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All Journal Majalah Kedokteran Bandung Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal of Syiah Kuala Dentistry Society
Felisha Febriane Balafif
Microbiology, Department Of Oral Biology Faculty Of Dentistry Universitas Padjadjaran, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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AKTIVITAS ANTIJAMUR FRAKSI AIR SARANG SEMUT MYRMECODIA PENDENS PADA CANDIDA ALBICANS ATCC 10231 Balafif, Felisha Febriane; Satari, Mieke Hemiawati; Dhianawaty, Diah
Majalah Kedokteran Bandung Vol 49, No 1 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2339.104 KB) | DOI: 10.15395/mkb.v49n1.984

Abstract

Penggunaan tanaman herbal untuk pengobatan dan pencegahan penyakit semakin populer sehingga penelitian mengenai senyawa aktif dari tumbuhan yang berkhasiat semakin menjadi perhatian. Umbi sarang semut (Myrmecodia pendens) mengandung senyawa aktif berupa terpenoid, tanin, fenol, flavonoid, dan saponin yang memiliki efek antijamur pada Candida albicans. Penelitian ini bertujuan mengukur konsentrasi hambat minimum (KHM) dan konsentrasi bunuh minimum (KBM) fraksi air M. pendens dan menguji perbedaan efek antijamur antara fraksi air M. pendens dan nistatin pada C. albicans ATCC 10231. Penelitian dilaksanakan pada bulan Juni?Juli 2015 di Laboratorium Penelitian Jurusan Kimia Fakultas MIPA Universitas Padjadjaran. Penelitian ini menggunakan metode mikrodilusi dan nilai KHM diukur dengan  enzyme linked immunosorbent assay reader dan nilai KBM diukur dengan pengujian pada media agar. Data dianalisis menggunakan uji-t dengan level signifikan p<0,05 untuk menentukkan perbedaan efek antijamur fraksi air M. pendens dengan nistatin pada C. albicans. Hasil penelitian menunjukkan bahwa nilai KHM ialah 1.250 ?g/mL dan nilai KBM ialah 2.500 ?g/mL. Simpulan penelitian ini ialah nilai KHM serta KBM fraksi air M. pendens ialah 1.250 dan 2.500 ?g/mL dan terdapat perbedaan efek antijamur antara fraksi air dan nistatin terhadap C. albicans. [MKB. 2016;49(1):28?34]Kata kunci: Candida albicans, fraksi air, konsentrasi bunuh minimum, konsentrasi hambat minimum, Myrmecodia pendensAntifungal Activity of Ant Hill Myrmecodia Pendens Water Fraction against Candida Albicans ATCC 10231The use of herbal plant for treatment and prevention of diseases is getting more popular, emphasizing the need for studies on active compounds from plants. Ant hill (Myrmecodia pendens) contains active compounds such as terpenoid, tannin, phenol, flavonoid, and saponin which have antifungal effects on Candida albicans. The objectives of the study were to measure the value of minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of water fraction of M. pendens and antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. This study used microdilution and the effects were measured with enzyme linked immunosorbent assay reader to determine MIC value, followed by agar media assay to determine  MFC. Data were analyzed using T test with significant level p < 0.05 to determine antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. The result showed that MIC value was 1.250 ?g/ml and MFC value was 2.500 ?g/ml. T test showed significant difference of % inhibition cells growth effect between M. pendens water fraction and nystatin (p=0.014 < 0.05). It is concluded that the M. pendens water fraction has an antifungal effect against C. albicans with MIC and MFC values of 1.250 and 2.500 ?g/ml.There are differences in antifungal effects between water fraction of M. pendens and nystatin against C. albicans. [MKB. 2016;49(1):28?34]                                        Key words: Candida albicans, minimum fungicidal concentration, minimum inhibitory concentration,  Myrmecodia pendens, water fraction
The Role of Nutrition on the Immune Response Felisha Febriane Balafif; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.861 KB)

