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All Journal Majalah Kedokteran Bandung Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal of Syiah Kuala Dentistry Society
Balafif, Felisha Febriane
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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AKTIVITAS ANTIJAMUR FRAKSI AIR SARANG SEMUT MYRMECODIA PENDENS PADA CANDIDA ALBICANS ATCC 10231 Balafif, Felisha Febriane; Satari, Mieke Hemiawati; Dhianawaty, Diah
Majalah Kedokteran Bandung Vol 49, No 1 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2339.104 KB) | DOI: 10.15395/mkb.v49n1.984

Abstract

Penggunaan tanaman herbal untuk pengobatan dan pencegahan penyakit semakin populer sehingga penelitian mengenai senyawa aktif dari tumbuhan yang berkhasiat semakin menjadi perhatian. Umbi sarang semut (Myrmecodia pendens) mengandung senyawa aktif berupa terpenoid, tanin, fenol, flavonoid, dan saponin yang memiliki efek antijamur pada Candida albicans. Penelitian ini bertujuan mengukur konsentrasi hambat minimum (KHM) dan konsentrasi bunuh minimum (KBM) fraksi air M. pendens dan menguji perbedaan efek antijamur antara fraksi air M. pendens dan nistatin pada C. albicans ATCC 10231. Penelitian dilaksanakan pada bulan Juni?Juli 2015 di Laboratorium Penelitian Jurusan Kimia Fakultas MIPA Universitas Padjadjaran. Penelitian ini menggunakan metode mikrodilusi dan nilai KHM diukur dengan  enzyme linked immunosorbent assay reader dan nilai KBM diukur dengan pengujian pada media agar. Data dianalisis menggunakan uji-t dengan level signifikan p<0,05 untuk menentukkan perbedaan efek antijamur fraksi air M. pendens dengan nistatin pada C. albicans. Hasil penelitian menunjukkan bahwa nilai KHM ialah 1.250 ?g/mL dan nilai KBM ialah 2.500 ?g/mL. Simpulan penelitian ini ialah nilai KHM serta KBM fraksi air M. pendens ialah 1.250 dan 2.500 ?g/mL dan terdapat perbedaan efek antijamur antara fraksi air dan nistatin terhadap C. albicans. [MKB. 2016;49(1):28?34]Kata kunci: Candida albicans, fraksi air, konsentrasi bunuh minimum, konsentrasi hambat minimum, Myrmecodia pendensAntifungal Activity of Ant Hill Myrmecodia Pendens Water Fraction against Candida Albicans ATCC 10231The use of herbal plant for treatment and prevention of diseases is getting more popular, emphasizing the need for studies on active compounds from plants. Ant hill (Myrmecodia pendens) contains active compounds such as terpenoid, tannin, phenol, flavonoid, and saponin which have antifungal effects on Candida albicans. The objectives of the study were to measure the value of minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of water fraction of M. pendens and antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. This study used microdilution and the effects were measured with enzyme linked immunosorbent assay reader to determine MIC value, followed by agar media assay to determine  MFC. Data were analyzed using T test with significant level p < 0.05 to determine antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. The result showed that MIC value was 1.250 ?g/ml and MFC value was 2.500 ?g/ml. T test showed significant difference of % inhibition cells growth effect between M. pendens water fraction and nystatin (p=0.014 < 0.05). It is concluded that the M. pendens water fraction has an antifungal effect against C. albicans with MIC and MFC values of 1.250 and 2.500 ?g/ml.There are differences in antifungal effects between water fraction of M. pendens and nystatin against C. albicans. [MKB. 2016;49(1):28?34]                                        Key words: Candida albicans, minimum fungicidal concentration, minimum inhibitory concentration,  Myrmecodia pendens, water fraction
Antifungal effect of ethyl acetate fraction of Sarang semut (Myrmecodia pendens Merr.& Perry) against Candida albicans Balafif, Felisha Febriane; Satari, Mieke Hemiawati; Dhianawaty, Diah
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.36703

