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All Journal Majalah Kedokteran Bandung Syntax Literate: Jurnal Ilmiah Indonesia Majalah Sainstekes Indonesian Community Journal Info Abdi Cendekia Yarsi Journal of Pharmacology Yarsi Dental Journal YARSI Medical and Dental Science (YASMINE)
Attamimi, Fathimah Azzahra
Dentistry, Faculty Of Dentistry, Universitas YARSI
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK KASAR UMBI SARANG SEMUT (MYRMECODIA PENDENS) DIBANDING DENGAN KLORHEKSIDIN TERHADAP STREPTOCOCCUS SANGUINIS Attamimi, Fathimah Azzahra; Ruslami, Rovina; Maskoen, Ani Melani
Majalah Kedokteran Bandung Vol 49, No 2 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.593 KB) | DOI: 10.15395/mkb.v49n2.1053

Abstract

Streptococcus sanguinis merupakan bakteri pionir penyebab plak gigi. Penggunaan obat kumur klorheksidin merupakan tindakan untuk mengontrol pembentukan plak gigi, namun karena efek sampingnya, klorheksidin tidak dapat digunakan untuk jangka panjang. Umbi sarang semut (Myrmecodia pendens) merupakan tanaman obat yang memiliki banyak aktivitas biologis untuk kesehatan. Penelitian ini bertujuan menguji aktivitas antibakteri ekstrak kasar umbi sarang semut terhadap bakteri S. sanguinis dibandingkan dengan klorheksidin dan pengaruh pemberian konsentrasinya terhadap kematian sel bakteri. Metode penelitian menggunakan uji  Kirby-Bauer untuk menentukan diameter hambat pertumbuhan bakteri, dilanjutkan dengan uji MIC untuk mengetahui nilai MIC dari sampel dan pengaruhnya terhadap kematian sel bakteri. Penelitian dilakukan pada bulan Agustus-Oktober 2015 di Laboratorium Kimia Organik Universitas Padjadjaran Hasil uji Kirby-Bauer ekstrak kasar umbi sarang semut menunjukkan aktivitas antibakteri. Zona hambat yang dihasilkan oleh ekstrak kasar tidak berbeda signifikan dengan klorheksidin (12 mm vs 15 mm, p>0,05). Nilai MIC ekstrak kasar berada diantara 9,77 ppm dan 19,53 ppm, nilai ini lebih kecil dibanding dengan klorheksidin, yaitu sebesar 1,935 ppm. Selain itu, terdapat korelasi positif dan kuat antara konsentrasi ekstrak kasar dan kematian sel bakteri S. sanguinis (r=0,867). Dapat disimpulkan ekstrak kasar umbi sarang semut memiliki efek antibakteri lebih kecil dibanding dengan klorheksidin. Peningkatan konsentrasi eksrak kasar umbi sarang semut memiliki korelasi positif dan kuat terhadap peningkatan kematian sel bakteri S. sanguinis. [MKB. 2017;49(2):94?101] Kata kunci: Antibakteri, ekstrak kasar, klorheksidin, S. sanguinis, umbi sarang semut  Antibacterial Activity Test of Ant Nest Tuber (Myrmecodia Pendens) Crude Extract against  Streptococcus Sanguinis Compared to Chlorhexidine Streptococcus sanguinis is a pioneer bacterium that causes dental plaque formation. The use of chlorhexidine mouthwash is one of the treatments to control dental plaque. However, due to its side effects, chlorhexidine cannot be used in a long period. Ant nest tuber (Myrmecodia pendens) is one of the medicinal plants with variousbiological activities that are beneficial to human health. The purpose of this study was to examine the antibacterial activity of ant nest tuber crude extract against bacteria S. sanguinis compared to chlorhexidine and measure the effect of increased concentration on bacterial cell death. This study was conducted using Kirby-Bauer method to measure the diameter of bacterial growth inhibition in August?October 2015 at the Organic Chemistry Laboratory of Universitas Padjadjaran. The MIC was then measured to determine the MIC values of the sample and the effect on bacterial cell death. Kirby-Bauer test showed that the inhibition zone produced by crude extract was not significantly different from the one produced by chlorhexidine (12 mm vs 15 mm, p>0.05) when both were used to inhibith the growth of S. sanguinis. The MIC value of crude extract was between 9.77 ppm and 19.53 ppm, smaller than the MIC value of the chlorhexidine of 1.93 ppm. In addition, there was a positive and strong correlation (r=0.867) between the concentration of crude extract and S. sanguinis cell death.  Hence,  crude extract from ant nest tuber has a lower antibacterial effect than chlorhexidine in inhibiting the growth of S. sanguinis. Additionally, there is a strong correlation between the increased concentration of crude extract and increased S. sanguinis cell death. [MKB. 2017;49(2):94?101] Key words: Antibacterial, ant nest tuber, chlorhexidine, crude extract, S. sanguinis 
Aktifitas Antibakteri Terpenoid dari Umbi Sarang Semut (Myrmecodia pendens) Terhadap Streptococcus Sanguinis ATCC10556 Fathimah Azzahra Attamimi; Indah Permata Yuda
Yarsi Journal of Pharmacology Vol. 3 No. 2 (2022): July 2022
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v3i2.2653