Abstract

The immune system reaction against infections and other foreign substances is known as the immune response. Nutrition is a critical component in the modulation of the immune system, hence the importance of a balanced diet. Better nutrition improves health, reinforces the immune system, contributes to longevity, and decreases the chance of non-communicable diseases. Thus, nutrition, health, and immune system are strongly connected. The aim of the present study is to evaluate current knowledge on the role of nutrition on the immune response. The article was conducted of two databases and were limited to the period from January 2018 to April 2023 with a combination of the following keywords: “role" and "nutrition" and "immune response. The results obtained were 17 articles found at the beginning of the search in both databases, and the 10 full text articles were selected for further review and discussion. The results of this study shows that immunonutrition plays a role in immune function. Nutrition such as vitamins A, B6, B12, C, D, E, and folate; and trace elements (zinc, iron, selenium, magnesium, and copper) play important and complementary roles in supporting both the innate and adaptive immune systems. The development and maintenance of our immune system are very intricately tied to our dietary pattern. Therefore, working on our food habits and improving our nutrition seem to be a pragmatic approach to strengthen our immune response. Multiple micronutrients play vital roles in supporting the immune response.
Early Childhood Caries Among Overweight and Obese Children Anggun Rafisa; Felisha Febriane Balafif; Nuroh Najmi; Faisal Kuswandani
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.313 KB)

Abstract

Dental caries and obesity are both global public health issues that can have an impact on overall systemic health. Despite numerous studies investigating the link between dental caries and obesity, the findings remain inconclusive. This review aimed to determine the relationship between overweight, obese and ECC, as well as the impact of other potential risk factors. Research articles were searched using electronic databases such as Pubmed and Scopus. The selection of studies was following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocols. The initial phase of searching for articles in databases yielded 1176 results. There were twenty-three articles that received full-text appraisals, and fourteen studies were eliminated for not meeting the eligibility criteria. Finally, the study included nine articles. Only one of the nine articles considered in this review was a cohort study. The years of publishing range from 2019 to 2023. The majority of the study settings (n=5) were in high-income countries. Five of the studies reviewed found no association between overweight or obesity and ECC, whereas four identified a significant association. Based on the findings of this review, the association between overweight, obesity, and ECC appears undetermined. The differences in the findings of the studies included in this review could be attributed to the various BMI indicators employed to define the nutritional status of children. Other risk factors such as family socioeconomic status, parental educational level, and parental awareness of oral hygiene and dental visits may influence the association between overweight, obesity, and ECC.
Efficacy of Local Anesthetic: A Narrative Literature Review and Clinical Update in Dentistry Faisal Kuswandani; Felisha Febriane Balafif; Nuroh Najmi; Anggun Rafisa
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.295 KB)

Abstract

Achieving adequate anesthesia in patients is one of the most important aspects of the practice of dentistry to control or eliminate of pain. Pain is one of the most commonly experienced symptoms in dentistry and is a major concern to the dentist. The most essential skill of all dental practitioners is the ability to provide safe and effective local anesthesia. Several local anesthetics are used by the dentist, lidocaine has been considered as the golden standard for local anesthetic agents in dentistry for years. Articaine and mepivacaine both relatively new anesthetic agents are now widely used too. The purpose of this article is to provide a pharmacological profile of the various local anesthetic formulations in current use and their technical considerations.
Oral Inflammation and The Role of Cytokine Nuroh Najmi; Faisal Kuswandani; Anggun Rafisa; Felisha Febriane Balafif
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.087 KB)

Abstract

Acute inflammation becomes chronic when inflammation prolongs. Oral inflammation can develop become chronic and can be serious disease. Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. Based on studied that cytokine can be one of markers of inflammation. In many diseases cytokines can be biomarkers of inflammation and recently many studies use cytokines as one of the biomarkers in additional examination for their studies
Oral Candida Albicans Colonization In Denture Wearer: A Literature Review Febriane Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Abstract

