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All Journal JURNAL BIOLOGI INDONESIA Global Health Management Journal Social Pedagogy: Journal of Social Science Education
Kusumah, Indra
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PENGARUH PLATELET-RICH PLASMA (PRP) TERHADAP PROLIFERASI DAN VIABILITAS HUMAN DERMAL FIBROBLAST (HDF) DALAM KONSENTRASI GLUKOSA TINGGI Hadi, Restu Syamsul; Kusumah, Indra; Sandra, Yurika
JURNAL BIOLOGI INDONESIA Vol 15, No 2 (2019): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v15i2.3815

Abstract

ABSTRACTThe administration of Platelet Rich Plasma (PRP) is expected to be a supplement for treatment of diabetic wounds and hyperglycemia by increasing growth factors. The purpose of this study was to examine the effect of Platelet Rich Plasma (PRP) on the proliferation and viability of human dermal fibroblast (HDF) in high glucose conditions, as a model for healing diabetic wounds in vitro. HDF cells are grown in DMEM medium containing high glucose which are then with PRP. To measure the effect of PRP on the HDF cell proliferation, CCK-8 kit was used and evaluated by using a microplate reader. To evaluate the viability of HDF, an automated cell counter. The results of the research showed that PRP stimulate the HDF cells proliferation. The optimal dose of PRP to increase HDF cell proliferation is at dose of PRP 10%.  Supplementation of PRP is significantly increased cell viability and HDF cell counts within 48 hours. The results showed PDGF growth factor secreted by PRP is increased significantly. The conclusion is PRP stimulated HDF cell proliferation and viability in a high glucose condition. This finding support the used of PRP as a therapy for diabetic wounds.  Keywords: proliferation, viability, human dermal fibroblast, platelet-rich plasma, diabetic
PENGARUH PLATELET-RICH PLASMA (PRP) TERHADAP PROLIFERASI DAN VIABILITAS HUMAN DERMAL FIBROBLAST (HDF) DALAM KONSENTRASI GLUKOSA TINGGI Hadi, Restu Syamsul; Kusumah, Indra; Sandra, Yurika
JURNAL BIOLOGI INDONESIA Vol 15, No 2 (2019): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v15i2.3815

Abstract

ABSTRACTThe administration of Platelet Rich Plasma (PRP) is expected to be a supplement for treatment of diabetic wounds and hyperglycemia by increasing growth factors. The purpose of this study was to examine the effect of Platelet Rich Plasma (PRP) on the proliferation and viability of human dermal fibroblast (HDF) in high glucose conditions, as a model for healing diabetic wounds in vitro. HDF cells are grown in DMEM medium containing high glucose which are then with PRP. To measure the effect of PRP on the HDF cell proliferation, CCK-8 kit was used and evaluated by using a microplate reader. To evaluate the viability of HDF, an automated cell counter. The results of the research showed that PRP stimulate the HDF cells proliferation. The optimal dose of PRP to increase HDF cell proliferation is at dose of PRP 10%.  Supplementation of PRP is significantly increased cell viability and HDF cell counts within 48 hours. The results showed PDGF growth factor secreted by PRP is increased significantly. The conclusion is PRP stimulated HDF cell proliferation and viability in a high glucose condition. This finding support the used of PRP as a therapy for diabetic wounds.  Keywords: proliferation, viability, human dermal fibroblast, platelet-rich plasma, diabetic
Perceived of Survivors, Families, and Health Professionals on the Recovery Process of Schizophrenia in Indonesia: A Scoping Review Widianti, Efri; Hidayati, Nur Oktavia; Rafiyah, Imas; Kusumah, Indra
GHMJ (Global Health Management Journal) Vol. 6 No. 2 (2023)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-62975

Abstract

Background: The recovery process of people with Schizophrenia in Indonesia is still not optimal. The lack of success in the recovery process is indicated by the relapse rate in people with schizophrenia, which is still high. Aims: This literature review aims to describe the views of ODS, families, and health workers in the ODS recovery process in Indonesia. Methods: A literature search was carried out using Google Scholar and also The databases PubMed and CINAHL with the keywords Schizophrenia OR psychosis AND family OR Caregiver OR relatives OR care OR spouse OR sibling OR parents AND psychiatrist AND mental health nurse AND mental health professionals AND Perspective OR Perceived AND Recovery AND Indonesia with free-full text criteria in English and Indonesian, and publication time has no limitations. Results: Based on a literature review of 13 articles, different views were obtained between survivors, families, and mental health professionals.  Conclusion: The results of these findings recommend that mental health policymakers consider the views of survivors, families, and health workers regarding recovery in survivors to produce appropriate strategies to help survivors achieve a state of recovery.   Received: 21 November 2023, Revised: 21 December 2023, Accepted: 25 December 2023.
BASRENG: Inovasi Pembelajaran IPS Berbasis Gamifikasi dan Diferensiasi Soal dalam Meningkatkan Motivasi Belajar Siswa Ibrahim, Bagus; Adam, Fakih; Kusumah, Indra
SOCIAL PEDAGOGY: Journal of Social Science Education Vol. 6 No. 2 (2025): Social Pedagogy: Journal of Social Science Education
Publisher : Fakultas Tarbiyah dan Ilmu Keguruan Universitas Islam Negeri Jurai Siwo Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32332/social-pedagogy.v6i2.10898

Abstract

Pembelajaran Ilmu Pengetahuan Sosial (IPS) abad ke-21 menghadapi tantangan berupa keberagaman karakteristik siswa dan rendahnya keterlibatan dalam metode pembelajaran konvensional. Penelitian ini bertujuan untuk mengevaluasi efektivitas model pembelajaran BASRENG dalam meningkatkan motivasi belajar dan partisipasi siswa pada pembelajaran IPS. Penelitian menggunakan pendekatan deskriptif kuantitatif dengan melibatkan 28 siswa kelas VIII SMP Negeri 10 Bandung yang dipilih secara purposive sampling. Data dikumpulkan melalui angket. Validitas isi instrumen diuji melalui expert judgement oleh dosen pembimbing dan guru pamong. Data dianalisis menggunakan statistik deskriptif berupa perhitungan rata-rata skor tiap indikator. Implementasi BASRENG dilakukan selama tiga sesi pembelajaran berturut-turut tanpa media digital, menggunakan sistem soal bertingkat (ringan-hijau 5 poin, sedang-kuning 10 poin, berat-merah 15 poin) dengan elemen gamifikasi berupa poin dan papan peringkat. Hasil penelitian menunjukkan dampak positif model BASRENG terhadap pembelajaran IPS dengan skor rata-rata keseluruhan 3,93 (kategori baik). Indikator tertinggi adalah manfaat kerja kelompok (4,20), diikuti motivasi belajar akibat gamifikasi (4,08), kenyamanan menyampaikan pendapat (4,00), dan pemahaman materi (3,44). Model pembelajaran BASRENG efektif meningkatkan motivasi, partisipasi, dan kenyamanan, sementara diferensiasi soal memberikan ruang bagi keberagaman kemampuan siswa dalam pembelajaran kolaboratif IPS. BASRENG berpotensi menjadi alternatif strategis untuk sekolah dengan sumber daya terbatas dalam mengembangkan pembelajaran IPS yang bermakna dan kontekstual.
Co-Authors Adam, Fakih Efri Widianti Ibrahim, Bagus Imas Rafiyah Nur Oktavia Hidayati Restu Syamsul Hadi TATI NURHAYATI Yurika Sandra