Abstract

Latar belakang: Streptococcus sanguinis  dapat memfasilitasi perlekatan bakteri patogen penyebab periodontitis dan menjadi salah satu organisme penyebab endokarditits infektif. Kontrol plak berperan penting dalam pencegahan dan penanganan penyakit jaringan periodontal dan kondisi patologis yang terkait. Tanaman obat sarang semut (Myrmecodia pendans) memiliki kandungan senyawa terpenoid yang memiliki aktivitas biologis sebagai antibakteri dan diharapkan dapat menjadi agen alternatif dalam mengontrol pembentukan plak.Tujuan: Penelitian ini bertujuan untuk menguji aktifitas antibakteri senyawa terpenoid dari M. pendens dalam menghambat pertumbuhan bakteri S. sanguinis.Metode: Proses pemisahan dan pemurnian terpenoid dari M. pendens menggunakan teknik kromatografi kolom dengan pelarut n-heksana dan etil asetat. Isolat terpenoid yang didapatkan kemudian diuji dengan metode mikrodilusi untuk menentukan nilai minimal inhibitory concentration (MIC) dalam menghambat pertumbuhan S. Sanguinis. Hasil: Nilai MIC terpenoid dari M. pendens terhadap  S. sanguinis adalah 78.13 ppm. Inhibisi pertumbuhan S. sanguinis terlihat pada konsentrasi 78.13 ppm, 156.25 ppm, dan 312.5 ppm. Berdasarkan uji korelasi pearson, terdapat hubungan yang  kuat dan positif  (p< 0.001) antara pemberian terpenoid M. pendens terhadap inhibisi  S. sanguinisKesimpulan: Terpenoid M. pendens memiliki aktivitas antibakteri tehadap pertumbuhan S. sanguinis. Peningkatan konsentrasi terpenoid dari M. pendens mempengaruhi peningkatan inhibisi pertumbuhan bakteri S. sanguinis secara kuat dan signifikan.
Pengaruh Faktor Sosiodemografis dan Pengetahuan terhadap Perilaku Rasional Dokter Gigi dalam Penggunaan Antibiotik di Jakarta Selatan Attamimi, Fathimah Azzahra; Suseno, Challen Damara; Hatta, Ridhayani; Pratiwi, Alisa Novianty; Riani, Siti Nur
Majalah Sainstekes Vol. 12 No. 1 (2025): JUNI 2025
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v12i1.5549

Abstract

Tingginya prevalensi penyakit infeksi di Indonesia telah menyebabkan peningkatan penggunaan antibiotik, namun sering kali penggunaan tersebut tidak rasional, yang berisiko memicu resistensi bakteri dan efek samping. Penelitian ini difokuskan pada dokter gigi di Jakarta Selatan. Penelitian ini bertujuan untuk menganalisis pengaruh faktor sosiodemografi dan tingkat pengetahuan terhadap perilaku dokter gigi dalam penggunaan antibiotik yang rasional di Jakarta Selatan. Penelitian ini merupakan studi analitik observasional dengan desain cross-sectional. Sebanyak 106 responden dipilih menggunakan metode purposive sampling. Pengumpulan data dilakukan melalui kuesioner, dan analisis data dilakukan dengan uji chi-square dan regresi logistik. Mayoritas dokter gigi menunjukkan tingkat pengetahuan yang rendah (59,4%) dan perilaku yang kurang baik (51,9%) terkait penggunaan antibiotik yang rasional. Analisis chi-square menunjukkan hubungan signifikan antara usia, pengalaman praktik, dan pengetahuan dengan perilaku dokter gigi dalam penggunaan antibiotik rasional (p<0,05). Regresi logistik mengidentifikasi usia (POR 3,2; CI 1,4-7,4) dan pengetahuan (POR 2,8; CI 1,2-6,4) sebagai faktor determinan perilaku tersebut. Perilaku dokter gigi di Jakarta Selatan terkait penggunaan antibiotik yang rasional masih tergolong kurang baik, dipengaruhi oleh tingkat pengetahuan yang rendah dan faktor sosiodemografi (usia dan pengalaman praktik).
Antibacterial Effect of Black Ethanol Extract (Camellia sinensis) on The Growth of Porphyromonas gingivalis Bacteria Nurniza, Nita; Kartika, Dewi; Maulani, Chaerita; Attamimi, Fathimah Azzahra; Riani, Siti Nur
YARSI Dental Journal Vol. 1 No. 01 (2023): YARSI DENTAL JOURNAL
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ydj.v1i01.86

