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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Malluka, Rifka
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI DAN PENGUJIAN STABILITAS FISIK GEL ANTIJERAWAT LIOFILISAT LIMBAH KOKON ASAL KABUPATEN SOPPENG Dambur, An Maria Redi; Malluka, Rifka; Anton, Nurafiat; Kursia, Sukriani
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 2 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (653.215 KB) | DOI: 10.35799/pmj.2.2.2019.26529

Abstract

ABSTRACT Lyophilisate of cocoon silkworm (Bombyx mori L.) possess antibacterial activity against Propionibacterium acne, Staphylococcus epidermidis, and S. aureus which belong to the group of bacteria that cause acne. Therefore, this research was carried out to make a formula for anti-acne gel based on Carbopol 940®. The gel dosage form was chosen because it is easier to clean from the surface of the skin after use and contains no oil which can increase the severity of acne. The formulation was tested on the physical stability of the preparations in the form of organoleptic, homogeneity, pH, dispersibility, adhesion and viscosity tests. The results of the study showed that the anti-acne gel formulat had a good preparation quality and anti-acne activity. Keywords : Cocoon, gel, anti-acne, Propionibacterium acne, Staphylococcus epidermidis, Staphylococcus aureus   ABSTRAK Liofilisat kokon ulat sutera (Bombyx mori L.) memiliki aktivitas antibakteri terhadap Propionibacterium acne, Staphylococcus epidermidis, dan S. aureus yang merupakan bakteri penyebab jerawat. Oleh karena itu, penelitian ini dilakukan untuk membuat formula sediaan gel antijerawat dengan basis gel Carbopol 940®. Bentuk sediaan gel dipilih karena lebih mudah dibersihkan dari permukaan kulit setelah pemakaian dan tidak mengandung minyak yang dapat meningkatkan keparahan jerawat. Hasil formulasi dilakukan uji stabilitas fisik sediaan berupa uji organoleptik, homogenitas, pH, daya sebar, daya lekat dan viskositas. Hasil penelitian menunjukkan bahwa formulagel antijerawat liofilisat kokon memiliki kualitas sediaan yang baik. Kata kunci: Kokon, gel, antijerawat, Propionibacterium acne, Staphylococcus epidermidis, Staphylococcus aureus
Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves : Studi Difusi Formula Krim Ekstrak Etanol Terliofilisasi Daun Kelor (Moringa oleifera L.) Sapra, Amriani; Mus, Suwahyuni; Dwirandy, Dwirandy; Malluka, Rifka; Khairi, Nur
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15275

Abstract

Background: Moringa oleifera L. leaves have analgesic activity due to their flavonoids content. These polar antioxidants compounds usually have difficulty to diffuse through the skin. Objectives: The purpose of this study was to evaluate the diffusion parameters of cream contains the lyophilized of M. oleifera leaves ethanol extract. Material and Methods: The lyophilized of M.oleifera leaves ethanol extract (5%) formulated as an o/w cream with 2% of cetyl alcohol as a stiffening agent. The physical characteristics of the cream were determined for organoleptic, homogeneity, pH, viscosity, spreadability, and type of emulsion parameters. The diffusion parameters were determined with Franz cell diffusion using the skin's snake as a membrane with 0; 10; 30; 60 and 90 minutes sampling time. Results: Physical characteristics of the cream showed that o/w as the cream type with pH, viscosity, and spreadability value were 4.72±0.03; 14.000±225 cps; and 5.7±0.20 cm, respectively. The diffusion parameter showed total flavonoids penetrate through the membrane was 360.134±0.20 µg/cm2 with flux 239,875 µg/cm2hr. Conclusions: This study showed a cream formulation that fulfills the required physical characteristics standard and can deliver active compounds to penetrate through the membrane.
Co-Authors Anton, Nurafiat Dambur, An Maria Redi Dwirandy, Dwirandy Khairi, Nur Mus, Suwahyuni Sapra, Amriani Sukriani Kursia, Sukriani