Abstract

ABSTRACTIntroduction: Oral candidiasis is a fungal infection of the oral cavity that is caused by Candida albicans (C. albicans). Treatment of oral candidiasis usually uses topical agents such as nystatin, but it comes with side effects. Research on medicinal materials from plants can be an alternative to chemical drugs. It has increasingly become a concern such as the tuber of sarang semut (Myrmecodia pendens Merr. & L.M. Perry). The aim of the study is to determine the effect of ethyl acetate and hexane fractions of M. pendens against C. albicans. Methods: M. pendens methanol extract used maceration method. As much as 33 g concentrated M. pendens methanol extract was partitioned with a separating funnel based on the polarity of the substances to obtain ethyl acetate fraction. The minimum inhibitory concentration (MIC) procedure was carried out by the microdilution method and measured by an ELISA reader. The minimum fungicidal concentration (MFC) was obtained conclusively on Mueller Hinton agar media at concentrations above MIC of ethyl acetate fraction of M. pendens. Results: Ethyl acetate fraction had antifungal effect against C. albicans. The MIC and MFC of ethyl acetate fraction were 625 μg/ml and 1.250 μg/ml. Conclusion: Ethyl acetate fraction of M. pendens can inhibit the growth of C. albicans. M. pendens can be developed as the prevention agent of oral candidiasis.Keywords: antifungal; candida albicans; ethyl acetate fraction; Myrmecodia pendens
Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen (Garcinia mangostana Linn.) rind extract against Aggregatibacter actinomycetemcomitans Hendiani, Ina; Susanto, Agus; Carolina, Dyah Nindita; Ibrahim, Rahmat; Balafif, Felisha Febriane
Padjadjaran Journal of Dentistry Vol 32, No 2 (2020): July 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no2.27366

Abstract

Introduction: The main contents of mangosteen (Garcinia mangostana Linn.) is xanthone with antibacterial activity. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) was a gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localised aggressive periodontitis (LAP). Mangosteen rind extract could inhibit the growth of Porphyromonas gingivalis and A. actinomycetemcomitans. This study was aimed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen rind extract against A. actinomycetemcomitans. Methods: This study was an experimental and in-vitro study of antimicrobial properties of mangosteen (Garcinia mangostana Linn.).The extract of mangosteen was made by the maceration method using 70% ethanol solvent. A. actinomycetemcomitans (ATCC 43718) obtained from Laboratorium of Microbiology Airlangga University Surabaya. This study used a microdilution method and analysed using the Enzyme Linked Immune Sorbent Assay (ELISA). The determination of the MIC was measured using the formula for cell inhibition percentage. Three concentrations higher than the MIC standard were cultured on the Mueller Hinton agar. The lowest concentration on agar which was not found any growth of the bacterial colonies was determined as the MBC. Results: The results of this study indicated that the MIC and MBC of mangosteen rind extract against A. actinomycetemcomitans were 195.3 ppm and 1562.5 ppm, respectively. Conclusion: Mangosteen rind extract can inhibit and bactericide the growth of A. actinomycetemcomitans.
DIABETES MELITUS GESTASIONAL DAN KESEHATAN RONGGA MULUT IBU DAN ANAK: TINJAUAN LITERATUR Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25042

Abstract

Diabetes melitus gestasional (DMG) merupakan kondisi hiperglikemia spontan selama kehamilan, didiagnosis pada trimester kedua atau ketiga pada individu yang tidak menunjukkan tanda-tanda diabetes sebelum kehamilan. Sejumlah penelitian telah menemukan implikasi DMG terhadap kesehatan ibu dan anak, termasuk terhadap kesehatan rongga mulut. Tinjauan ini bertujuan untuk mengkaji secara komprehensif literatur-literatur yang mengevaluasi mengenai hubungan antara diabetes gestasional dan kesehatan rongga mulut ibu-anak, menyoroti aspek penting dari perawatan prenatal dan potensi dampak jangka panjang terhadap kesehatan rongga mulut. Kondisi hiperglikemia pada penderita DMG berkontribusi terhadap berbagai perubahan pada rongga mulut, seperti perubahan mikrobiota dan peningkatan risiko penyakit periodontal pada ibu maupun anak. Periodontitis juga dapat berkontribusi terhadap kondisi DMG, dimana translokasi bakteri periodontitis maupun faktor virulensinya ke sirkulasi sistemik dapat membebani kinerja sel imun inflamasi secara terus menerus sehingga meningkatkan pelepasan mediator proinflamasi dan vesikel ekstraseluler. Tinjauan ini menggaris bawahi perlunya penelitian lebih lanjut untuk mengeksplorasi strategi pencegahan dan intervensi yang dapat diterapkan untuk meningkatkan kesejahteraan ibu dan anak.
Bacteriology in Diagnosing Oral Odontogenic Infections: A Scoping Review Hazhiyyah, Nabila Ghassania; Dewi, Warta; Balafif, Felisha Febriane
Journal of Syiah Kuala Dentistry Society Vol 8, No 2 (2023): December 2023
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v8i2.32710