Abstract

Background: Chronic periodontitis is one of the inflammatory diseases in the oral cavity that can cause damage to the structure of the supporting tissues of the teeth. The bacterium Porphyromonas gingivalis is the cause of chronic periodontitis which has specific virulence factors that produce lipopolysaccharides by destroying the host cell wall mechanism. Black tea with the Latin name Camellia sinensis contains theaflavins with antibacterial effects. Materials and methods: This study was an in vitro experimental laboratory study with disc diffusion method (Kirby Bauer), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The samples of this study were black tea ethanol extract with a concentration of 10%, 20%, 40%, 60%, 80%, and 100% with positive control group is  chlorhexidine 0,2%, and negative control group is BHI broth, which tested Porphyromonas gingivalis. The Kruskal Wallis test results showed that there were statistically significant differences between the diameter of the bacterial inhibitory zone produced from the concentration group of black tea ethanol extract (7 mm), 40% (8,6 mm), 60% (10 mm), 80% (10,6 mm), and 100% (11,2 mm) (P <0.05). The Spearman correlation test results (r=0.431) showed a positive correlation with moderate strength between an increase in the concentration of black tea ethanol extract to the diameter of the bacterial inhibitory zone. Result: The MIC value in this study is 10% and the result of MBC is 20%. Conclusion: the ethanol extract of black tea has an antibacterial effect on Porphyromonas gingivalis. There is an increase in inhibition zone diameter along with an increase in the concentration of black tea extract, which indicates black tea ethanol extract has concentration-dependent antibacterial properties.
Edukasi Makanan Risiko Rendah Karies Pada Ibu-Ibu di Ruang Publik Terpadu Ramah Anak Harapan Mulia Jakarta Pusat Okky Marita Ardy; Fathimah Azzahra Attamimi; Nur Hidayati Nosi; Alisa Novianty Pratiwi; Dharma Satya Aprianto
I-Com: Indonesian Community Journal Vol 4 No 3 (2024): I-Com: Indonesian Community Journal (September 2024)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/i-com.v4i3.5240

Abstract

The results of the 2018 Riskesdas stated that 93% of young children have dental caries. One of the reasons is provision of food and drinks that cause caries. A mother has a major role in caring of children, such as teach healthy habits because children often imitate the adults. This education can help reduce the risk of dental caries in the family and increase awareness about the important role of food in dental health. This activity was carried out at RPTRA Harapan Mulia, Central Jakarta, with the aim of increasing mothers' knowledge about foods with low caries risk. The methods used include counseling using educational books about foods and drinks that are good for teeth, toothbrushes, and oral dental examinations. The results showed that there was a statistically significant difference P <0.05 regarding knowledge before and after being given education. Educational books make it easier for participants to catch information.
Edukasi Penyakit Periodontal untuk Mencegah Stunting pada Ibu-Ibu Usia Subur di RPTRA Harapan Mulia Jakarta Pusat Maulani, Chaerita; Marita Ardy, Okky; Hidayati Nosi P, Nur; Azzahra Attamimi, Fathimah; Satya Aprianto, Dharma; Ghisani M, Shabrina; Decita, Sekar
Info Abdi Cendekia Vol. 8 No. 2: Desember 2025
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/iac.v8i2.182

