Article Per Year (5 Year)
p-Index From 2020 - 2025
0.778
P-Index
This Author published in this journals
All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Farmasi Simplisia Media Farmasi
Siswandono, Siswandono
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Antihypertensive Activity Profile of Bangkirai Leaves (Shorea laevis Ridl.) Ethanol Extract on Angiotensin II (4ZUD) and β-Adrenergic (6PS5) Receptors Agus, Adhe; Siswandono, Siswandono; Butar-Butar, Maria; Fernandes, Andrian; Maharani, Rizki
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.994

Abstract

Hypertensive is a cardiovascular system disorder characterized by systolic pressure ≥ 140mmHg and diastolic ≥ 90mmHg. The increase in blod pressure is due to the mechanism of angiotensin II and β-adrenergic receptors, so in developing medicine for hypertension, compounds are needed to inhibit the activation of angiotensin II to angiotensin II, as well as β-adrenergic. Kalimantan, Indonesia has a biodiversity that has the potential as medicine such as Bangkirai (Shorea laevis Ridl.). Based on previous research on secondary metabolites, various compounds have been identified that have potential as new drug candidates, for example as antihypertensive. This study aims to determine the pharmacological profile and mechanism of angiotensin I inhibition at the 4ZUD and β-adrenergic receptors inhibition at the 6PS5 receptor, from ethanol extract of bangkirai leaves by carrying out molecular docking which begins with several stages including preparation and optimization of the structure of the test compound and structure preparation of 3D receptors 4ZUD and 6PS5. To find out the correctness of the method, validation was carried out on the Olmesartan ligand compound for 4ZUD and the propranolol ligand for 6PS5. Based on research carried out on both receptors, results were obtained for the test compounds in the form of MolDockScore, the pharmacological profile of absorption, distribution, metabolism, excretion, and toxicity. MolDockScore results show that the compound Colchicine, N-desacetyl-N-[4-hydroxy-3,5-dimethoxycinnamoyl] has the lowest values, namely -146.503 at the 4ZUD receptor dan -129.718 at the 6PS5 receptor, which is close to the natural ligand value compared to other metabolite compounds. Apart from that, it also provides good results based on the pharmacological profile of the 4ZUD and 6PS5 receptors including HIA (95.73%), Caco2 (35.14nm/second), and PPB (87.67%). Negative test results are also shown in the mutagenic toxicity profile (Ames Test Method), non-mutagenic, and carcinogenic tests which include genotoxic and nongenotoxic.
Inovasi Produk Olahan Tahu dan Pengemasannya serta Pengembangan Pemasaran dalam Upaya Meningkatkan Pendapatan Perajin Tahu di Desa Karanganyar Kecamatan Wates Kabupaten Kediri: Innovation in Processed Tofu Products and Their Packaging and Marketing Development in an Effort to Increase the Income of Tofu Crafters in Karanganyar Village, Wates District, Kediri Regency Purwanto, Bambang Tri; Ekowati, Juni; Widiandani, Tri; Hariyadi, Dewi Melany; Hendradi, Esti; Yusuf, Helmy; Purnomo, Ahmad Toto; Ramadhani, Firmansyah Ardian; Siswandono, Siswandono; Wiyono, Anang Setyo; Yuliati, Ninis; Kristianingsih, Ida; Savitri, Orchidea Meidy Nurintan; Maulia, Arwinda; Rahman, Ave
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 11 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i11.8698

Abstract

MSMEs in the food sector are among the main supporters of Indonesia's economic activities. As a food production center in the form of tofu products, Kediri Regency is well known to the public, with white, yellow, silk, and other tofu products. Most of the tofu production carried out to date is only in the form of tofu products in their original form. This is because tofu craftsmen have not utilized other processed tofu products to increase their income. This community service activity aims to introduce innovations in processed tofu products, packaging, marketing, and processing of liquid tofu waste into new products which are expected to increase the income of tofu makers in Karanganyar village, Wates District, Kediri Regency. This community service activity was carried out using the media of presenting several materials and carrying out two-way interactive discussions. Evaluation of this activity was carried out with pre- and post-tests from the participants by answering 10 questions related to the three materials. The results obtained after being analyzed using the SPSS program showed differences between the pre-and post-tests of the participants, whereas the post-test results showed that the participants had understood the material provided during this activity. Thus, it can be concluded that this activity can be proven to be understood by the participants regarding innovation in processed tofu products and processing of tofu liquid waste.
Andrographis paniculata Burm. F. in-silico analysis compounds that function as an insulin sensitizer therapy for type 2 diabetes via peroxisome proliferator activated gamma receptors (pparγ) receptor activator Pristiyantoro, Pristiyantoro; Siswandono, Siswandono; Mumpuni, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1651

