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All Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Media Farmasi
Butar-Butar, Maria
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Keluhan Gangguan Kulit pada Pemulung Wanita Di Tempat Pembuangan Akhir (TPA) Terjun Ferusgel, Agnes; Nasution, Rina Mahyurni; Butar-Butar, Maria
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 3, No 2 (2018): December
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.744 KB) | DOI: 10.30604/jika.v3i2.127

Abstract

Female scavengers at Terjun Landfill when working are still found who have not used a complete PPE and are still lacking in personal hygiene, this can cause health problems, one of which is complaints of skin disorders such as itching, redness, and burning. The hypothesis in this study is that there is a relationship between working period, personal hygiene, and the use of PPE with complaints of skin disorders in female scavengers at TPA Falls. This research is an analytic observational survey research with cross-sectional approach. The population and sample in this study were all 53 female scavengers carried out at the Terjun Landfill in Marelan, Medan. Analysis of the data used is a multiple linear regression test. The results showed that there was a relationship between personal hygiene (p = 0.022) and PPE use (P = 0.025) with complaints of skin disorders in female dwellers at Terjun Landfill Marelan, while there was no relationship between work expectations with complaints of skin disorders in female scavengers. The results showed the need for cross-sectoral cooperation to improve the health status of scavengers, one of which was by conducting socialization on occupational safety and health, including in terms of personal hygiene at work and the importance of using PPE for scavengers.
Antihypertensive Activity Profile of Bangkirai Leaves (Shorea laevis Ridl.) Ethanol Extract on Angiotensin II (4ZUD) and β-Adrenergic (6PS5) Receptors Agus, Adhe; Siswandono, Siswandono; Butar-Butar, Maria; Fernandes, Andrian; Maharani, Rizki
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.994

Abstract

Hypertensive is a cardiovascular system disorder characterized by systolic pressure ≥ 140mmHg and diastolic ≥ 90mmHg. The increase in blod pressure is due to the mechanism of angiotensin II and β-adrenergic receptors, so in developing medicine for hypertension, compounds are needed to inhibit the activation of angiotensin II to angiotensin II, as well as β-adrenergic. Kalimantan, Indonesia has a biodiversity that has the potential as medicine such as Bangkirai (Shorea laevis Ridl.). Based on previous research on secondary metabolites, various compounds have been identified that have potential as new drug candidates, for example as antihypertensive. This study aims to determine the pharmacological profile and mechanism of angiotensin I inhibition at the 4ZUD and β-adrenergic receptors inhibition at the 6PS5 receptor, from ethanol extract of bangkirai leaves by carrying out molecular docking which begins with several stages including preparation and optimization of the structure of the test compound and structure preparation of 3D receptors 4ZUD and 6PS5. To find out the correctness of the method, validation was carried out on the Olmesartan ligand compound for 4ZUD and the propranolol ligand for 6PS5. Based on research carried out on both receptors, results were obtained for the test compounds in the form of MolDockScore, the pharmacological profile of absorption, distribution, metabolism, excretion, and toxicity. MolDockScore results show that the compound Colchicine, N-desacetyl-N-[4-hydroxy-3,5-dimethoxycinnamoyl] has the lowest values, namely -146.503 at the 4ZUD receptor dan -129.718 at the 6PS5 receptor, which is close to the natural ligand value compared to other metabolite compounds. Apart from that, it also provides good results based on the pharmacological profile of the 4ZUD and 6PS5 receptors including HIA (95.73%), Caco2 (35.14nm/second), and PPB (87.67%). Negative test results are also shown in the mutagenic toxicity profile (Ames Test Method), non-mutagenic, and carcinogenic tests which include genotoxic and nongenotoxic.
Co-Authors Agus, Adhe Andrian Fernandes, Andrian Ferusgel, Agnes Nasution, Rina Mahyurni Rizki Maharani Siswandono, Siswandono