was a significant time difference in preying time of Electric Yellow Cichlid and Tinfoil Barb. It’sconcluded that Electric Yellow Cichlid was more effective as an Ae. aegypti larvae predator.
Agonis Reseptor Glucagon-Like Peptide-1 (GLP-1) sebagai Terapi Neuroprotektif Baru pada Penyakit Parkinson: Dari Mekanisme Molekuler hingga Perspektif Klinis Arief Gunawan Darmanto
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 7 No. 2 (2026): Keluwih: Jurnal Kesehatan dan Kedokteran (June) - In Progress
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V7i2.8471

Abstract

Abstract—Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, which cause motor and non-motor symptoms. Current therapies, such as levodopa, are only symptomatic and have not yet been able to slow the process of neurodegeneration. Recent research indicates a close association between PD and type 2 diabetes mellitus through mechanisms involving insulin resistance, oxidative stress, chronic inflammation, and mitochondrial dysfunction. This opens up opportunities for the use of antidiabetic drugs, particularly glucagon-like peptide-1 (GLP-1) receptor agonists, as potential neuroprotective therapies. GLP-1 receptor agonists are known to work by activating signaling pathways to enhance neurogenesis, strengthen the antioxidant system, suppress inflammatory pathways, and inhibit apoptosis. Preclinical and clinical studies demonstrate the neuroprotective potential of GLP-1 agonists in PD, although their efficacy requires further confirmation due to inconsistent clinical trial results. Nevertheless, GLP-1 receptor agonists have offered a promising new therapeutic approach for modifying the course of the disease. Further research is needed to optimize drug delivery to the brain, identify the most responsive patient subgroups, and assess their long-term safety and efficacy. Keywords: parkinson's disease, GLP-1 agonists, neuroprotection, oxidative stress, inflammation, apoptosis, neurogenesis Abstrak—Penyakit Parkinson (PD) merupakan gangguan neurodegeneratif progresif yang ditandai oleh kehilangan neuron dopaminergik di substantia nigra dan pembentukan Lewy bodies, yang menyebabkan gangguan motorik dan non-motorik. Terapi yang ada saat ini, seperti levodopa, hanya bersifat simptomatik dan belum mampu memperlambat proses neurodegenerasi. Penelitian terkini menunjukkan adanya hubungan erat antara PD dan diabetes melitus tipe 2 melalui mekanisme resistensi insulin, stres oksidatif, inflamasi kronis, dan disfungsi mitokondria. Hal ini membuka peluang pemanfaatan obat antidiabetes, khususnya agonis reseptor glucagon-like peptide-1 (GLP-1), sebagai terapi potensial yang bersifat neuroprotektif. Agonis reseptor GLP-1 diketahui bekerja melalui aktivasi jalur pensinyalan untuk meningkatkan neurogenesis, memperkuat sistem antioksidan, menekan jalur inflamasi, serta penghambatan apoptosis. Studi preklinis dan klinis menunjukkan potensi neuroprotektif agonis GLP-1 pada PD, meskipun efektivitasnya masih memerlukan konfirmasi lebih lanjut karena hasil uji klinis yang belum konsisten. Bagaimanapun juga, agonis reseptor GLP-1 telah menawarkan pendekatan terapeutik baru yang menjanjikan dalam memodifikasi perjalanan penyakit. Penelitian lanjutan diperlukan untuk mengoptimalkan penghantaran obat ke otak, mengidentifikasi subkelompok pasien yang paling responsif, serta menilai keamanan dan efektivitas jangka panjangnya. Kata kunci: penyakit parkinson, agonis GLP-1, neuroproteksi, stres oksidatif, inflamasi, apoptosis, neurogenesis
Effectiveness of Microteaching in Improving Basic Life Support Knowledge at SMK Pawiyatan Surabaya Lyndia Effendy; Natalia Yuwono; Maria Jessica Rachman; Arief Gunawan Darmanto
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/wjpmzh04

