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All Journal Manuju : Malahayati Nursing Journal Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Indonesia Sosial Sains Biomedika
Adiyaksa, Jongga
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Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review Adiyaksa, Jongga; Tjampakasari, Conny Riana
Biomedika Vol 16, No 1 (2024): Biomedika Februari 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i1.2799

Abstract

Bordetella Perussis transmits pertussis disease, known as whooping cough, through airborne secretions from the respiratory tract. The bacteria then attach to the epithelial cilia of the respiratory tract of other hosts. One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which in its inactivated form is the main component of all acellular pertussis vaccines. In addition, PTx also activates several receptors and can affect various signaling pathways independent of ADP ribosylation and adenylate cyclase. PTx has been used in many research fields due to its strong ADP-ribosylation properties. To detect PTx Bordetella pertussis can use diagnostic tests such as serology test. Aim of this literary study is to determine the types of examinations for the detection of Bordetella pertussis. This study used a narrative review method sourced from searches on PubMed and ScienceDirect. The results of this search showed various types of Bordetella pertussis detection, including detection by culture, serology, and PCR. In conclusion, culture is still recommended to assess vaccine efficacy and future vaccine development, serological tests are one of the main diagnostic procedures in cases of unvaccinated adolescents and adults using specific B. pertussis proteins as antigens, in the presence of increased IgA or IgG titers against the toxin pertussis (PT) and filamentous hemmagglutinin (FHA). PCR as a diagnostic tool for pertussis in neonates and children.
Latent Tuberculosis: Interaction of Mycobacterium tuberculosis with Macrophages Adiyaksa, Jongga; Rukmana, Andriansjah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/490

Abstract

Latent TB infection (LTBI) is a state of persistent immune response to Mycobacterium tuberculosis antigen stimulation but does not yet show clinically active TB. Macrophages can eliminate Mycobacterium tuberculosis through various mechanisms. The aim of this research is to determine the interaction of macrophages against Mycobacterium tuberculosis. Of the 116 articles screened, there were 42 articles that were in accordance with this literature study. Results from the studies reviewed It is possible that some individuals diagnosed with LTBI have recovered from the bacteria, while others have a very small chance of being reinfected.  Granulomas are a pathological sign of Mtb infection. The location of bacteria in the granuloma may influence the immune response necessary to control the infection. Mtb produces lipid and protein effectors that control inflammation and macrophage activity. By preventing Mtb-macrophage interactions and entry into human cells, tuberculosis can be avoided. In addition, many mycobacterial factors play important roles in immune evasion or aid reactivation. The class of proteins encoded by the rpf gene are known as resuscitation promoting factors, which appear to play an important role in reactivation. The Rpf gene is thought to be important in driving mycobacteria out of a dormant (and possibly latent) state.  
Development of Vaccine Candidates Against Mycobacterium Tuberculosis in 2019-2023 Adiyaksa, Jongga; Sjatha, Fithriyah
Malahayati Nursing Journal Vol 6, No 5 (2024): Volume 6 Nomor 5 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i5.14396

Abstract

ABSTRACT With extensive use of the Bacillus Calmette–Guérin (BCG) vaccine, the global prevalence of Mycobacterium tuberculosis (MTB) remains. A number of vaccines proposed to cure and prevent tuberculosis (TB) infection are undergoing various stages of clinical trials. Although vaccine production is progressing, more attention is needed. A number of TB vaccines are currently undergoing clinical trials, most of which rely on a combination of proteins and/or adjuvants or recombinant viral vectors specific for MTB antigens. We tried to cover the range of TB vaccines in this study by analyzing their composition, the immunological responses they elicit, and the stages of clinical trials. To find out the Development Of Prospective Vaccines Against Mycobacterium Tuberculosis. This research uses a literature review, between August 2023 and November 2023, the authors of this literature review checked PubMed, Science Direct, Google Scholar, and other databases containing research findings or scientific articles. Only studies that met the above search criteria were included in the systematic review. Many recently developed tuberculosis vaccines are reportedly in the final stages of clinical trials, where they have significantly strengthened the immune system and even produced protection against the host. Immunization produced by vaccines that have successfully passed the initial stages of clinical trials is safe and effective, and can even surpass BCG in terms of immunity.  Based on the description above, it can be concluded that many recently developed tuberculosis vaccines are reported to be in the final stages of clinical trials, where they have significantly strengthened the immune system and even produced protection against the host. Immunization produced by vaccines that have successfully passed the initial stages of clinical trials is safe and effective, and can even surpass BCG in terms of immunity. With the development of new TB vaccines that strengthen the body's immunity and create effective delivery mechanisms, hopes for TB treatment and prevention are increasing. The development of vaccine effects can be facilitated, in part, through the use of effective delivery mechanisms, which have also been used in TB vaccines. Keywords: Tuberculosis, Vaccine, Bacteria, Mycobacterium Tuberculosis, BCG
The Role of Type 2 Diabetes Mellitus Education in Preventing Type 2 Diabetes Mellitus in Students of the Nutrition DIII Study Program Cirebon Tasikmalaya Polytechnic Adiyaksa, Jongga; Vimala, Dewi; Sasi, Maheswari Adya; Rahmadina, Regita
Jurnal Indonesia Sosial Sains Vol. 6 No. 10 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i10.1935

Abstract

The International Diabetes Federation (IDF) reports that the global prevalence of type 2 diabetes mellitus (T2DM) was 9.3% in 2019, with projections indicating that the number of people affected will reach 578 million by 2030 and 700 million by 2045. Indonesia ranks seventh globally, with 10.7 million people living with diabetes—figures expected to rise to 13.7 million by 2030 and 16.6 million by 2045. West Java Province ranks 18th nationally based on diagnoses in populations aged ≥15 years. The purpose of this study is to examine the effectiveness of type 2 diabetes mellitus education in prevention efforts. This study employed a quantitative descriptive design to assess the impact of T2DM education on prevention among 77 nutrition students at Tasikmalaya Polytechnic, selected using Slovin’s formula with a 5% margin of error. Data were collected through structured questionnaires administered before and after the educational intervention, and analyzed using frequency distribution. Results revealed significant improvements in knowledge: prior to education, 53% of respondents demonstrated good knowledge, 44.1% adequate knowledge, and 2.9% poor knowledge. Following the intervention, 93.5% exhibited good knowledge, 6.5% adequate knowledge, and 0% poor knowledge—representing an increase of 31 respondents in the good knowledge category. The educational program was highly effective in enhancing students’ understanding of T2DM prevention. This improvement provides a vital foundation for fostering preventive health behaviors among future nutritionists, who will serve as health promoters in their communities. The findings offer implications for curriculum development, community health education initiatives, and long-term behavioral change strategies.
Co-Authors . Andriansjah Rahmadina, Regita Sasi, Maheswari Adya SJATHA, FITHRIYAH Tjampakasari, Conny Riana Vimala, Dewi