Denture stomatitis is the most prevalent multifactorial, chronic inflammatory oral condition amongs denture wearers. One of the primary roles of dentures in denture stomatitis is their potential to cause irritation and inflammation of the oral tissues. This continuous irritation creates an environment where fungal infections, notably C. albicans. The traumatic factors such as mechanical trauma caused by loose prosthesis can increase the risk of tissue penetration and colonization of Candida species. This literature review aimed to explore the colonization of C. albicans in the denture wearer. The article was conducted of two databases and were limited to the period from 2019 to 2024 with a combination of the following keywords: “oral Candida albicans” "colonization" "denture wearer". The results obtained A total of 243 articles were initially identified through the designated keywords in PubMed and Google scholar. After meticulous removal of duplicate articles and application of the inclusion and exclusion criteria, 7 articles met the study’s eligibility criteria. C. albicans was the predominant species recovered from oral caviproty of both denture wearers and non-denture wearers. C. albicans can not only adhere to the oral mucosa but also can colonize the surface of the acrylic denture when it is poorly maintained. The presence of prosthetic appliances changes the microenvironment of the oral cavity through the facilitation of Candida colonization and proliferation. The biofilm on the denture can enhance its adhesion adding to its virulence. Wearing of a denture has been found to enhance adhesion of C. albicans.
Antifungal effect of ethyl acetate fraction of Sarang semut (Myrmecodia pendens Merr.& Perry) against Candida albicans Balafif, Felisha Febriane; Satari, Mieke Hemiawati; Dhianawaty, Diah
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.36703

Abstract

ABSTRACTIntroduction: Oral candidiasis is a fungal infection of the oral cavity that is caused by Candida albicans (C. albicans). Treatment of oral candidiasis usually uses topical agents such as nystatin, but it comes with side effects. Research on medicinal materials from plants can be an alternative to chemical drugs. It has increasingly become a concern such as the tuber of sarang semut (Myrmecodia pendens Merr. & L.M. Perry). The aim of the study is to determine the effect of ethyl acetate and hexane fractions of M. pendens against C. albicans. Methods: M. pendens methanol extract used maceration method. As much as 33 g concentrated M. pendens methanol extract was partitioned with a separating funnel based on the polarity of the substances to obtain ethyl acetate fraction. The minimum inhibitory concentration (MIC) procedure was carried out by the microdilution method and measured by an ELISA reader. The minimum fungicidal concentration (MFC) was obtained conclusively on Mueller Hinton agar media at concentrations above MIC of ethyl acetate fraction of M. pendens. Results: Ethyl acetate fraction had antifungal effect against C. albicans. The MIC and MFC of ethyl acetate fraction were 625 μg/ml and 1.250 μg/ml. Conclusion: Ethyl acetate fraction of M. pendens can inhibit the growth of C. albicans. M. pendens can be developed as the prevention agent of oral candidiasis.Keywords: antifungal; candida albicans; ethyl acetate fraction; Myrmecodia pendens
Chemical And Physical Evaluation Of Herbal Artificial Saliva Formulations-Scoping Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.
Metabolic Disorders And Periodontal Disease: A Scoping Review Of Recent Studies Rafisa, Anggun; Febriane Balafif, Felisha; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

The bidirectional relationship between periodontal disease and metabolic disorders is of particular concern, as these conditions may exacerbate each other through shared inflammatory pathways and metabolic disturbances. This scoping review aims to comprehensively explore the current body of literature on the interconnection between metabolic disorders and periodontal disease. A comprehensive literature search was conducted across databases, such as PubMed and Scopus. This review included studies that focusing on the relationship between metabolic disorders and periodontal disease, as well as articles written in English and published between 2019 and 2024. Non-peer-reviewed articles, articles that were not available in full text, and animal studies were excluded. A total 186 studies met the inclusion and exclusion criteria and were included in the review. Only 2.2% of the studies employed an experimental design, while a substantial majority (77.4%) utilized observational methodologies The majority of the research (72.0%) focused on adults, with a relatively small proportion (16.1%) dedicated to children and adolescents. Research focusing on specific populations, such as women with obesity or gestational diabetes, was limited (7.5%). This review identified a significant gap in intervention studies specifically targeting metabolic disorders to improve periodontal outcomes. Furthermore, it underscores the need for more focused research on vulnerable populations such as children, adolescents, and pregnant women.
SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.
Co-Authors Agus Susanto Agus Susanto Anggun Rafisa Anisauma UTAMANİNGYAS Diah Dhianawaty Dyah Nindita Carolina Faisal Kuswandani Faisal Kuswandani Gondowidjojo, Yolanda Dwiutami Hazhiyyah, Nabila Ghassania Hening Tjaturina Pramesti Ibrahim Rahmat Ina Hendiani, Ina Indah Suasani Wahyuni Kuswandani , Faisal Mieke Hemiawati Satari Nuroh Najmi Ong, Paulus Anam Sari, Kartika Indah Syamila, Rahmi Hasna Warta Dewi, Warta