Abstract

Background: Basic Life Support (BLS) skills are vital competencies that are often under-trained among adolescents due to time constraints in education. As an active demographic group, teenagers are vulnerable to emergency situations, making efficient and effective training essential. Objective: To measure the effectiveness of a 10-15 minutes BLS microteaching intervention combined with hands-on practice in improving the knowledge and skills of vocational high school (SMK) students at SMK Pawiyatan Surabaya. Methods: This study used a pretest-posttest design. The intervention was conducted from February 2024 at SMK Pawiyatan Surabaya, involving 147 tenth-grade students from various majors. The session included a 10-15 minutes microteaching module, live demonstrations, and hands-on practice using QCPR manikins. Student knowledge was assessed through questionnaires before and after the intervention. Results: The average knowledge score increased from 58% (pretest) to 85% (posttest), showing a 27% improvement. 78% of participants achieved technical competency in chest compressions according to AHA standards. Conclusion: A 10-15 minutes BLS microteaching session proved effective in enhancing vocational students' knowledge and skills. This approach is recommended for integration into school curricula as an efficient emergency health education strategy.
Setetes Darah, Sejuta Harapan: Edukasi Donor Darah melalui Kolaborasi Lintas Institusi Desak Nyoman Surya Suameitria Dewi; Arief Gunawan Darmanto; Maria Jessica Rachman; Natalia Yuwono; Patricia Priscilla
Jurnal Pengabdian Masyarakat dan aplikasi Teknologi Vol 05 No 02: Oktober 2026 (in progress)
Publisher : Institut Teknologi Adhi Tama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31284/j.adipati.2026.v5i2.8793

Abstract

Donor darah merupakan kegiatan kemanusiaan yang berperan penting dalam menjaga ketersediaan stok darah, namun partisipasi masyarakat dirasa kurang maksimal dikarenakan masih dipengaruhi oleh kurangnya pengetahuan, kecemasan akan efek dari donor darah, persepsi yang kurang tepat, dan kepercayaan diri calon pendonor. Kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan untuk meningkatkan pengetahuan mengenai manfaat donor darah, keamanan prosedur, dampak sosial dari kegiatan donor darah serta kesiapan calon pendonor melalui intervensi edukasi berbasis audiovisual yang dikombinasikan dengan pelaksanaan donor darah kolaboratif. Evaluasi dilakukan menggunakan desain pengerjaan pre-test dan post-test untuk menilai perubahan tingkat pengetahuan peserta. Hasil analisis menunjukkan adanya peningkatan pengetahuan yang signifikan setelah intervensi diberikan (p = 0.0001) dengan sebagian besar responden mendapatkan skor post-test yang lebih tinggi dibandingkan pre-test. Di samping itu, pendonor juga menunjukkan tingkat kepuasan yang baik serta keinginan untuk menjadi pendonor ulang di masa mendatang. Temuan ini menunjukkan bahwa edukasi berbasis audiovisual efektif dalam meningkatkan pemahaman pendonor dan berpotensi menjadi strategi dalam peningkatan partisipasi donor darah di masyarakat. Namun, penelitian lanjutan masih sangat diperlukan untuk membandingkan efektivitas metode audiovisual dengan metode edukasi lainnya secara langsung.
Intervensi Edukasi Kesehatan tentang Tuberkulosis Meningkatkan Pengetahuan Siswa SMK di Surabaya Arief Gunawan Darmanto; Lyndia Effendy; Natalia Yuwono; Maria Jessica Rachman
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 9 No 3 (2025): Volume 9 Nomor 3 Tahun 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v9i3.25804

Abstract

Tuberkulosis (TB) masih menjadi tantangan utama kesehatan masyarakat di Indonesia dan semakin banyak menyerang kelompok remaja, yang termasuk kelompok rentan dengan tingkat literasi kesehatan yang rendah. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan siswa Sekolah Menengah Kejuruan (SMK) tentang TB melalui edukasi interaktif berbasis sekolah. Intervensi dilaksanakan pada bulan Februari 2025 kepada 144 siswa kelas X dari empat jurusan di SMK Pawiyatan Surabaya dalam bentuk ceramah interaktif berbasis audio-visual. Desain evaluasi menggunakan one-group pretest-posttest. Hasil menunjukkan peningkatan rerata skor pengetahuan dari 68,70 (pre-test) menjadi 85,42 (post-test), atau meningkat sebesar 25.15%. Temuan ini menunjukkan bahwa edukasi TB yang terstruktur dan ramah remaja efektif dalam meningkatkan pengetahuan dan dapat menjadi strategi preventif dalam promosi kesehatan remaja.
Co-Authors Andriani, Nathania Disa Ariesta Desak Nyoman Surya Suameitria Dewi Florence Pribadi Gianina Angelia Santoso Gianina Angelina Santoso Hebert Adrianto Jonathan Loody Lukas Kevin Carwyn Dedwydd Lukas, Jonathan Loody Luke, Kevin Lyndia Effendy Mardhika, Della Maria Jessica Rachman Natalia Yuwono Nathania Disa Ariesta Andriani Patricia Priscilla Rosalind Angkawidjaja, Valerie Setiawan, Adinda Sucahyo, Yoselyn Tambuang, Christ Ummu Habibah, Ummu Wiraputri, Arini