Abstract

Stunting masih menjadi masalah kesehatan yang serius di Indonesia, termasuk di DKI Jakarta. Penelitian menunjukkan adanya hubungan antara penyakit periodontal pada ibu hamil dengan peningkatan risiko berat badan lahir rendah (BBLR) dan risiko stunting. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan kesadaran wanita usia subur, khususnya ibu hamil, serta mengetahui status gizi ibu dan anak menggunakan pengukuran Lingkar Lengan Atas Tengah (LILA). Kegiatan dilakukan dalam bentuk ceramah interaktif dan demonstrasi menyikat gigi. Evaluasi dilakukan dengan menggunakan kuesioner pre-test dan post-test. Kegiatan diikuti oleh 38 peserta, dengan 30 orang terlibat aktif dalam pengukuran LILA dan mengisi pre-test serta post-test. Hasil pengukuran LILA menunjukkan 4 orang ibu mengalami malnutrisi energi kronis dan terjadi peningkatan pengetahuan ibu yang signifikan setelah intervensi edukasi. Rata-rata skor pre-test sebesar 59,67 dan meningkat menjadi 81,67 pada post-test. Kesimpulannya, edukasi kesehatan periodontal merupakan intervensi efektif yang dapat diintegrasikan ke dalam program pencegahan stunting di tingkat masyarakat. Kolaborasi antara tenaga kesehatan gigi, bidan, dan kader posyandu sangat penting untuk keberlanjutan program.
The Relationship Between Parents Level of Knowledge Regarding Topical Fluoride and the Prevalence of Dental Caries in Children Aged 9–11 Years shafa adilla putri mahesa; Djuned Prasonto; Fathimah Azzahra Attamimi; Siti Nur Riani
YARSI Dental Scientific Meeting - e Journal Vol 2 No 2 (2026): YARSI Medical and Dental Science (YASMINE) Journal
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yasmine.v2i2.6123

Abstract

Background: Dental caries is a significant oral health issue among school-aged children. Parental knowledge plays a crucial role in shaping children's oral health behavior, including preventive efforts through topical fluoride application. Purpose: This study aims to determine the relationship between parental knowledge regarding topical fluoride and dental caries prevalence in children aged 9-11 years at SDN Kelapa Gading Timur 01 North Jakarta, as well as its review from an Islamic perspective. Research method: The research method used is a correlational study with a quantitative approach, where knowledge data were collected via questionnaires and caries data through clinical examinations using DMFT and deft indices, subsequently analyzed with the Spearman correlation test. Results: The results showed that the level of parental knowledge was in the fair to good category and the prevalence of dental caries in children was in the low to moderate category. Statistical analysis revealed significant relationship between parental knowledge regarding topical fluoride and the prevalence of dental caries in the study subjects (p < 0.05). From an Islamic perspective, efforts to prevent dental caries are a form of parental responsibility in maintaining the child's physical health as an amanah (mandate) from Allah SWT. Keywords: Parental Knowledge, Topical Fluoride, Dental Caries, DMFT
The Effect of Ethanol Extract of Miana Leaves (Plectranthus scutellarioides (L.) Benth.) on the Viability of Human Gingival Fibroblasts Muhammad Rizqi; Bambang S Trenggono; Fathimah Azzahra Attamimi; Siti Nur Riani
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i5.64374

Abstract

Miana leaves (Plectranthus scutellarioides (L.) Benth.) are herbal plants containing bioactive compounds such as flavonoids, tannins, saponins, and alkaloids that potentially exhibit antibacterial and anti-inflammatory activities in dentistry. However, the safety of herbal materials on normal cells needs to be evaluated, including gingival fibroblasts which play an important role in wound healing and tissue regeneration. To determine the effect of ethanol extract of miana leaves on the viability of human gingival fibroblasts at various concentrations and to review its potential utilization from an Islamic perspective. This study was an in vitro experimental laboratory study. Human gingival fibroblast cells were cultured using DMEM medium and treated with ethanol extract of miana leaves at concentrations of 12.5, 25, 50, 100, and 200 µg/mL. The control groups consisted of solvent control, untreated control, and 10% DMSO control. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) method. Data were analyzed using Kruskal–Wallis test, Post Hoc Mann–Whitney test, and Spearman correlation analysis. The mean viability of gingival fibroblasts at concentrations of 12.5, 25, 50, 100, and 200 µg/mL were 121.48%, 116.69%, 117.09%, 117.09%, and 113.35%, respectively. The Kruskal–Wallis test showed a significant difference between the treatment and control groups (p0.05). There were differences in the viability of human gingival fibroblasts after treatment with ethanol extract of miana leaves, with a tendency for cell viability to decrease as the extract concentration increased.
Co-Authors Alisa Novianty Pratiwi Ani Melani Maskoen Bambang S Trenggono Decita, Sekar Dewi Kartika Dharma Satya Aprianto Djuned Prasonto Ghisani M, Shabrina Hidayati Nosi P, Nur Indah Permata Yuda Marita Ardy, Okky Maulani, Chaerita Muhammad Rizqi Nur Hidayati Nosi Nurniza, Nita Okky Marita Ardy Pratiwi, Alisa Novianty Riani, Siti Nur Ridhayani Hatta, Ridhayani Rovina Ruslami, Rovina Satya Aprianto, Dharma Shafa Adilla Putri Mahesa Siti Nur Riani Siti Nur Riani Suseno, Challen Damara