Abstract

Background: Odontogenic infection is an invasion of pathogenic microbes that originate from the tooth or its supporting structures and can spread to the surrounding tissue. Bacteriological examination to support the diagnosis. Objective: This study aims to discuss the role of bacteriological examination in helping to diagnose odontogenic infections. Method: Scoping review research type. Search for research gaps using the PCC strategy. PubMed, Scopus, ScienceDirect and Google Scholar databases were used to search for articles by entering keywords using Boolean Operators. Reporting of scoping review results using PRISMA-ScR guidelines. Results: Oral Streptococcus species in caries samples included S. mutans, S. salivarius, S. mitis and S. sanguis with the dominant bacteria being S. mutans. Results: The highest bacterial prevalence of odontogenic infections was Staphylococcus bacteria with high sensitivity to penicillin antibiotics. Periodontal pocket samples showed the highest differences in bacterial prevalence from the three articles, including Staphylococcus aureus, Fusobacterium nucleatum and Actinobacillus actinomycetemcomitans. Enterococcus was the dominant bacteria in two articles with samples taken from root canals. Odontogenic abscess samples showed that Gram-positive bacteria were more dominant than Gram-negative bacteria, which were the most common in the culture results of abscess patients. The spread of odontogenic infections in the facial space shows that Methicillin resistant Staphylococcus aureus (MRSA) strains are the dominant bacteria found. Conclusion: Bacteriological examination should be carried out to show the dominant bacteria that cause odontogenic infections, so that it has benefits to support the diagnosis and treatment plan by the dentist
Differences in handgrip strength and tooth loss between cognitively normal and impaired elderly: cross-sectional study Syamila, Rahmi Hasna; Sari, Kartika Indah; Balafif, Felisha Febriane; Gondowidjojo, Yolanda Dwiutami; Ong, Paulus Anam
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.62743

Abstract

Introduction: The aging process in elderly individuals triggers changes in the brain that can lead to a decline in cognitive function, impacting quality of life. Age-related physiological changes affect the muscles around the oral cavity and the musculoskeletal system. These changes manifest as a decrease in the mass and strength of the chewing muscles. Tooth loss further exacerbates the ability to chew. This study aims to analyze differences in handgrip strength and tooth loss between cognitively normal and impaired elderly. Methods: Observational analytic with cross-sectional design using the Mann-Whitney comparative significance test and independent sample t-test with a significance level of p<0.05 was conducted. A purposive sampling technique was applied to a population residing in Dago Village, Bandung. The inclusion criteria included elderly individuals aged ≥60 years, both male and female, able to communicate effectively, and willing to participate in the study by signing an informed consent form. Cognitive function was assessed through interviews using the Mini Mental State Examination (MMSE), along with an examination of the number of missing teeth and hand grip strength measured with the Electronic Hand Dynamometer (Camry EH101). Analyzed data used the Mann–Whitney test. Results: A total of 34 subjects met the inclusion criteria from the total population of 71 older adults examined. The independent sample t-test for handgrip strength showed that elderly individuals with cognitive impairment had weaker handgrip strength (mean=14.250, SD=5.0285) compared to cognitively normal individuals (mean=22.281, SD=6.0204), with a p-value of 0.0001 (p<0.05). The Mann–Whitney test results for tooth loss indicated that elderly individuals with cognitive impairment experienced greater tooth loss (range=11–32 teeth, mean=20.78) compared to cognitively normal individuals (range=0–10 teeth, mean=13.81), with a p-value of 0.041 (p<0.05). Conclusion: There are differences in hand grip strength and tooth loss were found between cognitively normal and impaired elderly.
Co-Authors Agus Susanto Anggun Rafisa Diah Dhianawaty Dyah Nindita Carolina Faisal Kuswandani Gondowidjojo, Yolanda Dwiutami Hazhiyyah, Nabila Ghassania Ibrahim Rahmat Ina Hendiani, Ina Mieke Hemiawati Satari Nuroh Najmi Ong, Paulus Anam Sari, Kartika Indah Syamila, Rahmi Hasna Warta Dewi, Warta