Abstract

Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, requires safer PPARγ-targeting therapies to overcome the limitations of current thiazolidinediones (e.g., hepatotoxicity of pioglitazone). Andrographis paniculata, a traditional medicinal plant, contains bioactive flavonoids with putative insulin-sensitizing effects, although their PPARγ binding mechanisms remain unexplored. This study conducted in silico screening of eight A. paniculata compounds against PPARγ (PDB:5Y2O) using: (1) molecular docking (Molegro Virtual Docker 2013.6.0.0) to calculate binding affinities (MolDock/Rerank scores) and hydrogen bond interactions; (2) physicochemical profiling (ChemDraw Ultra 22.2/Chem3D Ultra 22.2) for drug-likeness parameters; and (3) ADMET prediction (pkCSM) for pharmacokinetic and toxicity assessment, with pioglitazone as the positive control. The results showed that 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone exhibited near-native binding (MolDock: -111.653 vs pioglitazone -137.994) with optimal ligand-receptor stabilization through strong hydrogen bonds (-7.840 kcal/mol) with Ser289, His323, and Tyr473, as well as hydrophobic interactions with Phe282 and Leu330. This compound also demonstrated better aqueous solubility (-3.404 vs -4.309 log mol/L; p<0.05) and a favorable safety profile (non-hepatotoxic, AMES-negative) despite lower Caco-2 permeability (0.141×10⁻⁶ cm/s). This study identifies 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone as a lead PPARγ agonist from A. paniculata with enhanced safety and drug-like properties. The HBond score of -7.840 suggests improved target specificity compared to pioglitazone. In vitro validation of glucose uptake modulation is recommended to confirm its therapeutic potential.
Studi Molecular Docking dan Prediksi Toksisitas Senyawa Kimia dari Salvia officinalis sebagai Antidiabetes Panca Bayu Chandra, Pra; Siswandono, Siswandono; Prasetiyo, Andri; Mumpuni, Esti; Aey Fadilah, Yasin; Sari Dewi, Rika
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 2 (2025): Desember 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i2.866

Abstract

Salvia officinalis digunakan secara luas sebagai obat tradisional untuk pengobatan diabetes tetapi mekanisme kerjanya masih belum jelas. Penelitian bertujuan memprediksi senyawa dalam Salvia officinalis yang berkhasiat sebagai antidiabetes secara in-silico dengan menggunakan perangkat lunak Molegro Virtual Docking. Docking dilakukan terhadap 17 senyawa uji dalam Salvia officinalis yaitu (-)-Camphor, (-)-Epicatechin, (3R)-Linalyl diphosphate, (E)-p-Coumaric acid, 1-Hydroxypinoresionol 1-glucoside, 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid, 5,7,3’,4’-Tetrahydroxyflavone, Apigenin, Borneol, Carnosolic acid, Gallocatechin 3-O-gallate, Geranyl diphosphate, Limonene, Methyl 2-[bis(2,2,2-trifluoroethoxy)phosphory]propanoate, Octadecanoic acid, Rosmadial, dan Rosmanol dengan reseptor peroxisome proliferator activated gamma (PDB: 3K8S) serta senyawa pembanding Pioglitazone HCl. Dari 17 senyawa uji, Gallocatechin 3-O-gallate diprediksi memiliki aktivitas sebagai antidiabetes yang bekerja pada peroxisome proliferator activated gamma dengan nilai rerank score -135.132 kcal/mol dengan aktivitas lebih baik dibandingkan obat Pioglitazone HCl. Gallocatechin 3-O-gallate diprediksi pada toksisitas berdasarkan AMES (mutagenik), Max. Tolerated Dose (human) (maximum recommended therapeutic dose atau MRTD rendah), oral rat acute toxicity (LD50) (tidak toksik), oral rat chronic toxicity (LOAEL) 4.209 (log dosis terendah yang bisa menimbulkan efek samping 4.209 mg/kg BB/hari), tidak hepatotoksis dan tidak menimbulkan sensitisasi pada kulit
Co-Authors Aey Fadilah, Yasin Agus, Adhe Anang Setyo Wiyono Andri Prasetiyo Andrian Fernandes, Andrian Bambang Tri Purwanto Butar-Butar, Maria Esti Hendradi Esti Mumpuni, Esti Hariyadi, Dewi Melany Ida Kristianingsih Juni Ekowati Maulia, Arwinda Ninis Yuliati, Ninis Panca Bayu Chandra, Pra Pristiyantoro, Pristiyantoro Purnomo, Ahmad Toto Rahman, Ave Ramadhani, Firmansyah Ardian Rizki Maharani Sari Dewi, Rika Savitri, Orchidea Meidy Nurintan Tri Widiandani Yusuf, Helmy